About the importance of being desulfated

Genes and Development

Volumn 22, Issue 20, 2008, Pages 2750-2754

  Khatri, Richa ^a   Schipani, Ernestina ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chondrocytes; Desulfation; FGF; Proteoglycan

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; PROTEIN SUMF 1; PROTEOGLYCAN; SULFATASE; UNCLASSIFIED DRUG;

AUTOPHAGY; CARTILAGE CELL; CHONDRODYSPLASIA; HUMAN; HYDROLYSIS; METABOLISM; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SULFATION;

AUTOPHAGY; CHONDROCYTES; CHONDRODYSPLASIA PUNCTATA; FIBROBLAST GROWTH FACTORS; HUMANS; SIGNAL TRANSDUCTION; SULFATASES;

EID: 54349090356     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1735508     Document Type: Review

References (37)

1. Azad, M., Chen, Y., Henson, E., Cizeau, J., McMillan-Ward, E., Israels, S., and Gibson, S. 2008. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 4: 195-204.
2. Bernales, S., McDonald, K., and Walter, P. 2006. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 4: e423. doi: 10.1371/journal.pbio.0040423.
3. Bohensky, J., Shapiro, I., Leshinsky, S., Terkhorn, S., Adams, C., and Srinvas, V. 2007. HIF-1 regulation of chondrocyte apoptosis: Induction of the autophagic pathway. Autophagy 3: 207-214.
4. Cosma, M., Pepe, S., Annunziata, I., Newbold, R., Grompe, M., Parenti, G., and Ballabio, A. 2003. The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell 113: 445-446.
5. Dierks, T., Schmidt, B., Borissenko, L., Peng, J., Preusser, A., Mariappan, M., and v Figura, K. 2003. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C-α formylglycine generating enzyme. Cell 113: 435-444.
6. Ding, W., Ni, H., Gao, W., Yoshimori, T., Stolz, D., Ron, D., and Yin, X. 2007. Linking the autophagy to biquitin-proteosome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am. J. Pathol. 171: 513-524.
7. Farah-Carson, M., Hecht, J., and Carson, D. 2005. Heparan sulfate proteoglicans: Key players in cartilage biology. Crit. Rev. Eukaryot. Gene Expr. 15: 29-48.
8. Feldman, D., Chauhan, V., and Koong, A. 2005. The unfolded protein response: A novel component of the hypoxic stress response in tumors. Mol. Cancer Res. 3: 597-605.
9. Hinoi, E., Bialek, P., Chen, Y., Rached, M., Groner, Y., Behringer, R., Ornitz, D., and Karsenty, G. 2006. Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes & Dev. 20: 2937-2942.
10. Jackson, R., Nurcombe, V., and Cool, S. 2006. Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene 379: 79-91.
11. Jin, S. and White, E. 2008. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 4: 563-566.
12. Karsenty, G. 2003. The complexities of skeletal biology. Nature 423: 316-318.
13. Karsenty, G. and Wagner, E. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2: 389-406.
14. Klionsky, D. 2008. Autophagy revisited: A converation with Christian de Duve. Autophagy 4: 740-743.
15. Knudson, C. and Knudson, W. 2001. Cartilage proteoglycans. Semin. Cell Dev. Biol. 2001: 69-78.
16. Kronenberg, H. 2003. Developmental regulation of the growth plate. Nature 423: 332-336.
17. Lefebvre, V. and Smits, P. 2005. Transcriptional control of cell fate and differentiation. Birth Defects Res. C Embryo Today 75: 200-212.
18. Levine, B. and Klionsky, D. 2004. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell 6: 463-477.
19. Liu, Z., Xu, J., Colvin, J., and Ornitz, D. 2002. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes & Dev. 16: 859-869.
20. Olsen, B. 1996. Role of cartilage collagens in formation of the skeleton. Ann. N. Y. Acad. Sci. 8: 124-130.
21. Ornitz, D.M. and Marie, P.J. 2002. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes & Dev. 16: 1446-1465.
22. Papandreou, I., Lim, A., Laderoute, K., and Denko, N. 2008. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of Hif-1, BNIP3, and BNIP3L. Cell Death Differ. 15: 1572-1581.
23. Provot, S. and Schipani, E. 2005. Molecular mechanisms of endochondral bone development. Biochem. Biophys. Res. Commun. 328: 658-665.
24. Sardiello, M., Annunziata, I., Roma, G., and Ballabio, A. 2005. Sulfatases and sulfatases modifying factors: An exclusive and promiscuous relantionship. Hum. Mol. Genet. 14: 3203-3217.
25. Schipani, E., Ryan, H., Didrickson, S., Kobayashi, T., Knight, M., and Johnson, R. 2001. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes & Dev. 15: 2865-2876.
26. Settembre, C., Annunziata, I., Spampanato, C., Zarcone, D., Cobellis, G., Nusco, E., Zito, E., Tacchetti, C., Cosma, M., and Ballabio, A. 2007. Sytemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. Proc. Natl. Acad. Sci. 104: 4506-4511.
27. Settembre, C., Arteaga-Solis, E., McKee, M.D., de Pablo, R., Al Awqati, Q., Ballabio, A., and Karsenty, G. 2008a. Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. Genes & Dev. 22: 2645-2650.
28. Settembre, C., Fraldi, A., Jahreiss, L., Spampanato, C., Venturi, C., Medina, D., DePablo, R., Tacchetti, C., Rubinsztein, D., and Ballabio, A. 2008b. A block of autophagy in lyososomal storage disorders. Hum. Mol. Genet. 17: 119-129.
29. Shintani, T. and Klionsky, D. 2004. Autophagy in health and disease: A double-edged sword. Science 306: 990-995.
30. Srinivas, V. and Shapiro, I. 2006. Chondrocytes embedded in the epipheseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis. Autophagy 3: 215-216.
31. Tracy, K., Dibling, B., Spike, B., Knabb, J., Shumacker, P., and MacLeod, K. 2007. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol. Cell. Biol. 27: 6229-6242.
32. Vajo, Z., Francomano, C., and Wilkin, D. 2000. The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: The achondroplasia family of skeletal dysplasias, muenke craniosynostosis, and crouzon syndrome with acanthosis nigricans. Endocr. Rev. 21: 23-39.
33. Yorimitsu, T. and Klionsky, D. 2007. Eating the endoplasmic reticulum: Quality control by autophagy. Trends Cell Biol. 17: 279-285.
34. Yorimitsu, T., Nair, U., Yang, Z., and Klionsky, D. 2006. Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 281: 30299-30304.
35. Zelzer, E. and Olsen, B. 2003. The genetic basis for skeletal diseases. Nature 423: 343-348.
36. Zhang, H., Bosch-Marce, M., Shimoda, L., Tan, Y., Baek, J., Wesley, J., Gonzalez, F., and Semenza, G. 2008. Mitochondrial autophagy is an Hif-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283: 10892-10903.
37. Zito, E., Buono, M., Pepe, S., Settembre, C., Annunziata, I., Surace, E., Dierks, T., Monti, M., Cozzolino, M., Pucci, P., et al. 2007. Sulfatase modifying factor 1 trafficking through the cells: From endoplasmic reticulum to the endoplasmic reticulum. EMBO J. 26: 2443-2453.