메뉴 건너뛰기




Volumn 32, Issue 1, 2008, Pages 21-29

Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: A population-based study

Author keywords

Glioblastoma; MGMT polymorphism; MGMT promoter methylation; TP53 mutations

Indexed keywords

ISOLEUCINE; LEUCINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHENYLALANINE; PROTEIN P53; VALINE;

EID: 55449122220     PISSN: 02515350     EISSN: None     Source Type: Journal    
DOI: 10.1159/000170088     Document Type: Article
Times cited : (89)

References (59)
  • 2
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki H, Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 2005;64:479-489.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 4
    • 2642574948 scopus 로고    scopus 로고
    • Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go
    • Kaina B: Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. Cytogenet Genome Res 2004;104:77-86.
    • (2004) Cytogenet Genome Res , vol.104 , pp. 77-86
    • Kaina, B.1
  • 5
    • 0034028030 scopus 로고    scopus 로고
    • 6-alkylguanine by alkyltransferases
    • 6-alkylguanine by alkyltransferases. Mutat Res 2000;462:83-100.
    • (2000) Mutat Res , vol.462 , pp. 83-100
    • Pegg, A.E.1
  • 6
    • 0016715086 scopus 로고
    • 6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N- nitrosourea
    • 6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N- nitrosourea. Biochem J 1975;148:521-525.
    • (1975) Biochem J , vol.148 , pp. 521-525
    • Margison, G.P.1    Kleihues, P.2
  • 7
    • 0016042235 scopus 로고
    • 6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosourea
    • 6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci USA 1974;71:639-643.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 639-643
    • Goth, R.1    Rajewsky, M.F.2
  • 9
    • 0033557903 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999;59:793-797.
    • (1999) Cancer Res , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 10
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • Mollemann M, Wolter M, Felsberg J, Collins VP, Reifenberger G: Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer 2005;113:379-385.
    • (2005) Int J Cancer , vol.113 , pp. 379-385
    • Mollemann, M.1    Wolter, M.2    Felsberg, J.3    Collins, V.P.4    Reifenberger, G.5
  • 13
    • 33847364433 scopus 로고    scopus 로고
    • MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
    • Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK: MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer 2007;48:403-407.
    • (2007) Pediatr Blood Cancer , vol.48 , pp. 403-407
    • Donson, A.M.1    Addo-Yobo, S.O.2    Handler, M.H.3    Gore, L.4    Foreman, N.K.5
  • 17
  • 18
    • 0036832075 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase SNPs: A frequency comparison of patients with familial melanoma and healthy individuals in Sweden
    • 6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden. Hum Mutat 2002;20:408-409.
    • (2002) Hum Mutat , vol.20 , pp. 408-409
    • Egyhazi, S.1    Ma, S.2    Smoczynski, K.3    Hansson, J.4    Platz, A.5    Ringborg, U.6
  • 19
    • 0033584567 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland
    • 6-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland. Hum Mutat 1999;14:269-270.
    • (1999) Hum Mutat , vol.14 , pp. 269-270
    • Rusin, M.1    Samojedny, A.2    Harris, C.C.3    Chorazy, M.4
  • 21
    • 0036021002 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy
    • 6-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy. Melanoma Res 2002;12:335-342.
    • (2002) Melanoma Res , vol.12 , pp. 335-342
    • Ma, S.1    Egyhazi, S.2    Martenhed, G.3    Ringborg, U.4    Hansson, J.5
  • 22
    • 22944466050 scopus 로고    scopus 로고
    • 6-methylguanine-DNA- methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. Pharmacogenet Genomics 2005;15:571-578.
    • 6-methylguanine-DNA- methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. Pharmacogenet Genomics 2005;15:571-578.
  • 26
    • 4444220781 scopus 로고    scopus 로고
    • Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland
    • Krzesniak M, Butkiewicz D, Samojedny A, Chorazy M, Rusin M: Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet 2004;68:300-312.
    • (2004) Ann Hum Genet , vol.68 , pp. 300-312
    • Krzesniak, M.1    Butkiewicz, D.2    Samojedny, A.3    Chorazy, M.4    Rusin, M.5
  • 27
    • 0345491859 scopus 로고    scopus 로고
    • A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma
    • Inoue R , Isono M, Abe M, Abe T, Kobayashi H: A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. Neurol Res 2003;25:875-879.
    • (2003) Neurol Res , vol.25 , pp. 875-879
    • Inoue, R.1    Isono, M.2    Abe, M.3    Abe, T.4    Kobayashi, H.5
  • 32
    • 0032751267 scopus 로고    scopus 로고
    • A novel assay for allelic discrimination that combines the fluorogenic 5′ nuclease polymerase chain reaction (TaqMan) and mismatch amplification mutation assay
    • Glaab WE, Skopek TR: A novel assay for allelic discrimination that combines the fluorogenic 5′ nuclease polymerase chain reaction (TaqMan) and mismatch amplification mutation assay. Mutat Res 1999;430:1-12.
    • (1999) Mutat Res , vol.430 , pp. 1-12
    • Glaab, W.E.1    Skopek, T.R.2
  • 33
    • 34447320481 scopus 로고    scopus 로고
    • Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma
    • Huang J, Ye F, Chen H, Lu W, Xie X: Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis 2007;28:1314-1322.
    • (2007) Carcinogenesis , vol.28 , pp. 1314-1322
    • Huang, J.1    Ye, F.2    Chen, H.3    Lu, W.4    Xie, X.5
  • 35
    • 0028218474 scopus 로고
    • Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
    • Ohshima H, Bartsch H: Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 1994;305:253-264.
    • (1994) Mutat Res , vol.305 , pp. 253-264
    • Ohshima, H.1    Bartsch, H.2
  • 36
    • 0021196260 scopus 로고
    • Chemical neurooncogenesis: Role of structural DNA modifications, DNA repair and neural target cell population
    • Kleihues P, Rajewsky MF: Chemical neurooncogenesis: role of structural DNA modifications, DNA repair and neural target cell population. Prog Exp Tumor Res 1984;27:1-16.
    • (1984) Prog Exp Tumor Res , vol.27 , pp. 1-16
    • Kleihues, P.1    Rajewsky, M.F.2
  • 37
    • 6544255873 scopus 로고    scopus 로고
    • Animal models of tumors of the nervous system
    • Berger MS, Wilson C eds, Philadelphia, WB Saunders
    • Kleihues P, Wiestler OD, Ohgaki H, Aguzzi A: Animal models of tumors of the nervous system; in Berger MS, Wilson C (eds): The Gliomas. Philadelphia, WB Saunders, 1998, pp 124-133.
    • (1998) The Gliomas , pp. 124-133
    • Kleihues, P.1    Wiestler, O.D.2    Ohgaki, H.3    Aguzzi, A.4
  • 38
    • 0017367498 scopus 로고
    • 6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-nitrosourea
    • 6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-nitrosourea. Chem Biol Interact 1977;16:325-333.
    • (1977) Chem Biol Interact , vol.16 , pp. 325-333
    • Buecheler, J.1    Kleihues, P.2
  • 40
    • 0021287831 scopus 로고
    • 6-alkylguanine- DNA alkyltransferase activity in normal human tissues and cells
    • 6-alkylguanine- DNA alkyltransferase activity in normal human tissues and cells. Cancer Res 1984;44:2855-2857.
    • (1984) Cancer Res , vol.44 , pp. 2855-2857
    • Grafstrom, R.C.1    Pegg, A.E.2    Trump, B.F.3    Harris, C.C.4
  • 42
    • 14244265590 scopus 로고    scopus 로고
    • Epidemiology and etiology of gliomas
    • Ohgaki H, Kleihues P: Epidemiology and etiology of gliomas. Acta Neuropathol 2005;109:93-108.
    • (2005) Acta Neuropathol , vol.109 , pp. 93-108
    • Ohgaki, H.1    Kleihues, P.2
  • 43
    • 0031050843 scopus 로고    scopus 로고
    • Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA)
    • Lee M, Wrensch M, Miike R: Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA). Cancer Causes Control 1997;8:13-24.
    • (1997) Cancer Causes Control , vol.8 , pp. 13-24
    • Lee, M.1    Wrensch, M.2    Miike, R.3
  • 45
    • 11144305238 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course
    • 6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course. Int J Cancer 2005;113:581-587.
    • (2005) Int J Cancer , vol.113 , pp. 581-587
    • Watanabe, T.1    Katayama, Y.2    Komine, C.3    Yoshino, A.4    Ogino, A.5    Ohta, T.6    Fukushima, T.7
  • 46
    • 0037227642 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase: Promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors
    • 6-methylguanine-DNA methyltransferase: promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors. Mol Carcinog 2003;36:23-31.
    • (2003) Mol Carcinog , vol.36 , pp. 23-31
    • Yin, D.1    Xie, D.2    Hofmann, W.K.3    Zhang, W.4    Asotra, K.5    Wong, R.6    Black, K.L.7    Koeffler, H.P.8
  • 47
    • 0034795045 scopus 로고    scopus 로고
    • Promoter hypermethylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C-A:T mutations of the TP53 tumor suppressor gene
    • Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H: Promoter hypermethylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C-A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis 2001;22:1715-1719.
    • (2001) Carcinogenesis , vol.22 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 48
    • 19544392006 scopus 로고    scopus 로고
    • 6-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. Gut 2005;54:797-802.
    • 6-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. Gut 2005;54:797-802.
  • 50
    • 0035890742 scopus 로고    scopus 로고
    • 6- methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer
    • 6- methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. Cancer Res 2001;61:8113-8117.
    • (2001) Cancer Res , vol.61 , pp. 8113-8117
    • Wolf, P.1    Hu, Y.C.2    Doffek, K.3    Sidransky, D.4    Ahrendt, S.A.5
  • 53
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki H, Kleihues P: Genetic pathways to primary and secondary glioblastoma. Am J Pathol 2007;170:1445-1453.
    • (2007) Am J Pathol , vol.170 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 55
    • 33750450047 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase and endometrial cancer risk
    • 6-methylguanine DNA methyltransferase and endometrial cancer risk. Carcinogenesis 2006;27:2281-2285.
    • (2006) Carcinogenesis , vol.27 , pp. 2281-2285
    • Han, J.1    Hankinson, S.E.2    De, V.3
  • 58
    • 33646366136 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    • 6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). Cancer Causes Control 2006;17:721-731.
    • (2006) Cancer Causes Control , vol.17 , pp. 721-731
    • Tranah, G.J.1    Bugni, J.2    Giovannucci, E.3    Ma, J.4    Fuchs, C.5    Hines, L.6    Samson, L.7    Hunter, D.J.8
  • 59
    • 0034813581 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage
    • 6-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. Mol Cell Biol 2001;21:7105-7114.
    • (2001) Mol Cell Biol , vol.21 , pp. 7105-7114
    • Teo, A.K.1    Oh, H.K.2    Ali, R.B.3    Li, B.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.