Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP–Dependent Manner

Journal of Bone and Mineral Research

Volumn 32, Issue 10, 2017, Pages 2128-2141

  Kang, Xiaomin ^a   Yang, Wei ^a   Feng, Dongxu ^a,b   Jin, Xinxin ^a   Ma, Zhengmin ^b   Qian, Zhuang ^a   Xie, Tianping ^a   Li, Huixia ^b   Liu, Jiali ^c   Wang, Ruiqi ^a   Li, Fang ^b   Li, Danhui ^b   Sun, Hongzhi ^b   Wu, Shufang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

ATG7; AUTOPHAGY; ENDOCHONDRAL OSSIFICATION; ER STRESS; GROWTH PLATE CHONDROCYTES

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AUTOPHAGY RELATED PROTEIN 7; COLLAGEN TYPE 10; COLLAGEN TYPE 10 ALPHA 1; COLLAGENASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ER KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN A; 4-PHENYLBUTYRIC ACID; ARYLBUTYRIC ACID DERIVATIVE; PERK KINASE; PROTEIN KINASE R;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; BONE GROWTH; CARTILAGE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROCYTE; CHONDROGENESIS; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; ENDOPLASMIC RETICULUM STRESS; EPIPHYSIS PLATE; GROWTH RETARDATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; ANTIBODY SPECIFICITY; BONE DEVELOPMENT; DEFICIENCY; DRUG EFFECT; EMBRYO DEVELOPMENT; EMBRYOLOGY; FEMUR; GENE DELETION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; METABOLISM; TIBIA; ULTRASTRUCTURE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 7; CARTILAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; EIF-2 KINASE; EMBRYONIC DEVELOPMENT; ENDOPLASMIC RETICULUM STRESS; FEMUR; GENE DELETION; GROWTH PLATE; MICE, KNOCKOUT; ORGAN SPECIFICITY; OSTEOGENESIS; PHENYLBUTYRATES; TIBIA; TRANSCRIPTION FACTOR CHOP;

EID: 85017476240     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.3134     Document Type: Article

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