Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

Osteoarthritis and Cartilage

Volumn 23, Issue 12, 2015, Pages 2279-2287

  Shen, C ^a   Cai, G Q ^a   Peng, J P ^a   Chen, X D ^a  

^a Xin Hua Hospital   (China)

Author keywords

Autophagy; Chondrocytes; Dexamethasone; Forkhead box class O3

Indexed keywords

AGGRECANASE 1; AGGRECANASE 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGENASE 3; DEXAMETHASONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN UKL1; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; URIDINE KINASE; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; AGGRECANASE-1; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; GLUCOCORTICOID; MMP1 PROTEIN, HUMAN; MMP13 PROTEIN, HUMAN; PROCOLLAGEN N PROTEINASE;

ADULT; APOPTOSIS; ARTICLE; AUTOPHAGY; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CELL CULTURE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; YOUNG ADULT; ADOLESCENT; ARTICULAR CARTILAGE; CASE CONTROL STUDY; CYTOLOGY; DRUG EFFECTS; FEMORACETABULAR IMPINGEMENT; GENETICS; HIP; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

ADAM PROTEINS; ADOLESCENT; ADULT; APOPTOSIS; AUTOPHAGY; CARTILAGE, ARTICULAR; CASE-CONTROL STUDIES; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; DEXAMETHASONE; DOWN-REGULATION; FEMALE; FEMORACETABULAR IMPINGEMENT; FORKHEAD TRANSCRIPTION FACTORS; GLUCOCORTICOIDS; HIP JOINT; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; PROCOLLAGEN N-ENDOPEPTIDASE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION; YOUNG ADULT;

EID: 84960267284     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.06.020     Document Type: Article

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