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Volumn 2017, Issue , 2017, Pages

Diagnostic and therapeutic biomarkers in glioblastoma: Current status and future perspectives

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GROWTH FACTOR RECEPTOR; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MDM2; PROTEIN P14; PROTEIN P53; PROTEIN TYROSINE KINASE; DNA LIGASE; DNA METHYLTRANSFERASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; MGMT PROTEIN, HUMAN; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

EID: 85017554924     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2017/8013575     Document Type: Review
Times cited : (249)

References (141)
  • 1
    • 84979857888 scopus 로고    scopus 로고
    • Alex's Lemonade stand foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007-2011
    • Q. T. Ostrom, P. M. De Blank, C. Kruchko et al., "Alex's Lemonade stand foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007-2011," Neuro-Oncology, vol. 16, supplement 10, pp. x1- x36, 2015.
    • (2015) Neuro-Oncology , vol.16 , pp. x1-x36
    • Ostrom, Q.T.1    De Blank, P.M.2    Kruchko, C.3
  • 2
    • 68149181745 scopus 로고    scopus 로고
    • Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy
    • M. L. Affronti, C. R. Heery, J. E. Herndon II et al., "Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy," Cancer, vol. 115, no. 15, pp. 3501-3511, 2009.
    • (2009) Cancer , vol.115 , Issue.15 , pp. 3501-3511
    • Affronti, M.L.1    Heery, C.R.2    Herndon, I.I.J.E.3
  • 3
    • 84952870767 scopus 로고    scopus 로고
    • Advances in the treatment of newly diagnosed glioblastoma
    • B. J. Theeler and M. R. Gilbert, "Advances in the treatment of newly diagnosed glioblastoma," BMC Medicine, vol. 13, article 293, 2015.
    • (2015) BMC Medicine , vol.13
    • Theeler, B.J.1    Gilbert, M.R.2
  • 4
    • 84904913239 scopus 로고    scopus 로고
    • Singleagent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): A randomised controlled phase 2 trial
    • W. Taal, H. M. Oosterkamp, A.M. E. Walenkamp et al., "Singleagent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial," The Lancet Oncology, vol. 15, no. 9, pp. 943-953, 2014.
    • (2014) The Lancet Oncology , vol.15 , Issue.9 , pp. 943-953
    • Taal, W.1    Oosterkamp, H.M.2    Walenkamp, A.M.E.3
  • 6
    • 84910597102 scopus 로고    scopus 로고
    • Emerging treatment strategies for glioblastoma multiforme
    • S. K. Carlsson, S. P. Brothers, and C. Wahlestedt, "Emerging treatment strategies for glioblastoma multiforme," EMBO Molecular Medicine, vol. 6, no. 11, pp. 1359-1370, 2014.
    • (2014) EMBO Molecular Medicine , vol.6 , Issue.11 , pp. 1359-1370
    • Carlsson, S.K.1    Brothers, S.P.2    Wahlestedt, C.3
  • 7
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • D. N. Louis, H. Ohgaki, O. D. Wiestler et al., "The 2007 WHO classification of tumours of the central nervous system," Acta Neuropathologica, vol. 114, no. 2, pp. 97-109, 2007.
    • (2007) Acta Neuropathologica , vol.114 , Issue.2 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3
  • 8
    • 84966687479 scopus 로고    scopus 로고
    • The 2016World Health Organization Classification of Tumors of the Central Nervous System: A summary
    • D. N. Louis, A. Perry, G. Reifenberger et al., "The 2016World Health Organization Classification of Tumors of the Central Nervous System: a summary," Acta Neuropathologica, vol. 131, no. 6, pp. 803-820, 2016.
    • (2016) Acta Neuropathologica , vol.131 , Issue.6 , pp. 803-820
    • Louis, D.N.1    Perry, A.2    Reifenberger, G.3
  • 9
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • H. Ohgaki and P. Kleihues, "The definition of primary and secondary glioblastoma," Clinical Cancer Research, vol. 19, no. 4, pp. 764-772, 2013.
    • (2013) Clinical Cancer Research , vol.19 , Issue.4 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 10
    • 4944255253 scopus 로고    scopus 로고
    • Genetic pathways to glioblastoma: A population-based study
    • H. Ohgaki, P. Dessen, B. Jourde et al., "Genetic pathways to glioblastoma: a population-based study," Cancer Research, vol. 64, no. 19, pp. 6892-6899, 2004.
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 6892-6899
    • Ohgaki, H.1    Dessen, P.2    Jourde, B.3
  • 11
    • 0034795045 scopus 로고    scopus 로고
    • Promoter methylation of theDNArepair geneMGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene
    • M. Nakamura, T. Watanabe, Y. Yonekawa, P. Kleihues, and H. Ohgaki, "Promoter methylation of theDNArepair geneMGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene," Carcinogenesis, vol. 22, no. 10, pp. 1715-1719, 2001.
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 12
  • 13
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • H. S. Phillips, S. Kharbanda, R. Chen et al., "Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis," Cancer Cell, vol. 9, no. 3, pp. 157-173, 2006.
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 14
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • R. G. W. Verhaak, K. A. Hoadley, E. Purdom et al., "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1," Cancer Cell, vol. 17, no. 1, pp. 98-110, 2010.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 15
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • C. W. Brennan, R. G. Verhaak, A. McKenna et al., "The somatic genomic landscape of glioblastoma," Cell, vol. 155, no. 2, pp. 462-477, 2013.
    • (2013) Cell , vol.155 , Issue.2 , pp. 462-477
    • Brennan, C.W.1    Verhaak, R.G.2    McKenna, A.3
  • 17
    • 77951599543 scopus 로고    scopus 로고
    • Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
    • J. T. Huse and E. C. Holland, "Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma," Nature Reviews Cancer, vol. 10, no. 5, pp. 319-331, 2010.
    • (2010) Nature Reviews Cancer , vol.10 , Issue.5 , pp. 319-331
    • Huse, J.T.1    Holland, E.C.2
  • 19
    • 84959149840 scopus 로고    scopus 로고
    • The challenges associated with molecular targeted therapies for glioblastoma
    • T. R. Jue and K. L. McDonald, "The challenges associated with molecular targeted therapies for glioblastoma," Journal of Neuro-Oncology, vol. 127, no. 3, pp. 427-434, 2016.
    • (2016) Journal of Neuro-Oncology , vol.127 , Issue.3 , pp. 427-434
    • Jue, T.R.1    McDonald, K.L.2
  • 20
    • 84858834921 scopus 로고    scopus 로고
    • Glioblastoma biomarkers from bench to bedside: Advances and challenges
    • G. Farias-Eisner, A. M. Bank, B. Y. Hwang et al., "Glioblastoma biomarkers from bench to bedside: advances and challenges," British Journal of Neurosurgery, vol. 26, no. 2, pp. 189-194, 2012.
    • (2012) British Journal of Neurosurgery , vol.26 , Issue.2 , pp. 189-194
    • Farias-Eisner, G.1    Bank, A.M.2    Hwang, B.Y.3
  • 21
    • 84883656941 scopus 로고    scopus 로고
    • Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
    • K. P. L. Bhat, V. Balasubramaniyan, B. Vaillant et al., "Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma," Cancer Cell, vol. 24, no. 3, pp. 331- 346, 2013.
    • (2013) Cancer Cell , vol.24 , Issue.3 , pp. 331-346
    • Bhat, K.P.L.1    Balasubramaniyan, V.2    Vaillant, B.3
  • 22
    • 84878151308 scopus 로고    scopus 로고
    • Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    • P. Mao, K. Joshi, J. Li et al., "Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3," Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 21, pp. 8644-8649, 2013.
    • (2013) Proceedings of the National Academy of Sciences of the United States of America , vol.110 , Issue.21 , pp. 8644-8649
    • Mao, P.1    Joshi, K.2    Li, J.3
  • 23
    • 84926076998 scopus 로고    scopus 로고
    • Stem cell signature in glioblastoma: Therapeutic development for a moving target
    • I. Nakano, "Stem cell signature in glioblastoma: therapeutic development for a moving target," Journal of Neurosurgery, vol. 122, no. 2, pp. 324-330, 2015.
    • (2015) Journal of Neurosurgery , vol.122 , Issue.2 , pp. 324-330
    • Nakano, I.1
  • 24
    • 84869045299 scopus 로고    scopus 로고
    • Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    • R. Chakrabarti, J. Hwang, M. Andres Blanco et al., "Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2," Nature Cell Biology, vol. 14, no. 11, pp. 1212-1222, 2012.
    • (2012) Nature Cell Biology , vol.14 , Issue.11 , pp. 1212-1222
    • Chakrabarti, R.1    Hwang, J.2    Andres Blanco, M.3
  • 26
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • P. Y. Wen and S. Kesari, "Malignant gliomas in adults," New England Journal of Medicine, vol. 359, no. 5, pp. 492-507, 2008.
    • (2008) New England Journal of Medicine , vol.359 , Issue.5 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 27
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • F. B. Furnari, T. Fenton, R. M. Bachoo et al., "Malignant astrocytic glioma: genetics, biology, and paths to treatment," Genes and Development, vol. 21, no. 21, pp. 2683-2710, 2007.
    • (2007) Genes and Development , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 28
    • 70449711757 scopus 로고    scopus 로고
    • Genetic alterations and signaling pathways in the evolution of gliomas
    • H. Ohgaki and P. Kleihues, "Genetic alterations and signaling pathways in the evolution of gliomas," Cancer Science, vol. 100, no. 12, pp. 2235-2241, 2009.
    • (2009) Cancer Science , vol.100 , Issue.12 , pp. 2235-2241
    • Ohgaki, H.1    Kleihues, P.2
  • 29
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • I. K. Mellinghoff, M. Y. Wang, I. Vivanco et al., "Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors," The New England Journal of Medicine, vol. 353, no. 19, pp. 2012-2024, 2005.
    • (2005) The New England Journal of Medicine , vol.353 , Issue.19 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 30
    • 84936756040 scopus 로고    scopus 로고
    • Current therapeutic advances targeting EGFR and EGFRvIII in glioblastoma
    • E. Padfield, H. P. Ellis, and K.M. Kurian, "Current therapeutic advances targeting EGFR and EGFRvIII in glioblastoma," Frontiers in Oncology, vol. 5, article no. 5, 2015.
    • (2015) Frontiers in Oncology , vol.5
    • Padfield, E.1    Ellis, H.P.2    Kurian, K.M.3
  • 31
    • 84928590179 scopus 로고    scopus 로고
    • Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
    • F. B. Furnari, T. F. Cloughesy, W. K. Cavenee, and P. S. Mischel, "Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma," Nature Reviews Cancer, vol. 15, no. 5, pp. 302-310, 2015.
    • (2015) Nature Reviews Cancer , vol.15 , Issue.5 , pp. 302-310
    • Furnari, F.B.1    Cloughesy, T.F.2    Cavenee, W.K.3    Mischel, P.S.4
  • 32
    • 84863813631 scopus 로고    scopus 로고
    • Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas
    • J. Hobbs, M. N. Nikiforova, D. W. Fardo et al., "Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas," The American Journal of Surgical Pathology, vol. 36, no. 8, pp. 1186-1193, 2012.
    • (2012) The American Journal of Surgical Pathology , vol.36 , Issue.8 , pp. 1186-1193
    • Hobbs, J.1    Nikiforova, M.N.2    Fardo, D.W.3
  • 33
    • 84895922426 scopus 로고    scopus 로고
    • Assessment and prognostic significance of the epidermal growth factor receptor VIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy
    • M. Weller, K. Kaulich, B. Hentschel et al., "Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy," International Journal of Cancer, vol. 134, no. 10, pp. 2437-2447, 2014.
    • (2014) International Journal of Cancer , vol.134 , Issue.10 , pp. 2437-2447
    • Weller, M.1    Kaulich, K.2    Hentschel, B.3
  • 34
    • 34250189213 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma
    • C. E. Pelloski, K. V. Ballman, A. F. Furth et al., "Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma," Journal of Clinical Oncology, vol. 25, no. 16, pp. 2288-2294, 2007.
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.16 , pp. 2288-2294
    • Pelloski, C.E.1    Ballman, K.V.2    Furth, A.F.3
  • 35
    • 84938920317 scopus 로고    scopus 로고
    • EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers
    • C. Faulkner, A. Palmer, H. Williams et al., "EGFR and EGFRvIII analysis in glioblastoma as therapeutic biomarkers," British Journal of Neurosurgery, vol. 29, no. 1, pp. 23-29, 2015.
    • (2015) British Journal of Neurosurgery , vol.29 , Issue.1 , pp. 23-29
    • Faulkner, C.1    Palmer, A.2    Williams, H.3
  • 36
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • A. B. Heimberger, R. Hlatky, D. Suki et al., "Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients," Clinical Cancer Research, vol. 11, no. 4, pp. 1462-1466, 2005.
    • (2005) Clinical Cancer Research , vol.11 , Issue.4 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3
  • 37
    • 21444450373 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    • D. A. Haas-Kogan, M. D. Prados, T. Tihan et al., "Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib," Journal of the National Cancer Institute, vol. 97, no. 12, pp. 880-887, 2005.
    • (2005) Journal of the National Cancer Institute , vol.97 , Issue.12 , pp. 880-887
    • Haas-Kogan, D.A.1    Prados, M.D.2    Tihan, T.3
  • 38
    • 34447343798 scopus 로고    scopus 로고
    • Lessons learned in the development of targeted therapy for malignant gliomas
    • A. M. P. Omuro, S. Faivre, and E. Raymond, "Lessons learned in the development of targeted therapy for malignant gliomas," Molecular CancerTherapeutics, vol. 6, no. 7, pp. 1909-1919, 2007.
    • (2007) Molecular CancerTherapeutics , vol.6 , Issue.7 , pp. 1909-1919
    • Omuro, A.M.P.1    Faivre, S.2    Raymond, E.3
  • 39
    • 34247218483 scopus 로고    scopus 로고
    • Gefitinib in patients with progressive high-grade gliomas: A multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    • E. Franceschi, G. Cavallo, S. Lonardi et al., "Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)," British Journal of Cancer, vol. 96, no. 7, pp. 1047-1051, 2007.
    • (2007) British Journal of Cancer , vol.96 , Issue.7 , pp. 1047-1051
    • Franceschi, E.1    Cavallo, G.2    Lonardi, S.3
  • 40
    • 84933672366 scopus 로고    scopus 로고
    • Glioblastomamultiforme: Pathogenesis and treatment
    • C. Alifieris andD. T. Trafalis, "Glioblastomamultiforme: pathogenesis and treatment," Pharmacology andTherapeutics, vol. 152, pp. 63-82, 2015.
    • (2015) Pharmacology AndTherapeutics , vol.152 , pp. 63-82
    • Alifieris, C.1    Trafalis, D.T.2
  • 42
    • 84878240099 scopus 로고    scopus 로고
    • EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms
    • C. A. Del Vecchio, C. P. Giacomini, H. Vogel et al., "EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms," Oncogene, vol. 32, no. 21, pp. 2670-2681, 2013.
    • (2013) Oncogene , vol.32 , Issue.21 , pp. 2670-2681
    • Del Vecchio, C.A.1    Giacomini, C.P.2    Vogel, H.3
  • 43
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • N. Shinojima, K. Tada, S. Shiraishi et al., "Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme," Cancer Research, vol. 63, no. 20, pp. 6962-6970, 2003.
    • (2003) Cancer Research , vol.63 , Issue.20 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3
  • 44
    • 84855441538 scopus 로고    scopus 로고
    • Expression of EGFRvIII in glioblastoma: Prognostic significance revisited
    • N. Montano, T. Cenci, M. Martini et al., "Expression of EGFRvIII in glioblastoma: prognostic significance revisited," Neoplasia, vol. 13, no. 12, pp. 1113-1121, 2011.
    • (2011) Neoplasia , vol.13 , Issue.12 , pp. 1113-1121
    • Montano, N.1    Cenci, T.2    Martini, M.3
  • 45
    • 84976489226 scopus 로고    scopus 로고
    • Targeted therapeutics in patients with high-grade gliomas: Past, present, and future
    • R. Chen, A. L. Cohen, and H. Colman, "Targeted therapeutics in patients with high-grade gliomas: past, present, and future," Current Treatment Options in Oncology, vol. 17, no. 8, article no. 42, 2016.
    • (2016) Current Treatment Options in Oncology , vol.17 , Issue.8
    • Chen, R.1    Cohen, A.L.2    Colman, H.3
  • 46
    • 84973547855 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
    • X. Li, C. Wu, N. Chen et al., "PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma," Oncotarget, vol. 7, no. 22, pp. 33440-33450, 2016.
    • (2016) Oncotarget , vol.7 , Issue.22 , pp. 33440-33450
    • Li, X.1    Wu, C.2    Chen, N.3
  • 47
    • 84881479778 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: Novel therapeutic agents and advances in understanding
    • A. Sami and M. Karsy, "Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding," Tumor Biology, vol. 34, no. 4, pp. 1991-2002, 2013.
    • (2013) Tumor Biology , vol.34 , Issue.4 , pp. 1991-2002
    • Sami, A.1    Karsy, M.2
  • 48
    • 80053187240 scopus 로고    scopus 로고
    • Aberrant signaling pathways in Glioma
    • M. Nakada, D. Kita, T. Watanabe et al., "Aberrant signaling pathways in Glioma," Cancers, vol. 3, no. 3, pp. 3242-3278, 2011.
    • (2011) Cancers , vol.3 , Issue.3 , pp. 3242-3278
    • Nakada, M.1    Kita, D.2    Watanabe, T.3
  • 49
    • 71649102124 scopus 로고    scopus 로고
    • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
    • D. A. Reardon, G. Dresemann, S. Taillibert et al., "Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma," British Journal of Cancer, vol. 101, no. 12, pp. 1995-2004, 2009.
    • (2009) British Journal of Cancer , vol.101 , Issue.12 , pp. 1995-2004
    • Reardon, D.A.1    Dresemann, G.2    Taillibert, S.3
  • 50
    • 84865805666 scopus 로고    scopus 로고
    • Transforming fusions of FGFR and TACC genes in human glioblastoma
    • D. Singh, J. M. Chan, P. Zoppoli et al., "Transforming fusions of FGFR and TACC genes in human glioblastoma," Science, vol. 337, no. 6099, pp. 1231-1235, 2012.
    • (2012) Science , vol.337 , Issue.6099 , pp. 1231-1235
    • Singh, D.1    Chan, J.M.2    Zoppoli, P.3
  • 51
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • R. Abounader and J. Laterra, "Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis," Neuro- Oncology, vol. 7, no. 4, pp. 436-451, 2005.
    • (2005) Neuro- Oncology , vol.7 , Issue.4 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 52
    • 84916887597 scopus 로고    scopus 로고
    • The evolving role of molecular markers in the diagnosis and management of diffuse glioma
    • J. T. Huse and K. D. Aldape, "The evolving role of molecular markers in the diagnosis and management of diffuse glioma," Clinical Cancer Research, vol. 20, no. 22, pp. 5601-5611, 2014.
    • (2014) Clinical Cancer Research , vol.20 , Issue.22 , pp. 5601-5611
    • Huse, J.T.1    Aldape, K.D.2
  • 53
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network, "Comprehensive genomic characterization defines human glioblastoma genes and core pathways," Nature, vol. 455, no. 7216, pp. 1061-1068, 2008.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 54
    • 84903701720 scopus 로고    scopus 로고
    • AKT pathway genes define 5 prognostic subgroups in glioblastoma
    • A. Joy, A. Ramesh, I. Smirnov et al., "AKT pathway genes define 5 prognostic subgroups in glioblastoma," PLoS ONE, vol. 9, no. 7, Article ID e100827, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.7
    • Joy, A.1    Ramesh, A.2    Smirnov, I.3
  • 55
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • D.W. Parsons, S. Jones, X. Zhang et al., "An integrated genomic analysis of human glioblastoma multiforme," Science, vol. 321, no. 5897, pp. 1807-1812, 2008.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 57
    • 0029397307 scopus 로고
    • The p53 gene and its role in human brain tumors
    • O. Bögler, H.-J. S. Huang, P. Kleihues, andW. K. Cavenee, "The p53 gene and its role in human brain tumors," Glia, vol. 15, no. 3, pp. 308-327, 1995.
    • (1995) Glia , vol.15 , Issue.3 , pp. 308-327
    • Bögler, O.1    Huang, H.-J.S.2    Kleihues, P.3    Cavenee, W.K.4
  • 58
    • 0030020689 scopus 로고    scopus 로고
    • Adenovirusmediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
    • C. Gomez-Manzano, J. Fueyo, A. P. Kyritsis et al., "Adenovirusmediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis," Cancer Research, vol. 56, no. 4, pp. 694-699, 1996.
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 694-699
    • Gomez-Manzano, C.1    Fueyo, J.2    Kyritsis, A.P.3
  • 59
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • H. Ohgaki and P. Kleihues, "Genetic pathways to primary and secondary glioblastoma," American Journal of Pathology, vol. 170, no. 5, pp. 1445-1453, 2007.
    • (2007) American Journal of Pathology , vol.170 , Issue.5 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 60
    • 0032169516 scopus 로고    scopus 로고
    • The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 andMDM2
    • F. J. Stott, S. Bates, M. C. James et al., "The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 andMDM2," EMBO Journal, vol. 17, no. 17, pp. 5001-5014, 1998.
    • (1998) EMBO Journal , vol.17 , Issue.17 , pp. 5001-5014
    • Stott, F.J.1    Bates, S.2    James, M.C.3
  • 61
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • C. J. Sherr and J. M. Roberts, "CDK inhibitors: positive and negative regulators of G1-phase progression," Genes and Development, vol. 13, no. 12, pp. 1501-1512, 1999.
    • (1999) Genes and Development , vol.13 , Issue.12 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 62
    • 84917692890 scopus 로고    scopus 로고
    • Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis
    • C. L. Appin and D. J. Brat, "Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis," Advances in Anatomic Pathology, vol. 22, no. 1, pp. 50-58, 2015.
    • (2015) Advances in Anatomic Pathology , vol.22 , Issue.1 , pp. 50-58
    • Appin, C.L.1    Brat, D.J.2
  • 63
    • 84927178674 scopus 로고    scopus 로고
    • Anovel literaturebased approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: Analysis of 14, 678 patients using systematic review and meta-analytical tools
    • M.N. T. Thuy, J. K. T. Kam, G. C. Y. Lee et al., "Anovel literaturebased approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: analysis of 14, 678 patients using systematic review and meta-analytical tools," Journal of Clinical Neuroscience, vol. 22, no. 5, pp. 785-799, 2015.
    • (2015) Journal of Clinical Neuroscience , vol.22 , Issue.5 , pp. 785-799
    • Thuy, M.N.T.1    Kam, J.K.T.2    Lee, G.C.Y.3
  • 64
    • 4043105583 scopus 로고    scopus 로고
    • Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel selfregulatory mechanism of activity
    • X. Xu, J. Zhao, Z. Xu et al., "Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel selfregulatory mechanism of activity," Journal of Biological Chemistry, vol. 279, no. 32, pp. 33946-33957, 2004.
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.32 , pp. 33946-33957
    • Xu, X.1    Zhao, J.2    Xu, Z.3
  • 65
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
    • Z. J. Reitman and H. Yan, "Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism," Journal of the National Cancer Institute, vol. 102, no. 13, pp. 932-941, 2010.
    • (2010) Journal of the National Cancer Institute , vol.102 , Issue.13 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 66
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • L. Dang, D. W. White, S. Gross et al., "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate," Nature, vol. 462, no. 7274, pp. 739-744, 2009.
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 67
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    • W. Xu, H. Yang, Y. Liu et al., "Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases," Cancer Cell, vol. 19, no. 1, pp. 17-30, 2011.
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 68
    • 78650682939 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase-1 mutations: A fundamentally new understanding of diffuse glioma?
    • N. K. Kloosterhof, L. B. Bralten, H. J. Dubbink, P. J. French, and M. J. van den Bent, "Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?" The Lancet Oncology, vol. 12, no. 1, pp. 83-91, 2011.
    • (2011) The Lancet Oncology , vol.12 , Issue.1 , pp. 83-91
    • Kloosterhof, N.K.1    Bralten, L.B.2    Dubbink, H.J.3    French, P.J.4    Van Den Bent, M.J.5
  • 69
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derivedmutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
    • S. Zhao, Y. Lin, W. Xu et al., "Glioma-derivedmutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α," Science, vol. 324, no. 5924, pp. 261-265, 2009.
    • (2009) Science , vol.324 , Issue.5924 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3
  • 70
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • S. Nobusawa, T. Watanabe, P. Kleihues, and H. Ohgaki, "IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas," Clinical Cancer Research, vol. 15, no. 19, pp. 6002-6007, 2009.
    • (2009) Clinical Cancer Research , vol.15 , Issue.19 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 71
    • 68349116524 scopus 로고    scopus 로고
    • IDH1 mutations are present in themajority of common adult gliomas but rare in primary glioblastomas
    • K. Ichimura, D. M. Pearson, S. Kocialkowski et al., "IDH1 mutations are present in themajority of common adult gliomas but rare in primary glioblastomas," Neuro-Oncology, vol. 11, no. 4, pp. 341-347, 2009.
    • (2009) Neuro-Oncology , vol.11 , Issue.4 , pp. 341-347
    • Ichimura, K.1    Pearson, D.M.2    Kocialkowski, S.3
  • 72
    • 84870538996 scopus 로고    scopus 로고
    • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation
    • C. G. Duncan, B. G. Barwick, G. Jin et al., "A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation," Genome Research, vol. 22, no. 12, pp. 2339- 2355, 2012.
    • (2012) Genome Research , vol.22 , Issue.12 , pp. 2339-2355
    • Duncan, C.G.1    Barwick, B.G.2    Jin, G.3
  • 73
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • H. Noushmehr, D. J. Weisenberger, K. Diefes et al., "Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma," Cancer Cell, vol. 17, no. 5, pp. 510- 522, 2010.
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 74
    • 84858796263 scopus 로고    scopus 로고
    • IDH1mutation is sufficient to establish the glioma hypermethylator phenotype
    • S. Turcan, D. Rohle, A. Goenka et al., "IDH1mutation is sufficient to establish the glioma hypermethylator phenotype," Nature, vol. 483, no. 7390, pp. 479-483, 2012.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 75
    • 0035133842 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RB1 gene in glioblastomas
    • M. Nakamura, Y. Yonekawa, P. Kleihues, and H. Ohgaki, "Promoter hypermethylation of the RB1 gene in glioblastomas," Laboratory Investigation, vol. 81, no. 1, pp. 77-82, 2001.
    • (2001) Laboratory Investigation , vol.81 , Issue.1 , pp. 77-82
    • Nakamura, M.1    Yonekawa, Y.2    Kleihues, P.3    Ohgaki, H.4
  • 77
    • 84891544864 scopus 로고    scopus 로고
    • IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection
    • J. Beiko, D. Suki, K. R. Hess et al., "IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection," Neuro-Oncology, vol. 16, no. 1, pp. 81-91, 2014.
    • (2014) Neuro-Oncology , vol.16 , Issue.1 , pp. 81-91
    • Beiko, J.1    Suki, D.2    Hess, K.R.3
  • 78
    • 84962526348 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase (IDH)1/2 mutations as prognostic markers in patients with glioblastomas
    • J.-R. Chen, Y. Yao, H.-Z. Xu, and Z.-Y. Qin, "Isocitrate dehydrogenase (IDH)1/2 mutations as prognostic markers in patients with glioblastomas," Medicine (Baltimore), vol. 95, no. 9, Article ID e2583, 2016.
    • (2016) Medicine (Baltimore) , vol.95 , Issue.9
    • Chen, J.-R.1    Yao, Y.2    Xu, H.-Z.3    Qin, Z.-Y.4
  • 79
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • D. Rohle, J. Popovici-Muller, N. Palaskas et al., "An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells," Science, vol. 340, no. 6132, pp. 626-630, 2013.
    • (2013) Science , vol.340 , Issue.6132 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3
  • 80
    • 84930914216 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase mutations: New opportunities for translational research
    • Y.-S. Keum and B. Y. Choi, "Isocitrate dehydrogenase mutations: new opportunities for translational research," BMB Reports, vol. 48, no. 5, pp. 266-270, 2015.
    • (2015) BMB Reports , vol.48 , Issue.5 , pp. 266-270
    • Keum, Y.-S.1    Choi, B.Y.2
  • 81
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • F. Wang, J. Travins, B. DeLaBarre et al., "Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation," Science, vol. 340, no. 6132, pp. 622-626, 2013.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3
  • 82
    • 84867355390 scopus 로고    scopus 로고
    • Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo
    • J. Popovici-Muller, J. O. Saunders, F. G. Salituro et al., "Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo," ACS Medicinal Chemistry Letters, vol. 3, no. 10, pp. 850-855, 2012.
    • (2012) ACS Medicinal Chemistry Letters , vol.3 , Issue.10 , pp. 850-855
    • Popovici-Muller, J.1    Saunders, J.O.2    Salituro, F.G.3
  • 83
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit fromtemozolomide in glioblastoma
    • M. E. Hegi, A.-C. Diserens, T. Gorlia et al., "MGMT gene silencing and benefit fromtemozolomide in glioblastoma," New England Journal ofMedicine, vol. 352, no. 10, pp. 997-1003, 2005.
    • (2005) New England Journal OfMedicine , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.-C.2    Gorlia, T.3
  • 84
    • 55449122220 scopus 로고    scopus 로고
    • Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: A population-based study
    • I. Zawlik, S. Vaccarella, D. Kita, M. Mittelbronn, S. Franceschi, and H. Ohgaki, "Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study," Neuroepidemiology, vol. 32, no. 1, pp. 21-29, 2009.
    • (2009) Neuroepidemiology , vol.32 , Issue.1 , pp. 21-29
    • Zawlik, I.1    Vaccarella, S.2    Kita, D.3    Mittelbronn, M.4    Franceschi, S.5    Ohgaki, H.6
  • 85
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • M. Esteller, J. Garcia-Foncillas, E. Andion et al., "Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents," The New England Journal of Medicine, vol. 343, no. 19, pp. 1350-1354, 2000.
    • (2000) The New England Journal of Medicine , vol.343 , Issue.19 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 86
    • 4143084896 scopus 로고    scopus 로고
    • CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
    • M. F. Paz, R. Yaya-Tur, I. Rojas-Marcos et al., "CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas," Clinical Cancer Research, vol. 10, no. 15, pp. 4933-4938, 2004.
    • (2004) Clinical Cancer Research , vol.10 , Issue.15 , pp. 4933-4938
    • Paz, M.F.1    Yaya-Tur, R.2    Rojas-Marcos, I.3
  • 87
    • 84928423267 scopus 로고    scopus 로고
    • EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide
    • M. Cominelli, S. Grisanti, S. Mazzoleni et al., "EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide," Journal of the National Cancer Institute, vol. 107, no. 5, Article IDdjv041, 2015.
    • (2015) Journal of the National Cancer Institute , vol.107 , Issue.5
    • Cominelli, M.1    Grisanti, S.2    Mazzoleni, S.3
  • 88
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
    • W. Wick, M. Platten, C. Meisner et al., "Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial," The Lancet Oncology, vol. 13, no. 7, pp. 707-715, 2012.
    • (2012) The Lancet Oncology , vol.13 , Issue.7 , pp. 707-715
    • Wick, W.1    Platten, M.2    Meisner, C.3
  • 89
    • 84864121917 scopus 로고    scopus 로고
    • Predictive impact of MGMT promoter methylation in glioblastoma of the elderly
    • G. Reifenberger, B. Hentschel, J. Felsberg et al., "Predictive impact of MGMT promoter methylation in glioblastoma of the elderly," International Journal of Cancer, vol. 131, no. 6, pp. 1342- 1350, 2012.
    • (2012) International Journal of Cancer , vol.131 , Issue.6 , pp. 1342-1350
    • Reifenberger, G.1    Hentschel, B.2    Felsberg, J.3
  • 90
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
    • A. Malmström, B. H. Grønberg, C. Marosi et al., "Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial," The Lancet Oncology, vol. 13, no. 9, pp. 916-926, 2012.
    • (2012) The Lancet Oncology , vol.13 , Issue.9 , pp. 916-926
    • Malmström, A.1    Grønberg, B.H.2    Marosi, C.3
  • 91
    • 84891791656 scopus 로고    scopus 로고
    • Net clinical benefit analysis of radiation therapy oncology group 0525: A phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma
    • T. S. Armstrong, J. S. Wefel, M. Wang et al., "Net clinical benefit analysis of radiation therapy oncology group 0525: a phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma," Journal of Clinical Oncology, vol. 31, no. 32, pp. 4076-4084, 2013.
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.32 , pp. 4076-4084
    • Armstrong, T.S.1    Wefel, J.S.2    Wang, M.3
  • 92
    • 84880678757 scopus 로고    scopus 로고
    • Malignant astrocytomas of elderly patients lack favorable molecular markers: An analysis of the NOA-08 study collective
    • B. Wiestler, R. Claus, S. A. Hartlieb et al., "Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective," Neuro-Oncology, vol. 15, no. 8, pp. 1017-1026, 2013.
    • (2013) Neuro-Oncology , vol.15 , Issue.8 , pp. 1017-1026
    • Wiestler, B.1    Claus, R.2    Hartlieb, S.A.3
  • 93
    • 84937939301 scopus 로고    scopus 로고
    • MGMT promoter methylation is a strong prognostic biomarker for benefit fromdose-intensified temozolomide rechallenge in progressive Glioblastoma: The DIRECTOR Trial
    • M. Weller, G. Tabatabai, B. Kästner et al., "MGMT promoter methylation is a strong prognostic biomarker for benefit fromdose-intensified temozolomide rechallenge in progressive Glioblastoma: the DIRECTOR Trial," Clinical Cancer Research, vol. 21, no. 9, pp. 2057-2064, 2015.
    • (2015) Clinical Cancer Research , vol.21 , Issue.9 , pp. 2057-2064
    • Weller, M.1    Tabatabai, G.2    Kästner, B.3
  • 95
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • M. F. Krummel and J. P. Allison, "CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells," Journal of ExperimentalMedicine, vol. 183, no. 6, pp. 2533-2540, 1996.
    • (1996) Journal of ExperimentalMedicine , vol.183 , Issue.6 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 96
    • 79960403316 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyteassociated antigen-4
    • A. K. S. Salama and F. S. Hodi, "Cytotoxic T-lymphocyteassociated antigen-4," Clinical Cancer Research, vol. 17, no. 14, pp. 4622-4628, 2011.
    • (2011) Clinical Cancer Research , vol.17 , Issue.14 , pp. 4622-4628
    • Salama, A.K.S.1    Hodi, F.S.2
  • 97
    • 84879484111 scopus 로고    scopus 로고
    • Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages
    • O. Bloch, C. A. Crane, R. Kaur, M. Safaee, M. J. Rutkowski, and A. T. Parsa, "Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages," Clinical Cancer Research, vol. 19, no. 12, pp. 3165-3175, 2013.
    • (2013) Clinical Cancer Research , vol.19 , Issue.12 , pp. 3165-3175
    • Bloch, O.1    Crane, C.A.2    Kaur, R.3    Safaee, M.4    Rutkowski, M.J.5    Parsa, A.T.6
  • 98
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • A. T. Parsa, J. S. Waldron, A. Panner et al., "Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma," Nature Medicine, vol. 13, no. 1, pp. 84-88, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.1 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 99
    • 84897527381 scopus 로고    scopus 로고
    • Immune heterogeneity of glioblastoma subtypes: Extrapolation from the cancer genome atlas
    • T. Doucette, G. Rao, A. Rao et al., "Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlas," Cancer Immunology Research, vol. 1, no. 2, pp. 112-122, 2013.
    • (2013) Cancer Immunology Research , vol.1 , Issue.2 , pp. 112-122
    • Doucette, T.1    Rao, G.2    Rao, A.3
  • 100
    • 84943241524 scopus 로고    scopus 로고
    • Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
    • A. S. Berghoff, B. Kiesel, G. Widhalm et al., "Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma," Neuro-Oncology, vol. 17, no. 8, pp. 1064-1075, 2015.
    • (2015) Neuro-Oncology , vol.17 , Issue.8 , pp. 1064-1075
    • Berghoff, A.S.1    Kiesel, B.2    Widhalm, G.3
  • 101
    • 84882988841 scopus 로고    scopus 로고
    • PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients
    • Y. Liu, R. Carlsson, M. Ambjørn et al., "PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients, "The Journal of Neuroscience, vol. 33, no. 35, pp. 14231-14245, 2013.
    • (2013) The Journal of Neuroscience , vol.33 , Issue.35 , pp. 14231-14245
    • Liu, Y.1    Carlsson, R.2    Ambjørn, M.3
  • 102
    • 84960407098 scopus 로고    scopus 로고
    • PD-L1 expression and prognostic impact in glioblastoma
    • E. K. Nduom, J. Wei, N. K. Yaghi et al., "PD-L1 expression and prognostic impact in glioblastoma," Neuro-Oncology, vol. 18, no. 2, pp. 195-205, 2016.
    • (2016) Neuro-Oncology , vol.18 , Issue.2 , pp. 195-205
    • Nduom, E.K.1    Wei, J.2    Yaghi, N.K.3
  • 103
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • C. Robert, G. V. Long, B. Brady et al., "Nivolumab in previously untreated melanoma without BRAF mutation," The New England Journal of Medicine, vol. 372, no. 4, pp. 320-330, 2015.
    • (2015) The New England Journal of Medicine , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 104
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • C. Robert, L. Thomas, I. Bondarenko et al., "Ipilimumab plus dacarbazine for previously untreated metastatic melanoma," The New England Journal ofMedicine, vol. 364, no. 26, pp. 2517- 2526, 2011.
    • (2011) The New England Journal OfMedicine , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 105
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • F. S. Hodi, S. J. O'Day, D. F. McDermott et al., "Improved survival with ipilimumab in patients with metastatic melanoma," New England Journal of Medicine, vol. 363, no. 8, pp. 711-723, 2010.
    • (2010) New England Journal of Medicine , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 106
    • 84921938937 scopus 로고    scopus 로고
    • Ipilimumab and whole brain radiation therapy for melanoma brain metastases
    • N. K. Gerber, R. J. Young, C. A. Barker et al., "Ipilimumab and whole brain radiation therapy for melanoma brain metastases," Journal of Neuro-Oncology, vol. 121, no. 1, pp. 159-165, 2015.
    • (2015) Journal of Neuro-Oncology , vol.121 , Issue.1 , pp. 159-165
    • Gerber, N.K.1    Young, R.J.2    Barker, C.A.3
  • 108
    • 84859258334 scopus 로고    scopus 로고
    • Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients
    • B. Fong, R. Jin, X. Wang et al., "Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients," PLoS ONE, vol. 7, no. 4, Article ID e32614, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.4
    • Fong, B.1    Jin, R.2    Wang, X.3
  • 109
    • 76749097367 scopus 로고    scopus 로고
    • Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusionMR imaging
    • R. F. Barajas Jr., J. S. Chang, M. R. Segal et al., "Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusionMR imaging," Radiology, vol. 253, no. 2, pp. 486-496, 2009.
    • (2009) Radiology , vol.253 , Issue.2 , pp. 486-496
    • Barajas, R.F.1    Chang, J.S.2    Segal, M.R.3
  • 110
    • 64649101485 scopus 로고    scopus 로고
    • Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: Direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusionMR imagingmeasurements
    • L. S. Hu, L. C. Baxter, K. A. Smith et al., "Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusionMR imagingmeasurements," American Journal ofNeuroradiology, vol. 30, no. 3, pp. 552-558, 2009.
    • (2009) American Journal OfNeuroradiology , vol.30 , Issue.3 , pp. 552-558
    • Hu, L.S.1    Baxter, L.C.2    Smith, K.A.3
  • 111
    • 84865413255 scopus 로고    scopus 로고
    • Percent change of perfusion skewness and kurtosis: A potential imaging biomarker for early treatment response in patients with newly diagnosed glioblastomas
    • H. J. Baek, H. S. Kim, N. Kim, Y. J. Choi, and Y. J. Kim, "Percent change of perfusion skewness and kurtosis: a potential imaging biomarker for early treatment response in patients with newly diagnosed glioblastomas," Radiology, vol. 264, no. 3, pp. 834- 843, 2012.
    • (2012) Radiology , vol.264 , Issue.3 , pp. 834-843
    • Baek, H.J.1    Kim, H.S.2    Kim, N.3    Choi, Y.J.4    Kim, Y.J.5
  • 112
    • 84862776826 scopus 로고    scopus 로고
    • 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDHmutated patients with gliomas
    • C. Choi, S. K. Ganji, R. J. DeBerardinis et al., "2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDHmutated patients with gliomas," Nature Medicine, vol. 18, no. 4, pp. 624-629, 2012.
    • (2012) Nature Medicine , vol.18 , Issue.4 , pp. 624-629
    • Choi, C.1    Ganji, S.K.2    DeBerardinis, R.J.3
  • 114
    • 84890189562 scopus 로고    scopus 로고
    • Potential role of preoperative conventional MRI including diffusion measurements in assessing epidermal growth factor receptor gene amplification status in patients with glioblastoma
    • R. J. Young, A. Gupta, A. D. Shah et al., "Potential role of preoperative conventional MRI including diffusion measurements in assessing epidermal growth factor receptor gene amplification status in patients with glioblastoma," American Journal of Neuroradiology, vol. 34, no. 12, pp. 2271-2277, 2013.
    • (2013) American Journal of Neuroradiology , vol.34 , Issue.12 , pp. 2271-2277
    • Young, R.J.1    Gupta, A.2    Shah, A.D.3
  • 116
    • 84876917549 scopus 로고    scopus 로고
    • Reoperations of patients with low-grade gliomas in eloquent or near eloquent brain areas
    • W. Kaspera, K. Majchrzak, B. Bobek-Billewicz et al., "Reoperations of patients with low-grade gliomas in eloquent or near eloquent brain areas," Neurologia i Neurochirurgia Polska, vol. 47, no. 2, pp. 116-125, 2013.
    • (2013) Neurologia i Neurochirurgia Polska , vol.47 , Issue.2 , pp. 116-125
    • Kaspera, W.1    Majchrzak, K.2    Bobek-Billewicz, B.3
  • 117
    • 84865447852 scopus 로고    scopus 로고
    • The assessment of prognostic factors in surgical treatment of lowgrade gliomas: A prospective study
    • K. Majchrzak, W. Kaspera, B. Bobek-Billewicz et al., "The assessment of prognostic factors in surgical treatment of lowgrade gliomas: a prospective study," Clinical Neurology and Neurosurgery, vol. 114, no. 8, pp. 1135-1144, 2012.
    • (2012) Clinical Neurology and Neurosurgery , vol.114 , Issue.8 , pp. 1135-1144
    • Majchrzak, K.1    Kaspera, W.2    Bobek-Billewicz, B.3
  • 118
    • 84930929713 scopus 로고    scopus 로고
    • Pretreatment dynamic susceptibility contrast MRI perfusion in Glioblastoma: Prediction of EGFR gene amplification
    • A. Gupta, R. J. Young, A. D. Shah et al., "Pretreatment dynamic susceptibility contrast MRI perfusion in Glioblastoma: prediction of EGFR gene amplification," Clinical Neuroradiology, vol. 25, no. 2, pp. 143-150, 2014.
    • (2014) Clinical Neuroradiology , vol.25 , Issue.2 , pp. 143-150
    • Gupta, A.1    Young, R.J.2    Shah, A.D.3
  • 119
    • 83055176496 scopus 로고    scopus 로고
    • Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and∗ unmethylated tumors: A radiographic study in 358 de novo human glioblastomas
    • B. M. Ellingson, T. F. Cloughesy, W. B. Pope et al., "Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas," NeuroImage, vol. 59, no. 2, pp. 908-916, 2012.
    • (2012) NeuroImage , vol.59 , Issue.2 , pp. 908-916
    • Ellingson, B.M.1    Cloughesy, T.F.2    Pope, W.B.3
  • 120
    • 84969855998 scopus 로고    scopus 로고
    • MRI texture features as biomarkers to predict MGMT methylation status in glioblastomas
    • P. Korfiatis, T. L. Kline, L. Coufalova et al., "MRI texture features as biomarkers to predict MGMT methylation status in glioblastomas," Medical Physics, vol. 43, no. 6, pp. 2835-2844, 2016.
    • (2016) Medical Physics , vol.43 , Issue.6 , pp. 2835-2844
    • Korfiatis, P.1    Kline, T.L.2    Coufalova, L.3
  • 121
    • 84878368482 scopus 로고    scopus 로고
    • Evaluation of dynamic contrast-enhanced T1- weighted perfusion MRI in the differentiation of tumor recurrence from radiation necrosis
    • V. A. Larsen, H. J. Simonsen, I. Law, H. B. W. Larsson, and A. E. Hansen, "Evaluation of dynamic contrast-enhanced T1- weighted perfusion MRI in the differentiation of tumor recurrence from radiation necrosis," Neuroradiology, vol. 55, no. 3, pp. 361-369, 2013.
    • (2013) Neuroradiology , vol.55 , Issue.3 , pp. 361-369
    • Larsen, V.A.1    Simonsen, H.J.2    Law, I.3    Larsson, H.B.W.4    Hansen, A.E.5
  • 122
    • 84864051629 scopus 로고    scopus 로고
    • Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: A multi-center study
    • W. B. Pope, X. J. Qiao, H. J. Kim et al., "Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study," Journal of Neuro-Oncology, vol. 108, no. 3, pp. 491-498, 2012.
    • (2012) Journal of Neuro-Oncology , vol.108 , Issue.3 , pp. 491-498
    • Pope, W.B.1    Qiao, X.J.2    Kim, H.J.3
  • 123
    • 84859553808 scopus 로고    scopus 로고
    • Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma
    • B.M. Ellingson, T. F. Cloughesy, T. Zaw et al., "Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma," Neuro-Oncology, vol. 14, no. 3, pp. 333-343, 2012.
    • (2012) Neuro-Oncology , vol.14 , Issue.3 , pp. 333-343
    • Ellingson, B.M.1    Cloughesy, T.F.2    Zaw, T.3
  • 124
    • 84868333386 scopus 로고    scopus 로고
    • 11C-methionine PET for grading and prognostication in gliomas: A comparison study with 18F-FDG PET and contrast enhancement on MRI
    • T. Singhal, T. K. Narayanan, M. P. Jacobs, C. Bal, and J. C. Mantil," 11C-methionine PET for grading and prognostication in gliomas: a comparison study with 18F-FDG PET and contrast enhancement on MRI," Journal of NuclearMedicine, vol. 53, no. 11, pp. 1709-1715, 2012.
    • (2012) Journal of NuclearMedicine , vol.53 , Issue.11 , pp. 1709-1715
    • Singhal, T.1    Narayanan, T.K.2    Jacobs, M.P.3    Bal, C.4    Mantil, J.C.5
  • 125
    • 36749085053 scopus 로고    scopus 로고
    • FET PET for the evaluation of untreated gliomas: Correlation of FET uptake and uptake kinetics with tumour grading
    • G. Pöpperl, F. W. Kreth, J. H. Mehrkens et al., "FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading," European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 12, pp. 1933-1942, 2007.
    • (2007) European Journal of Nuclear Medicine and Molecular Imaging , vol.34 , Issue.12 , pp. 1933-1942
    • Pöpperl, G.1    Kreth, F.W.2    Mehrkens, J.H.3
  • 126
    • 12444281700 scopus 로고    scopus 로고
    • 11C-methionine PET as a prognostic marker in patients with glioma: Comparison with 18F-FDG PET
    • S. Kim, J. K. Chung, S. H. Im et al., "11C-methionine PET as a prognostic marker in patients with glioma: comparison with 18F-FDG PET," European Journal of Nuclear Medicine and Molecular Imaging, vol. 32, no. 1, pp. 52-59, 2005.
    • (2005) European Journal of Nuclear Medicine and Molecular Imaging , vol.32 , Issue.1 , pp. 52-59
    • Kim, S.1    Chung, J.K.2    Im, S.H.3
  • 127
    • 15044344615 scopus 로고    scopus 로고
    • O-(2-[18F]fluoroethyl)- L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas
    • D. Pauleit, F. Floeth, K. Hamacher et al., "O-(2-[18F]fluoroethyl)- L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas," Brain, vol. 128, no. 3, pp. 678-687, 2005.
    • (2005) Brain , vol.128 , Issue.3 , pp. 678-687
    • Pauleit, D.1    Floeth, F.2    Hamacher, K.3
  • 128
    • 79851498484 scopus 로고    scopus 로고
    • Correlation of 6- 18F-fluoro-L-dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas
    • B. J. Fueger, J. Czernin, T. Cloughesy et al., "Correlation of 6- 18F-fluoro-L-dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas," Journal of Nuclear Medicine, vol. 51, no. 10, pp. 1532-1538, 2010.
    • (2010) Journal of Nuclear Medicine , vol.51 , Issue.10 , pp. 1532-1538
    • Fueger, B.J.1    Czernin, J.2    Cloughesy, T.3
  • 129
    • 52049120148 scopus 로고    scopus 로고
    • Regional hypoxia in glioblastoma multiforme quantified with [18F] fluoromisonidazole positron emission tomography before radiotherapy: Correlation with time to progression and survival
    • A. M. Spence, M. Muzi, K. R. Swanson et al., "Regional hypoxia in glioblastoma multiforme quantified with [18F] fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival," Clinical Cancer Research, vol. 14, no. 9, pp. 2623-2630, 2008.
    • (2008) Clinical Cancer Research , vol.14 , Issue.9 , pp. 2623-2630
    • Spence, A.M.1    Muzi, M.2    Swanson, K.R.3
  • 130
    • 84899556879 scopus 로고    scopus 로고
    • Current vaccine trials in glioblastoma: A review
    • L.W. Xu, K. K. Chow, M. Lim, and G. Li, "Current vaccine trials in glioblastoma: a review," Journal of Immunology Research, vol. 2014, Article ID796856, 10 pages, 2014.
    • (2014) Journal of Immunology Research , vol.2014
    • Xu, L.W.1    Chow, K.K.2    Lim, M.3    Li, G.4
  • 131
    • 84923116932 scopus 로고    scopus 로고
    • Clinical impact of molecular biomarkers in gliomas
    • T. Siegal, "Clinical impact of molecular biomarkers in gliomas," Journal of ClinicalNeuroscience, vol. 22, no. 3, pp. 437-444, 2015.
    • (2015) Journal of ClinicalNeuroscience , vol.22 , Issue.3 , pp. 437-444
    • Siegal, T.1
  • 132
    • 43749094544 scopus 로고    scopus 로고
    • MGMTpromoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • A. A. Brandes, E. Franceschi, A. Tosoni et al., "MGMTpromoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients," Journal of Clinical Oncology, vol. 26, no. 13, pp. 2192-2197, 2008.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.13 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 133
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating microvesicles allows real-timemonitoring of glioblastoma therapy
    • H. Shao, J. Chung, L. Balaj et al., "Protein typing of circulating microvesicles allows real-timemonitoring of glioblastoma therapy," Nature Medicine, vol. 18, no. 12, pp. 1835-1840, 2012.
    • (2012) Nature Medicine , vol.18 , Issue.12 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3
  • 134
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNAand proteins that promote tumour growth and provide diagnostic biomarkers
    • J. Skog, T. Würdinger, S. van Rijn et al., "Glioblastoma microvesicles transport RNAand proteins that promote tumour growth and provide diagnostic biomarkers," Nature Cell Biology, vol. 10, no. 12, pp. 1470-1476, 2008.
    • (2008) Nature Cell Biology , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    Van Rijn, S.3
  • 135
    • 84879724501 scopus 로고    scopus 로고
    • MGMT promoter methylation and glioblastoma prognosis: A systematic review and meta-analysis
    • Y. Chen, F. Hu, Y. Zhou, W. Chen, H. Shao, and Y. Zhang, "MGMT promoter methylation and glioblastoma prognosis: a systematic review and meta-analysis," Archives of Medical Research, vol. 44, no. 4, pp. 281-290, 2013.
    • (2013) Archives of Medical Research , vol.44 , Issue.4 , pp. 281-290
    • Chen, Y.1    Hu, F.2    Zhou, Y.3    Chen, W.4    Shao, H.5    Zhang, Y.6
  • 136
    • 75849146316 scopus 로고    scopus 로고
    • MGMT promotermethylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
    • A. L. Rivera, C. E. Pelloski, M. R. Gilbert et al., "MGMT promotermethylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma," Neuro-Oncology, vol. 12, no. 2, pp. 116-121, 2010.
    • (2010) Neuro-Oncology , vol.12 , Issue.2 , pp. 116-121
    • Rivera, A.L.1    Pelloski, C.E.2    Gilbert, M.R.3
  • 137
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6- methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • M. E. Hegi, L. Liu, J. G. Herman et al., "Correlation of O6- methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity," Journal of Clinical Oncology, vol. 26, no. 25, pp. 4189-4199, 2008.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.25 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3
  • 138
    • 0030033781 scopus 로고    scopus 로고
    • Prognostic significance of preoperative MRI scans in glioblastoma multiforme
    • M. A. Hammoud, R. Sawaya, W. Shi, P. F. Thall, and N. E. Leeds, "Prognostic significance of preoperative MRI scans in glioblastoma multiforme," Journal of Neuro-Oncology, vol. 27, no. 1, pp. 65-73, 1996.
    • (1996) Journal of Neuro-Oncology , vol.27 , Issue.1 , pp. 65-73
    • Hammoud, M.A.1    Sawaya, R.2    Shi, W.3    Thall, P.F.4    Leeds, N.E.5
  • 139
    • 84942447082 scopus 로고    scopus 로고
    • Peritumoral edema on magnetic resonance imaging predicts a poor clinical outcome in malignant glioma
    • C. X. Wu, G. S. Lin, Z. X. Lin et al., "Peritumoral edema on magnetic resonance imaging predicts a poor clinical outcome in malignant glioma," Oncology Letters, vol. 10, no. 5, pp. 2769- 2776, 2015.
    • (2015) Oncology Letters , vol.10 , Issue.5 , pp. 2769-2776
    • Wu, C.X.1    Lin, G.S.2    Lin, Z.X.3
  • 140
    • 84888229904 scopus 로고    scopus 로고
    • Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation
    • W. Wick, C. Meisner, B. Hentschel et al., "Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation," Neurology, vol. 81, no. 17, pp. 1515- 1522, 2013.
    • (2013) Neurology , vol.81 , Issue.17 , pp. 1515-1522
    • Wick, W.1    Meisner, C.2    Hentschel, B.3
  • 141
    • 84868019401 scopus 로고    scopus 로고
    • Personalized care in neuro-oncology coming of age: Why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice
    • M. Weller, R. Stupp, M. E. Hegi et al., "Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice," Neuro-Oncology, vol. 14, supplement 4, pp. iv100-iv108, 2012.
    • (2012) Neuro-Oncology , vol.14 , pp. iv100-iv108
    • Weller, M.1    Stupp, R.2    Hegi, M.E.3


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