The oxygen radicals involved in the toxicity induced by parthenolide in MDA-MB-231 cells

Oncology Reports

Volumn 32, Issue 1, 2014, Pages 167-172

  Carlisi, Daniela ^a   D'Anneo, Antonella ^a   Martinez, Roberta ^a   Emanuele, Sonia ^a   Buttitta, Giuseppina ^a   Di Fiore, Riccardo ^a   Vento, Renza ^a,b   Tesoriere, Giovanni ^a,b   Lauricella, Marianna ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Temple University   (United States)

Author keywords

Breast cancer cells; NADPH oxidase; Oxygen radicals; Parthenolide

Indexed keywords

APOCYNIN; DICHLOROFLUORESCEIN; DIPHENYLIODONIUM SALT; FLUORESCENT DYE; FLUOROCHROME; HYDROXYL RADICAL; HYDROXYPHENYL FLUORESCEIN; MITOSOX RED; OXYGEN RADICAL; PARTHENOLIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; COPPER ZINC SUPEROXIDE DISMUTASE; HYDROGEN PEROXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; BREAST CARCINOMA; CARCINOMA CELL; CELL COUNT; CELL LABELING; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EXPOSURE; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; SIGNAL DETECTION; BREAST NEOPLASMS; CELL SURVIVAL; DRUG EFFECTS; FEMALE; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; NADPH OXIDASE; SESQUITERPENES; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 84903203708     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3212     Document Type: Article

References (19)

1. Nauseef WM: Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases. Biochim Biophys Acta 1840: 757-767, 2014.
2. Paletta-Silva R, Rocco-Machado N and Meyer-Fernandes JR: NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity. Int J Mol Sci 14: 3683-3704, 2013.
3. Fukai T and Fukai MU: Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15: 1583-1606, 2011.
4. Landis GN and Tower J: Superoxide dismutase evolution and life span regulation. Mech Ageing Dev 126: 365-337, 2005.
5. Bartosz G: Reactive oxygen species: destroyers or messengers? Biochem Pharmacol 77: 1303-1315, 2009.
6. Zunino SJ, Ducore JM and Storms DH: Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells. Cancer Lett 254: 119-127, 2007. (Pubitemid 47058812)
7. Pacher P, Beckman JS and Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87: 315-424, 2007. (Pubitemid 46217686)
8. Ghantous A, Sinjab A, Herceg Z and Darwiche N: Parthenolide: from plant shoots to cancer roots. Drug Discov Today 18: 894-905, 2013.
9. Kreuger MR, Grootjans S, Biavatti MW, Vandenabeele P and D'Herde K: Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs 23: 883-896, 2012.
10. Wang W, Adachi M, Kawamura R, et al: Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity. Apoptosis 11: 2225-2235, 2006. (Pubitemid 44885398)
11. Nakabayashi H and Shimizu K: Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer 12: 453, 2012.
12. D'Anneo A, Carlisi D, Lauricella M, Emanuele S, Di Fiore R, Vento R and Tesoriere G: Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. J Cell Physiol 228: 952-967, 2013.
13. D'Anneo A, Carlisi D, Lauricella M, Martinez R, Emanuele S, Vento R and Tesoriere G: Parthenolide generates reactive oxygen species and autophagy in MDA-MB-231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis 4: e891, 2013.
14. Sun Y, St Clair DK, Xu Y, Crooks PA and St Clair WH: A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res 70: 2880-2890, 2010.
15. D'Anneo A, Carlisi D, Emanuele S, Buttitta G, Vento R, Tesoriere G and Lauricella M: Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells. Int J Oncol 43: 1895-1900, 2013.
16. Carlisi D, D'Anneo A, Angileri L, Lauricella M, Emanuele S, Vento R and Tesoriere G: Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation. J Cell Physiol 226: 1632-1641, 2011.
17. Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH and Alevriadou BR: Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther 329: 94-101, 2009.
18. Setsukinai K, Urano Y, Kakinuma K, Majima H and Nagano T: Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 278: 3170-3175, 2003. (Pubitemid 36801227)
19. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951.