WIN induces apoptotic cell death in human colon cancer cells through a block of autophagic flux dependent on PPARγ down-regulation

Apoptosis

Volumn 19, Issue 6, 2014, Pages 1029-1042

  Pellerito, Ornella ^a   Notaro, Antonietta ^b   Sabella, Selenia ^b   De Blasio, Anna ^b   Vento, Renza ^b   Calvaruso, Giuseppe ^b   Giuliano, Michela ^b  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Autophagy apoptosis interplay; Cannabinoids; Colon carcinoma cells; ER stress; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; BECLIN 1; CASPASE 3; CASPASE 9; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN FOS; PROTEIN P62; TRANSCRIPTION FACTOR JUND; ANTINEOPLASTIC AGENT; BENZOXAZINE DERIVATIVE; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL SURVIVAL; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; HUMAN; HUMAN CELL; LIGHT CHAIN; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; COLONIC NEOPLASMS; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BENZOXAZINES; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; MITOCHONDRIA; MORPHOLINES; NAPHTHALENES; PPAR GAMMA; SIGNAL TRANSDUCTION;

EID: 84902383141     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0985-0     Document Type: Article

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