Multifaceted health benefits of Mangifera indica L. (Mango): The inestimable value of orchards recently planted in sicilian rural areas

Nutrients

Volumn 9, Issue 5, 2017, Pages

  Lauricella, Marianna ^a   Emanuele, Sonia ^a   Calvaruso, Giuseppe ^a   Giuliano, Michela ^a   D’Anneo, Antonella ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Mangifera indica L. fruit; Nutraceutical properties

Indexed keywords

CAROTENOID; CYCLOOXYGENASE 2 INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 6; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIPID PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; MANGIFERIN; MINERAL; NUTRACEUTICAL; NUTRITION SUPPLEMENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXYNITRITE; PLANT MEDICINAL PRODUCT; POLYPHENOL; POTASSIUM; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; VITAMIN;

AGING; AGRICULTURAL MANAGEMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOCHEMICAL COMPOSITION; CARDIOVASCULAR DISEASE; CELL DEATH; DEGENERATIVE DISEASE; EUROPEAN; HUMAN; ITALY; MANGO; NONHUMAN; NUTRITIONAL VALUE; ORCHARD; OXIDATIVE STRESS; REVIEW; AGRICULTURE; CHEMISTRY; FRUIT; MANGIFERA; SICILY;

AGRICULTURE; FRUIT; HUMANS; MANGIFERA; NUTRITIVE VALUE; SICILY;

EID: 85019563035     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9050525     Document Type: Review

References (82)

1. Liu, R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am. J. Clin. Nutr. 2003, 78, 517S-520S. [PubMed]
2. Micha, R.; Peñalvo, J.L.; Cudhea, F.; Imamura, F.; Rehm, C.D.; Mozaffarian, D. Association between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States. JAMA 2017, 317, 912-924. [CrossRef] [PubMed]
3. Willett,W.C. Diet, nutrition, and avoidable cancer. Environ. Health Perspect. 1995, 103, 165-170. [CrossRef] [PubMed]
4. Temple, N.J. Antioxidants and disease: more questions than answers. Nutr. Res. 2000, 20, 449-459. [CrossRef]
5. Usman, M.; Fatima, B.; Muhammad, M.J. Breeding in Mango. Int. J. Agric. Biol. 2001, 3, 522-526.
6. Kostermans, A.J.G.H.; Bompard, J.M. The Mangoes, Their Botany, Nomenclature, Horticulture and Utilization; Academic Press: London, UK, 1993. Available online: https://books.google.it/books/about/The_Mangoes. html?id=UpstquPSMYoC&redir_esc=y (accessed on 23 March 2017).
7. Mukherjee, S.K. Origin, distribution and phylogenetic affinities of the species of Mangifera indica L. J. Linn. Soc. Bot. 1953, 55, 65-83. [CrossRef]
8. Blancas-Benitez, F.J.; Mercado-Mercado, G.; Quirós-Sauceda, A.E.; Montalvo-González, E.; González-Aguilar, G.A.; Sáyago-Ayerdi, S.G. Bioaccessibility of polyphenols associated with dietary fiber and in vitro kinetics release of polyphenols in Mexican ‘Ataulfo’ mango (Mangifera indica L.) by-products. Food Funct. 2015, 6, 859-868. [CrossRef] [PubMed]
9. Khakimov, B.; Mongi, R.J.; Sørensen, K.M.; Ndabikunze, B.K.; Chove, B.E.; Engelsen, S.B. A comprehensive and comparative GC-MS metabolomics study of non-volatiles in Tanzanian grown mango, pineapple, jackfruit, baobab and tamarind fruits. Food Chem. 2016, 213, 691-699. [CrossRef] [PubMed]
10. San, A.T.; Joyce, D.C.; Hofman, P.J.; Macnish, A.J.; Webb, R.I.; Matovic, N.J.; Williams, C.M.; De Voss, J.J.; Wong, S.H.; Smyth, H.E. Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chem. 2017, 221, 613-619. [CrossRef] [PubMed]
11. Rodríguez Pleguezuelo, C.R.; Durán Zuazo, V.H.; Muriel Fernández, J.L.; Franco Tarifa, D. Physico-chemical Quality Parameters of Mango (Mangifera indica L.) Fruits Grown in a Mediterranean Subtropical Climate (SE Spain). J. Agric. Sci. Technol. 2012, 14, 365-374.
12. Ismail, A.M.; Cirvilleri, G.; Lombard, L.; Crous, P.W.; Groenewald, J.Z.; Polizzi, G. Characterisation of neofusicoccum species causing mango dieback in Italy. J. Plant Pathol. 2013, 95, 549-557. [CrossRef]
13. Aiello, D.; Ferrante, P.; Vitale, A.; Polizzi, G.; Scortichini, M.; Cirvilleri, G. Characterization of Pseudomonas syringae pv. syringae isolated from mango in Sicily and occurrence of copper-resistant strains. J. Plant Pathol. 2015, 97, 273-282. [CrossRef]
14. Farina, V.; Corona, O.; Mineo, V.; D’Asaro, A.; Barone, F. Qualitative characteristics of Mango fruits (Mangifera indica L.), which have undergone preservation (Italian). Acta Italus Hortus 2013, 12, 70-73.
15. Masud Parvez,G.M. PharmacologicalActivities ofMango (Mangifera indica): AReview. J. Pharmacogn. Phytochem.2016, 5, 1-7.
16. United States Department of Agriculture (USDA). National Nutrient Database for Standard Reference, SR-28, Full Report (All Nutrients): 09176, Mangos, Raw National Agricultural Library. USDA. Available online:https://ndb.nal.usda.gov/ndb/foods/show/2271. (accessed on 25 January 2016).
17. Shahidi, F.; Janitha, P.K.; Wanasundara, P.D. Phenolic antioxidants. Crit. Rev. Food Sci. Nutr. 1992, 32, 67-103. [CrossRef] [PubMed]
18. Berardini, N.; Carle, R.; Schieber, A. Characterization of gallotannins and benzophenone derivatives from mango (Mangifera indica L. cv. ‘Tommy Atkins’) peels, pulp and kernels by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 2004, 18, 2208-2216. [CrossRef] [PubMed]
19. Berardini, N.; Fezer, R.; Conrad, J.; Beifuss, U.; Carle, R.; Schieber, A. Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. J. Agric. Food Chem. 2005, 53, 1563-1570. [CrossRef] [PubMed]
20. Masibo, M.; He, Q. Major Mango Polyphenols and Their Potential Significance to Human Health. Compr. Rev. Food Sci. Food Saf. 2008, 7, 309-319. [CrossRef]
21. Jahurul, M.H.; Zaidul, I.S.; Ghafoor, K.; Al-Juhaimi, F.Y.; Nyam, K.L.; Norulaini, N.A.; Sahena, F.; Mohd Omar, A.K. Mango (Mangifera indica L.) by-products and their valuable components: A review. Food Chem. 2015, 183, 173-180. [CrossRef] [PubMed]
22. Ajila, C.M.; Bhat, S.G.; Prasada Rao, U.J.S. Valuable components of raw and ripe peels from two Indian mango varieties. Food Chem. 2007, 102, 1006-1011. [CrossRef]
23. Guevara Garcia, M.; Gonzalez Laime, S.; Alvarez Leon, A.; Riano Montalvo, A.; Garrido, G.G.; Nunez Selles, A.J. Ethnomedical uses of Mangifera indica L. stem bark extract in Cuba (spanish). Rev. Cuba Plant Med.2004, 9, 27-32.
24. Sairam, K.; Hemalatha, S.; Kumar, A.; Srinivasan, T.; Ganesh, J.; Sarkar, M.; Venkataraman, S. Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica. J. Ethnopharmacol. 2003, 84, 11-15. [CrossRef]
25. Thambi, P.A.; John, S.; Lydia, E.; Iyer, P.; Sarah Jane Monica, S.J. Antimicrobial efficacy of mango peel powder and formulation of recipes using mango peel powder (Mangifera indica L.). Int. J. Home Sci. 2016, 2, 155-161.
26. Bbosa, G.S.; Kyegombe, D.B.; Ogwal-Okeng, J.; Bukenya-Ziraba, R.; Odyek, O.; Waako, P. Antibacterial activity of Mangifera indica (L.). Afric. J. Ecol. 2007, 45, 13-16. [CrossRef]
27. Masibo, M.; He, Q. Mango Bioactive Compounds and Related Nutraceutical Properties-A Review. Food Rev. Int. 2009, 25, 346-370. [CrossRef]
28. Ahmed, S.M.; Luo, L.; Namani, A.;Wang, X.J.; Tang, X. Nrf2 signaling pathway: Pivotal roles in inflammation. Biochim. Biophys. Acta 2017, 1863, 585-597. [CrossRef] [PubMed]
29. Done, A.J.; Traustadóttir, T. Nrf2 mediates redox adaptations to exercise. Redox Biol. 2016, 10, 191-199. [CrossRef] [PubMed]
30. Afifa, K.; Kamruzzaman, M.; Mahfuza, I.; Afzal, H.; Arzina, H.; Roksana, H. A comparison with antioxidant and functional properties among five mango (Mangifera indica L.) varieties in Bangladesh. Int. Food Res. J.2014, 21, 1501-1506.
31. Carlisi, D.; D’Anneo, A.; Martinez, R.; Emanuele, S.; Buttitta, G.; Di Fiore, R.; Vento, R.; Tesoriere, G.; Lauricella, M. The oxygen radicals involved in the toxicity induced by parthenolide in MDA-MB-231 cells. Oncol. Rep. 2014, 32, 167-172. [CrossRef] [PubMed]
32. Lauricella, M.; Carlisi, D.; Giuliano, M.; Calvaruso, G.; Cernigliaro, C.; Vento, R.; D’Anneo, A. The analysis of estrogen receptor-_ positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possible regulatory mechanisms. Int. J. Oncol. 2016, 49, 352-360. [CrossRef] [PubMed]
33. Notaro, A.; Sabella, S.; Pellerito, O.; Vento, R.; Calvaruso, G.; Giuliano, M. The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells. Int. J. Oncol. 2016, 48, 1039-1044. [CrossRef] [PubMed]
34. Campanella, C.; D’Anneo, A.; Marino Gammazza, A.; Caruso Bavisotto, C.; Barone, R.; Emanuele, S.; Lo Cascio, F.; Mocciaro, E.; Fais, S.; Conway De Macario, E.; et al. The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells. Oncotarget 2016, 7, 28849-28867. [CrossRef] [PubMed]
35. D’Anneo, A.; Carlisi, D.; Lauricella, M.; Puleio, R.; Martinez, R.; Di Bella, S.; Di Marco, P.; Emanuele, S.; Di Fiore, R.; Guercio, A.; et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013, 4, e891. [CrossRef] [PubMed]
36. Pellerito, O.; Notaro, A.; Sabella, S.; De Blasio, A.; Vento, R.; Calvaruso, G.; Giuliano, M. WIN induces apoptotic cell death in human colon cancer cells through a block of autophagic flux dependent on PPAR down-regulation. Apoptosis 2014, 19, 1029-1042. [CrossRef] [PubMed]
37. Marino Gammazza, A.; Campanella, C.; Barone, R.; Caruso Bavisotto, C.; Gorska, M.; Wozniak, M.; Carini, F.; Cappello, F.; D’Anneo, A.; Lauricella, M.; et al. Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence. Cancer Lett. 2017, 385, 75-86. [CrossRef] [PubMed]
38. Dhananjaya, B.L.; Shivalingaiah, S. The anti-inflammatory activity of standard aqueous stem bark extract of Mangifera indica L. as evident in inhibition of Group IA sPLA2. An. Acad. Bras. Cienc. 2016, 88, 197-209. [CrossRef] [PubMed]
39. Impellizzeri, D.; Talero, E.; Siracusa, R.; Alcaide, A.; Cordaro, M.; Maria Zubelia, J.; Bruschetta, G.; Crupi, R.; Esposito, E.; Cuzzocrea, S.; et al. Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. Br. J. Nutr. 2015, 114, 853-865. [CrossRef] [PubMed]
40. Duricova, D. What CanWe Learn from Epidemiological Studies in Inflammatory Bowel Disease? Dig. Dis. 2017, 35, 69-73. [CrossRef] [PubMed]
41. Papadakis, K.A.; Targan, S.R. Role of cytokines in the pathogenesis of inlammatory bowel disease. Ann. Rev.Med. 2000, 51, 289-298. [CrossRef] [PubMed]
42. Rogler, G.; Andus, T. Cytokines in inlammatory bowel disease. World J. Surg. 1998, 22, 382-389. [CrossRef] [PubMed]
43. Andresen, L.; Jørgensen, V.; Perner, A.; Hansen, A.; Eugen-Olsen, J.; Rask-Madsen, J. Activation of nuclear factor kB in colonic mucosa from patients with collagenous and ulcerative colitis. Gut 2005, 54, 503-509. [CrossRef] [PubMed]
44. Márquez, L.; Pérez-Nievas, B.G.; Gárate, I.; García-Bueno, B.; Madrigal, J.L.; Menchén, L.; Garrido, G.; Leza, J.C. Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis. World J. Gastroenterol. 2010, 16, 4922-4931. [CrossRef] [PubMed]
45. Garrido, G.; Blanco-Molina, M.; Sancho, R.; Macho, A.; Delgado, R.; Muñoz, E. An aqueous stem bark extract of Mangifera indica (Vimang) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB. Phytother. Res. 2005, 19, 211-215. [CrossRef] [PubMed]
46. Kim, H.; Banerjee, N.; Ivanov, I.; Pfent, C.M.; Prudhomme, K.R.; Bisson, W.H.; Dashwood, R.H.; Talcott, S.T.; Mertens-Talcott, S.U. Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Mol. Nutr. Food Res. 2016, 60, 1912-1923. [CrossRef] [PubMed]
47. Kim, H.; Banerjee, N.; Barnes, R.C.; Pfent, C.M.; Talcott, S.T.; Dashwood, R.H.; Mertens-Talcott, S.U. Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo. Mol. Carcinog. 2017, 56, 197-207. [CrossRef] [PubMed]
48. Severi, J.A.; Lima, Z.P.; Kushima, H.; Brito, A.R.; dos Santos, L.C.; Vilegas, W.; Hiruma Lima, C.A. Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.). Molecules 2009, 14, 1098-1110. [CrossRef] [PubMed]
49. Mahmoud-Awny, M.; Attia, A.S.; Abd-Ellah, M.F.; El-Abhar, H.S. Mangiferin Mitigates Gastric Ulcer in Ischemia/Reperfused Rats: Involvement of PPAR-, NF-_B and Nrf2/HO-1 Signaling Pathways. PLoS ONE 2015, 10, e0132497. [CrossRef] [PubMed]
50. Sharma, S.R.; Dwivedi, S.K.; Swarup, D. Hypoglycemic potential of Mangifera indica leaves in rats. Int. J. Pharmacol. 1997, 35, 130-133. [CrossRef]
51. Aderibigbe, A.O.; Emudianughe, T.S.; Lawal, B.A. Antihyperglycaemic effect of Mangifera indica in rat. Phytother. Res. 1999, 13, 504-507. [CrossRef]
52. Perpetuo, G.F.; Salgado, J.M. Effect of mango (Mangifera indica L.) ingestion on blood glucose levels of normal and diabetic rats. J. Plant Foods Hum. Nutr. 2003, 58, 1-12. [CrossRef]
53. Gondi, M.; Prasada Rao, U.J.S. Ethanol extract of mango (Mangifera indica L.) peel inhibits _-amylase and _-glucosidase activities, and ameliorates diabetes related biochemical parameters in streptozotocin (STZ)-induced diabetic rats. J. Food Sci. Technol. 2015, 52, 7883-7889. [CrossRef] [PubMed]
54. Nguyen, H.X.; Do, T.N.; Le, T.H.; Nguyen, M.T.; Nguyen, N.T.; Esumi, H.; Awale, S. Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. J. Nat. Prod. 2016, 79, 2053-2059. [CrossRef] [PubMed]
55. Kim, H.; Kim, H.; Mosaddik, A.; Gyawali, R.; Ahn, K.S.; Cho, S.K. Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. Food Chem. 2012, 133, 416-422. [CrossRef] [PubMed]
56. Corrales-Bernal, A.; Amparo Urango, L.; Rojano, B.; Maldonado, M.E. In vitro and in vivo effects of mango pulp (Mangifera indica cv. Azucar) in colon carcinogenesis. Arch. Latinoam. Nutr. 2014, 64, 16-23. [PubMed]
57. Abdullah, A.S.; Mohammed, A.S.; Rasedee, A.; Mirghani, M.E.; Al-Qubaisi, M.S. Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract. BMC Complement. Altern. Med. 2015, 15, 45-51. [CrossRef] [PubMed]
58. Banerjee, N.; Kim, H.; Krenek, K.; Talcott, S.T.; Mertens-Talcott, S.U. Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: role of the PI3K/AKT pathway and associated microRNAs. Nutr. Res. 2015, 35, 744-751. [CrossRef] [PubMed]
59. Oka, K.; Saito, F.; Yasuhara, T.; Sugimoto, A. A study of cross-reactions between mango contact allergens and urushiol. Contact Dermat. 2004, 51, 292-296. [CrossRef] [PubMed]
60. Matkowski, A.; Kuś, P.; Góralska, E.;Woźniak, D. Mangiferin-A bioactive xanthonoid, not only from mango and not just antioxidant. Mini Rev. Med. Chem. 2013, 13, 439-455. [CrossRef] [PubMed]
61. Andreu, G.P.; Delgado, R.; Velho, J.A.; Curti, C.; Vercesi, A.E. Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-Citrate. Eur. J. Pharmacol. 2005, 513, 47-55. [CrossRef] [PubMed]
62. Barreto, J.C.; Trevisan, M.T.; Hull,W.E.; Erben, G.; de Brito, E.S.; Pfundstein, B.; Würtele, G.; Spiegelhalder, B.; Owen, R.W. Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). J. Agric. Food Chem. 2008, 56, 5599-5610. [CrossRef] [PubMed]
63. Hewavitharana, A.K.; Tan, Z.W.; Shimada, R.; Shaw, P.N.; Flanagan, B.M. Between fruit variability of the bioactive compounds, _-carotene and mangiferin, in mango (Mangifera indica). Nutr. Diet. 2013, 70, 158-163. [CrossRef]
64. Lei, J.; Zhou, C.; Hu, H.; Hu, L.; Zhao, M.; Yang, Y.; Chuai, Y.; Ni, J.; Cai, J. Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells. J. Cell. Biochem. 2012, 113, 2633-2642. [CrossRef] [PubMed]
65. Kawpoomhae, K.; Sukma, M.; Ngawhirunpat, T.; Opanasopit, P.; Sripattanaporn, A. Antioxidant and neuroprotective effects of standardized extracts of Mangifera indica leaf. Thai J. Pharm. Sci. 2010, 34, 32-43.
66. Gold-Smith, F.; Fernandez, A.; Bishop, K.Mangiferin and Cancer: Mechanisms of Action. Nutrients 2016, 28, 396. [CrossRef] [PubMed]
67. Zhang, B.-P.; Zhao, J.; Li, S.-S.; Yang, L.-J.; Zeng, L.-L.; Chen, Y.; Fang, J. Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacol. Sin. 2014, 35, 257-266. [CrossRef] [PubMed]
68. Zhao, J.; Zhang, B.; Li, S.; Zeng, L.; Chen, Y.; Fang, J. Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells. Int. J. Mol. Med. 2014, 33, 1348-1354. [CrossRef] [PubMed]
69. Khurana, R.K.; Kaur, R.; Lohan, S.; Singh, K.K.; Singh, B. Mangiferin: a promising anticancer bioactive. Pharm. Pat. Anal. 2016, 5, 169-181. [CrossRef] [PubMed]
70. Núñez Selles, A.J.; Daglia, M.; Rastrelli, L. The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects. Biofactors 2016, 42, 475-491. [CrossRef] [PubMed]
71. Telang, M.; Dhulap, S.; Mandhare, A.; Hirwani, R. Therapeutic and cosmetic applications of mangiferin:A patent review. Expert Opin. Ther. Pat. 2013, 23, 1561-1580. [CrossRef] [PubMed]
72. Kawakami, C.M.; Gaspar, L.R. Mangiferin and naringenin affect the photostability and phototoxicity of sunscreens containing avobenzone. J. Photochem. Photobiol. B 2015, 151, 239-247. [CrossRef] [PubMed]
73. Saleh, S.; El-Maraghy, N.; Reda, E.; Baraka, W. Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-_. Ann. Braz. Acad. Sci. 2014, 86, 1935-1948. [CrossRef] [PubMed]
74. Hou, J.; Zheng, D.; Fung, G.; Deng, H.; Chen, L.; Liang, J.; Jiang, Y.; Hu, Y. Mangiferin suppressed advanced glycation end products (AGEs) through NF-_B deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats. Can. J. Physiol. Pharmacol. 2016, 94, 332-340. [CrossRef] [PubMed]
75. Liu, Y.W.; Zhu, X.; Zhang, L.; Lu, Q.; Wang, J.Y.; Zhang, F.; Guo, H.; Yin, J.L.; Yin, X.X. Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2013, 721, 355-364. [CrossRef] [PubMed]
76. Garrido, G.; Rodeiro, I.; Hernández, I.; García, G.; Pérez, G.; Merino, N.; Núñez-Sellés, A.; Delgado, R. In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang). Drug Chem. Toxicol. 2009, 32, 53-58. [CrossRef] [PubMed]
77. Pardo-Andreu, G.L.; Dorta, D.J.; Delgado, R.; Cavalheiro, R.A.; Santos, A.C.; Vercesi, A.E.; Curti, C. Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang’s main component. Chem. Biol. Interact. 2006, 159, 141-148. [CrossRef] [PubMed]
78. Pardo-Andreu, G.L.; Paim, B.A.; Castilho, R.F.; Velho, J.A.; Delgado, R.; Vercesi, A.E.; Oliveira, H.C. Mangifera indica L. extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. Pharmacol. Res. 2008, 57, 332-338. [CrossRef] [PubMed]
79. Martinez, G.; Delgado, R.; Pérez, G.; Garrido, G.; Núñez Sellés, A.J.; León, O.S. Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang). Phytother. Res. 2000, 4, 424-427. [CrossRef]
80. Wattanathorn, J.; Muchimapura, S.; Thukham-Mee, W.; Ingkaninan, K.; Wittaya-Areekul, S. Mangifera indica fruit extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model ofmild cognitive impairment. Oxid. Med. Cell. Longev. 2014, 2014, 132097-132104. [CrossRef] [PubMed]
81. Farina, V.; Mazzaglia, A.; Padoan, D.; Barone, F. Chemical-physical and sensory characterization of mango fruits (Mangifera indica L.) cultivated in Sicily (Italian). Acta Italus Hortus 2013, 12, 113.
82. Mazzaglia, A.; Piva, G.; D’Asaro, A.; Farina, V. Sensory profile of mango fruits (Mangifera indica L.) Cultivated in Sicily (Italian). Acta Italus Hortus 2013, 12, 113-115.