Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells

Investigational New Drugs

Volumn 30, Issue 4, 2012, Pages 1279-1288

  Omene, Coral O ^a   Wu, Jing ^a   Frenkel, Krystyna ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer stem cells; CAPE; CD44; Cell cycle; Chemoresistant; Mammospheres; Self renewal

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CD24 ANTIGEN; HERMES ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER STEM CELL; CELL MIGRATION; CELL POPULATION; CELL RENEWAL; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRIPLE NEGATIVE BREAST CANCER; TUMOR XENOGRAFT;

AGAR; ANIMALS; APOPTOSIS; BEES; BREAST NEOPLASMS; CAFFEIC ACIDS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HONEY; HUMANS; MICE; NEOPLASTIC STEM CELLS; PHENOTYPE; PHENYLETHYL ALCOHOL; PROPOLIS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84866772722     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9667-8     Document Type: Article

References (45)

1. Al-Hajj M, Wicha SM, Benito-Hernandez A, Morrison SJ, Mf C. (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988
2. Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65:10946-10951
3. O'Brien CA, Kresco DJE. (2009) Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol 19(2):71-77
4. Ricci-Vitiani L, Lonbardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R. (2007) Identification and expansion of human colon cancer-initiating cells. Nature 445:111-115
5. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821-5828
6. Dontu G, Wicha MS. (2005) Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 10:75-86
7. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17:1253-1270
8. Fillmore CM, Kuperwasser C. (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10(2):1-13
9. Platt VM, Szoska FC. (2008) Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm 5(4):474-486
10. Pilarski LM, Masellis-Smith A, Belch AR, Yang B, Savani RC, Turley EA. (1994) RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malig- nant B cells: a mediator in B cell malignancy? Leuk Lymphoma 14:363-374
11. Bourguignon LY, Zhu H, Shao L, Chen YW. (2000) CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem 275:1829-1838
12. Bourguignon LY, Singleton PA, Zhu H, Diedrich F. (2003) Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine. (macrophage-colony stimulating factor) production and breast tumor progression. J Biol Chem 278:29420-29434
13. Bourguignon LY, Peyrollier K, Gilad E, Brightman A. (2007) Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein. (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor cells. J Biol Chem 282:1265-1280
14. Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y. (2002) CD44 in cancer. Crit Rev Clin Lab Sci 39:527-579
15. Akima K, Ito H, Iwata Y, Matsuo K, Watari N, Yanagi M, Hagi H, Oshima K, Yagita A, Atomi Y, Tatekawa I. (1996) Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity. J Drug Target 4:1-8
16. Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC. (2009) Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase. Mol Pharm 6(3):801-812
17. Sy MS, Guo YJ, Stamenkovic I. (1992) Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein. J Exp Med 176:623-627
18. Son S, Lewis BA. (2002) Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship. J Agric Food Chem 50:468-472
19. Koltuksuz U, Mutus HM, Kutlu R, Ozyurt H, Cetin S, Karaman A, Gurbuz N, Akyol O, Aydin NE. (2001) Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J Pediatr Surg 36:1504-1509
20. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ. (1999) Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59:2347-2352
21. Borrelli F, Izzo AA, Di Carlo G, Maffia P, Russo A, Maiello FM, Capasso F, Mascolo N. (2002) Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia 73:S38-S43
22. Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc Natl Acad Sci USA 93:9090-9095
23. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T. (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NF-κB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279:6017-6026
24. Fitzpatrick LR, Wang J, Le T. (2001) Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J Pharmacol Exp Ther 299:915-920
25. Xiang D, Wang D, He Y, Xie J, Zhong Z, Li Z, Xie J. (2006) Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. Anti-Cancer Drugs 17(7):753-762
26. Chen MF, Keng PC, Lin PY, Yang CT, Liao SK, Chen WC. (2004) Cell killing and radiosensitization by caffeic acid phenethyl ester. (CAPE) in lung cancer cells. J Radiat Res 45. (2):253-260
27. Guarini L, Su ZZ, Zucker S, Lin J, Grunberger D, Fisher PB. (1992) Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenethyl ester. (CAPE). Cell Mol Biol 38(5):513-527
28. Kuo HS, Kuo WH, Lee YJ, Lin WL, Chou FP, Tseng TH. (2006) Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Cancer Letters 28; 234. (2):199-208
29. Chen MJ, Chang WH, Lin CC, Liu CY, Wang TE, Chu CH, Shih SC, Chen YJ. (2008) Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. Pancreatology 8. (6):566-576
30. Wu CS, Chen MF, Lee IL, Tung SY. (2007) Predictive role of nuclear factor-kappa B activity in gastric cancer: a promising adjuvant approach with caffeic acid phenethyl ester. J Clin Gastroenterol 41(10):871-873
31. Onori P, DeMorrow S, Gaudio E, Franchitto A, Mancinelli R, Venter J et al. (2009) Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis. Int J Cancer 125(3):565-576
32. Lee KW, Kang NJ, Kim JH, Lee KM et al. (2008) Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappaB. Genes Nutr 2(4):319-322
33. Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. (2005) Caffeic acid phenethyl ester. (CAPE) prevents transformation of human cells by arsenite. (As) and suppresses growth of As-transformed cells. Toxicology 15;213(1-2):81-96
34. Frenkel K, Wei H, Bhimani R, Ye J, Zadunaisky JA, Huang MT, Ferraro T, Conney AH, Grunberger D. (1993) Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res. 15;53. (6):1255-61
35. Wu J, Horton L, Bosland M, Karkoszka J, Frenkel K. (2007) Caffeic Acid Phenethyl Ester. (CAPE) as a preventive agent in a preclinical model of breast cancer. Proceedings of the American Association for Cancer Research, Abstract # 4202
36. Wu J, Omene C, Karkaszka J, Bosland M, Eckard J, Klein CB, Frenkel K. (2011) Caffeic acid phenethyl ester. (CAPE), derived from a honeybee product propolis, exhibits a diversity of antitumor effects in preclinical models of human breast cancer. Cancer Lett. doi:10.1016/j.canlet.2011.04.012
37. Wu J, Omene C, Karkoszka J, Klein CB, Smith J, Frenkel K. (2009) CAPE, a honeybee product, inhibits growth of human breast cancer xenografts by oral and topical routes and suppresses self-renewal of breast cancer stem cells. Proceedings of the American Association for Cancer Research. Abstract. # 2324
38. Wu J, Omene C, Smith J, Frenkel K. (2010) Inhibition of breast cancer stem cells. (CSC) self-renewal and growth by CAPE, a product of propolis. Proceedings of the American Association for Cancer Research, Abstract. # 3555
39. Omene C, Wu J, Qu S, Smith J, Frenkel K. (2011) CAPE-induced Inhibition of Breast Cancer Stem Cells. (CSC) Self-renewal and Growth by Differentiation to a less Malignant Phenotype, Proceedings of the American Association for Cancer Research, Abstract # 3344
40. Velasco-Velasquez M, Yu Z, Jiao X, Pestell R. (2009) Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Expert Rev Anticancer Ther 9(3):275-279
41. Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC. (2003) Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res 63:887-892
42. Weber GF, Bronson RT, Ilagan J, Cantor H, Schmits R, Mak TW. (2002) Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62:2281-2286
43. Yu Q, Toole BP, Stamenkovic I. (1997) Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J Exp Med 186:1985-1996
44. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y, Chen Q. (2008) CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 1;14. (21):6751-60
45. Bourguignon LY, Peyrollier K, Xia W, Gilad E. (2008) Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem 20;283(25):17635-51