An insight into the putative role of victuals like honey and its polyphenols in breast cancer

Current Science

Volumn 112, Issue 9, 2017, Pages 1839-1854

  Subramanian, Aruna Priyadharshni ^a   John, Agnes Aruna ^a   Vellayappan, Muthu Vignesh ^a   Balaji, Arunpandian ^a   Jaganathan, Saravana Kumar ^a,b   Manikandan, A ^c   Supriyanto, Eko ^a  

^a UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

^b TON DUC THANG UNIVERSITY   (Viet Nam)

^c BHARATH UNIVERSITY   (India)

Author keywords

Anti cancer; Apoptosis; Breast cancer; Honey; Phenolic

Indexed keywords

EID: 85019096548     PISSN: 00113891     EISSN: None     Source Type: Journal    
DOI: 10.18520/cs/v112/i09/1839-1854     Document Type: Review

References (117)

1. Defining Cancer. National Cancer Institute; available at: https://www.cancer.gov/
2. Bernard, S. and Christopher, P., World Cancer Report, IARC Nonserial Publication. WHO Press, 2014
3. Breast Cancer Facts and Figures. American Cancer Society, 2014; http://www.cancer.org/research/cancerfactsstatistics/breastcancerf actsfigures2014/
4. Gaffield, M. E., Culwell, K. R. and Ravi, A., Oral contraceptives and family history of breast cancer. Contraception, 2009, 80(4), 372-380
5. DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, Blackwell, Oxford, 2001, 2nd edn
6. Lof, M. and Weiderpass, E., Impact of diet on breast cancer risk. Curr. Opin. Obstet. Gynecol., 2009, 21(1), 80-85
7. Tonelli, D., Gattavecchia, E., Ghini, S., Porrini, C., Celli, G. and Mercuri, A. M., Honey bees and their products as indicators of environmental radioactive pollution. J. Radioanal. Nucl. Chem., 1990, 141(2), 427-436
8. Spence, J., The Cartoon History of the Universe II from the springtime of China to the Fall of Rome-Gonick, Broadway Books, New York, 1994, pp. 15-16
9. Altman, N., The Honey Prescription: The Amazing Power of Honey as Medicine, Inner Traditions/Bear & Co., 2010, pp. 60-62
10. Jaganathan, S. K. and Mandal, M., Antiproliferative effects of honey and of its polyphenols: a review. BioMed. Res. Int., 2009, 830616, 1-13; http://dx.doi.org/10.1155/2009/830616
11. Saunders, C. and Jassal, S., Breast Cancer, Oxford University Press, Oxford, 2009, 1st edn, p. 13; https://global.oup.com/academic/product/breast-cancer-9780199558698?cc=my&lang=en&
12. 'Genome Dictionary'; Retrieved 6 June 2015
13. Duncan, J. A., Reeves, J. R. and Cooke, T. G., BRCA1 and BRCA2 proteins: roles in health and disease. Mol. Pathol., 1998, 51(5), 237-247
14. Dennis, J., Ghadirian, P. and Little, J., Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast, 2010, 19(6), 479-483
15. Sotiriou, C. and Pusztai, L., Gene-expression signatures in breast cancer. N. Engl. J. Med., 2009, 360(8), 790-800
16. Lind, M. J., Principles of cytotoxic chemotherapy. Medicine, 2008, 36(1), 19-23
17. Corrie, P. G. and Pippa, G., Cytotoxic chemotherapy: clinical aspects. Medicine, 2008, 36(1), 24-28
18. David, W. B., The chemical composition of honey. J. Chem. Educ., 2007, 84(10), 1643-1647
19. Yao, L., Jiang, Y. M., D'Arcy, B., Singanosung, R., Datta, N., Caffin, N. and Raymont, K., Quantitative high performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys. J. Agric. Food Chem., 2004, 52(2), 210-214
20. Dimitrova, B., Gevrenova, R. and Anklam, E., Analysis of phenolic acids in honeys of different floral origin by solid-phase extraction and high-performance liquid chromatography. Phytochem. Anal., 2007, 18, 24-32
21. Jaganathan, S. K. and Mandal, M., Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Invest. New Drugs, 2010, 28, 624-633
22. Ahmed, S. and Othman, N. H., Review of the medicinal effects of Tualang honey and a comparison with manuka honey. Malays. J. Med. Sci., 2013, 20(3), 6-13
23. Socha, R., Juszczak, L., Pietrzyk, S. and Fortuna, T., Antioxidant activity and phenolic composition of herbhoneys. Food. Chem., 2009, 113(2009), 568-574
24. Yao, L., Datta, N., Tomás-Barberán, F. A., Ferreres, F., Martos, I. and Singanosung, R., Flavonoids, phenolic acids and abscicic acid in Australian and New Zealand Leptospermum honeys. Food. Chem., 2003, 81, 159-168
25. Ioannis, K., Karabagias, Elpida, Dimitriou, Stavros and Kontakos, Michael, G. Kontominas, Phenolic profile, colour intensity, and radical scavenging activity of Greek unifloral honeys. Eur. Food. Res. Technol., 2016, 242(8), 1-10
26. Lachman, J., Orsák, M., Hejtmánková, A. and Kovárová, E., Honey and health 155 Evaluation of antioxidant activity and total phenolics of selected Czech honeys. LWT-Food. Sci. Technol., 2010, 43(1), 52-58
27. Aljadi, A. M. and Kamaruddin, M. Y., Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chem., 2004, 85, 513-518
28. Ferreira, I. C. F. R., Aires, E., Barreira, J. C. M. and Estevinho, L. M., Antioxidant activity of Portuguese honey samples: different contributions of the entire honey and phenolic extract. Food Chem., 2009, 114, 1438-1443
29. Fatimah Buba, Abubakar, Gidado and Aliyu, Shugaba, Analysis of biochemical composition of honey samples from North-East Nigeria. Biochem. Anal. Biochem., 2013, 2(3), 1000139-1000146
30. Cossentini, M., Ferreres, F. and Tomás-Barberán, F. A., Flavonoid composition of tunisian honeys and propolis. J. Agric. Food Chem., 1997, 45, 2824-2829
31. Jaganathan, S. K., Can flavonoids from honey alter multidrug resistance? Med. Hypo., 2011, 76, 535-537
32. Jaganathan, S. K. and Mandal, M., Honey constituents and their apoptotic effect in colon cancer cells. J. ApiProd. ApiMed. Sci., 2009, 1(2), 29-36
33. Abdulaziz, S., Alqarni., Ayman, A. Owayss, Awad, A. Mahmoud, Physicochemical characteristics, total phenols and pigments of national and international honeys in Saudi Arabia. Arab. J. Chem., 2016, 9(1), 114-120
34. Schramm, D. D., Karim, M., Schrader, H. R., Holt, R. R., Cardetti, M. and Keen, C. L., Honey with high levels of antioxidants can provide protection to healthy human subjects. J. Agric. Food Chem., 2003, 51, 1732-1735
35. Manach, C., Scalbert, A., Morand, C. H., Rémesy, C. H. and Jimenez, L., Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr., 2004, 79, 727-747
36. Manach, C., Williamsom, G., Morand, C. H., Scalbert, A. and Rémesy, C. H., Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 2005, 81, 230S-242S
37. Scalbert, A. and Williamson, G., Dietary intake and bioavailability of polyphenols. J. Nutr., 2000, 130, 2073-2085
38. Alvarez-Suarez, J. M., Giampieri, F. and Battino, M., Honey as a source of dietary antioxidants structures, bioavailability and evidence of protective effects against human chronic diseases. Curr. Med. Chem., 2013, 20(5), 621-638
39. Tallarida, R. J., Drug synergism: its detection and applications. J. Pharmacol. Exp. Ther., 2001, 298, 865-872
40. Choi, E. J. and Kim, G. H., 5-Fluorouracil combined with apigenin enhances anti-cancer activity through induction of apoptosis in humanbreast cancer MDA-MB-453 cells. Oncol. Rep., 2009, 22(6), 1533-1537
41. Ayse, A. K., Ayse, B., Miris, D., Didem, T. C., Irfan, D. and Hasan, V. G., Evaluation of effects of Quercetin (3, 3', 4', 5, 7-pentohidroxyflavon) on apoptosis and telomerase enzyme activity in MCF-7 and NIH-3T3 cell lines compared with Tamoxifen. Balkan. Med. J., 2011, 28, 293-299
42. Huang, C., Lee, S. Y., Lin, C. L., Tu, T. H., Chen, L. H., Chen, Y. J. and Huang, H. C., Co-treatment with quercetin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose causes cell cycle arrest and apoptosis inhuman breast cancer MDA-MB-231 and AU565 cells. J. Agric. Food. Chem., 2013, 61(26), 6430-6445
43. Takahiro, E., Naoto, T., Hiroshi, N., Tadao, K., Kiyotaka, N. and Teruo, M., Synergistic inhibition of cancer cell proliferation with a combination of d-tocotrienol and ferulic acid. Biochem. Biophys. Res. Commun., 2014, 453(3), 606-611
44. Henry, P. C., Phillip, J. D. and Grace, C. Y., Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. Biochem. J., 1999, 340, 715-722
45. Kanokkarn, P., Supachai, Y., Songyot, A. and Pornngarm, L., Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. Acta Pharmacol. Sin., 2009, 30(8), 1169-1176
46. Margaret, L. A., Simone, V. D. W. and Rod, J., Synergistic Antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines. In vivo, 2005, 19, 69-76
47. Anna, V. T., Mari, J., Ioanna, C., Konstadia, G., Tiina, T., Vesa, V. and Paraskevi, M., Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: profile analysis of extracts. Food Chem., 2009, 116, 702-708
48. Mervat, M. A. and El-Gendy, In vitro, evaluation of medicinal activity of Egyptian honey from different floral sources as anticancer and antimycotic infective agents. J. Micro. Biochem. Technol., 2010, 2(5), 118-125
49. Jaganathan, S. K., Mandal, M. S., Saikat, K. J., Soumen, D. and Mandal, M., Studies on the phenolic profiling, anti-oxidant and cytotoxic activity of Indian honey: in vitro evaluation. Nat. Prod. Res., 2010, 24(14), 1295-1306
50. Jaganathan, S. K., Mondhe, D., Wani, Z. A., Pal, H. C. and Mandal, M., Effect of Honey and Eugenol on Ehrlich ascites and solid carcinoma. J. Biomed. Biotechnol., 2010, 1-5
51. Fauzi, A. N., Norazmi, M. N. and Yaacob, N. S., Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem. Toxicol., 2011, 49(4), 871-878
52. Yaacob, N. S., Nengsih, A. and Norazmi, M. N., Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines. Evid. Based. Complement. Alternat. Med., 2013, 989841, 1-9; http://dx.doi.org/10.1155/2013/989841
53. Yaacob, N. S. and Ismail, N. F., Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7and MCF-10A cells. BMC Complement. Altern. Med., 2014, 14, 106-115
54. Saxena, S., Kumar, D., Maurya, G. S. and Sharma, A., Effect of radiation hygienization of honey on its health protective properties. Food. Biosci., 2014, 8, 14-20
55. Kadir, E. A., Sulaiman, S. A., Yahya, N. K. and Othman, N. H., Inhibitory effects of Tualang honey on experimental breast cancer in rats: a preliminary study. Asian. Pac. J. Cancer. Prev., 2013, 14(4), 2249-2254
56. Orsolic, N., Knezevic, A., Sver, L., Terzic, S., Hackenberger, B. K. and Basic, I., Influence of honey bee products on transplantable murine tumours. Vet. Comp. Oncol., 2003, 1(4), 216-226
57. Yin, F., Giuliano, A. E., Law, R. E. and Van, H. A. J., Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer. Res., 2001, 21(1A), 413-420
58. Way, T. D., Kao, M. C. and Lin, J. K., Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activationin HER2/neu-overexpressing breast cancer cells. FEBS. Lett., 2005, 579(1), 145-152
59. Jin, X. Y. and Ren, C. S., Effect and mechanism of apigenin on VEGF expression in human breast cancer cells. Zhonghua. Zhong. Liu. Za Zhi, 2007, 29(7), 495-499
60. Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L. and Tseng, T. H., Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol. Appl. Pharmacol., 2008, 226(2), 178-191
61. Choi, E. J. and Kim, G. H., Apigenin induces apoptosis through a mitochondria/Caspase-pathway in human breast cancer MDAMB-453 cells. J. Clin. Biochem. Nutr., 2009, 44(3), 260-265
62. Choi, E. J. and Kim, G. H., Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SKBR-3 cells. J. Nutr. Biochem., 2009, 20(4), 285-290
63. Seo, H. S. et al., Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκ signaling in HER2-overexpressing breast cancer cells. Mol. Cell. Biochem., 2012, 366(1-2), 319-334
64. Mafuvadze, B., Benakanakere, I. and Hyder, S. M., Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. Menopause., 2010, 17(5), 1055-1063
65. Way, T. D., Kao, M. C. and Lin, J. K., Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breastcancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J. Biol. Chem., 2004, 279(6), 4479-4489
66. Seo, S. H., Ku, J. M., Choi, H. S., Woo, J. K., Jang, H. B., Shin, Y. C. and Ko, S. G., Induction of Caspase-dependent Apoptosis by Apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. Anticancer Res., 2014, 34, 2869-2882
67. Bowen, L., Bin, Z., Yue, Z., Weihong, F., Yuanyuan, L. J., Weiran, Z. and Xuchen, C., Apigenin Induces p53-dependent apoptosis and G2/M arrest in breast cancer T47D cells. Chinese J. Clin. Oncol., 2012, 39(6), 315-317
68. Weiran, Z., Bin, Z., Bowen, L. and Xuchen, C., Apigenin induction of p53-independent apoptosis in MDA-MB-231 breast cancers. Chinese J. Clin. Oncol., 2013, 40(3), 134-139
69. Megan, E. H., Melanie, R. P. C., Leanne, M. D. and David, W. H., Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. Exp. Mol. Pathol., 2014, 97, 211-217
70. Coral, O., Matko, K., Jing, W., Enrica, M., Krystyna, F. and Owen, A. O. C., Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J. Cancer. Sci. Ther., 2013, 5(10), 334-342
71. Jayaprakasam, B., Vanisree, M., Yanjun, Z., David, L. D. and Muraleedharan, G. N., Impact of alkyl esters of caffeic and ferulic acids on tumour cell proliferation, cyclooxygenase enzyme and lipid peroxidation. J. Agric. Food Chem., 2006, 54, 5375-5381
72. Luc, H. B., Nadia, P., Jeremie, D., Benoit, V., Marc, E. S., Gilles, A. R. and Mohamed, T., Caffeoyl and cinnamoyl clusters with anti-inflammatory and anti-cancer effects: synthesis and structure-activity relationship. New J. Chem., 2009, 33, 1932-1940
73. Qu, X. J. et al., Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2, to suppress tumour invasion and metastasis. Int. J. Mol. Med., 2006, 18(4), 609-614
74. Bailly, F., Toillon, R. A., Tomavo, O., Jouy, N., Hondermarck, H. and Cotelle, P., Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells. Bioorg. Med. Chem. Lett., 2013, 23(2), 574-578
75. Omene, C. O., Wu, J. and Frenkel, K., Caffeic acid phenethyl ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells. Invest. New. Drugs, 2012, 30(4), 1279-1288
76. Ahn, C. H., Choi, W. C. and Kong, J. Y., Chemosensitizing activity of caffeic acid in multidrug-resistant MCF-7/Dox human breast carcinoma cells. Anticancer Res., 1997, 17(3C), 1913-1917
77. Choi, J. A. et al., Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int. J. Oncol., 2001, 19(4), 837-844
78. Choi, E. J., Bae, S. M. and Ahn, W. S., Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch. Pharm. Res., 2008, 31(10), 1281-1285
79. Chien, S. Y. et al., Quercetin-induced apoptosis acts through mitochondrial-and caspase-3-dependent pathways in human breastcancer MDA-MB-231 cells. Hum. Exper. Toxicol., 2009, 28(8), 493-503
80. Chou, C. C. et al., Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through themitochondrial pathway in human breast cancer MCF-7 cells. Arch. Pharm. Res., 2010, 33(8), 1181-1191
81. Soyocak, A., Didem, T. C., Ayse, B., Irfan, D., Hasan, V. G., Fezan, S. M. and Ertugrul, ç., The association between apoptotic Bak protein and quercetin in breast and colon cancer cell lines. FABAD J. Pharm. Sci., 2009, 34, 83-89
82. Lee, Y. K. and Park, O. J., Involvement of AMPK/mTOR/HIF-1γ in anti-cancer control of quercetin in hypoxic MCF-7 cells. Food Sci. Biotechnol., 2011, 20(2), 371-375
83. Zhang, H., Zhang, M., Yu, L., Zhao, Y., He, N. and Yang, X., Antitumour activities of quercetin and quercetin-5',8-disulfonate in human colon and breast cancer cell lines. Food. Chem. Toxicol., 2012, 50(5), 1589-1599
84. Deng, X. H., Song, H. Y., Zhou, Y. F., Yuan, G. Y. and Zheng, F. G., Effects of quercetin on the proliferation of breast cancer cells and expression of survivin in vitro. Exp. Ther. Med., 2013, 6(5), 1155-1158
85. Du, G. et al., Dietary quercetin combining intratumoural doxorubicin injection synergistically induces rejection of establishedbreast cancer in mice. Int. Immuno. Pharmacol., 2010, 10(7), 819-826
86. Zhong, X., Wu, K., He, S., Ma, S. and Kong, L., Effects of quercetin on the proliferation and apoptosis in transplantation tumour of breast cancer in nude mice. Sichuan. Da. Xue. Bao. Yi. Xue. Ban., 2003, 34(3), 439-442
87. Chang, Y. M. and Shen, Y. L., Linalool exhibits cytotoxic effects by activating antitumour immunity. Mol., 2014, 19, 6694-6706
88. Vesna, T. S., Jasna, C. B., Gordana, C., Sonja, D. and Dragana, C. S., Dried bilberry (Vacciniummyrtillus L.) extract fractions as antioxidants and cancer cell growth inhibitors. Food Sci. Technol., 2014, 61(2), 615-621
89. Vidya, N. and Niranjali, D. S., Induction of apoptosis by Eugenol in human breast cancer. Indian J. Exp. Biol., 2011, 49, 871-878
90. Ibtehaj, A. S., Adnane, R. and Abdelilah, A., Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin downregulation. BMC Cancer, 2013, 13, 600-612
91. Guoyi, M., Nurhayat, T., Husnu, C. B., Nese, K., David, S. P., Ikhlas, A. K. and Shabana, I. K., Inhibition of NF-B-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate. Cancer Chemother. Pharmacol., 2009, 63, 673-680
92. In, L. L., Azmi, M. N., Ibrahim, H., Awang, K. and Nagoor, N. H., 1'S-1'-acetoxyeugenol acetate: a novel phenylpropanoid from Alpiniaconchigera enhances the apoptotic effects of paclitaxel in MCF-7 cells through NF-κB inactivation. Anticancer Drugs, 2011, 22(5), 424-434
93. Hong, T. B., Anizah, R., Thaneswary, Y., Maimunah, A. and Khoo, B. Y., Potential effects of Chrysin on MDA-MB-231 cells. Int. J. Mol. Sci., 2010, 11(3), 1057-1069
94. Yang, B. et al., Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrixmetalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. J. Appl. Toxicol., 2014, 34(1), 105-112
95. Sun, L. P. et al., Chrysin: a histone deacetylase 8 inhibitor with anti-cancer activity and a suitable candidate for the standardization of Chinese Propolis. J. Agric. Food Chem., 2012, 60, 11748-11758
96. Lirdprapamongkol, K. et al., A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol. Rep., 2013, 30(5), 2357-2364
97. Zhao, X. C., Tian, L., Cao, J. G. and Liu, F., Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and Akt. Int. J. Oncol., 2010, 37(5), 1345-1352
98. Xiao, C. Z., Xiao, C. C., Fei, L., Quan, M. F., Ren, K. Q. and Cao, J. G., Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8-nitrochrysin in MDA-MB-453 breast cancer cells. Oncol. Lett., 2013, 5(3), 929-934
99. Huynh, H., Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol. J. Cell. Physio., 2004, 198, 197-208
100. Oh, S. M., Kim, Y. P. and Chung, K. H., Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells. Arch. Pharm. Res., 2006, 29(5), 354-362
101. Ajeng, D. et al., A. kaempferol-3-O-rhamnoside isolated from the leaves of Schimawallichii Korth. Inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol. Lett., 2012, 3(5), 1069-1072
102. Wang, Q., Min, H., Yu, H., Zhang, J. S., Zhou, S. F., Zeng, R. Q. and Yang, X. B., Synthesis, characterization, DNA interaction, and antitumour activities of mixed-ligand metal complexes of kaempferol and 1,10-phenanthroline/2,20-bipyridine. Med. Chem. Res., 2014, 23, 2659-2666
103. Kang, G. Y. et al., Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur. J. Pharmacol., 2009, 6(11), 17-21
104. Hao, Q., Zhao, P., Niu, J., Wang, J., Yu, J. and Xue, X., Effect of ferulic acid on proliferation and mechanism in human breast cancer cells. ZhongguoZhong. Yao. ZaZhi., 2010, 35(20), 2752-2755
105. Areti, S., Zoi, P., Evi, L. and Paraskevi, M., Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) α + β + transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin. Biochem., 2009, 42, 1358-1362
106. Zhang, T., Chen, H. S., Wang, L. F., Bai, M. H., Wang, Y. C., Jiang, X. F. and Liu, M., Ellagic acid exerts anti-proliferation effects via modulation of Tgf-β/Smad3 signaling in MCF-7 breast cancer cells. Asian. Pac. J. Cancer. Prev., 2014, 15(1), 273-276
107. Neng, W. et al., Ellagic acid, a phenolic compound, exerts antiangiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast. Cancer. Res. Treat., 2012, 134(3), 943-955
108. Kim, H. A., Lee, R. A., Moon, B. I. and Choe, K. J., Ellagic acid shows different anti-proliferative effects between the MDA-MB-231 and MCF-7 human breast cancer cell lines. J. Breast Cancer, 2009, 12(2), 85-91
109. Jack, N. L., Rishipal, R. B., Alfred, T., Hiba, A. B. and Robert, T., In vitro anti-proliferative activities of ellagic acid. J. Nutr. Biochem., 2004, 15, 672-678
110. Samer, H. H. A., Mothanna, A. Q., Mohamed, E. Z., Maznah, I. and Mohd, Z. H., Cytotoxicity and antimicrobial activity studies of an ellagic acid-zinc layered hydroxide intercalation compound. Sci. Adv. Mater., 2013, 5(10), 1-10
111. Choi, E. J., Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21. Nutr. Cancer, 2007, 59(1), 115-119
112. Yong, Y., Joy, W., Boom, K., Xiaohong, F., Haifa, S. and Mauro, F., Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells. Cell. Biochem. Funct., 2013, 31(5), 1-10
113. Lan, Y., Franky, L. C., Shiuan, C. and Lai, K. L., The citrus flavononehesperetin inhibits growth of aromatase-expressing MCF-7 tumour in ovariectomized athymic mice. J. Nutr. Biochem., 2012, 23, 1230-1237
114. Fengjuan, L., Simon, C., Cheung, W. H., Franky, L. C., Shiuan, C. and Lai, K. L., The citrus flavononehesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer. J. Nutr. Biochem., 2013, 24, 1112-1116
115. Hongzhuan, X. et al., Antitumour activity of Chinese propolis in human breast cancer MCF-7 and MDA-MB-231 cells. Evid. Based. Complement. Alternat. Med., 2014, 80120, 11; http://dx. doi.org/10.1155/2014/280120
116. Tessa, J. M., Xinhai, Y. and David, H. S., Growth of a human mammary tumour cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E and A. Breast Cancer Res., 2006, 8(2), 1-11
117. So, F. N., Guthrie, N., Chambers, N. F. and Carroll, K. K., Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett., 1997, 112, 127-133