Atg7 cooperates with Pten loss to drive prostate cancer tumor growth

Genes and Development

Volumn 30, Issue 4, 2016, Pages 399-407

  Santanam, Urmila ^a   Banach Petrosky, Whitney ^a   Abate Shen, Cory ^b   Shen, Michael M ^b   White, Eileen ^a,c   Dipaola, Robert S ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Autophagy; Castrate resistant; ER stress; Prostate cancer

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG; ATG7 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN 7; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENETICALLY ENGINEERED MOUSE STRAIN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN HOMEOSTASIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; CASTRATION RESISTANT PROSTATE CANCER; DEFICIENCY; DISEASE MODEL; GENE DELETION; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROSTATE TUMOR; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 7; CARCINOGENESIS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PROSTATIC NEOPLASMS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 84958980037     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.274134.115     Document Type: Article

References (27)

1. Alva A, Hussain M. 2013. The changing natural history of metastatic prostate cancer. Cancer J 19: 19-24.
2. Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, et al. 2012. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One 7: e41831.
3. Farrow JM, Yang JC, Evans CP. 2014. Autophagy as a modulator and target in prostate cancer. Nat Rev Urol 11: 508-516.
4. Floc'h N, KinkadeCW, Kobayashi T, Aytes A, Lefebvre C, Mitrofanova A, Cardiff RD, Califano A, Shen MM, Abate-Shen C. 2012. Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res 72: 4483-4493.
5. Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, et al. 2013a. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 27: 1447-1461.
6. Guo JY, Xia B, White E. 2013b. Autophagy-mediated tumor promotion. Cell 155: 1216-1219.
7. Heinlein CA, Chang C. 2004. Androgen receptor in prostate cancer. Endocr Rev 25: 276-308.
8. Hussain M, DiPaola RS. 2015. Clinical research in metastatic prostate cancer: a focus on impact and value. Am Soc Clin Oncol Educ Book 35: 17-21.
9. Irshad S, Bansal M, Castillo-Martin M, ZhengT, Aytes A, Wenske S, Le Magnen C, Guarnieri P, Sumazin P, Benson MC, et al. 2013. A molecular signature predictive of indolent prostate cancer. Sci Transl Med 5: 202ra122.
10. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, et al. 2014. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov 4: 914-927.
11. Komatsu M,Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, et al. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425-434.
12. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, et al. 2009. Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.
13. Moscat J, Diaz-Meco MT. 2009. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137: 1001-1004.
14. Nguyen HG, Yang JC, Kung HJ, Shi XB, Tilki D, Lara PN Jr, DeVere White RW, Gao AC, Evans CP. 2014. Targeting autophagy overcomes Enzalutamide resistance in castrationresistant prostate cancer cells and improves therapeutic response in a xenograft model. Oncogene 33: 4521-4530.
15. Pandini G, Mineo R, Frasca F, Roberts CT Jr, Marcelli M, Vigneri R, Belfiore A. 2005. Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells. Cancer Res 65: 1849-1857.
16. Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, DiPaola RS. 2012. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate 72: 1374-1381.
17. Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. 2013. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol 27: 280-295.
18. Siegel RL, Miller KD, Jemal A. 2015. Cancer statistics, 2015. CA Cancer J Clin 65: 5-29.
19. Strohecker AM, White E. 2014a. Autophagy promotes BrafV600Edriven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy 10: 384-385.
20. Strohecker AM, White E. 2014b. Targeting mitochondrial metabolism by inhibiting autophagy in Braf-driven cancers. Cancer Discov 4: 766-772.
21. Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, Wong YN, Hahn N, Kohli M, Cooney MM, et al. 2015. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med 373: 737-746.
22. Tsai YC, Weissman AM. 2010. The unfolded protein response, degradation from endoplasmic reticulum and cancer. Genes Cancer 1: 764-778.
23. Wang X, Kruithof-de Julio M, Economides KD, Walker D, Yu H, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM. 2009. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461: 495-500.
24. White E. 2012. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 12: 401-410.
25. White E. 2015. The role for autophagy in cancer. J Clin Invest 125: 42-46.
26. White E, Karp C, Strohecker AM, Guo Y, MathewR. 2010. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol 22: 212-217.
27. Xie X, Koh JY, Price S, White E, Mehnert JM. 2015. Atg7 overcomes senescence and promotes growth of BrafV600E-driven melanoma. Cancer Discov 5: 410-423.