Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence

Cancer Letters

Volumn 385, Issue , 2017, Pages 75-86

  Marino Gammazza, Antonella ^a,b   Campanella, Claudia ^a,b   Barone, Rosario ^a,b   Caruso Bavisotto, Celeste ^a,b   Gorska, Magdalena ^c   Wozniak, Michal ^c   Carini, Francesco ^a   Cappello, Francesco ^a,b   D'Anneo, Antonella ^a   Lauricella, Marianna ^a   Zummo, Giovanni ^a   Conway de Macario, Everly ^d,e   Macario, Alberto J L ^b,d,e   Di Felice, Valentina ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b Euro Mediterranean Institute of Science and Technology   (Italy)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE   (United States)

Author keywords

Acetylation; Doxorubicin; Hsp60; p53; Replicative senescence; Ubiquitination

Indexed keywords

CHAPERONIN; CHAPERONIN 60; DOXORUBICIN; PROTEIN P53; ANTINEOPLASTIC ANTIBIOTIC; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; H2AFX PROTEIN, HUMAN; HISTONE; HSPD1 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; PROTEIN BINDING; TP53 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; CELL VIABILITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN PROCESSING; REPLICATIVE SENESCENCE; SENESCENCE; UBIQUITINATION; ACETYLATION; CARCINOMA, MUCOEPIDERMOID; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; GENETICS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACETYLATION; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARCINOMA, MUCOEPIDERMOID; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHAPERONIN 60; CHAPERONINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; G2 PHASE CELL CYCLE CHECKPOINTS; HISTONES; HUMANS; LUNG NEOPLASMS; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84997272197     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.10.045     Document Type: Article

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