Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

Toxicology and Applied Pharmacology

Volumn 226, Issue 2, 2008, Pages 178-191

  Lee, Wei Jiunn ^a   Chen, Wen Kang ^c   Wang, Chau Jong ^a   Lin, Wea Lung ^a   Tseng, Tsui Hwa ^b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAINAN INSTITUTE OF NURSING   (Taiwan)

Author keywords

Adhesion; Apigenin; HGF; Integrin 4; Invasive growth; Met; Metastasis

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ACTIN; APIGENIN; BETA4 INTEGRIN; PROTEIN KINASE B; SCATTER FACTOR; SMALL INTERFERING RNA; WORTMANNIN;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CHICK EMBRYO; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LAMELLIPODIUM; LIVER CELL CARCINOMA; LUNG CARCINOMA; METASTASIS; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APIGENIN; BREAST NEOPLASMS; CELL ADHESION; CELL DIVISION; CELL LINE, TUMOR; CELL MOVEMENT; CHICK EMBRYO; FEMALE; FLAVANONES; GENISTEIN; HEPATOCYTE GROWTH FACTOR; HUMANS; INTEGRIN BETA4; KAEMPFEROLS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-AKT;

MUS MUSCULUS;

EID: 37349021728     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.09.013     Document Type: Article

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