메뉴 건너뛰기




Volumn 26, Issue 2, 2012, Pages 189-194

Glioblastoma biomarkers from bench to bedside: Advances and challenges

Author keywords

Biomarker; Genetics; Glioblastoma multiforme; Pathophysiology; Tumour

Indexed keywords

BIOLOGICAL MARKER; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 10; ISOCITRATE DEHYDROGENASE; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84858834921     PISSN: 02688697     EISSN: 1360046X     Source Type: Journal    
DOI: 10.3109/02688697.2011.629698     Document Type: Review
Times cited : (18)

References (46)
  • 2
    • 38049144280 scopus 로고    scopus 로고
    • Glioblastoma multiforme: Evidence-based approach to therapy
    • Nicholas MK. Glioblastoma multiforme: evidence-based approach to therapy. Expert Rev Anticancer Ther 2007;7(12 Suppl):S23-7.
    • (2007) Expert Rev Anticancer Ther , vol.7 , Issue.12 SUPPL.
    • Nicholas, M.K.1
  • 3
    • 70350449411 scopus 로고    scopus 로고
    • Advances in the genetics of glioblastoma: Are we reaching critical mass?
    • Purow B, SchiffD. Advances in the genetics of glioblastoma: are we reaching critical mass? Nat Rev Neurol 2009;5:419-26.
    • (2009) Nat Rev Neurol , vol.5 , pp. 419-426
    • Purow, B.1    Schiff, D.2
  • 4
    • 45249119952 scopus 로고    scopus 로고
    • Glioma stem cells: A midterm exam
    • Stiles CD, Rowitch DH. Glioma stem cells: a midterm exam. Neuron 2008;58:832-46.
    • (2008) Neuron , vol.58 , pp. 832-46
    • Stiles, C.D.1    Rowitch, D.H.2
  • 5
    • 79953189403 scopus 로고    scopus 로고
    • Cancer stem cells in glioblastoma-molecular signaling and therapeutic targeting
    • Huang Z, Cheng L, Guryanova OA, Wu Q, Bao S. Cancer stem cells in glioblastoma-molecular signaling and therapeutic targeting. Protein Cell 2010;1:638-55.
    • (2010) Protein Cell , vol.1 , pp. 638-655
    • Huang, Z.1    Cheng, L.2    Guryanova, O.A.3    Wu, Q.4    Bao, S.5
  • 6
    • 33845785589 scopus 로고    scopus 로고
    • Differentiation profile of brain tumor stem cells: A comparative study with neural stem cells
    • Zhang QB, Ji XY, Huang Q, Dong J, Zhu YD, Lan Q. Differentiation profile of brain tumor stem cells: a comparative study with neural stem cells. Cell Res 2006;16:909-15.
    • (2006) Cell Res , vol.16 , pp. 909-15
    • Zhang, Q.B.1    Ji, X.Y.2    Huang, Q.3    Dong, J.4    Zhu, Y.D.5    Lan, Q.6
  • 8
    • 0032763824 scopus 로고    scopus 로고
    • Expression of activated epidermal growth factor receptors, ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens
    • Feldkamp MM, Lala P, Lau N, Roncari L, Guha A. Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens. Neurosurgery 1999;45: 1442-53.
    • (1999) Neurosurgery , vol.45 , pp. 1442-53
    • Feldkamp, M.M.1    Lala, P.2    Lau, N.3    Roncari, L.4    Guha, A.5
  • 9
    • 70349653793 scopus 로고    scopus 로고
    • Idh1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • Nobusawa S, Watanabe T, Kleihues P, Ohgaki H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 2009;15:6002-7.
    • (2009) Clin Cancer Res , vol.15 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 10
    • 30144442616 scopus 로고    scopus 로고
    • Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications
    • discussion 1-
    • Gottfried ON, Viskochil DH, Fults DW, Couldwell WT. Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications. Neurosurgery 2006;58:1-16; discussion 1.-
    • (2006) Neurosurgery , vol.58 , pp. 1-16
    • Gottfried, O.N.1    Viskochil, D.H.2    Fults, D.W.3    Couldwell, W.T.4
  • 11
    • 34247115020 scopus 로고    scopus 로고
    • Cellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic t lymphocytes reveals their up-regulated synthesis of biologically active tgf-beta
    • Gomez GG, Kruse CA. Cellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes reveals their up-regulated synthesis of biologically active TGF-beta. J Immunother 2007; 30:261-73.
    • (2007) J Immunother , vol.30 , pp. 261-273
    • Gomez, G.G.1    Kruse, C.A.2
  • 15
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in pdgfra, idh1, egfr, and nf1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 16
    • 0038156165 scopus 로고    scopus 로고
    • Genes and pathways driving glioblastomas in humans and murine disease models
    • Merlo A. Genes and pathways driving glioblastomas in humans and murine disease models. Neurosurg Rev 2003;26:145-58.
    • (2003) Neurosurg Rev , vol.26 , pp. 145-58
    • Merlo, A.1
  • 17
    • 0032601166 scopus 로고    scopus 로고
    • Primary and secondary glioblastomas: From concept to clinical diagnosis
    • Kleihues P, Ohgaki H. Primary and secondary glioblastomas: from concept to clinical diagnosis. Neuro Oncol 1999;1:44-51.
    • (1999) Neuro Oncol , vol.1 , pp. 44-51
    • Kleihues, P.1    Ohgaki, H.2
  • 18
  • 20
    • 77954358148 scopus 로고    scopus 로고
    • Pten loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(adp-ribose) polymerase inhibitors
    • McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, et al PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res 2010;70:5457-64.
    • (2010) Cancer Res , vol.70 , pp. 5457-64
    • McEllin, B.1    Camacho, C.V.2    Mukherjee, B.3    Hahm, B.4    Tomimatsu, N.5    Bachoo, R.M.6
  • 21
    • 77953230474 scopus 로고    scopus 로고
    • Effect of combination treatment of rapamycin and isoflavones on mtor pathway in human glioblastoma (u87) cells
    • Puli S, Jain A, Lai JC, Bhushan A. Effect of combination treatment of rapamycin and isoflavones on mTOR pathway in human glioblastoma (U87) cells. Neurochem Res 2010;35:986-93.
    • (2010) Neurochem Res , vol.35 , pp. 986-993
    • Puli, S.1    Jain, A.2    Lai, J.C.3    Bhushan, A.4
  • 23
    • 33748376520 scopus 로고    scopus 로고
    • Phase i/ii study of imatinib mesylate for recurrent malignant gliomas: North american brain tumor consortium study 99-08
    • Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, et al Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 2006;12:4899-907.
    • (2006) Clin Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1    Yung, W.K.2    Lamborn, K.R.3    Dahia, P.L.4    Wang, Y.5    Peng, B.6
  • 24
    • 77955003681 scopus 로고    scopus 로고
    • Ribozyme-mediated inhibition of 801-bp deletion-mutant epidermal growth factor receptor mrna expression in glioblastoma multiforme
    • Karpel-Massler G, Wirtz CR, Halatsch ME. Ribozyme-mediated inhibition of 801-bp deletion-mutant epidermal growth factor receptor mRNA expression in glioblastoma multiforme. Molecules 2010;15:4670-8.
    • (2010) Molecules , vol.15 , pp. 4670-8
    • Karpel-Massler, G.1    Wirtz, C.R.2    Halatsch, M.E.3
  • 25
    • 0033964013 scopus 로고    scopus 로고
    • Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor receptor messenger RNA
    • Halatsch ME, Schmidt U, Botefur IC, Holland JF, Ohnuma T. Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor receptor messenger RNA. J Neurosurg 2000;92:297-305.
    • (2000) J Neurosurg , vol.92 , pp. 297-305
    • Halatsch, M.E.1    Schmidt, U.2    Botefur, I.C.3    Holland, J.F.4    Ohnuma, T.5
  • 26
    • 0032522815 scopus 로고    scopus 로고
    • Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression
    • Yamazaki H, Kijima H, Ohnishi Y, Abe Y, Oshika Y, Tsuchida T, et al Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression. J Natl Cancer Inst 1998;90:581-7.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 581-7
    • Yamazaki, H.1    Kijima, H.2    Ohnishi, Y.3    Abe, Y.4    Oshika, Y.5    Tsuchida, T.6
  • 28
    • 10744229118 scopus 로고    scopus 로고
    • Inverse correlation of epidermal growth factor receptor messenger rna induction and suppression of anchorageindependent growth by osi-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines
    • Halatsch ME, Gehrke EE, Vougioukas VI, Botefur IC, A-Borhani F, Efferth T, et al Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorageindependent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines. J Neurosurg 2004;100:523-33.
    • (2004) J Neurosurg , vol.100 , pp. 523-533
    • Halatsch, M.E.1    Gehrke, E.E.2    Vougioukas, V.I.3    Botefur, I.C.4    A-Borhani, F.5    Efferth, T.6
  • 29
    • 67651154339 scopus 로고    scopus 로고
    • Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: Where do we stand?
    • Karpel-Massler G, Schmidt U, Unterberg A, Halatsch ME. Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: where do we stand? Mol Cancer Res 2009;7:1000-12.
    • (2009) Mol Cancer Res , vol.7 , pp. 1000-12
    • Karpel-Massler, G.1    Schmidt, U.2    Unterberg, A.3    Halatsch, M.E.4
  • 30
    • 33644836724 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours
    • Halatsch ME, Schmidt U, Behnke-Mursch J, Unterberg A, Wirtz CR. Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours. Cancer Treat Rev 2006;32:74-89.
    • (2006) Cancer Treat Rev , vol.32 , pp. 74-89
    • Halatsch, M.E.1    Schmidt, U.2    Behnke-Mursch, J.3    Unterberg, A.4    Wirtz, C.R.5
  • 31
    • 77956631020 scopus 로고    scopus 로고
    • Cetuximab insufficiently inhibits glioma cell growth due to persistent egfr downstream signaling
    • Hasselbalch B, Lassen U, Poulsen HS, Stockhausen MT. Cetuximab insufficiently inhibits glioma cell growth due to persistent EGFR downstream signaling. Cancer Invest 2010;28:775-87.
    • (2010) Cancer Invest , vol.28 , pp. 775-87
    • Hasselbalch, B.1    Lassen, U.2    Poulsen, H.S.3    Stockhausen, M.T.4
  • 32
    • 70349333060 scopus 로고    scopus 로고
    • Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse
    • Yang SH, Hong YK, Jeun SS, Kim IS, Hong JT, Sung JH, e t al. Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse. J Neurooncol 2009;95:23-8.
    • (2009) J Neurooncol , vol.95 , pp. 23-28
    • Yang, S.H.1    Hong, Y.K.2    Jeun, S.S.3    Kim, I.S.4    Hong, J.T.5    Sung, J.H.6
  • 33
    • 53049092916 scopus 로고    scopus 로고
    • Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2
    • Martens T, Laabs Y, Gunther HS, Kemming D, Zhu Z, Witte L, e t al. Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2. Clin Cancer Res 2008;14:5447-58.
    • (2008) Clin Cancer Res , vol.14 , pp. 5447-58
    • Martens, T.1    Laabs, Y.2    Gunther, H.S.3    Kemming, D.4    Zhu, Z.5    Witte, L.6
  • 34
    • 34447303334 scopus 로고    scopus 로고
    • Cpg island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme
    • Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, et al CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis 2007;28:1264-8.
    • (2007) Carcinogenesis , vol.28 , pp. 1264-1268
    • Martinez, R.1    Setien, F.2    Voelter, C.3    Casado, S.4    Quesada, M.P.5    Schackert, G.6
  • 36
    • 79955382989 scopus 로고    scopus 로고
    • O6-methylguanine dna methyltransferase gene promoter methylation in high-grade gliomas: A review of current status
    • Suri V, Jha P, Sharma MC, Sarkar C. O6-methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: a review of current status. N eurol India 2011;59:229-35.
    • (2011) N eurol India , vol.59 , pp. 229-235
    • Suri, V.1    Jha, P.2    Sharma, M.C.3    Sarkar, C.4
  • 37
    • 73349103157 scopus 로고    scopus 로고
    • Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: A prospective translational study of the german glioma network
    • Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, et al Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol 2009;27:5743-50.
    • (2009) J Clin Oncol , vol.27 , pp. 5743-50
    • Weller, M.1    Felsberg, J.2    Hartmann, C.3    Berger, H.4    Steinbach, J.P.5    Schramm, J.6
  • 38
    • 47649131468 scopus 로고    scopus 로고
    • Validation of real-time methylation-specific pcr to determine o6-methylguanine-dna methyltransferase gene promoter methylation in glioma
    • Vlassenbroeck I, Califice S, Diserens AC, Migliavacca E, Straub J, Di Stefano I, et al Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma. J Mol Diagn 2008;10:332-7.
    • (2008) J Mol Diagn , vol.10 , pp. 332-337
    • Vlassenbroeck, I.1    Califice, S.2    Diserens, A.C.3    Migliavacca, E.4    Straub, J.5    Di Stefano, I.6
  • 39
    • 0033934907 scopus 로고    scopus 로고
    • Expression of tgf-beta isoforms, tgf-beta receptors, and smad molecules at different stages of human glioma
    • Kjellman C, Olofsson SP, Hansson O, Von Schantz T, Lindvall M, Nilsson I, et al Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma. Int J Cancer 2000;89:251-8.
    • (2000) Int J Cancer , vol.89 , pp. 251-8
    • Kjellman, C.1    Olofsson, S.P.2    Hansson, O.3    Von Schantz, T.4    Lindvall, M.5    Nilsson, I.6
  • 40
    • 67650077101 scopus 로고    scopus 로고
    • Modulation of tgf-beta activity by latent tgfbeta-binding protein 1 in human malignant glioma cells
    • Tritschler I, Gramatzki D, Capper D, Mittelbronn M, Meyermann R, Saharinen J, et al Modulation of TGF-beta activity by latent TGFbeta-binding protein 1 in human malignant glioma cells. Int J Cancer 2009;125:530-40.
    • (2009) Int J Cancer , vol.125 , pp. 530-540
    • Tritschler, I.1    Gramatzki, D.2    Capper, D.3    Mittelbronn, M.4    Meyermann, R.5    Saharinen, J.6
  • 41
    • 33745962224 scopus 로고    scopus 로고
    • Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma
    • Schneider T, Sailer M, Ansorge S, Firsching R, Reinhold D. Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma. J Neurooncol 2006;79:61-5.
    • (2006) J Neurooncol , vol.79 , pp. 61-5
    • Schneider, T.1    Sailer, M.2    Ansorge, S.3    Firsching, R.4    Reinhold, D.5
  • 42
    • 0035464801 scopus 로고    scopus 로고
    • Prognostic value of plasma transforming growth factor-beta in patients with glioblastoma multiforme
    • Hulshof MC, Sminia P, Barten-Van Rijbroek AD, Gonzalez Gonzalez D. Prognostic value of plasma transforming growth factor-beta in patients with glioblastoma multiforme. Oncol Rep 2001;8:1107-10.
    • (2001) Oncol Rep , vol.8 , pp. 1107-1110
    • Hulshof, M.C.1    Sminia, P.2    Barten-Van Rijbroek, A.D.3    Gonzalez Gonzalez, D.4
  • 43
    • 0030778631 scopus 로고    scopus 로고
    • Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro
    • Huettner C, Czub S, Kerkau S, Roggendorf W, Tonn JC. Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro. Anticancer Res 1997; 17:3217-24.
    • (1997) Anticancer Res , vol.17 , pp. 3217-24
    • Huettner, C.1    Czub, S.2    Kerkau, S.3    Roggendorf, W.4    Tonn, J.C.5
  • 44
    • 11144229294 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody cetuximab augments radiation effects in glioblastoma multiforme in vitro and in vivo
    • discussion 62
    • Eller JL, Longo SL, Kyle MM, Bassano D, Hicklin DJ, Canute GW. Anti-epidermal growth factor receptor monoclonal antibody cetuximab augments radiation effects in glioblastoma multiforme in vitro and in vivo. Neurosurgery 2005;56:155-62; discussion 62.
    • (2005) Neurosurgery , vol.56 , pp. 155-162
    • Eller, J.L.1    Longo, S.L.2    Kyle, M.M.3    Bassano, D.4    Hicklin, D.J.5    Canute, G.W.6
  • 45
    • 79957516708 scopus 로고    scopus 로고
    • Response assessment in neuro-oncology (a report of the rano group): Assessment of outcome trials in low-grade gliomas
    • Epub 2011 April 5
    • Van Den Bent MJ, Wefel JS, SchiffD, Taphoorn MJ, Jeackle K, Junck L. Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome trials in low-grade gliomas. Lancet Oncol 2011;12:583-93. Epub 2011 April 5.
    • (2011) Lancet Oncol , vol.12 , pp. 583-593
    • Van Den Bent, M.J.1    Wefel, J.S.2    Schiff, D.3    Taphoorn, M.J.4    Jeackle, K.5    Junck, L.6
  • 46
    • 76749097367 scopus 로고    scopus 로고
    • Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility- weighted contrast-enhanced perfusion mr imaging
    • Barajas RF Jr., Chang JS, Segal MR, Parsa AT, McDermott MW, Berger MS, et al Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 2009;253:486-96.
    • (2009) Radiology , vol.253 , pp. 486-96
    • Barajas Jr., R.F.1    Chang, J.S.2    Segal, M.R.3    Parsa, A.T.4    McDermott, M.W.5    Berger, M.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.