Defective intracellular trafficking of uromodulin mutant isoforms

Traffic

Volumn 7, Issue 11, 2006, Pages 1567-1579

  Bernascone, Ilenia ^a   Vavassori, Stefano ^a   Di Pentima, Alessio ^b   Santambrogio, Sara ^a   Lamorte, Giuseppe ^c   Amoroso, Antonio ^d   Scolari, Francesco ^e   Ghiggeri, Gian Marco ^f   Casari, Giorgio ^g   Polishchuk, Roman ^b   Rampoldi, Luca ^a  

^a DULBECCO TELETHON INSTITUTE   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e UNIVERSITY OF BRESCIA   (Italy)

^f G GASLINI INSTITUTE   (Italy)

^g SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Chronic renal diseases; ER retention; Familial juvenile hyperuricemic nephropathy; Medullary cystic kidney disease; Protein trafficking; Tamm Horsfall protein; Uromodulin

Indexed keywords

CYSTEINE; ISOPROTEIN; MUTANT PROTEIN; TAMM HORSFALL GLYCOPROTEIN;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; GENE MUTATION; GENETIC TRANSFECTION; GOLGI COMPLEX; HENLE LOOP; HUMAN; HUMAN CELL; HYPERURICEMIA; IMAGING; IMMUNOFLUORESCENCE; IN VIVO STUDY; INTRACELLULAR TRANSPORT; KIDNEY CELL; KIDNEY CYST; KIDNEY DISTAL TUBULE; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; MEDULLARY SPONGE KIDNEY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN URINE LEVEL; URIC ACID NEPHROPATHY; WILD TYPE;

ANIMALS; CALRETICULIN; CELL LINE; CELL MEMBRANE; DOGS; ENDOPLASMIC RETICULUM; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENETIC DISEASES, INBORN; GLYCOSYLATION; GLYCOSYLPHOSPHATIDYLINOSITOLS; GOLGI APPARATUS; HUMANS; HYPERURICEMIA; KIDNEY DISEASES; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; MUCOPROTEINS; MUTATION, MISSENSE; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TRANS-GOLGI NETWORK; TRANSFECTION; UROMODULIN;

EID: 33749532096     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2006.00481.x     Document Type: Article

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