Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response

PLoS ONE

Volumn 12, Issue 4, 2017, Pages

  Schaeffer, Céline ^a   Merella, Stefania ^a   Pasqualetto, Elena ^a   Lazarevic, Dejan ^a   Rampoldi, Luca ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; MUTANT PROTEIN; PDI PROTEIN; PROTEASOME; PROTEIN DISULFIDE ISOMERASE; TAMM HORSFALL GLYCOPROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; AUTOPHAGY; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; HOMEOSTASIS; KIDNEY DISEASE; METABOLISM; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SPLICING; UMOD GENE; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; CELL LINE; CELL SURVIVAL; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GENE EXPRESSION PROFILING; GENETICS; MUTATION; PROTEIN TRANSPORT;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GENE EXPRESSION PROFILING; HOMEOSTASIS; KIDNEY DISEASES; MICE; MUTATION; PROTEIN TRANSPORT; UNFOLDED PROTEIN RESPONSE; UROMODULIN;

EID: 85018595437     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0175970     Document Type: Article

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