-
1
-
-
67649876115
-
New insights into the regulation of T cells by γc family cytokines
-
Rochman Y, Spolski R, Leonard WJ. 2009. New insights into the regulation of T cells by γc family cytokines. Nat. Rev. Immunol. 9(7):480-90
-
(2009)
Nat. Rev. Immunol.
, vol.9
, Issue.7
, pp. 480-490
-
-
Rochman, Y.1
Spolski, R.2
Leonard, W.J.3
-
2
-
-
0035752146
-
Cytokines and immunodeficiency diseases
-
Leonard WJ. 2001. Cytokines and immunodeficiency diseases. Nat. Rev. Immunol. 1(3):200-8
-
(2001)
Nat. Rev. Immunol.
, vol.1
, Issue.3
, pp. 200-208
-
-
Leonard, W.J.1
-
3
-
-
9644295710
-
Cytokines and immunodeficiency diseases: Critical roles of the γcdependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
-
Kovanen PE, Leonard WJ. 2004. Cytokines and immunodeficiency diseases: critical roles of the γcdependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 202:67-83
-
(2004)
Immunol. Rev.
, vol.202
, pp. 67-83
-
-
Kovanen, P.E.1
Leonard, W.J.2
-
4
-
-
33746547247
-
The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
-
Waldmann TA. 2006. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. 6(8):595-601
-
(2006)
Nat. Rev. Immunol.
, vol.6
, Issue.8
, pp. 595-601
-
-
Waldmann, T.A.1
-
5
-
-
84961554501
-
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: Implications for cancer therapy
-
Waldmann TA. 2015. The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy. Cancer Immunol. Res. 3(3):219-27
-
(2015)
Cancer Immunol. Res.
, vol.3
, Issue.3
, pp. 219-227
-
-
Waldmann, T.A.1
-
6
-
-
78650012116
-
Cooperative epigenetic modulation by cancer amplicon genes
-
Rui LX, Emre NCT, Kruhlak MJ, Chung HJ, Steidl C, et al. 2010. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell 18(6):590-605
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 590-605
-
-
Rui, L.X.1
Emre, N.C.T.2
Kruhlak, M.J.3
Chung, H.J.4
Steidl, C.5
-
7
-
-
84859957094
-
Janus kinase deregulation in leukemia and lymphoma
-
Chen E, Staudt LM, Green AR. 2012. Janus kinase deregulation in leukemia and lymphoma. Immunity 36(4):529-41
-
(2012)
Immunity
, vol.36
, Issue.4
, pp. 529-541
-
-
Chen, E.1
Staudt, L.M.2
Green, A.R.3
-
8
-
-
70349975711
-
JAK2 phosphorylates histone H3Y41 and excludes HP1afrom chromatin
-
Dawson MA, Bannister AJ, Gottgens B, Foster SD, Bartke T, et al. 2009. JAK2 phosphorylates histone H3Y41 and excludes HP1afrom chromatin. Nature 461(7265):819-22
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 819-822
-
-
Dawson, M.A.1
Bannister, A.J.2
Gottgens, B.3
Foster, S.D.4
Bartke, T.5
-
9
-
-
85010008853
-
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma
-
Yan J, Li B, Lin B, Lee PT, Chung TH, et al. 2016. EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma. Blood 128(7):948-58
-
(2016)
Blood
, vol.128
, Issue.7
, pp. 948-958
-
-
Yan, J.1
Li, B.2
Lin, B.3
Lee, P.T.4
Chung, T.H.5
-
10
-
-
59849101586
-
Function of mitochondrial Stat3 in cellular respiration
-
Wegrzyn J, Potla R, Chwae Y-J, Sepuri NBV, Zhang Q, et al. 2009. Function of mitochondrial Stat3 in cellular respiration. Science 323(5915):793-97
-
(2009)
Science
, vol.323
, Issue.5915
, pp. 793-797
-
-
Wegrzyn, J.1
Potla, R.2
Chwae, Y.-J.3
Sepuri, N.B.V.4
Zhang, Q.5
-
11
-
-
84878232331
-
JAK/STAT signaling in hematological malignancies
-
Vainchenker W, Constantinescu SN. 2013. JAK/STAT signaling in hematological malignancies. Oncogene 32(21):2601-13
-
(2013)
Oncogene
, vol.32
, Issue.21
, pp. 2601-2613
-
-
Vainchenker, W.1
Constantinescu, S.N.2
-
12
-
-
0029005549
-
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
-
Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, et al. 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269(5220):79-81
-
(1995)
Science
, vol.269
, Issue.5220
, pp. 79-81
-
-
Migone, T.S.1
Lin, J.X.2
Cereseto, A.3
Mulloy, J.C.4
O'Shea, J.J.5
-
13
-
-
84861023172
-
Somatic STAT3 mutations in large granular lymphocytic leukemia
-
Koskela HLM, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmaki H, et al. 2012. Somatic STAT3 mutations in large granular lymphocytic leukemia. N. Engl. J. Med. 366(20):1905-913
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.20
, pp. 1905-1913
-
-
Koskela, H.L.M.1
Eldfors, S.2
Ellonen, P.3
Van Adrichem, A.J.4
Kuusanmaki, H.5
-
14
-
-
84867815120
-
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
-
Jerez A, Clemente MJ, Makishima H, Koskela H, LeBlanc F, et al. 2012. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 120(15):3048-57
-
(2012)
Blood
, vol.120
, Issue.15
, pp. 3048-3057
-
-
Jerez, A.1
Clemente, M.J.2
Makishima, H.3
Koskela, H.4
LeBlanc, F.5
-
15
-
-
84887320457
-
STAT3mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia
-
Ohgami RS, Ma L, Merker JD, Martinez B, Zehnder JL, Arber DA. 2013. STAT3mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. Leukemia 27(11):2244-47
-
(2013)
Leukemia
, vol.27
, Issue.11
, pp. 2244-2247
-
-
Ohgami, R.S.1
Ma, L.2
Merker, J.D.3
Martinez, B.4
Zehnder, J.L.5
Arber, D.A.6
-
16
-
-
84928015700
-
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma
-
Crescenzo R, Abate F, Lasorsa E, Tabbo F, Gaudiano M, et al. 2015. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell 27(4):516-32
-
(2015)
Cancer Cell
, vol.27
, Issue.4
, pp. 516-532
-
-
Crescenzo, R.1
Abate, F.2
Lasorsa, E.3
Tabbo, F.4
Gaudiano, M.5
-
17
-
-
20944435271
-
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
-
Chiarle R, Simmons WJ, Cai HY, Dhall G, Zamo A, et al. 2005. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat. Med. 11(6):623-29
-
(2005)
Nat. Med.
, vol.11
, Issue.6
, pp. 623-629
-
-
Chiarle, R.1
Simmons, W.J.2
Cai, H.Y.3
Dhall, G.4
Zamo, A.5
-
18
-
-
12444287592
-
Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK-anaplastic large cell lymphoma
-
Khoury JD, Medeiros LJ, Rassidakis GZ, Yared MA, Tsioli P, et al. 2003. Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK-anaplastic large cell lymphoma. Clin. Cancer Res. 9(10):3692-699
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.10
, pp. 3692-3699
-
-
Khoury, J.D.1
Medeiros, L.J.2
Rassidakis, G.Z.3
Yared, M.A.4
Tsioli, P.5
-
19
-
-
85018341646
-
Frequent activating mutations of JAK-STAT pathway genes in natural killer cell lymphomas
-
(Abstr.)
-
Kucuk C, Jiang B, Hu XZ, Gaulard P, Zhang Y, et al. 2013. Frequent activating mutations of JAK-STAT pathway genes in natural killer cell lymphomas. Blood 122(21):812 (Abstr.)
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 812
-
-
Kucuk, C.1
Jiang, B.2
Hu, X.Z.3
Gaulard, P.4
Zhang, Y.5
-
20
-
-
84893761035
-
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma
-
Bouchekioua A, Scourzic L, de Wever O, Zyang Y, Cervera P, et al. 2014. JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma. Leukemia 28(2):338-48
-
(2014)
Leukemia
, vol.28
, Issue.2
, pp. 338-348
-
-
Bouchekioua, A.1
Scourzic, L.2
De Wever, O.3
Zyang, Y.4
Cervera, P.5
-
21
-
-
70349322986
-
STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma
-
Coppo P, Gouilleux-Gruart V, Huang Y, Bouhlal H, Bouamar H, et al. 2009. STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma. Leukemia 23(9):1667-678
-
(2009)
Leukemia
, vol.23
, Issue.9
, pp. 1667-1678
-
-
Coppo, P.1
Gouilleux-Gruart, V.2
Huang, Y.3
Bouhlal, H.4
Bouamar, H.5
-
22
-
-
84866314162
-
Janus kinase 3-activating mutations identified in natural/killer/T-cell lymphoma
-
Koo GC, Tan SY, Tang T, Poon SL, Allen GE, et al. 2012. Janus kinase 3-activating mutations identified in natural/killer/T-cell lymphoma. Cancer Discov. 2(7):591-97
-
(2012)
Cancer Discov.
, vol.2
, Issue.7
, pp. 591-597
-
-
Koo, G.C.1
Tan, S.Y.2
Tang, T.3
Poon, S.L.4
Allen, G.E.5
-
23
-
-
84923076524
-
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
-
Kucuk C, Jiang B, Hu XZ, Zhang WY, Chan JKC, et al. 2015. Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. Nat. Commun. 6:6025
-
(2015)
Nat. Commun.
, vol.6
, pp. 6025
-
-
Kucuk, C.1
Jiang, B.2
Hu, X.Z.3
Zhang, W.Y.4
Chan, J.K.C.5
-
24
-
-
85027954433
-
Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas
-
Nicolae A, Xi L, Pittaluga S, Abdullaev Z, Pack SD, et al. 2014. Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas. Leukemia 28(11):2244-48
-
(2014)
Leukemia
, vol.28
, Issue.11
, pp. 2244-2248
-
-
Nicolae, A.1
Xi, L.2
Pittaluga, S.3
Abdullaev, Z.4
Pack, S.D.5
-
25
-
-
84894026125
-
Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia
-
Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, et al. 2014. Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Genes Chromosomes Cancer 53(4):309-16
-
(2014)
Genes Chromosomes Cancer
, vol.53
, Issue.4
, pp. 309-316
-
-
Bergmann, A.K.1
Schneppenheim, S.2
Seifert, M.3
Betts, M.J.4
Haake, A.5
-
26
-
-
84907317719
-
Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia
-
Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, et al. 2014. Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood 124(9):1460-72
-
(2014)
Blood
, vol.124
, Issue.9
, pp. 1460-1472
-
-
Kiel, M.J.1
Velusamy, T.2
Rolland, D.3
Sahasrabuddhe, A.A.4
Chung, F.5
-
27
-
-
84893803763
-
Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia
-
Bellanger D, Jacquemin V, Chopin M, Pierron G, Bernard OA, et al. 2014. Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. Leukemia 28(2):417-19
-
(2014)
Leukemia
, vol.28
, Issue.2
, pp. 417-419
-
-
Bellanger, D.1
Jacquemin, V.2
Chopin, M.3
Pierron, G.4
Bernard, O.A.5
-
28
-
-
0035017383
-
Constitutive STAT3-activation in Sezary syndrome: Tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells
-
Eriksen KW, Kaltoft K, Mikkelsen G, Nielsen M, Zhang Q, et al. 2001. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia 15(5):787-93
-
(2001)
Leukemia
, vol.15
, Issue.5
, pp. 787-793
-
-
Eriksen, K.W.1
Kaltoft, K.2
Mikkelsen, G.3
Nielsen, M.4
Zhang, Q.5
-
29
-
-
0029834676
-
Activation of Jak/STAT proteins involved in signal transduction pathwaymediated by receptor for interleukin 2 inmalignantTlymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
-
Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, et al. 1996. Activation of Jak/STAT proteins involved in signal transduction pathwaymediated by receptor for interleukin 2 inmalignantTlymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. PNAS 93(17):9148-53
-
(1996)
PNAS
, vol.93
, Issue.17
, pp. 9148-9153
-
-
Zhang, Q.1
Nowak, I.2
Vonderheid, E.C.3
Rook, A.H.4
Kadin, M.E.5
-
30
-
-
84940585634
-
Genomic landscape of cutaneous T cell lymphoma
-
Choi J, Goh G, Walradt T, Hong BS, Bunick CG, et al. 2015. Genomic landscape of cutaneous T cell lymphoma. Nat. Genet. 47(9):1011-19
-
(2015)
Nat. Genet.
, vol.47
, Issue.9
, pp. 1011-1019
-
-
Choi, J.1
Goh, G.2
Walradt, T.3
Hong, B.S.4
Bunick, C.G.5
-
31
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
Zhang JH, Ding L, Holmfeldt L, Wu G, Heatley SL, et al. 2012. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481(7380):157-63
-
(2012)
Nature
, vol.481
, Issue.7380
, pp. 157-163
-
-
Zhang, J.H.1
Ding, L.2
Holmfeldt, L.3
Wu, G.4
Heatley, S.L.5
-
32
-
-
84896617557
-
A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
-
Odejide O, Weigert O, Lane AA. 2014. A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood 123(9):1293-96
-
(2014)
Blood
, vol.123
, Issue.9
, pp. 1293-1296
-
-
Odejide, O.1
Weigert, O.2
Lane, A.A.3
-
33
-
-
13144276369
-
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
-
Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BKR, et al. 1997. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. PNAS 94(25):13897-902
-
(1997)
PNAS
, vol.94
, Issue.25
, pp. 13897-13902
-
-
Takemoto, S.1
Mulloy, J.C.2
Cereseto, A.3
Migone, T.S.4
Patel, B.K.R.5
-
34
-
-
84945344219
-
Integrated molecular analysis of adult T cell leukemia/lymphoma
-
Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, et al. 2015. Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat. Genet. 47(11):1304-15
-
(2015)
Nat. Genet.
, vol.47
, Issue.11
, pp. 1304-1315
-
-
Kataoka, K.1
Nagata, Y.2
Kitanaka, A.3
Shiraishi, Y.4
Shimamura, T.5
-
35
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V, Boureux A, DellaValle V, Poirel H, Quang CT, et al. 1997. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278(5341):1309-12
-
(1997)
Science
, vol.278
, Issue.5341
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
DellaValle, V.3
Poirel, H.4
Quang, C.T.5
-
36
-
-
0033639119
-
Stat5 is essential for the myelo-and lymphoproliferative disease induced by TEL/JAK2
-
Schwaller J, Parganas E, Wang DM, Cain D, Aster JC, et al. 2000. Stat5 is essential for the myelo-and lymphoproliferative disease induced by TEL/JAK2. Mol. Cell 6(3):693-704
-
(2000)
Mol. Cell
, vol.6
, Issue.3
, pp. 693-704
-
-
Schwaller, J.1
Parganas, E.2
Wang, D.M.3
Cain, D.4
Aster, J.C.5
-
37
-
-
0034660270
-
TEL-JAK2 transgenic mice develop T-cell leukemia
-
Carron C, Cormier F, Janin A, Lacronique V, Giovannini M, et al. 2000. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood 95(12):3891-99
-
(2000)
Blood
, vol.95
, Issue.12
, pp. 3891-3899
-
-
Carron, C.1
Cormier, F.2
Janin, A.3
Lacronique, V.4
Giovannini, M.5
-
38
-
-
84884700620
-
Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma
-
Feldman AL, Vasmatzis G, Asmann YW, Davila J, Middha S, et al. 2013. Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma. Genes Chromosomes Cancer 52(11):1097-102
-
(2013)
Genes Chromosomes Cancer
, vol.52
, Issue.11
, pp. 1097-1102
-
-
Feldman, A.L.1
Vasmatzis, G.2
Asmann, Y.W.3
Davila, J.4
Middha, S.5
-
39
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, et al. 2005. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365(9464):1054-61
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
-
40
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, andmyeloidmetaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, et al. 2005. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, andmyeloidmetaplasia with myelofibrosis. Cancer Cell 7(4):387-97
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
-
41
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, Teo S, Tiedt R, et al. 2005. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352(17):1779-90
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.4
Tiedt, R.5
-
42
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, et al. 2005. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434(7037):1144-48
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
Staerk, J.4
Delhommeau, F.5
-
43
-
-
84921325808
-
The JAK-STAT pathway: Impact on human disease and therapeutic intervention
-
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A. 2015. The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu. Rev. Med. 66:311-28
-
(2015)
Annu. Rev. Med.
, vol.66
, pp. 311-328
-
-
O'Shea, J.J.1
Schwartz, D.M.2
Villarino, A.V.3
Gadina, M.4
McInnes, I.B.5
Laurence, A.6
-
44
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, et al. 2012. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N. Engl. J. Med. 366(9):787-98
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.9
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
Gisslinger, H.4
Waltzman, R.5
-
45
-
-
84954369684
-
Tyrosine kinase inhibitors as a first-line treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase: Amixed-treatment comparison
-
Firwana B, Sonbol MB, Diab M, Raza S, Hasan R, et al. 2016. Tyrosine kinase inhibitors as a first-line treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase: amixed-treatment comparison. Int. J. Cancer 138(6):1545-53
-
(2016)
Int. J. Cancer
, vol.138
, Issue.6
, pp. 1545-1553
-
-
Firwana, B.1
Sonbol, M.B.2
Diab, M.3
Raza, S.4
Hasan, R.5
-
46
-
-
84872065897
-
JAKs and STATs in immunity, immunodeficiency, and cancer
-
O'Shea JJ, Holland SM, Staudt LM. 2013. JAKs and STATs in immunity, immunodeficiency, and cancer. N. Engl. J. Med. 368(2):161-70
-
(2013)
N. Engl. J. Med.
, vol.368
, Issue.2
, pp. 161-170
-
-
O'Shea, J.J.1
Holland, S.M.2
Staudt, L.M.3
-
47
-
-
85018246739
-
Next-generation sequencing suggests complex, heterogeneous pathogenesis in peripheral T-cell lymphoma unspecified
-
(Abstr.)
-
Schatz JH, Horwitz SM, Lunning MA, Dolgalev I, Huberman K, et al. 2013. Next-generation sequencing suggests complex, heterogeneous pathogenesis in peripheral T-cell lymphoma unspecified. Blood 122(21):843 (Abstr.)
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 843
-
-
Schatz, J.H.1
Horwitz, S.M.2
Lunning, M.A.3
Dolgalev, I.4
Huberman, K.5
-
48
-
-
47249157224
-
Therapeutic targeting of Janus kinases
-
Pesu M, Laurence A, Kishore N, Zwillich SH, Chan G, O'Shea JJ. 2008. Therapeutic targeting of Janus kinases. Immunol. Rev. 223:132-42
-
(2008)
Immunol. Rev.
, vol.223
, pp. 132-142
-
-
Pesu, M.1
Laurence, A.2
Kishore, N.3
Zwillich, S.H.4
Chan, G.5
O'Shea, J.J.6
-
49
-
-
79951482172
-
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP
-
Ju W, Zhang ML, Jiang JK, Thomas CJ, Oh U, et al. 2011. CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood 117(6):1938-46
-
(2011)
Blood
, vol.117
, Issue.6
, pp. 1938-1946
-
-
Ju, W.1
Zhang, M.L.2
Jiang, J.K.3
Thomas, C.J.4
Oh, U.5
-
50
-
-
85018272878
-
Refractory T-cell prolymphocytic leukemia with JAK3mutation: In vitro and clinical synergy of tofacitinib and ruxolitinib
-
(Abstr.)
-
Wei M, Koshy N, van Besien K, Inghirami G, Horwitz SM. 2015. Refractory T-cell prolymphocytic leukemia with JAK3mutation: in vitro and clinical synergy of tofacitinib and ruxolitinib. Blood 126(23):5486 (Abstr.)
-
(2015)
Blood
, vol.126
, Issue.23
, pp. 5486
-
-
Wei, M.1
Koshy, N.2
Van Besien, K.3
Inghirami, G.4
Horwitz, S.M.5
-
51
-
-
85018343050
-
Ruxolitinib for adult T-cell leukemia
-
NCT01712659, updated Sep. 28. Natl. Inst. Health
-
Conlon KC, Waldmann TA. 2016. Ruxolitinib for adult T-cell leukemia. Clin. Study Rec. NCT01712659, updated Sep. 28. Natl. Inst. Health. https://clinicaltrials.gov/ct2/show/NCT01712659
-
(2016)
Clin. Study Rec.
-
-
Conlon, K.C.1
Waldmann, T.A.2
-
52
-
-
85047699293
-
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
-
Zamo A, Chiarle R, Piva R, Howes J, Fan Y, et al. 2002. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21(7):1038-47
-
(2002)
Oncogene
, vol.21
, Issue.7
, pp. 1038-1047
-
-
Zamo, A.1
Chiarle, R.2
Piva, R.3
Howes, J.4
Fan, Y.5
-
53
-
-
84872288990
-
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
-
Roskoski R Jr. 2013. Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. Pharmacol. Res. 68(1):68-94
-
(2013)
Pharmacol. Res.
, vol.68
, Issue.1
, pp. 68-94
-
-
Roskoski, R.1
-
54
-
-
46749096836
-
Induction of the IL-9 gene by HTLV-1 Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
-
Chen J, Petrus M, Bryant BR, Nguyen VP, Stamer M, et al. 2008. Induction of the IL-9 gene byHTLV-1 Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism. Blood 111(10):5163-72
-
(2008)
Blood
, vol.111
, Issue.10
, pp. 5163-5172
-
-
Chen, J.1
Petrus, M.2
Bryant, B.R.3
Nguyen, V.P.4
Stamer, M.5
-
55
-
-
78650659621
-
Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adultT-cell leukemia
-
Chen J, Petrus M, Bryant BR, Nguyen VP, Goldman CK, et al. 2010. Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adultT-cell leukemia. Blood 116(26):5948-56
-
(2010)
Blood
, vol.116
, Issue.26
, pp. 5948-5956
-
-
Chen, J.1
Petrus, M.2
Bryant, B.R.3
Nguyen, V.P.4
Goldman, C.K.5
-
56
-
-
70649096122
-
SH2 domains: Modulators of nonreceptor tyrosine kinase activity
-
Filippakopoulos P, Muller S, Knapp S. 2009. SH2 domains: modulators of nonreceptor tyrosine kinase activity. Curr. Opin. Struct. Biol. 19(6):643-49
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, Issue.6
, pp. 643-649
-
-
Filippakopoulos, P.1
Muller, S.2
Knapp, S.3
-
57
-
-
0028946158
-
Contribution of STATSH2groups to specific interferon signaling by the Jak-STAT pathway
-
Heim MH, Kerr IM, Stark GR, Darnell JE. 1995. Contribution of STATSH2groups to specific interferon signaling by the Jak-STAT pathway. Sci.267(5202):1347-49
-
(1995)
Sci.
, vol.267
, Issue.5202
, pp. 1347-1349
-
-
Heim, M.H.1
Kerr, I.M.2
Stark, G.R.3
Darnell, J.E.4
-
58
-
-
84937931145
-
Whole-genome sequening reveals oncogenic mutations in mycosis fungoides
-
McGirt LY, Jia P, Baerenwald DA, Duszynski RJ, Dahlman KB, et al. 2015. Whole-genome sequening reveals oncogenic mutations in mycosis fungoides. Blood 126(4):508-19
-
(2015)
Blood
, vol.126
, Issue.4
, pp. 508-519
-
-
McGirt, L.Y.1
Jia, P.2
Baerenwald, D.A.3
Duszynski, R.J.4
Dahlman, K.B.5
-
59
-
-
84880768462
-
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
-
Rajala HLM, Eldfors S, Kuusanmaki H, van Adrichem AJ, Olson T, et al. 2013. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood 121(22):4541-50
-
(2013)
Blood
, vol.121
, Issue.22
, pp. 4541-4550
-
-
Rajala, H.L.M.1
Eldfors, S.2
Kuusanmaki, H.3
Van Adrichem, A.J.4
Olson, T.5
-
60
-
-
84899842603
-
Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations
-
Rajala HLM, Porkka K, Maciejewski JP, Loughran TP, Mustjoki S. 2014. Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. Ann. Med. 46(3):114-22
-
(2014)
Ann. Med.
, vol.46
, Issue.3
, pp. 114-122
-
-
Rajala, H.L.M.1
Porkka, K.2
Maciejewski, J.P.3
Loughran, T.P.4
Mustjoki, S.5
-
61
-
-
0037033012
-
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
-
Saharinen P, Silvennoinen O. 2002. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J. Biol. Chem. 277(49):47954-63
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.49
, pp. 47954-47963
-
-
Saharinen, P.1
Silvennoinen, O.2
-
62
-
-
0034012330
-
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
-
Saharinen P, Takaluoma K, Silvennoinen O. 2000. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell Biol. 20(10):3387-95
-
(2000)
Mol. Cell Biol.
, vol.20
, Issue.10
, pp. 3387-3395
-
-
Saharinen, P.1
Takaluoma, K.2
Silvennoinen, O.3
-
63
-
-
80053638747
-
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma
-
Elliott NE, Cleveland SM, Grann V, Janik J, Waldmann TA, Dave UP. 2011. FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. Blood 118(14):3911-21
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3911-3921
-
-
Elliott, N.E.1
Cleveland, S.M.2
Grann, V.3
Janik, J.4
Waldmann, T.A.5
Dave, U.P.6
-
64
-
-
84881510143
-
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia
-
Yamashita Y, Shimada A, Yamada T, Yamaji K, Hon T, et al. 2013. IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia. Pediatr. Blood Cancer 60(10):1587-92
-
(2013)
Pediatr. Blood Cancer
, vol.60
, Issue.10
, pp. 1587-1592
-
-
Yamashita, Y.1
Shimada, A.2
Yamada, T.3
Yamaji, K.4
Hon, T.5
-
65
-
-
42249091014
-
Somatically acquired JAK1mutations in adult acute lymphoblastic leukemia
-
Flex E, Petrangeli V, Stella L, Chiaretti S, Hornakova T, et al. 2008. Somatically acquired JAK1mutations in adult acute lymphoblastic leukemia. J. Exp. Med. 205(4):751-58
-
(2008)
J. Exp. Med.
, vol.205
, Issue.4
, pp. 751-758
-
-
Flex, E.1
Petrangeli, V.2
Stella, L.3
Chiaretti, S.4
Hornakova, T.5
-
66
-
-
67249146555
-
JAK mutations in high-risk childhood acute lymphoblastic leukemia
-
Mullighan CG, Zhang JH, Harvey RC, Collins-Underwood JR, Schulman BA, et al. 2009. JAK mutations in high-risk childhood acute lymphoblastic leukemia. PNAS 106(23):9414-18
-
(2009)
PNAS
, vol.106
, Issue.23
, pp. 9414-9418
-
-
Mullighan, C.G.1
Zhang, J.H.2
Harvey, R.C.3
Collins-Underwood, J.R.4
Schulman, B.A.5
-
67
-
-
30044437118
-
Expression of a homodimeric type i cytokine receptor is required for JAK2V617F-mediated transformation
-
Lu XH, Levine R, Tong W, Wernig G, Pikman Y, et al. 2005. Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. PNAS 102(52):18962-67
-
(2005)
PNAS
, vol.102
, Issue.52
, pp. 18962-18967
-
-
Lu, X.H.1
Levine, R.2
Tong, W.3
Wernig, G.4
Pikman, Y.5
-
68
-
-
65449160177
-
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor ahomodimers
-
Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, et al. 2009. Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor ahomodimers. J. Biol. Chem. 284(11):6773-81
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.11
, pp. 6773-6781
-
-
Hornakova, T.1
Staerk, J.2
Royer, Y.3
Flex, E.4
Tartaglia, M.5
-
69
-
-
79956108320
-
Gain-of-function mutations in interleukin-7 receptor-a (IL7R) in childhood acute lymphoblastic leukemias
-
Shochat C, Tal N, Bandapalli OR, Palmi C, Ganmore I, et al. 2011. Gain-of-function mutations in interleukin-7 receptor-a (IL7R) in childhood acute lymphoblastic leukemias. J. Exp. Med. 208(5):901
-
(2011)
J. Exp. Med.
, vol.208
, Issue.5
, pp. 901
-
-
Shochat, C.1
Tal, N.2
Bandapalli, O.R.3
Palmi, C.4
Ganmore, I.5
-
70
-
-
80053385665
-
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
-
Zenatti PP, Ribeiro D, Li WQ, Zuurbier L, Silva MC, et al. 2011. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat. Genet. 43(10):932-39
-
(2011)
Nat. Genet.
, vol.43
, Issue.10
, pp. 932-939
-
-
Zenatti, P.P.1
Ribeiro, D.2
Li, W.Q.3
Zuurbier, L.4
Silva, M.C.5
-
71
-
-
0025286634
-
Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: Pathogenic implications and a rationale for immunotherapy
-
Tendler CL, Greenberg SJ, Blattner WA, Manns A, Murphy E, et al. 1990. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. PNAS 87(13):5218-22
-
(1990)
PNAS
, vol.87
, Issue.13
, pp. 5218-5222
-
-
Tendler, C.L.1
Greenberg, S.J.2
Blattner, W.A.3
Manns, A.4
Murphy, E.5
-
72
-
-
0032478333
-
Human T cell lymphotropic virus type i Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site
-
Azimi N, Brown K, Bamford RN, Tagaya Y, Siebenlist U, Waldmann TA. 1998. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site. PNAS 95(5):2452-57
-
(1998)
PNAS
, vol.95
, Issue.5
, pp. 2452-2457
-
-
Azimi, N.1
Brown, K.2
Bamford, R.N.3
Tagaya, Y.4
Siebenlist, U.5
Waldmann, T.A.6
-
73
-
-
0035724431
-
Interleukin-15 expression in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)
-
Leroy S, Dubois S, Tenaud I, Chebassier N, Godard A, et al. 2001. Interleukin-15 expression in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). Br. J. Dermatol. 144(5):1016-23
-
(2001)
Br. J. Dermatol.
, vol.144
, Issue.5
, pp. 1016-1023
-
-
Leroy, S.1
Dubois, S.2
Tenaud, I.3
Chebassier, N.4
Godard, A.5
-
74
-
-
2642629701
-
Interleukin-15 is an autocrine/ paracrine viability factor for cutaneous T-cell lymphoma cells
-
Dobbeling U, Dummer R, Laine E, Potoczna N, Gin JZ, Burg G. 1998. Interleukin-15 is an autocrine/ paracrine viability factor for cutaneous T-cell lymphoma cells. Blood 92(1):252-58
-
(1998)
Blood
, vol.92
, Issue.1
, pp. 252-258
-
-
Dobbeling, U.1
Dummer, R.2
Laine, E.3
Potoczna, N.4
Gin, J.Z.5
Burg, G.6
-
75
-
-
85018297671
-
Epigenetic disruption of ZEB1 binding causes constitutive activation of IL-15 in cutaneous T-cell lymphoma
-
Mishra A, Kwiatkowski S, Sullivan L, Grinshpun L, Russo G, et al. 2015. Epigenetic disruption of ZEB1 binding causes constitutive activation of IL-15 in cutaneous T-cell lymphoma. Blood 126(23):2
-
(2015)
Blood
, vol.126
, Issue.23
, pp. 2
-
-
Mishra, A.1
Kwiatkowski, S.2
Sullivan, L.3
Grinshpun, L.4
Russo, G.5
-
76
-
-
77954952693
-
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma
-
Nakahata S, Yamazaki S, Nakauchi H, Morishita K. 2010. Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma. Oncogene 29(29):4157-69
-
(2010)
Oncogene
, vol.29
, Issue.29
, pp. 4157-4169
-
-
Nakahata, S.1
Yamazaki, S.2
Nakauchi, H.3
Morishita, K.4
-
77
-
-
84945251939
-
IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma
-
Jain S, Chen J, Nicolae A, Wang HS, Shin DM, et al. 2015. IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma. Am. J. Pathol. 185(11):3102-14
-
(2015)
Am. J. Pathol.
, vol.185
, Issue.11
, pp. 3102-3114
-
-
Jain, S.1
Chen, J.2
Nicolae, A.3
Wang, H.S.4
Shin, D.M.5
-
78
-
-
77952887619
-
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
-
Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, et al. 2010. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat. Genet. 42(6):530-35
-
(2010)
Nat. Genet.
, vol.42
, Issue.6
, pp. 530-535
-
-
Kleppe, M.1
Lahortiga, I.2
El Chaar, T.3
De Keersmaecker, K.4
Mentens, N.5
-
79
-
-
79959826613
-
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia
-
Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, et al. 2011. PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia. Blood 117(26):7090-98
-
(2011)
Blood
, vol.117
, Issue.26
, pp. 7090-7098
-
-
Kleppe, M.1
Soulier, J.2
Asnafi, V.3
Mentens, N.4
Hornakova, T.5
-
80
-
-
84861070995
-
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
-
Porcu M, Kleppe M, Gianfelici V, Geerdens E, De Keersmaecker K, et al. 2012. Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia. Blood 119(19):4476-79
-
(2012)
Blood
, vol.119
, Issue.19
, pp. 4476-4479
-
-
Porcu, M.1
Kleppe, M.2
Gianfelici, V.3
Geerdens, E.4
De Keersmaecker, K.5
-
81
-
-
0036595049
-
Suppressors of cytokine signalling (SOCS) in the immune system
-
Alexander WS. 2002. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2(6):410-16
-
(2002)
Nat. Rev. Immunol.
, vol.2
, Issue.6
, pp. 410-416
-
-
Alexander, W.S.1
-
82
-
-
84927621119
-
Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma
-
Kucuk C, Hu X, Jiang B, Klinkebiel D, Geng HM, et al. 2015. Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma.Clin. Can. Res. 21(7):1699-711
-
(2015)
Clin. Can. Res.
, vol.21
, Issue.7
, pp. 1699-1711
-
-
Kucuk, C.1
Hu, X.2
Jiang, B.3
Klinkebiel, D.4
Geng, H.M.5
-
83
-
-
25444519432
-
Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study
-
Baslund B, Tvede N, Danneskiold-Samsoe B, Larsson P, Panayi G, et al. 2005. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum. 52(9):2686-692
-
(2005)
Arthritis Rheum.
, vol.52
, Issue.9
, pp. 2686-2692
-
-
Baslund, B.1
Tvede, N.2
Danneskiold-Samsoe, B.3
Larsson, P.4
Panayi, G.5
-
84
-
-
33846868833
-
Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: A 25-year personal odyssey
-
Waldmann TA. 2007. Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey. J. Clin. Immunol. 27(1):1-18
-
(2007)
J. Clin. Immunol.
, vol.27
, Issue.1
, pp. 1-18
-
-
Waldmann, T.A.1
-
85
-
-
84910096506
-
Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma
-
Berkowitz JL, Janik JE, Stewart DM, Jaffe ES, Stetler-Stevenson M, et al. 2014. Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma. Clin. Immunol. 155(2):176-87
-
(2014)
Clin. Immunol.
, vol.155
, Issue.2
, pp. 176-187
-
-
Berkowitz, J.L.1
Janik, J.E.2
Stewart, D.M.3
Jaffe, E.S.4
Stetler-Stevenson, M.5
-
86
-
-
84941584635
-
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum
-
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, et al. 2015. Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J. Biol. Chem. 290(37):22338-51
-
(2015)
J. Biol. Chem.
, vol.290
, Issue.37
, pp. 22338-22351
-
-
Nata, T.1
Basheer, A.2
Cocchi, F.3
Van Besien, R.4
Massoud, R.5
-
87
-
-
84929692931
-
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps
-
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, et al. 2015. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity 42(5):826-38
-
(2015)
Immunity
, vol.42
, Issue.5
, pp. 826-838
-
-
Mitra, S.1
Ring, A.M.2
Amarnath, S.3
Spangler, J.B.4
Li, P.5
-
88
-
-
0031440585
-
Advances in the understanding of cytokine signal transduction: The role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency
-
O'Shea JJ, Notarangelo LD, Johnston JA, Candotti F. 1997. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J. Clin. Immunol. 17(6):431-47
-
(1997)
J. Clin. Immunol.
, vol.17
, Issue.6
, pp. 431-447
-
-
O'Shea, J.J.1
Notarangelo, L.D.2
Johnston, J.A.3
Candotti, F.4
-
90
-
-
84951567838
-
Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia
-
Bilori B, Thota S, Clemente MJ, Patel B, Jerez A, et al. 2015. Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia. Leukemia 29(12):2427-29
-
(2015)
Leukemia
, vol.29
, Issue.12
, pp. 2427-2429
-
-
Bilori, B.1
Thota, S.2
Clemente, M.J.3
Patel, B.4
Jerez, A.5
-
91
-
-
79953043687
-
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors
-
Haan C, Rolvering C, Raulf F, Kapp M, Druckes P, et al. 2011. Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors. Chem. Biol. 18(3):314-23
-
(2011)
Chem. Biol.
, vol.18
, Issue.3
, pp. 314-323
-
-
Haan, C.1
Rolvering, C.2
Raulf, F.3
Kapp, M.4
Druckes, P.5
-
92
-
-
84961722011
-
Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling
-
Smith GA, Uchida K, Weiss A, Taunton J. 2016. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat. Chem. Biol. 12(5):373-79
-
(2016)
Nat. Chem. Biol.
, vol.12
, Issue.5
, pp. 373-379
-
-
Smith, G.A.1
Uchida, K.2
Weiss, A.3
Taunton, J.4
-
93
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner R, Mora LB, Jove R. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8(4):945-54
-
(2002)
Clin. Cancer Res.
, vol.8
, Issue.4
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
94
-
-
84943251142
-
Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia
-
Zhang ML, Griner LAM, Ju W, Duveau DY, Guha R, et al. 2015. Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. PNAS 112(40):12480-85
-
(2015)
PNAS
, vol.112
, Issue.40
, pp. 12480-12485
-
-
Zhang, M.L.1
Griner, L.A.M.2
Ju, W.3
Duveau, D.Y.4
Guha, R.5
-
95
-
-
84920670383
-
Targeting mutational profiling of peripheral T-cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis
-
Schatz JH, Horwitz SM, Teruya-Feldstein J, Lunning MA, Viale A, et al. 2015. Targeting mutational profiling of peripheral T-cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis. Leukemia 29(1):237-41
-
(2015)
Leukemia
, vol.29
, Issue.1
, pp. 237-241
-
-
Schatz, J.H.1
Horwitz, S.M.2
Teruya-Feldstein, J.3
Lunning, M.A.4
Viale, A.5
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