Review of the medicinal effects of tualang honey and a comparison with Manuka honey

Malaysian Journal of Medical Sciences

Volumn 20, Issue 3, 2013, Pages 6-13

  Ahmed, Sarfarz ^a   Othman, Nor Hayati ^a  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

Author keywords

Ailments; Antitumor; Properties of Tualang honey; Tualang honey; Wound healing

Indexed keywords

5 HYDROXYMETHYLFURFURAL; FLAVONOID; GLIBENCLAMIDE; METFORMIN; NATURAL PRODUCT; PHENOL DERIVATIVE;

ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIMUTAGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; BACTERIAL STRAIN; BURN; COMPARATIVE STUDY; DIABETES MELLITUS; DIABETIC FOOT; DRUG ACTIVITY; DRUG EFFICACY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HONEY; HONEYBEE; HUMAN; MALAYSIA; MANUKA HONEY; NONHUMAN; PHYSICAL CHEMISTRY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ROCK BEE; TUALANG HONEY; WOUND; WOUND HEALING;

EID: 84877134609     PISSN: 1394195X     EISSN: 21804303     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Allsop KF, Miller JB. Honey revisited: a reappraisal of honey in pre-industrial diets. Br J Nutr. 1996;75(4):513-520.
2. Sherlock O, Dolan A, Athman R, Power A, Gethin G, Cowman S, et al. Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complement Altern Med. 2010;10(47):5.
3. Othman NH. Honey and Cancer: Sustainable Inverse Relationship Particularly for Developing Nations: A Review. Evid Based Complement Alternat Med. 2012;2012(2012):10.
4. Erejuwa OO, Sulaiman SA, Wahab MS. Honey: A Novel Antioxidant. Molecules. 2012;17(4):4400-4423.
5. Al-Mamary M, Al-Meeri A, Al-Habori M. Antioxidant activities and total phenolics of different types of honey. Nutr Res. 2002;22(9):1041-1047.
6. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Ann Endocrinol. 2010;71(4):291-296.
7. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Comparison of Antioxidant Effects of Honey, Glibenclamide, Metformin, and Their Combinations in the Kidneys of Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2011;12(1):829-843.
8. Wang XH, Andrae L, Engeseth NJ. Antimutagenic effect of various honeys and sugars against Trp-p-1. J Agric Food Chem. 2002;50(23):6923-6928.
9. Sukur SM, Halim AS, Singh KK. Evaluations of bacterial contaminated full thickness burn wound healing in Sprague Dawley rats Treated with Tualang honey. Indian J Plast Surg. 2011;44(1):112-117.
10. Gupta SS, Singh O, Bhagel PS, Moses S, Shukla S, Mathur RK. Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients: A retrospective study. J Cutan Aesthet Surg. 2011;4(3):183-187.
11. Lusby PE, Coombes A, Wilkinson JM. Honey: A potent agent for wound healing? J Wound Ostomy Continence Nurs. 2002;29(6):295-300.
12. Swellam T, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, et al. Antineoplastic activity of honey in an experimental bladder cancer implantation model: In vivo and in vitro studies. Int J Urol. 2003;10(4):213-219.
13. Ghashm AA, Othman NH, Khattak MN, Ismail NM, Saini R. Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement Altern Med. 2010;10(49):8.
14. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS. Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res. 2010;80(1):74-82.
15. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. Int J Mol Sci. 2010;11(5):2056-2066.
16. Chen L, Mehta A, Berenbaum M, Zangerl AR, Engeseth NJ. Honeys from Different Floral Sources as Inhibitors of Enzymatic Browning in Fruit and Vegetable Homogenates. J Agric Food Chem. 2000;48(10):4997-5000.
17. Kannan TP, Ali AQ, Abdullah SF, Ahmad A. Evaluation of Tualang honey as a supplement to fetal bovine serum in cell culture. Food Chem Toxicol. 2009;47(7):1696-1702.
18. Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: A preliminary study. Support Care Cancer. 2003;11(4):242-248.
19. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. Int J Biol Sci. 2011;7(2):244-252.
20. Fauzi AN, Norazmi MN, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem Toxicol. 2011;49(4):871-878.
21. Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, et al. The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey. BMC Complement Altern Med. 2009;9(34):1-8.
22. Mohamed M, Sirajudeen KN, Swamy M, Yaacob NS, Sulaiman SA. Studies on the antioxidant properties of Tualang honey of Malaysia. Afr J Tradit Complement Altern Med. 2010;7(1):59-63.
23. Molan PC. Manuka honey as a medicine. Global Bioactives Summit; The University of Waikato. New Zealand (NZ): Waikato Honey Research Unit; 2001. p. 1-20.
24. Russell KM, Molan PC, Wilkins AL, Holland PT. Identification of some antibacterial constituents of New Zealand manuka honey. J Agric Food Chem. 1990;38(1):10-13.
25. Visavadia BG, Honeysett J, Danford MH. Manuka honey dressing: An effective treatment for chronic wound infections. Br J Oral Maxillofac Surg. 2008;46(1):55-56.
26. Perez RA, Sanchez-Brunete C, Calvo RM, Tadeo JL. Analysis of volatiles from Spanish honeys by solid-phase microextraction and gas chromatography-mass spectrometry. J Agric Food Chem. 2002;50(9):2633-2637.
27. Terrab A, González AG, Díez MJ, Heredia FJ. Characterisation of Moroccan unifloral honeys using multivariate analysis. Eur Food Res Technol. 2003;218:88-95.
28. Al-Jabri A, Al Mahrooqi Z, Nzeako B, Nsanze H. Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro. Int J Food Microbiol. 2005;103(3):347-351.
29. Ghazali FC. Morphological characterization study of Malaysian honey-A VPSEM, EDX randomised attempt. Annal Microsco. 2009;9:93-102.
30. Khalil MI, Sulaiman SA, Gan SH. High 5-hydroxymethylfurfural concentrations are found in Malaysian honey samples stored for more than one year. Food Chem Toxicol. 2010;48(8-9):2388-2392.
31. Emmertz E. Mineral composition of New Zealand monofloral honeys. Uppsala (SE): Swedish University of Agricultural Sciences; 2010. p. 26.
32. Kishore RK, Halim AS, Syazana MS, Sirajudeen KN. Tualang honey has higher phenolic content and greater radical scavenging activity compared with other honey sources. Nutr Res. 2011;31(4):322-325.
33. Khalil MI, Alam N, Moniruzzaman M, Sulaiman SA, Gan SH. Phenolic Acid Composition and Antioxidant Properties of Malaysian Honeys. J Food Sci. 2011;76(6):C921-8.
34. Khalil MI, Mahaneem M, Jamalullail SMS, Alam N, Sulaiman SA. Evaluation of Radical Scavenging Activity and Colour Intensity of Nine Malaysian Honeys of Different Origin. J ApiPro ApiMedic Sci. 2011;3(1):4-11.
35. Syazana MSN, Halim AS, Gan SH, Shamsuddin S. Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts. BMC Complement Altern Med. 2011;11(1):82.
36. Nasir NA, Halim AS, Singh KK, Dorai AA, Haneef MN. Antibacterial properties of tualang honey and its effect in burn wound management: A comparative study. BMC Complement Altern Med. 2010;10(31):1-7.
37. Hafizah AH, Yusof N, Maimon A. Potential of Malaysian local honey as an antibacterial agent. Sains Malays. 2005;34(1):17-20.
38. Tumin N, Halim ANA, Shahjahan M, Ijazani NNJ, Sattar, Munavvar A, et al. Antibacterial activity of local Malaysian honey. Malays J Pharmac Sci. 2005;3(2):1-10.
39. Norizah T, Nurul AAH, Noor INJ, Shahjahan M. Antibacterial studies on some selected brands of Malaysian honey. Malays J Medic Sci. 2004;11(1):127-128.
40. KirnpalKaur BS, Tan HT, Boukraa L, Gan SH. Different Solid Phase Extraction Fractions of Tualang (Koompassia excelsa) Honey Demonstrated Diverse Antibacterial Properties Against Wound and Enteric Bacteria. J ApiPro ApiMedic Sci. 2011;3(1):59-65.
41. Halima AS, Kirnpal Kaur BS, Doraia AA, Azmana WS, Khooa YT. Wound contraction and anti-microbial properties of Tualang honey on full thickness burn wound in rats. J ApiPro ApiMedic Sci. 2010;2(1):31-60.
42. Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tons A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003;21(5):242-247.
43. Molan PC, Smith IM, Reid GM. A comparison of the antibacterial activities of some New Zealand honeys. J Apic Res. 1988;27(4):252-256.
44. Nur Azida MN, Dorai AA, Halim AS, Norimah Y. A comparative pilot study using tualang honey with aquacel and aquacel dressing on superficial burn wounds. Malays J Medic Sci. 2008;15(1 Supp):204.
45. Khoo YT, Halim AS, Singh KK, Mohamad NA. Wound contraction effects and antibacterial properties of Tualang honey on full-thickness burn wounds in rats in comparison to hydrofibre. BMC Complement Altern Med. 2010;10(48):1-8.
46. Zaharil MSA, Sulaiman WAW, Halim AS, Jumaat MYS, Hasnan J. The Efficacy of Tualang Honey in Comparison to Silver in Dressing Wounds in Rats. J ApiPro ApiMedic Sci. 2011;3(1):45-53.
47. Imran FH, Dorai AA, Halim AS, Sulaiman WAW. Tualang Honey Hydrogel in the Treatment of Split-Skin Graft Donor Sites. J ApiPro ApiMedic Sci. 2011;3(1):33-37.
48. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment. Int J Mol Sci. 2011;12(3):1888-1907.
49. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salzihan. Effects of Malaysian Tualang honey supplementation on glycemia, free radical scavenging enzymes and markers of oxidative stress in kidneys of normal and streptozotocin-induced diabetic rats. Int J Cardiol. 2009;137(Oct):S45-S45.
50. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999;59(10):2347-2352.
51. Attia WY, Gabry MS, El-Shaikh KA, Othman GA. The anti-tumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. Egypt J Immunol. 2008;15(2):169-183.
52. Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Effect of Glibenclamide alone versus Glibenclamide and Honey on Oxidative Stress in Pancreas of Streptozotocin-Induced Diabetic Rats. Intl J App Res Nat Prod. 2011;4(2):1-10.
53. Robert SD, Ismail AAS. Two varieties of honey that are available in Malaysia gave intermeidate glycemic index values when tested among healthy inidividuals. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009;153(2):145-147.
54. Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 2010;90(1):23-46.
55. Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SM, Abasalti Z, Yaghoobi Z, et al. Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. Scientific World J. 2008;8:463-469. doi: 10.1100/tsw.2008.64
56. Sulaiman SA, Hasan H, Deris ZZ, Wahab MS, Yusof RC, Naing NN, et al. The Benefit of Tualang Honey in Reducing Acute Respiratory Symptoms Among Malaysian Hajj Pilgrims: A Preliminary Study. J ApiPro ApiMedic Sci. 2011;3(1):38-44.
57. Mohamed M, Sulaiman SA, Jaafar H, Sirajudeen KN. Effect of different doses of Malaysian honey on reproductive parameters in adult male rats. Andrologia. 2012;44(1):182-186.
58. Zaid SS, Sulaiman SA, Sirajudeen KN, Othman NH. The effects of Tualang honey on female reproductive organs, tibia bone and hormonal profile in ovariectomised rats--animal model for menopause. BMC Complement Altern Med. 2010;10:82. doi: 10.1186/1472-6882-10-82.
59. Mahaneem M, Sulaiman SA, Jaafar H, Sirajudeen KN, Ismail IM, Islam MN. Effect of Honey on Testicular Functions in Rats Exposed to Cigarette Smoke. J ApiPro ApiMedic Sci. 2011;3(1):12-17.
60. Othman Z, Shafin N, Zakaria R, Hussain NH, Mohammad WM. Improvement in immediate memory after 16 weeks of tualang honey (Agro Mas) supplement in healthy postmenopausal women. Menopause. 2011;18(11):1219-1224.