Effects of quercetin on the proliferation of breast cancer cells and expression of survivin in vitro

Experimental and Therapeutic Medicine

Volumn 6, Issue 5, 2013, Pages 1155-1158

  Deng, Xiao Hui ^a   Song, Hai Yan ^a   Zhou, Ying Feng ^b   Yuan, Guo Yan ^b   Zheng, Feng Jin ^c  

^a XINXIANG MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Breast cancer; Cell cycle; Proliferation; Quercetin; Survivin

Indexed keywords

QUERCETIN; SURVIVIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84884789465     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1285     Document Type: Article

References (18)

1. Huang X, Wong MK, Yi H, et al: Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein. Cancer Res 62: 5727-5735, 2002.
2. Duo J, Ying GG, Wang GW and Zhang L: Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Rep 5: 1453-1456, 2012.
3. Jemal A, Bray F, Center M.M., Ferlay J., Ward E. and Forman D.: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
4. Mallin K, Palis BE, Watroba N, et al: Completeness of American Cancer Registry Treatment Data: implications for quality of care research. J Am Coll Surg 216: 428-437, 2013.
5. Slusarz A, Shenouda NS, Sakla MS, et al: Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer Res 70: 3382-3390, 2010.
6. Cheng S, Gao N, Zhang Z, et al: Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clin Cancer Res 16: 5679-5691, 2010.
7. Psahoulia FH, Drosopoulos KG, Doubravska L, Andera L and Pintzas A: Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol Cancer Ther 6: 2591-2599, 2007.
8. Qin Y, He LY, Chen Y, Wang WY, Zhao XH and Wu MY: Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28: 12-16, 2012 (In Chinese).
9. Neibert KD and Maysinger D: Mechanisms of cellular adaptation to quantum dots the role of glutathione and transcription factor EB. Nanotoxicology 6: 249-262, 2012.
10. Chen SS, Corteling R, Stevanato L and Sinden J: Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity a role of immunomodulation in chemoprevention. Discov Med 14: 327-333, 2012.
11. Heinritz W, Paasch U, Sticherling M, et al: Evidence for a founder effect of the germline fumarate hydratase gene mutation R58P causing hereditary leiomyomatosis and renal cell cancer (HLRCC). Ann Hum Genet 72 (Pt 1): 35-40, 2008.
12. Comalada M, Camuesco D, Sierra S, et al: In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Eur J Immunol 35: 584-592, 2005.
13. Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH and Huynh H: The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25: 647-659, 2004.
14. Kuo PC, Liu HF and Chao JI: Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. J Biol Chem 279: 55875-55885, 2004.
15. Kim WK, Bang MH, Kim ES, et al: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem 16: 155-162, 2005.
16. Li F and Altieri DC: The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression. Cancer Res 59: 3143-3151, 1999.
17. Yoshida M, Yamamoto M and Nikaido T: Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res 52: 6676-6681, 1992.
18. Ryan BM, O'Donovan N and Duffy MJ: Survivin: a new target for anti-cancer therapy. Cancer Treat Rev 35: 553-562, 2009.