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Volumn 20, Issue 2, 2011, Pages 371-375

Involvement of AMPK/mTOR/HIF-1α in anticancer control of quercetin in hypoxic MCF-7 cells

Author keywords

AMP activated protein kinase (AMPK); Breast cancer; Hypoxia; Hypoxia inducible factor 1 (HIF 1 ); Mammalian target of rapamycin (mTOR); Quercetin

Indexed keywords

ANTIBIOTICS; CELL DEATH; CELL SIGNALING; DISEASES; ENZYMES; MAMMALS; PHENOLS;

EID: 79959724273     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10068-011-0052-3     Document Type: Article
Times cited : (7)

References (25)
  • 1
    • 77949462458 scopus 로고    scopus 로고
    • AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth
    • Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth. Future Oncol. 6: 457-470 (2010)
    • (2010) Future Oncol. , vol.6 , pp. 457-470
    • Luo, Z.1    Zang, M.2    Guo, W.3
  • 2
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • Shaw R. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol. 196: 65-80 (2009)
    • (2009) Acta Physiol. , vol.196 , pp. 65-80
    • Shaw, R.1
  • 3
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Update 11: 32-50 (2008)
    • (2008) Drug Resist. Update , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 4
    • 33745213627 scopus 로고    scopus 로고
    • AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer
    • Motoshima H, Goldstein BJ, Igata M, Araki E. AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol. 574: 63-71 (2006)
    • (2006) J. Physiol. , vol.574 , pp. 63-71
    • Motoshima, H.1    Goldstein, B.J.2    Igata, M.3    Araki, E.4
  • 5
    • 63849104290 scopus 로고    scopus 로고
    • AMP-activated protein kinase and cancer
    • Wang W, Guan KL. AMP-activated protein kinase and cancer. Acta Physiol. 196: 55-63 (2009)
    • (2009) Acta Physiol. , vol.196 , pp. 55-63
    • Wang, W.1    Guan, K.L.2
  • 6
    • 59849113536 scopus 로고    scopus 로고
    • Curcumin exerts antidifferentiation effect through AMPKα-PPAR-γ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells
    • Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ. Curcumin exerts antidifferentiation effect through AMPKα-PPAR-γ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells. J. Agr. Food Chem. 57: 305-310 (2009)
    • (2009) J. Agr. Food Chem. , vol.57 , pp. 305-310
    • Lee, Y.K.1    Lee, W.S.2    Hwang, J.T.3    Kwon, D.Y.4    Surh, Y.J.5    Park, O.J.6
  • 7
    • 0141905919 scopus 로고    scopus 로고
    • Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
    • Rutter GA, Da Silva Xavier G, Leclerc I. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem. J. 375: 1-16 (2003)
    • (2003) Biochem. J. , vol.375 , pp. 1-16
    • Rutter, G.A.1    da Silva Xavier, G.2    Leclerc, I.3
  • 8
    • 33745840203 scopus 로고    scopus 로고
    • 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    • Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol. Cell Biol. 26: 5336-5347 (2006)
    • (2006) Mol. Cell Biol. , vol.26 , pp. 5336-5347
    • Laderoute, K.R.1    Amin, K.2    Calaoagan, J.M.3    Knapp, M.4    Le, T.5    Orduna, J.6    Foretz, M.7    Viollet, B.8
  • 9
    • 33745225026 scopus 로고    scopus 로고
    • AMP-activated protein kinase--development of the energy sensor concept
    • Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase--development of the energy sensor concept. J. Physiol. 574: 7-15 (2006)
    • (2006) J. Physiol. , vol.574 , pp. 7-15
    • Hardie, D.G.1    Hawley, S.A.2    Scott, J.W.3
  • 10
    • 24344440832 scopus 로고    scopus 로고
    • Hypoxia-induced dedifferentiation of tumor cells--a mechanism behind heterogeneity and aggressiveness of solid tumors
    • Axelson H, Fredlund E, Ovenberger M, Landberg G, Påhlman S. Hypoxia-induced dedifferentiation of tumor cells--a mechanism behind heterogeneity and aggressiveness of solid tumors. Semin. Cell Dev. Biol. 16: 554-563 (2005)
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 554-563
    • Axelson, H.1    Fredlund, E.2    Ovenberger, M.3    Landberg, G.4    Påhlman, S.5
  • 11
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443 (2006)
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 12
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 5: 10-17 (2004)
    • (2004) Oncologist , vol.5 , pp. 10-17
    • Vaupel, P.1
  • 13
    • 33645822306 scopus 로고    scopus 로고
    • Natural product-based inhibitors of hypoxiainducible factor-1 (HIF-1)
    • Nagle DG, Zhou YD. Natural product-based inhibitors of hypoxiainducible factor-1 (HIF-1). Curr. Drug Targets 7: 355-369 (2006)
    • (2006) Curr. Drug Targets , vol.7 , pp. 355-369
    • Nagle, D.G.1    Zhou, Y.D.2
  • 14
    • 73049091140 scopus 로고    scopus 로고
    • Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway
    • Manolescu B, Oprea E, Busu C, Cercasov C. Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway. Biochimie 91: 1347-1358 (2009)
    • (2009) Biochimie , vol.91 , pp. 1347-1358
    • Manolescu, B.1    Oprea, E.2    Busu, C.3    Cercasov, C.4
  • 15
    • 41849094797 scopus 로고    scopus 로고
    • Reactive oxygen species stabilize hypoxia-inducible factor-1α protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells
    • Jung SN, Yang WK, Kim J, Kim HS, Kim EJ, Yun H, Park H, Kim SS, Choe W, Kang I, Ha J. Reactive oxygen species stabilize hypoxia-inducible factor-1α protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis 29: 713-721 (2008)
    • (2008) Carcinogenesis , vol.29 , pp. 713-721
    • Jung, S.N.1    Yang, W.K.2    Kim, J.3    Kim, H.S.4    Kim, E.J.5    Yun, H.6    Park, H.7    Kim, S.S.8    Choe, W.9    Kang, I.10    Ha, J.11
  • 19
    • 0032190614 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
    • Semenza GL. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis. Curr. Opin. Genet. Dev. 8: 588-594 (1998)
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 588-594
    • Semenza, G.L.1
  • 20
    • 4644370374 scopus 로고    scopus 로고
    • Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications
    • Brahimi-Horn C, Mazure N, Pouysségur J. Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications. Cell Signal 1: 1-9 (2005)
    • (2005) Cell Signal , vol.1 , pp. 1-9
    • Brahimi-Horn, C.1    Mazure, N.2    Pouysségur, J.3
  • 21
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. P. Natl. Acad. Sci. USA 92: 5510-5514 (1995)
    • (1995) P. Natl. Acad. Sci. USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 22
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 545: 1337-1340 (2001)
    • (2001) Science , vol.545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 23
    • 54849432592 scopus 로고    scopus 로고
    • Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis
    • Lee DH, Lee YJ. Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis. J. Cell Biochem. 105: 546-553 (2008)
    • (2008) J. Cell Biochem. , vol.105 , pp. 546-553
    • Lee, D.H.1    Lee, Y.J.2
  • 24
    • 41849117298 scopus 로고    scopus 로고
    • Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1α/2α is mediated through chelation of iron
    • Park SS, Bae I, Lee YJ. Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1α/2α is mediated through chelation of iron. J. Cell Biochem. 103: 1989-1998 (2008)
    • (2008) J. Cell Biochem. , vol.103 , pp. 1989-1998
    • Park, S.S.1    Bae, I.2    Lee, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.