Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

FASEB Journal

Volumn 30, Issue 3, 2016, Pages 1207-1217

  Popov, Violeta B ^a   Jornayvaz, Francois R ^a   Akgul, Emin O ^a   Kanda, Shoichi ^a   Jurczak, Michael J ^a   Zhang, Dongyan ^a   Abudukadier, Abulizi ^a   Majumdar, Sachin K ^a   Guigni, Blas ^a   Petersen, Kitt Falk ^a   Manchem, Vara Prasad ^c   Bhanot, Sanjay ^c   Shulman, Gerald I ^a   Samuel, Varman T ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

Lipid induced insulin resistance; Nonalcoholic fatty liver disease; Wnt pathway

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BETA CATENIN; CERAMIDE; DIACYLGLYCEROL ACYLTRANSFERASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; LIVER TRIACYLGLYCEROL LIPASE; MESSENGER RNA; PROTEIN KINASE B BETA; PROTEIN KINASE C EPSILON; 1,2-DIACYLGLYCEROL; DIACYLGLYCEROL; FAT INTAKE; FATTY ACID; GLUCOSE; INSULIN; LIPID; PROTECTIVE AGENT; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; ENERGY METABOLISM; FATTY LIVER; GENE EXPRESSION; GLUCOSE METABOLISM; HEPATIC INSULIN RESISTANCE; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID COMPOSITION; LIPID LIVER LEVEL; LIVER; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; PERIPHERAL INSULIN RESISTANCE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; FAT INTAKE; GENETICS; METABOLISM; PHYSIOLOGY;

ADIPOSE TISSUE, WHITE; ANIMALS; BETA CATENIN; DIETARY FATS; DIGLYCERIDES; FATTY ACIDS; FATTY LIVER; GLUCOSE; INSULIN; INSULIN RESISTANCE; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; PROTECTIVE AGENTS; TRIGLYCERIDES;

EID: 84963934397     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-271999     Document Type: Article

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