-
1
-
-
33748428203
-
T-cell costimulation - Biology, therapeutic potential, and challenges
-
DOI 10.1056/NEJMp068087
-
Sharpe AH, Abbas AK. T-cell costimulation-biology, therapeutic potential, and challenges. N Engl J Med 2006;355:973-5. (Pubitemid 44343539)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.10
, pp. 973-975
-
-
Sharpe, A.H.1
Abbas, A.K.2
-
2
-
-
65349119978
-
CD28 and CTLA-4 coreceptor expression and signal transduction
-
Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009;229:12-26.
-
(2009)
Immunol Rev
, vol.229
, pp. 12-26
-
-
Rudd, C.E.1
Taylor, A.2
Schneider, H.3
-
4
-
-
33646794392
-
Checkpoint Blockade in Cancer Immunotherapy
-
DOI 10.1016/S0065-2776(06)90008-X, PII S006527760690008X
-
Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006;90:297-339. (Pubitemid 43765802)
-
(2006)
Advances in Immunology
, vol.90
, pp. 297-339
-
-
Korman, A.J.1
Peggs, K.S.2
Allison, J.P.3
-
5
-
-
49249089425
-
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
-
Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 2008;224:166-82.
-
(2008)
Immunol Rev
, vol.224
, pp. 166-182
-
-
Fife, B.T.1
Bluestone, J.A.2
-
6
-
-
36849035139
-
Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies
-
DOI 10.1002/cncr.23086
-
O'Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer 2007;110:2614-27. (Pubitemid 350250330)
-
(2007)
Cancer
, vol.110
, Issue.12
, pp. 2614-2627
-
-
O'Day, S.J.1
Hamid, O.2
Urba, W.J.3
-
7
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995;182:459-65.
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
8
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
DOI 10.1038/nrc2051, PII NRC2051
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 2007;7:95-106. (Pubitemid 46160986)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
9
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
DOI 10.1016/S1074-7613(00)80480-X
-
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996;4:535-43. (Pubitemid 26233307)
-
(1996)
Immunity
, vol.4
, Issue.6
, pp. 535-543
-
-
Linsley, P.S.1
Bradshaw, J.2
Greene, J.3
Peach, R.4
Bennett, K.L.5
Mittler, R.S.6
-
10
-
-
0036301503
-
CTLA-4: New insights into its biological function and use in tumor immunotherapy
-
DOI 10.1038/ni0702-611
-
Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002;3:611-8. (Pubitemid 34752469)
-
(2002)
Nature Immunology
, vol.3
, Issue.7
, pp. 611-618
-
-
Egen, J.G.1
Kuhns, M.S.2
Allison, J.P.3
-
11
-
-
17044429848
-
Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells
-
Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F, et al. Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. J Immunol 2005;174:4803-11.
-
(2005)
J Immunol
, vol.174
, pp. 4803-4811
-
-
Mead, K.I.1
Zheng, Y.2
Manzotti, C.N.3
Perry, L.C.4
Liu, M.K.5
Burke, F.6
-
12
-
-
0033567050
-
Cytolytic T lymphocyte-associated antigen-4 and the TCRzeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
-
Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, et al. Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol 1999;163:1868-79. (Pubitemid 29382187)
-
(1999)
Journal of Immunology
, vol.163
, Issue.4
, pp. 1868-1879
-
-
Schneider, H.1
Martin, M.2
Agarraberes, F.A.3
Yin, L.4
Rapoport, I.5
Kirchhausen, T.6
Rudd, C.E.7
-
13
-
-
0033985191
-
The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
-
Baroja ML, Luxenberg D, Chau T, Ling V, Strathdee CA, Carreno BM, et al. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol 2000;164:49-55. (Pubitemid 30012971)
-
(2000)
Journal of Immunology
, vol.164
, Issue.1
, pp. 49-55
-
-
Baroja, M.L.1
Luxenberg, D.2
Chau, T.3
Ling, V.4
Strathdee, C.A.5
Carreno, B.M.6
Madrenas, J.7
-
14
-
-
1842854703
-
Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo
-
DOI 10.1093/intimm/dxh055
-
Yi LA, Hajialiasgar S, Chuang E. Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo. Int Immunol 2004;16:539-47. (Pubitemid 38489428)
-
(2004)
International Immunology
, vol.16
, Issue.4
, pp. 539-547
-
-
Yi, L.A.1
Hajialiasgar, S.2
Chuang, E.3
-
15
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
DOI 10.1126/science.1131078
-
Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, et al. Reversal of the TCR stop signal by CTLA-4. Science 2006;313:1972-5. (Pubitemid 44498006)
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1972-1975
-
-
Schneider, H.1
Downey, J.2
Smith, A.3
Zinselmeyer, B.H.4
Rush, C.5
Brewer, J.M.6
Wei, B.7
Hogg, N.8
Garside, P.9
Rudd, C.E.10
-
16
-
-
0037093856
-
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
-
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, et al. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol 2002;168:5070-8. (Pubitemid 34495970)
-
(2002)
Journal of Immunology
, vol.168
, Issue.10
, pp. 5070-5078
-
-
Baroja, M.L.1
Vijayakrishnan, L.2
Bettelli, E.3
Darlington, P.J.4
Chau, T.A.5
Ling, V.6
Collins, M.7
Carreno, B.M.8
Madrenas, J.9
Kuchroo, V.K.10
-
17
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-5.
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
-
18
-
-
42949105127
-
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
-
DOI 10.1073/pnas.0712237105
-
Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008;105:3005-10. (Pubitemid 351723658)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3005-3010
-
-
Hodi, F.S.1
Butler, M.2
Oble, D.A.3
Seiden, M.V.4
Haluska, F.G.5
Kruse, A.6
MacRae, S.7
Nelson, M.8
Canning, C.9
Lowy, I.10
Korman, A.11
Lautz, D.12
Russell, S.13
Jaklitsch, M.T.14
Ramaiya, N.15
Chen, T.C.16
Neuberg, D.17
Allison, J.P.18
Mihm, M.C.19
Dranoff, G.20
more..
-
19
-
-
78651072784
-
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance
-
Pedicord VA, Montalvo W, Leiner IM, Allison JP. Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A 2011;108:266-71.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 266-271
-
-
Pedicord, V.A.1
Montalvo, W.2
Leiner, I.M.3
Allison, J.P.4
-
20
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985-8.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
-
21
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
22
-
-
0026778697
-
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule
-
Linsley PS, Wallace PM, Johnson J, Gibson MG, Greene JL, Ledbetter JA, et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 1992;257:792-5.
-
(1992)
Science
, vol.257
, pp. 792-795
-
-
Linsley, P.S.1
Wallace, P.M.2
Johnson, J.3
Gibson, M.G.4
Greene, J.L.5
Ledbetter, J.A.6
-
23
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony- stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
DOI 10.1084/jem.190.3.355
-
van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999;190:355-66. (Pubitemid 29374833)
-
(1999)
Journal of Experimental Medicine
, vol.190
, Issue.3
, pp. 355-366
-
-
Van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
24
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
-
DOI 10.1084/jem.194.4.481
-
van Elsas A, Sutmuller RP, Hurwitz AA, Ziskin J, Villasenor J, Medema JP, et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 2001;194:481-9. (Pubitemid 32835043)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.4
, pp. 481-489
-
-
Van Elsas, A.1
Sutmuller, R.P.M.2
Hurwitz, A.A.3
Ziskin, J.4
Villasenor, J.5
Medema, J.-P.6
Overwijk, W.W.7
Restifo, N.P.8
Melief, C.J.M.9
Offringa, R.10
Allison, J.P.11
-
25
-
-
79960402722
-
Hair depigmentation as an indicator of durable response to CTLA-4 therapy
-
Pavlick AC, Ott PA, Kannan R, Madden KM, Sorlie C, Escano C, et al. Hair depigmentation as an indicator of durable response to CTLA-4 therapy. J Clin Oncol 2010;28:s8571.
-
(2010)
J Clin Oncol
, vol.28
-
-
Pavlick, A.C.1
Ott, P.A.2
Kannan, R.3
Madden, K.M.4
Sorlie, C.5
Escano, C.6
-
26
-
-
78449244037
-
The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications
-
Di Giacomo AM, Biagioli M, Maio M. The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications. Semin Oncol 2010;37:499-507.
-
(2010)
Semin Oncol
, vol.37
, pp. 499-507
-
-
Di Giacomo, A.M.1
Biagioli, M.2
Maio, M.3
-
27
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbé C, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009;15:7412-20.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
Weber, J.S.4
Hamid, O.5
Lebbé, C.6
-
28
-
-
55949122351
-
Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody
-
Hodi FS, Hoos A, Ibrahim R, Chin K, Pehamberger H, Harmankaya K, et al. Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody. J Clin Oncol 2008;26:3008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3008
-
-
Hodi, F.S.1
Hoos, A.2
Ibrahim, R.3
Chin, K.4
Pehamberger, H.5
Harmankaya, K.6
-
29
-
-
55949083407
-
Anti-cytotoxic T-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
-
Fong L, Small EJ. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol 2008;26:5275-83.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5275-5283
-
-
Fong, L.1
Small, E.J.2
-
30
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
DOI 10.1200/JCO.2005.01.109
-
Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 2005;23:8968-77. (Pubitemid 46217464)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.35
, pp. 8968-8977
-
-
Ribas, A.1
Camacho, L.H.2
Lopez-Berestein, G.3
Pavlov, D.4
Bulanhagui, C.A.5
Millham, R.6
Comin-Anduix, B.7
Reuben, J.M.8
Seja, E.9
Parker, C.A.10
Sharma, A.11
Glaspy, J.A.12
Gomez-Navarro, J.13
-
31
-
-
55949137090
-
Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma
-
Ribas A, Hauschild A, Kefford R, Punt CJ, Haanen JB, Marmol M, et al. Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma. J Clin Oncol 2008;26:LBA9011.
-
(2008)
J Clin Oncol
, vol.26
-
-
Ribas, A.1
Hauschild, A.2
Kefford, R.3
Punt, C.J.4
Haanen, J.B.5
Marmol, M.6
-
32
-
-
78649237899
-
Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma
-
Marshall MA, Ribas A, Huang B. Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma. J Clin Oncol 2010;28:2609.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2609
-
-
Marshall, M.A.1
Ribas, A.2
Huang, B.3
-
33
-
-
0003311698
-
MDX-010 (human anti-CTLA4): A phase I trial in malignant melanoma
-
Tchekmedyian S, Glasby J, Korman A, Keler T, Deo Y, Davis TA. MDX-010 (human anti-CTLA4): a phase I trial in malignant melanoma. Proc Am Soc Clin Oncol 2002;21:56.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 56
-
-
Tchekmedyian, S.1
Glasby, J.2
Korman, A.3
Keler, T.4
Deo, Y.5
Davis, T.A.6
-
34
-
-
77955256254
-
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: A multicenter singlearm phase II study
-
O'Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter singlearm phase II study. Ann Oncol 2010;21:1712-7.
-
(2010)
Ann Oncol
, vol.21
, pp. 1712-1717
-
-
O'Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
Gajewski, T.F.4
Pehamberger, H.5
Bondarenko, I.N.6
-
35
-
-
69949095926
-
A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
-
Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res 2009;15:5591-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5591-5598
-
-
Weber, J.1
Thompson, J.A.2
Hamid, O.3
Minor, D.4
Amin, A.5
Ron, I.6
-
36
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010;11:155-64.
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
Negrier, S.4
Lutzky, J.5
Thomas, L.6
-
37
-
-
34548257760
-
Review: Anti-CTLA-4 antibody ipilimumab: Case studies of clinical response and immune-related adverse events
-
DOI 10.1634/theoncologist.12-7-864
-
Weber J. Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events. Oncologist 2007;12:864-72. (Pubitemid 47328229)
-
(2007)
Oncologist
, vol.12
, Issue.7
, pp. 864-872
-
-
Weber, J.1
-
38
-
-
69949088914
-
An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: Prevention of gastrointestinal perforation and/or colectomy
-
Lin R, Yellin MJ, Lowy I, Safferman A, Chin K, Ibrahim R. An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: Prevention of gastrointestinal perforation and/or colectomy. J Clin Oncol 2008;26:9063.
-
(2008)
J Clin Oncol
, vol.26
, pp. 9063
-
-
Lin, R.1
Yellin, M.J.2
Lowy, I.3
Safferman, A.4
Chin, K.5
Ibrahim, R.6
-
39
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
41
-
-
34250223096
-
A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
-
DOI 10.1158/1078-0432.CCR-06-2318
-
Small EJ, Tchekmedyian NS, Rini BI, Fong L, Lowy I, Allison JP. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res 2007;13:1810-5. (Pubitemid 46952950)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.6
, pp. 1810-1815
-
-
Small, E.J.1
Tchekmedyian, N.S.2
Rini, B.I.3
Fong, L.4
Lowy, I.5
Allison, J.P.6
-
42
-
-
58349090027
-
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GMCSF
-
Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GMCSF. Cancer Res 2009;69:609-15.
-
(2009)
Cancer Res
, vol.69
, pp. 609-615
-
-
Fong, L.1
Kwek, S.S.2
O'Brien, S.3
Kavanagh, B.4
McNeel, D.G.5
Weinberg, V.6
-
43
-
-
78449251207
-
Clinical studies with anti-CTLA-4 antibodies in non-melanoma indications
-
Calabrò L, Danielli R, Sigalotti L, Maio M. Clinical studies with anti-CTLA-4 antibodies in non-melanoma indications. Semin Oncol 2010;37:460-7.
-
(2010)
Semin Oncol
, vol.37
, pp. 460-467
-
-
Calabrò, L.1
Danielli, R.2
Sigalotti, L.3
Maio, M.4
-
44
-
-
84855675121
-
-
Bethesda (MD): NIH; cited 2011 Jan 7. Available from
-
ClinicalTrials.gov. Bethesda (MD): NIH; 2011 - [cited 2011 Jan 7]. Neoadjuvant ipilimumab in prostate cancer. Available from: http:// clinicaltrials.gov/ct2/results?term=NCT01194271.
-
(2011)
Neoadjuvant Ipilimumab in Prostate Cancer
-
-
-
45
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
DOI 10.1097/CJI.0b013e318156e47e, PII 0000237120071100000005
-
Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007;30:825-30. (Pubitemid 350295361)
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.8
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
Royal, R.4
Sherry, R.M.5
Topalian, S.L.6
Suri, K.B.7
Levy, C.8
Allen, T.9
Mavroukakis, S.10
Lowy, I.11
White, D.E.12
Rosenberg, S.A.13
-
46
-
-
79551717184
-
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
-
Rini BI, Stein M, Shannon P, Eddy S, Tyler A, Stephenson JJ Jr, et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer 2011;117:758-67.
-
(2011)
Cancer
, vol.117
, pp. 758-767
-
-
Rini, B.I.1
Stein, M.2
Shannon, P.3
Eddy, S.4
Tyler, A.5
Stephenson Jr., J.J.6
-
47
-
-
78449264515
-
Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NSCLC)
-
Lynch TJ, Bondarenko IN, Luft A, Serwatowski P, Barlesi F, Chacko RT, et al. Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28:7531.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7531
-
-
Lynch, T.J.1
Bondarenko, I.N.2
Luft, A.3
Serwatowski, P.4
Barlesi, F.5
Chacko, R.T.6
-
48
-
-
77957273591
-
Improved endpoints for cancer immunotherapy trials
-
Hoos A, Eggermont AM, Janetzki S, Hodi FS, Ibrahim R, Anderson A, et al. Improved endpoints for cancer immunotherapy trials. J Natl Cancer Inst 2010;102:1388-97.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 1388-1397
-
-
Hoos, A.1
Eggermont, A.M.2
Janetzki, S.3
Hodi, F.S.4
Ibrahim, R.5
Anderson, A.6
-
49
-
-
42949105127
-
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
-
DOI 10.1073/pnas.0712237105
-
Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008;105:3005-10. (Pubitemid 351723658)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3005-3010
-
-
Hodi, F.S.1
Butler, M.2
Oble, D.A.3
Seiden, M.V.4
Haluska, F.G.5
Kruse, A.6
MacRae, S.7
Nelson, M.8
Canning, C.9
Lowy, I.10
Korman, A.11
Lautz, D.12
Russell, S.13
Jaklitsch, M.T.14
Ramaiya, N.15
Chen, T.C.16
Neuberg, D.17
Allison, J.P.18
Mihm, M.C.19
Dranoff, G.20
more..
-
50
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 2010;107:4275-80.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
51
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010;28: 3167-75.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
-
53
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
DOI 10.1200/JCO.2006.06.2984
-
Curtin JA, Busam K, Pinkel D, Bastian BC. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006;24:4340-6. (Pubitemid 46630793)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
54
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
55
-
-
42949128595
-
Major response to imatinib mesylate in KIT-mutated melanoma
-
Hodi FS, Friedlander P, Corless CL, Heinrich MC, Mac Rae S, Kruse A, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 2008;26:2046-51.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2046-2051
-
-
Hodi, F.S.1
Friedlander, P.2
Corless, C.L.3
Heinrich, M.C.4
Mac Rae, S.5
Kruse, A.6
-
56
-
-
78649353270
-
A phase II study of imatinib for advanced melanoma patients with KIT aberrations
-
Guo J, Si L, Kong Y, Xu X, Flaherty KT, Corless CL, et al. A phase II study of imatinib for advanced melanoma patients with KIT aberrations. J Clin Oncol 2010;28:8527.
-
(2010)
J Clin Oncol
, vol.28
, pp. 8527
-
-
Guo, J.1
Si, L.2
Kong, Y.3
Xu, X.4
Flaherty, K.T.5
Corless, C.L.6
-
57
-
-
77954373338
-
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
-
Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010;70:5213-9.
-
(2010)
Cancer Res
, vol.70
, pp. 5213-5219
-
-
Boni, A.1
Cogdill, A.P.2
Dang, P.3
Udayakumar, D.4
Njauw, C.N.5
Sloss, C.M.6
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