Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation

Journal of Bone and Mineral Research

Volumn 30, Issue 12, 2015, Pages 2249-2261

  Vuppalapati, Karuna K ^a   Bouderlique, Thibault ^a   Newton, Phillip T ^a   Kaminskyy, Vitaliy O ^a   Wehtje, Henrik ^b   Ohlsson, Claes ^c   Zhivotovsky, Boris ^a   Chagin, Andrei S ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

APOPTOSIS; AUTOPHAGY; GROWTH PLATE; BONE; CHONDROCYTE

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BAFILOMYCIN A1; CASPASE; CASPASE 3; CASPASE 9; COLLAGEN TYPE 2; CRE RECOMBINASE; CYTOCHROME C; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; ATG5 PROTEIN, MOUSE; ATG5 PROTEIN, RAT; ATG7 PROTEIN, MOUSE; ATG7 PROTEIN, RAT; AUTOPHAGY RELATED PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; MACROLIDE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BONE GROWTH; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CHONDROGENESIS; CONTROLLED STUDY; EX VIVO STUDY; GENE DELETION; GENE TARGETING; GROWTH INHIBITION; GROWTH PLATE; GROWTH RETARDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; METATARSAL BONE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PROTEIN SECRETION; STUNTING; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; CELL LINE; CHONDROCYTE; CYTOLOGY; EPIPHYSIS PLATE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RAT;

ADENINE; ANIMALS; APOPTOSIS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEIN 7; CASPASES; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHONDROCYTES; COLLAGEN TYPE II; CYTOCHROMES C; GENE DELETION; GROWTH PLATE; HUMANS; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROLIDES; METATARSAL BONES; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PROTEINS; RATS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84954076828     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2575     Document Type: Article

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