메뉴 건너뛰기




Volumn 134, Issue 10, 2014, Pages 2437-2447

Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy

(15)  Weller, Michael a   Kaulich, Kerstin b,c   Hentschel, Bettina d   Felsberg, Joerg b,c   Gramatzki, Dorothee a   Pietsch, Torsten e   Simon, Matthias e   Westphal, Manfred f   Schackert, Gabriele g   Tonn, Joerg C h   Von Deimling, Andreas i   Davis, Thomas j   Weiss, William Andrew k   Loeffler, Markus d   Reifenberger, Guido b,d  


Author keywords

EGFRvIII; epidermal growth factor receptor; glioblastoma; immunotherapy; prognosis; rindopepimut

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 84895922426     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28576     Document Type: Article
Times cited : (104)

References (35)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-96.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 2
    • 84863562673 scopus 로고    scopus 로고
    • Glioblastoma survival in the United States before and during the temozolomide era
    • Johnson DR, O'Neill BP,. Glioblastoma survival in the United States before and during the temozolomide era. J Neurooncol 2012; 107: 359-64.
    • (2012) J Neurooncol , vol.107 , pp. 359-364
    • Johnson, D.R.1    O'Neill, B.P.2
  • 3
    • 84880791777 scopus 로고    scopus 로고
    • Molecular neuro-oncology in clinical practice: A new horizon
    • Weller M, Pfister SM, Wick W, et al. Molecular neuro-oncology in clinical practice: a new horizon. Lancet Oncol 2013; 14: e370-9.
    • (2013) Lancet Oncol , vol.14
    • Weller, M.1    Pfister, S.M.2    Wick, W.3
  • 4
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S,. Malignant gliomas in adults. N Engl J Med 2008; 359: 492-507.
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 5
    • 78651082266 scopus 로고    scopus 로고
    • Patients with IDH1 wild-type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomas
    • Hartmann C, Hentschel B, Wick W, et al. Patients with IDH1 wild-type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol 2010; 120: 707-18.
    • (2010) Acta Neuropathol , vol.120 , pp. 707-718
    • Hartmann, C.1    Hentschel, B.2    Wick, W.3
  • 6
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352: 997-1003.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 7
    • 80052254518 scopus 로고    scopus 로고
    • RTOG 0525: A randomized phase III trial comparing standard adjuvant temozolomide (TMZ) with a dose-dense(dd) schedule in newly diagnosed glioblastoma (GBM)
    • abstr 2006
    • Gilbert MR WM, Aldape KD, Stupp R, et al. RTOG 0525: a randomized phase III trial comparing standard adjuvant temozolomide (TMZ) with a dose-dense(dd) schedule in newly diagnosed glioblastoma (GBM). J Clin Oncol 2011; 29 (suppl; abstr 2006).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Gilbert, M.R.W.1    Aldape, K.D.2    Stupp, R.3
  • 8
    • 73349103157 scopus 로고    scopus 로고
    • Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: A prospective translational study of the German Glioma Network
    • Weller M, Felsberg J, Hartmann C, et al. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol 2009; 27: 5743-50.
    • (2009) J Clin Oncol , vol.27 , pp. 5743-5750
    • Weller, M.1    Felsberg, J.2    Hartmann, C.3
  • 9
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
    • Wick W, Platten M, Meisner C, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol 2012; 13: 707-15.
    • (2012) Lancet Oncol , vol.13 , pp. 707-715
    • Wick, W.1    Platten, M.2    Meisner, C.3
  • 10
    • 0027551467 scopus 로고
    • Amplified genes in human gliomas
    • Collins VP,. Amplified genes in human gliomas. Semin Cancer Biol 1993; 4: 27-32.
    • (1993) Semin Cancer Biol , vol.4 , pp. 27-32
    • Collins, V.P.1
  • 11
    • 39749169093 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in neuro-oncology: Hopes and disappointments
    • Brandes AA, Franceschi E, Tosoni A, et al. Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments. Clin Cancer Res 2008; 14: 957-60.
    • (2008) Clin Cancer Res , vol.14 , pp. 957-960
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 12
    • 84870065591 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: A re-emerging target in glioblastoma
    • Hegi ME, Rajakannu P, Weller M,. Epidermal growth factor receptor: a re-emerging target in glioblastoma. Curr Opin Neurol 2012; 25: 774-9.
    • (2012) Curr Opin Neurol , vol.25 , pp. 774-779
    • Hegi, M.E.1    Rajakannu, P.2    Weller, M.3
  • 13
    • 67349137902 scopus 로고    scopus 로고
    • The EGFRvIII variant in glioblastoma multiforme
    • Gan HK, Kaye AH, Luwor RB,. The EGFRvIII variant in glioblastoma multiforme. J Clin Neurosci 2009; 16: 748-54.
    • (2009) J Clin Neurosci , vol.16 , pp. 748-754
    • Gan, H.K.1    Kaye, A.H.2    Luwor, R.B.3
  • 14
    • 79955784386 scopus 로고    scopus 로고
    • Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
    • Sampson JH, Aldape KD, Archer GE, et al. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro Oncol 2011; 13: 324-33.
    • (2011) Neuro Oncol , vol.13 , pp. 324-333
    • Sampson, J.H.1    Aldape, K.D.2    Archer, G.E.3
  • 15
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 2010; 28: 4722-9.
    • (2010) J Clin Oncol , vol.28 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3
  • 16
    • 0029999601 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in oligodendroglial tumors
    • Reifenberger J, Reifenberger G, Ichimura K, et al. Epidermal growth factor receptor expression in oligodendroglial tumors. Am J Pathol 1996; 149: 29-35.
    • (1996) Am J Pathol , vol.149 , pp. 29-35
    • Reifenberger, J.1    Reifenberger, G.2    Ichimura, K.3
  • 17
    • 33748058820 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells
    • Wang MY, Lu KV, Zhu S, et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res 2006; 66: 7864-9.
    • (2006) Cancer Res , vol.66 , pp. 7864-7869
    • Wang, M.Y.1    Lu, K.V.2    Zhu, S.3
  • 18
    • 84885356671 scopus 로고    scopus 로고
    • EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    • Fan QW, Cheng C, Gustafson WC, et al. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell, 2013; 24:438-49.
    • (2013) Cancer Cell , vol.24 , pp. 438-449
    • Fan, Q.W.1    Cheng, C.2    Gustafson, W.C.3
  • 19
    • 70350741355 scopus 로고    scopus 로고
    • Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients
    • Felsberg J, Rapp M, Loeser S, et al. Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients. Clin Cancer Res 2009; 15: 6683-93.
    • (2009) Clin Cancer Res , vol.15 , pp. 6683-6693
    • Felsberg, J.1    Rapp, M.2    Loeser, S.3
  • 20
    • 3042757984 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    • Aldape KD, Ballman K, Furth A, et al. Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol 2004; 63: 700-7.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 700-707
    • Aldape, K.D.1    Ballman, K.2    Furth, A.3
  • 21
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand AJ, Sugawa N, James CD, et al. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci USA 1992; 89: 4309-13.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3
  • 22
    • 38949117993 scopus 로고    scopus 로고
    • Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples
    • Yoshimoto K, Dang J, Zhu S, et al. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res 2008; 14: 488-93.
    • (2008) Clin Cancer Res , vol.14 , pp. 488-493
    • Yoshimoto, K.1    Dang, J.2    Zhu, S.3
  • 23
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • Ohgaki H, Kleihues P,. The definition of primary and secondary glioblastoma. Clin Cancer Res 2013; 19: 764-72.
    • (2013) Clin Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 24
    • 0027407245 scopus 로고
    • Subsets of glioblastoma multiforme defined by molecular genetic analysis
    • von Deimling A, von Ammon K, Schoenfeld D, et al. Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol 1993; 3: 19-26.
    • (1993) Brain Pathol , vol.3 , pp. 19-26
    • Von Deimling, A.1    Von Ammon, K.2    Schoenfeld, D.3
  • 25
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • Watanabe K, Tachibana O, Sata K, et al. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6: 217-23.
    • (1996) Brain Pathol , vol.6 , pp. 217-223
    • Watanabe, K.1    Tachibana, O.2    Sata, K.3
  • 26
    • 58849087233 scopus 로고    scopus 로고
    • Worse outcome in primary glioblastoma multiforme with concurrent epidermal growth factor receptor and p53 alteration
    • Ruano Y, Ribalta T, de Lope AR, et al. Worse outcome in primary glioblastoma multiforme with concurrent epidermal growth factor receptor and p53 alteration. Am J Clin Pathol 2009; 131: 257-63.
    • (2009) Am J Clin Pathol , vol.131 , pp. 257-263
    • Ruano, Y.1    Ribalta, T.2    De Lope, A.R.3
  • 27
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • Shinojima N, Tada K, Shiraishi S, et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res 2003; 63: 6962-70.
    • (2003) Cancer Res , vol.63 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3
  • 28
    • 84855441538 scopus 로고    scopus 로고
    • Expression of EGFRvIII in glioblastoma: Prognostic significance revisited
    • Montano N, Cenci T, Martini M, et al. Expression of EGFRvIII in glioblastoma: prognostic significance revisited. Neoplasia 2011; 13: 1113-21.
    • (2011) Neoplasia , vol.13 , pp. 1113-1121
    • Montano, N.1    Cenci, T.2    Martini, M.3
  • 29
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • Heimberger AB, Hlatky R, Suki D, et al. Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin Cancer Res 2005; 11: 1462-6.
    • (2005) Clin Cancer Res , vol.11 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3
  • 30
    • 34250189213 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma
    • Pelloski CE, Ballman KV, Furth AF, et al. Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol 2007; 25: 2288-94.
    • (2007) J Clin Oncol , vol.25 , pp. 2288-2294
    • Pelloski, C.E.1    Ballman, K.V.2    Furth, A.F.3
  • 31
    • 84860358785 scopus 로고    scopus 로고
    • Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: Implications for immunotherapy
    • Crane CA, Ahn BJ, Han SJ, et al. Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy. Neuro Oncol 2012; 14: 584-95.
    • (2012) Neuro Oncol , vol.14 , pp. 584-595
    • Crane, C.A.1    Ahn, B.J.2    Han, S.J.3
  • 32
    • 2442676505 scopus 로고    scopus 로고
    • Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
    • Biernat W, Huang H, Yokoo H, et al. Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol 2004; 14: 131-6.
    • (2004) Brain Pathol , vol.14 , pp. 131-136
    • Biernat, W.1    Huang, H.2    Yokoo, H.3
  • 33
    • 18944393158 scopus 로고    scopus 로고
    • Immunohistochemically determined total epidermal growth factor receptor levels not of prognostic value in newly diagnosed glioblastoma multiforme: Report from the Radiation Therapy Oncology Group
    • Chakravarti A, Seiferheld W, Tu X, et al. Immunohistochemically determined total epidermal growth factor receptor levels not of prognostic value in newly diagnosed glioblastoma multiforme: report from the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2005; 62: 318-27.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 318-327
    • Chakravarti, A.1    Seiferheld, W.2    Tu, X.3
  • 34
    • 69949123875 scopus 로고    scopus 로고
    • Robust detection of EGFR copy number changes and EGFR variant III: Technical aspects and relevance for glioma diagnostics
    • Jeuken J, Sijben A, Alenda C, et al. Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics. Brain Pathol 2009; 19: 661-71.
    • (2009) Brain Pathol , vol.19 , pp. 661-671
    • Jeuken, J.1    Sijben, A.2    Alenda, C.3
  • 35
    • 8744234208 scopus 로고    scopus 로고
    • Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma
    • Nishikawa R, Sugiyama T, Narita Y, et al. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol 2004; 21: 53-6.
    • (2004) Brain Tumor Pathol , vol.21 , pp. 53-56
    • Nishikawa, R.1    Sugiyama, T.2    Narita, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.