-
1
-
-
0037124885
-
Asymmetric catalysis: science and opportunities (Nobel lecture)
-
Noyori, R. (2002) Asymmetric catalysis: science and opportunities (Nobel lecture). Angew. Chem., Int. Ed., 41, 2008-2022.
-
(2002)
Angew. Chem., Int. Ed.
, vol.41
, pp. 2008-2022
-
-
Noyori, R.1
-
2
-
-
79952171232
-
-
Direct Book Publishing, Harvard University, Cambridge
-
Corey, E.J., and Kürti, L. (2007) Enantioselective Chemical Synthesis, Direct Book Publishing, Harvard University, Cambridge.
-
(2007)
Enantioselective Chemical Synthesis
-
-
Corey, E.J.1
Kürti, L.2
-
4
-
-
0034697497
-
-
Wiley-VCH Verlag GmbH,Weinheim, Germany
-
Blaser, H.-U., and Schmidt, E. (2004) Asymmetric Catalysis on Industrial Scales, Wiley-VCH Verlag GmbH,Weinheim, Germany.
-
(2004)
Asymmetric Catalysis on Industrial Scales
-
-
Blaser, H.-U.1
Schmidt, E.2
-
5
-
-
79959865225
-
Asymmetric hydrogenation of alkenes lacking coordinating groups
-
Woodmansee, D.H., and Pfaltz, A. (2011) Asymmetric hydrogenation of alkenes lacking coordinating groups. Chem. Commun., 47, 7912-7916.
-
(2011)
Chem. Commun.
, vol.47
, pp. 7912-7916
-
-
Woodmansee, D.H.1
Pfaltz, A.2
-
6
-
-
10944220196
-
A metal-free transfer hydrogenation: organocatalytic conjugate reduction of a,b-unsaturated aldehydes
-
Yang, J.W., Hechavarria Fonseca, M.T., and List, B. (2004) A metal-free transfer hydrogenation: organocatalytic conjugate reduction of a,b-unsaturated aldehydes. Angew. Chem., Int. Ed., 43, 6660-6662.
-
(2004)
Angew. Chem., Int. Ed.
, vol.43
, pp. 6660-6662
-
-
Yang, J.W.1
Hechavarria Fonseca, M.T.2
List, B.3
-
7
-
-
11844277087
-
Enantioselective organocatalytic hydride reduction
-
Ouellet, S.G., Tuttle, J.B., and MacMillan, D.W.C. (2005) Enantioselective organocatalytic hydride reduction. J. Am. Chem. Soc., 127, 32-33.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 32-33
-
-
Ouellet, S.G.1
Tuttle, J.B.2
MacMillan, D.W.C.3
-
8
-
-
27544489337
-
Catalytic asymmetric reductive Michael cyclization
-
Yang, J.W., Hechavarria Fonseca, M.T., and List, B. (2005) Catalytic asymmetric reductive Michael cyclization. J. Am. Chem. Soc., 127, 15036-15037.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 15036-15037
-
-
Yang, J.W.1
Hechavarria Fonseca, M.T.2
List, B.3
-
9
-
-
33749516633
-
Organocatalytic transfer hydrogenation of cyclic enones
-
Tuttle, J.B., Ouellet, S.G., and MacMillan, D.W.C. (2006) Organocatalytic transfer hydrogenation of cyclic enones. J. Am. Chem. Soc., 128, 12662-12663.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 12662-12663
-
-
Tuttle, J.B.1
Ouellet, S.G.2
MacMillan, D.W.C.3
-
10
-
-
70349777766
-
Cyclespecific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis
-
Simmons, B., Walji, A.M., and MacMillan, D.W.C. (2009) Cyclespecific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis. Angew. Chem., Int. Ed., 48, 4349-4353.
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 4349-4353
-
-
Simmons, B.1
Walji, A.M.2
MacMillan, D.W.C.3
-
11
-
-
54249149436
-
Organocatalytic asymmetric transferhydrogenation of b-nitroacrylates: accessing b-amino acids
-
Martin, N.J.A., Cheng, X., and List, B. (2008) Organocatalytic asymmetric transferhydrogenation of b-nitroacrylates: accessing b-amino acids. J. Am. Chem. Soc., 130, 13862-13863.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 13862-13863
-
-
Martin, N.J.A.1
Cheng, X.2
List, B.3
-
12
-
-
34447306019
-
Recent developments in asymmetric transfer hydrogenation with Hantzsch esters: a biomimetic approach
-
You, S.-L. (2007) Recent developments in asymmetric transfer hydrogenation with Hantzsch esters: a biomimetic approach. Chem. Asian J., 2, 820-827.
-
(2007)
Chem. Asian J.
, vol.2
, pp. 820-827
-
-
You, S.-L.1
-
13
-
-
79955587229
-
Advances in catalytic metal-free reductions: from bio-inspired concepts to application in the organocatalytic synthesis of pharmaceuticals and natural products
-
Rueping, M., Dufour, J., and Schoepke, F.R. (2011) Advances in catalytic metal-free reductions: from bio-inspired concepts to application in the organocatalytic synthesis of pharmaceuticals and natural products. Green Chem., 13, 1084-1105.
-
(2011)
Green Chem.
, vol.13
, pp. 1084-1105
-
-
Rueping, M.1
Dufour, J.2
Schoepke, F.R.3
-
14
-
-
82255192231
-
Chiral dihydrobenzo [1,4]oxazines as catalysts for the asymmetric transfer-hydrogenation of a,b-unsaturated aldehydes
-
Ebner, C. and Pfaltz, A. (2011) Chiral dihydrobenzo [1,4]oxazines as catalysts for the asymmetric transfer-hydrogenation of a,b-unsaturated aldehydes. Tetrahedron, 67, 10287-10290.
-
(2011)
Tetrahedron
, vol.67
, pp. 10287-10290
-
-
Ebner, C.1
Pfaltz, A.2
-
15
-
-
84874075148
-
-
3rd edn, Wiley-VCH Verlag GmbH,Weinheim
-
Drauz, K., Gröger, H., and May, O. (2012) Enzyme Catalysis in Organic Chemistry, vol. I-III, 3rd edn, Wiley-VCH Verlag GmbH,Weinheim.
-
(2012)
Enzyme Catalysis in Organic Chemistry
, vol.1-3
-
-
Drauz, K.1
Gröger, H.2
May, O.3
-
16
-
-
84889331179
-
-
2nd edn, Wiley-VCH Verlag GmbH,Weinheim
-
Liese, A., Seelbach, K., and Wandrey, C. (2006) Industrial Biotransformations, 2nd edn, Wiley-VCH Verlag GmbH,Weinheim.
-
(2006)
Industrial Biotransformations
-
-
Liese, A.1
Seelbach, K.2
Wandrey, C.3
-
17
-
-
84889311151
-
-
Wiley-VCH Verlag GmbH,Weinheim
-
Tao, J., Lin, G.-Q., and Liese, A. (2009) Biocatalysis for the Pharmaceutical Industry, Wiley-VCH Verlag GmbH,Weinheim.
-
(2009)
Biocatalysis for the Pharmaceutical Industry
-
-
Tao, J.1
Lin, G.-Q.2
Liese, A.3
-
18
-
-
84891006345
-
-
Wiley-VCH Verlag GmbH,Weinheim
-
Gotor, V., Alfonso, I., and García-Urdiales, E. (2008) Asymmetric Organic Synthesis with Enzymes, Wiley-VCH Verlag GmbH,Weinheim.
-
(2008)
Asymmetric Organic Synthesis with Enzymes
-
-
Gotor, V.1
Alfonso, I.2
García-Urdiales, E.3
-
19
-
-
84871651706
-
Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds
-
Winkler, C.K., Tasnádi, G., Clay, D., Hall, M., and Faber, K. (2012) Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds. J. Biotechnol., 162, 381-389.
-
(2012)
J. Biotechnol.
, vol.162
, pp. 381-389
-
-
Winkler, C.K.1
Tasnádi, G.2
Clay, D.3
Hall, M.4
Faber, K.5
-
20
-
-
84887122693
-
Reduction of C=C double bonds
-
eds K. Drauz, H. Gröger, and O. May, Wiley-VCH Verlag GmbH, Weinheim
-
Bougioukou, D.J. and Stewart, J.D. (2012) Reduction of C=C double bonds, in Enzyme Catalysis in Organic Synthesis (eds K. Drauz, H. Gröger, and O. May), Wiley-VCH Verlag GmbH, Weinheim, pp. 1111-1203.
-
(2012)
In Enzyme Catalysis in Organic Synthesis
, pp. 1111-1203
-
-
Bougioukou, D.J.1
Stewart, J.D.2
-
21
-
-
79960612358
-
Enantioenriched compounds via enzyme-catalyzed redox reactions
-
Hall, M. and Bommarius, A.S. (2011) Enantioenriched compounds via enzyme-catalyzed redox reactions. Chem. Rev., 111, 4088-4110.
-
(2011)
Chem. Rev.
, vol.111
, pp. 4088-4110
-
-
Hall, M.1
Bommarius, A.S.2
-
22
-
-
34047189417
-
Asymmetric bioreduction of activated C=C bonds using enoate reductases from the old yellow enzyme family
-
Stuermer, R., Hauer, B., Hall, M., and Faber, K. (2007) Asymmetric bioreduction of activated C=C bonds using enoate reductases from the old yellow enzyme family. Curr. Opin. Chem. Biol., 11, 203-213.
-
(2007)
Curr. Opin. Chem. Biol.
, vol.11
, pp. 203-213
-
-
Stuermer, R.1
Hauer, B.2
Hall, M.3
Faber, K.4
-
24
-
-
0000939067
-
Uber das gelbe Ferment und seine Wirkungen
-
Warburg, O. and Christian,W. (1933) Uber das gelbe Ferment und seine Wirkungen. Biochem. Z., 266, 377-411.
-
(1933)
Biochem. Z.
, vol.266
, pp. 377-411
-
-
Warburg, O.1
Christian, W.2
-
25
-
-
78149436277
-
Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
-
Toogood, H.S., Gardiner, J.M., and Scrutton, N.S. (2010) Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases. ChemCatChem, 2, 892-914.
-
(2010)
ChemCatChem
, vol.2
, pp. 892-914
-
-
Toogood, H.S.1
Gardiner, J.M.2
Scrutton, N.S.3
-
26
-
-
0035987236
-
New uses for an old enzyme - the old yellow enzyme family of flavoenzymes
-
Williams, R.E. and Bruce, N. C. (2002) New uses for an old enzyme - the old yellow enzyme family of flavoenzymes. Microbiology, 148, 1607-1614.
-
(2002)
Microbiology
, vol.148
, pp. 1607-1614
-
-
Williams, R.E.1
Bruce, N.C.2
-
27
-
-
0029557273
-
Structure-function relations for old yellow enzyme
-
Karplus, P.A., Fox, K.M., and Massey, V. (1995) Structure-function relations for old yellow enzyme. FASEB J., 9, 1518-1526.
-
(1995)
FASEB J.
, vol.9
, pp. 1518-1526
-
-
Karplus, P.A.1
Fox, K.M.2
Massey, V.3
-
28
-
-
0141694128
-
Enoate reductase family
-
eds S.K. Chapman, R. Perham, and N.S. Scrutton, RudolfWeber, Berlin
-
Steinbacher, S., Stumpf, M.,Weinkauf, S., Rohdich, F., Bacher, A., and Simon, H. (2002) Enoate reductase family, in Flavins and Flavoproteins (eds S.K. Chapman, R. Perham, and N.S. Scrutton), RudolfWeber, Berlin, pp. 941-949.
-
(2002)
In Flavins and Flavoproteins
, pp. 941-949
-
-
Steinbacher, S.1
Stumpf M.Weinkauf, S.2
Rohdich, F.3
Bacher, A.4
Simon, H.5
-
29
-
-
0032483986
-
The oxidative half-reaction of old yellow enzyme
-
Kohli, R. and Massey, V. (1998) The oxidative half-reaction of old yellow enzyme. J. Biol. Chem., 273, 32763-32770.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32763-32770
-
-
Kohli, R.1
Massey, V.2
-
30
-
-
22844450431
-
Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphine reductase
-
Messiha, H.L., Bruce, N.C., Sattelle, B.M., Sutcliffe, M.J., Munro, A.W., and Scrutton, N.S. (2005) Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphine reductase. J. Biol. Chem., 280, 27103-27110.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 27103-27110
-
-
Messiha, H.L.1
Bruce, N.C.2
Sattelle, B.M.3
Sutcliffe, M.J.4
Munro, A.W.5
Scrutton, N.S.6
-
31
-
-
25444502896
-
Proton transfer in the oxidative halfreaction of pentaerythritol tetranitrate reductase
-
Khan, H., Barna, T., Bruce, N.C., Munro, A.W., Leys, D., and Scrutton, N.S. (2005) Proton transfer in the oxidative halfreaction of pentaerythritol tetranitrate reductase. FEBS J., 272, 4660-4671.
-
(2005)
FEBS J.
, vol.272
, pp. 4660-4671
-
-
Khan, H.1
Barna, T.2
Bruce, N.C.3
Munro, A.W.4
Leys, D.5
Scrutton, N.S.6
-
32
-
-
77955581308
-
Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions
-
Pudney, C.R., Johannissen, L.O., Sutcliffe, M.J., Hay, S., and Scrutton, N.S. (2010) Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions. J. Am. Chem. Soc., 132, 11329- 11335.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 11329- 11335
-
-
Pudney, C.R.1
Johannissen, L.O.2
Sutcliffe, M.J.3
Hay, S.4
Scrutton, N.S.5
-
33
-
-
84857515422
-
Good vibrations in enzyme-catalysed reactions
-
Hay, S. and Scrutton, N.S. (2012) Good vibrations in enzyme-catalysed reactions. Nature Chem., 4, 161-168.
-
(2012)
Nature Chem.
, vol.4
, pp. 161-168
-
-
Hay, S.1
Scrutton, N.S.2
-
34
-
-
79956148088
-
Asymmetric bioreduction of alkenes using ene-reductase YersER and KYE1 and effects of organic solvents
-
Yanto, Y., Winkler, C.K., Lohr, S., Hall, M., Faber, K., and Bommarius, A.S. (2011) Asymmetric bioreduction of alkenes using ene-reductase YersER and KYE1 and effects of organic solvents. Org. Lett., 13, 2540-2543.
-
(2011)
Org. Lett.
, vol.13
, pp. 2540-2543
-
-
Yanto, Y.1
Winkler, C.K.2
Lohr, S.3
Hall, M.4
Faber, K.5
Bommarius, A.S.6
-
35
-
-
38349186682
-
Stereocomplementary bioreduction of a,b-unsaturated dicarboxylic acids and dimethyl esters using enoate reductases: enzyme- and substrate-based stereocontrol
-
Stueckler, C., Hall, M., Ehammer, H., Pointner, E., Kroutil, W., Macheroux, P., and Faber, K. (2007) Stereocomplementary bioreduction of a,b-unsaturated dicarboxylic acids and dimethyl esters using enoate reductases: enzyme- and substrate-based stereocontrol. Org. Lett., 9, 5409-5411.
-
(2007)
Org. Lett.
, vol.9
, pp. 5409-5411
-
-
Stueckler, C.1
Hall, M.2
Ehammer, H.3
Pointner, E.4
Kroutil, W.5
Macheroux, P.6
Faber, K.7
-
36
-
-
84869069237
-
Steric effects on the stereochemistry of old yellow enzymemediated reductions of unsaturated diesters: flipping of the substrate within the enzyme active site induced by structural modifications
-
Brenna, E., Gatti, F.G., Manfredi, A., Monti, D., and Parmeggiani, F. (2012) Steric effects on the stereochemistry of old yellow enzymemediated reductions of unsaturated diesters: flipping of the substrate within the enzyme active site induced by structural modifications. Adv. Synth. Catal., 354, 2859-2864.
-
(2012)
Adv. Synth. Catal.
, vol.354
, pp. 2859-2864
-
-
Brenna, E.1
Gatti, F.G.2
Manfredi, A.3
Monti, D.4
Parmeggiani, F.5
-
38
-
-
79960595425
-
Application of designed enzymes in organic synthesis
-
Strohmeier, G.A., Pichler, H., May, O., and Gruber-Khadjawi, M. (2011) Application of designed enzymes in organic synthesis. Chem. Rev., 111, 4141-4164.
-
(2011)
Chem. Rev.
, vol.111
, pp. 4141-4164
-
-
Strohmeier, G.A.1
Pichler, H.2
May, O.3
Gruber-Khadjawi, M.4
-
39
-
-
84874640883
-
Rational design of enzymes
-
eds K. Drauz, H. Gröger, and O. May, Wiley-VCH Verlag GmbH,Weinheim
-
Pleiss, J. (2012) Rational design of enzymes, in Enzyme Catalysis in Organic Synthesis, vol. 3 (eds K. Drauz, H. Gröger, and O. May), Wiley-VCH Verlag GmbH,Weinheim, pp. 89-117.
-
(2012)
In Enzyme Catalysis in Organic Synthesis
, vol.3
, pp. 89-117
-
-
Pleiss, J.1
-
40
-
-
71849104042
-
Enzyme engineering for enantioselectivity: from trial-and-error to rational design?
-
Otten, L.G., Hollmann, F., and Arends, I.W.C.E. (2010) Enzyme engineering for enantioselectivity: from trial-and-error to rational design? Trends Biotechnol., 28, 46-54.
-
(2010)
Trends Biotechnol.
, vol.28
, pp. 46-54
-
-
Otten, L.G.1
Hollmann, F.2
Arends, I.W.C.E.3
-
41
-
-
80052441681
-
Engineering of biocatalysts: from evolution to creation
-
Quin, M.B. and Schmidt-Dannert, C. (2011) Engineering of biocatalysts: from evolution to creation. ACS Catal., 1, 1017-1021.
-
(2011)
ACS Catal.
, vol.1
, pp. 1017-1021
-
-
Quin, M.B.1
Schmidt-Dannert, C.2
-
42
-
-
70450242805
-
Exploring protein fitness landscapes by directed evolution
-
Romero, P.A. and Arnold, F.H. (2009) Exploring protein fitness landscapes by directed evolution. Nat. Rev. Mol. Cell Biol., 10, 866-876.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 866-876
-
-
Romero, P.A.1
Arnold, F.H.2
-
43
-
-
68049106179
-
Directed evolution drives the next generation of biocatalysts
-
Turner, N.J. (2009) Directed evolution drives the next generation of biocatalysts. Nat. Chem. Biol., 5, 567-573.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 567-573
-
-
Turner, N.J.1
-
44
-
-
48249098990
-
Protein design by directed evolution
-
Jäckel, C., Kast, P., and Hilvert, D. (2008) Protein design by directed evolution. Annu. Rev. Biophys. Biomol. Struct., 37, 153-173.
-
(2008)
Annu. Rev. Biophys. Biomol. Struct.
, vol.37
, pp. 153-173
-
-
Jäckel, C.1
Kast, P.2
Hilvert, D.3
-
45
-
-
43049123356
-
Advances in laboratory evolution of enzymes
-
Bershtein, S. and Tawfik, D.S. (2008) Advances in laboratory evolution of enzymes. Curr. Opin. Chem. Biol., 12, 151-158.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 151-158
-
-
Bershtein, S.1
Tawfik, D.S.2
-
46
-
-
84862807289
-
Biocatalyst development by directed evolution
-
Wang, M., Si, T., and Zhao, H. (2012) Biocatalyst development by directed evolution. Biresour. Technol., 115, 117-125.
-
(2012)
Biresour. Technol.
, vol.115
, pp. 117-125
-
-
Wang, M.1
Si, T.2
Zhao, H.3
-
47
-
-
84872199976
-
Directed evolution of enzymes
-
eds K. Drauz, H. Gröger, and O. May, Wiley-VCH Verlag GmbH, Weinheim, 3rd edn
-
Reetz, M.T. (2012) Directed evolution of enzymes, in Enzyme Catalysis in Organic Synthesis, vol. I, 3rd edn (eds K. Drauz, H. Gröger, and O. May), Wiley-VCH Verlag GmbH, Weinheim, pp. 119-190.
-
(2012)
In Enzyme Catalysis in Organic Synthesis
, vol.1
, pp. 119-190
-
-
Reetz, M.T.1
-
48
-
-
0027951524
-
Synthetic DNA and biology (Nobel lecture)
-
Smith, M. (1994) Synthetic DNA and biology (Nobel lecture). Angew. Chem., Int. Ed., 33, 1214-1221.
-
(1994)
Angew. Chem., Int. Ed.
, vol.33
, pp. 1214-1221
-
-
Smith, M.1
-
49
-
-
0041989850
-
Challenges in enzyme mechanism and energetics
-
Kraut, D.A., Carroll, K.S., and Herschlag, D. (2003) Challenges in enzyme mechanism and energetics. Annu. Rev. Biochem., 72, 517-571.
-
(2003)
Annu. Rev. Biochem.
, vol.72
, pp. 517-571
-
-
Kraut, D.A.1
Carroll, K.S.2
Herschlag, D.3
-
50
-
-
0025485877
-
Site directed mutagenesis: a tool for enzyme mechanism dissection
-
Wagner, C. R. and Benkovic, S.J. (1990) Site directed mutagenesis: a tool for enzyme mechanism dissection. Trends Biotechnol., 8, 263-270.
-
(1990)
Trends Biotechnol.
, vol.8
, pp. 263-270
-
-
Wagner, C.R.1
Benkovic, S.J.2
-
51
-
-
0027997157
-
Protein engineering to study enzyme catalytic mechanisms
-
Gerlt, J.A. (1994) Protein engineering to study enzyme catalytic mechanisms. Curr. Opin. Struct. Biol., 4, 593-600.
-
(1994)
Curr. Opin. Struct. Biol.
, vol.4
, pp. 593-600
-
-
Gerlt, J.A.1
-
52
-
-
1842263800
-
Protein engineering for studying enzyme catalytic mechanism
-
Atkins,W.M. and Sligar, S.G. (1991) Protein engineering for studying enzyme catalytic mechanism. Curr. Opin. Struct. Biol., 1, 611-616.
-
(1991)
Curr. Opin. Struct. Biol.
, vol.1
, pp. 611-616
-
-
Atkins, W.M.1
Sligar, S.G.2
-
53
-
-
0032491867
-
Creation of enantioselective biocatalysts for organic chemistry by in vitro evolution
-
Reetz, M.T., Zonta, A., Schimossek, K., Liebeton, K., and Jaeger, K.-E. (1997) Creation of enantioselective biocatalysts for organic chemistry by in vitro evolution. Angew. Chem., Int. Ed. Engl., 36, 2830- 2832.
-
(1997)
Angew. Chem., Int. Ed. Engl.
, vol.36
, pp. 2830- 2832
-
-
Reetz, M.T.1
Zonta, A.2
Schimossek, K.3
Liebeton, K.4
Jaeger, K.-E.5
-
54
-
-
78149432825
-
Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions
-
Reetz, M.T. (2011) Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions. Angew. Chem., Int. Ed., 50, 138-174.
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 138-174
-
-
Reetz, M.T.1
-
55
-
-
1642414512
-
Directed evolution library creation, methods and protocols
-
Humana Press, Totowa, NJ
-
Arnold, F.H. and Georgiou, G. (2003) Directed evolution library creation, methods and protocols, in Methods in Molecular Biology, vol. 231, Humana Press, Totowa, NJ.
-
(2003)
Methods in Molecular Biology
, vol.231
-
-
Arnold, F.H.1
Georgiou, G.2
-
56
-
-
84861228538
-
Site saturation mutagenesis: methods and applications in protein engineering
-
Siloto, R.M.P. and Weselake, R.J. (2012) Site saturation mutagenesis: methods and applications in protein engineering. Biocatal. Agric. Biotechnol., 1, 181-189.
-
(2012)
Biocatal. Agric. Biotechnol.
, vol.1
, pp. 181-189
-
-
Siloto, R.M.P.1
Weselake, R.J.2
-
57
-
-
84874034041
-
Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis
-
Kille, S., Acevedo Rocha, C.G., Parra, L. P., Zhang, Z.-G., Opperman, D.J., and Reetz, M.T. (2012) Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis. ACS Synth. Biol.10.1021/sb300037w.
-
(2012)
ACS Synth. Biol.
-
-
Kille, S.1
Acevedo Rocha, C.G.2
Parra, L.P.3
Zhang, Z.-G.4
Opperman, D.J.5
Reetz, M.T.6
-
58
-
-
84863280525
-
Construction of "smallintelligent" focused mutagenesis libraries using well-designed combinatorial degenerate primers
-
Tang, L., Gao, H., Zhu, X., Wang, X., Zhou, M., and Jiang, R. (2012) Construction of "smallintelligent" focused mutagenesis libraries using well-designed combinatorial degenerate primers. BioTechniques, 52 , 149-158.
-
(2012)
BioTechniques
, vol.52
, pp. 149-158
-
-
Tang, L.1
Gao, H.2
Zhu, X.3
Wang, X.4
Zhou, M.5
Jiang, R.6
-
59
-
-
54349090614
-
Addressing the numbers problem in directed evolution
-
Reetz, M.T., Kahakeaw, D., and Lohmer, R. (2008) Addressing the numbers problem in directed evolution. ChemBioChem, 9, 1797-1804.
-
(2008)
ChemBioChem
, vol.9
, pp. 1797-1804
-
-
Reetz, M.T.1
Kahakeaw, D.2
Lohmer, R.3
-
60
-
-
55849148481
-
Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions
-
Reetz, M.T. and Wu, S. (2008) Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions. Chem. Commun., 5499-5501.
-
(2008)
Chem. Commun
, pp. 5499-5501
-
-
Reetz, M.T.1
Wu, S.2
-
61
-
-
85017393429
-
Iterative saturation mutagenesis in protein engineering
-
accepted
-
Acevedo-Rocha, C., Kille, S., and Reetz, M. T. (2013) Iterative saturation mutagenesis in protein engineering. Methods Mol. Biol., accepted.
-
(2013)
Methods Mol. Biol
-
-
Acevedo-Rocha, C.1
Kille, S.2
Reetz, M.T.3
-
62
-
-
34248567845
-
Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes
-
Reetz, M.T. and Carballeira, J.D. (2007) Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes. Nat. Protoc., 2, 891-903.
-
(2007)
Nat. Protoc.
, vol.2
, pp. 891-903
-
-
Reetz, M.T.1
Carballeira, J.D.2
-
63
-
-
22144485602
-
Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test
-
Reetz, M.T., Bocola, M., Carballeira, J.D., Zha, D., and Vogel, A. (2005) Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test. Angew. Chem., Int. Ed., 44, 4192-4196.
-
(2005)
Angew. Chem., Int. Ed.
, vol.44
, pp. 4192-4196
-
-
Reetz, M.T.1
Bocola, M.2
Carballeira, J.D.3
Zha, D.4
Vogel, A.5
-
64
-
-
0035477024
-
Directed evolution of an enantioselective enzyme through combinatorial multiple-cassette mutagenesis
-
Reetz, M.T., Wilensek, S., Zha, D., and Jaeger, K.-E. (2001) Directed evolution of an enantioselective enzyme through combinatorial multiple-cassette mutagenesis. Angew. Chem., Int. Ed., 40, 3589-3591.
-
(2001)
Angew. Chem., Int. Ed.
, vol.40
, pp. 3589-3591
-
-
Reetz, M.T.1
Wilensek, S.2
Zha, D.3
Jaeger, K.-E.4
-
65
-
-
85017387785
-
-
accessed July 14 2013
-
Author' s homepage (2011) http://www .kofo.mpg.de/de/forschung/organischesynthese (accessed July 14, 2013).
-
(2011)
Author' s homepage
-
-
-
66
-
-
33744475011
-
Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space
-
Erratum 2494
-
Reetz, M.T.,Wang, L.-W., and Bocola, M. (2006) Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space. Angew. Chem., Int. Ed., 45, 1236-1241, Erratum 2494.
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 1236-1241
-
-
Reetz M.T.Wang, L.-W.1
Bocola, M.2
-
67
-
-
84860234014
-
Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima
-
Gumulya, Y., Sanchis, J., and Reetz, M.T. (2012) Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima. ChemBioChem, 13, 1060-1066.
-
(2012)
ChemBioChem
, vol.13
, pp. 1060-1066
-
-
Gumulya, Y.1
Sanchis, J.2
Reetz, M.T.3
-
68
-
-
0032484145
-
On the active site of old yellow enzyme
-
Brown, B.J., Deng, Z., Karplus, P., and Massey, V. (1998) On the active site of old yellow enzyme. J. Biol. Chem., 273, 32753-32762.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32753-32762
-
-
Brown, B.J.1
Deng, Z.2
Karplus, P.3
Massey, V.4
-
69
-
-
79952647597
-
A site-saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity
-
Toogood, H.S., Fryszkowska, A., Hulley, M., Sakuma, M., Mansell, D., Stephens, G. M., Gardiner, J.M., and Scrutton, N.S. (2011) A site-saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity. ChemBioChem, 12, 738-749.
-
(2011)
ChemBioChem
, vol.12
, pp. 738-749
-
-
Toogood, H.S.1
Fryszkowska, A.2
Hulley, M.3
Sakuma, M.4
Mansell, D.5
Stephens, G.M.6
Gardiner, J.M.7
Scrutton, N.S.8
-
70
-
-
0033616677
-
The role of threonine 37 in flavin reactivity of the old yellow enzyme
-
Xu, D., Kohli, R.M., and Massey, V. (1999) The role of threonine 37 in flavin reactivity of the old yellow enzyme. Proc. Nat. Acad. Sci. USA, 96, 3556-3561.
-
(1999)
Proc. Nat. Acad. Sci. USA
, vol.96
, pp. 3556-3561
-
-
Xu, D.1
Kohli, R.M.2
Massey, V.3
-
71
-
-
77950866209
-
Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study
-
Spiegelhauer, O., Mende, S., Dickert, F., Knauer, S.H., Ullmann, G.M., and Dobbek, H. (2010) Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study. J. Mol. Biol., 398, 66-82.
-
(2010)
J. Mol. Biol.
, vol.398
, pp. 66-82
-
-
Spiegelhauer, O.1
Mende, S.2
Dickert, F.3
Knauer, S.H.4
Ullmann, G.M.5
Dobbek, H.6
-
72
-
-
72149112288
-
Site-saturation mutagenesis of tryptophan 116 of Saccharomyces pastorianus old yellow enzyme uncovers stereocomplementary variants
-
Kumar Padhi, S., Bougioukou, D.J., and Stewart, J.D. (2009) Site-saturation mutagenesis of tryptophan 116 of Saccharomyces pastorianus old yellow enzyme uncovers stereocomplementary variants. J. Am. Chem. Soc., 131, 3271-3280.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 3271-3280
-
-
Kumar Padhi, S.1
Bougioukou, D.J.2
Stewart, J.D.3
-
73
-
-
80052429065
-
Biocatalytic reductions of Baylis-Hillman adducts
-
Walton, A.Z., Conerly, W.C., Pompeu, Y., Sullivan, B., and Stewart, J.D. (2011) Biocatalytic reductions of Baylis-Hillman adducts. ACS Catal., 1, 989-993.
-
(2011)
ACS Catal.
, vol.1
, pp. 989-993
-
-
Walton, A.Z.1
Conerly, W.C.2
Pompeu, Y.3
Sullivan, B.4
Stewart, J.D.5
-
74
-
-
73349113954
-
Directed evolution of an enantioselective enoate-reductase: testing the utility of iterative saturation mutagenesis
-
Bougioukou, D.J., Kille, S., Taglieber, A., and Reetz, M.T. (2009) Directed evolution of an enantioselective enoate-reductase: testing the utility of iterative saturation mutagenesis. Adv. Synth. Catal., 351, 3287-3305.
-
(2009)
Adv. Synth. Catal.
, vol.351
, pp. 3287-3305
-
-
Bougioukou, D.J.1
Kille, S.2
Taglieber, A.3
Reetz, M.T.4
-
75
-
-
78449253077
-
Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of sitesaturated libraries
-
Hulley, M.E., Toogood, H.S., Fryszkowska, A., Mansell, D., Stephens, G.M., Gardiner, J.M., and Scrutton, N.S. (2010) Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of sitesaturated libraries. ChemBioChem, 11, 2433-2447.
-
(2010)
ChemBioChem
, vol.11
, pp. 2433-2447
-
-
Hulley, M.E.1
Toogood, H.S.2
Fryszkowska, A.3
Mansell, D.4
Stephens, G.M.5
Gardiner, J.M.6
Scrutton, N.S.7
-
76
-
-
80053287591
-
Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with a,b-unsaturated nitroolefins
-
Fryszkowska, A., Toogood, H.S., Sakuma, M., Stephens, G.M., Gardiner, J.M., and Scrutton, N.S. (2011) Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with a,b-unsaturated nitroolefins. Catal. Sci. Technol., 1, 948-957.
-
(2011)
Catal. Sci. Technol.
, vol.1
, pp. 948-957
-
-
Fryszkowska, A.1
Toogood, H.S.2
Sakuma, M.3
Stephens, G.M.4
Gardiner, J.M.5
Scrutton, N.S.6
-
77
-
-
84868087352
-
Crystal structure determination and mutagenesis analysis of the ene reductase NCR
-
Reich, S., Hoeffken, H.W., Rosche, B., Nestl, B.M., and Hauer, B. (2012) Crystal structure determination and mutagenesis analysis of the ene reductase NCR. ChemBioChem, 13, 2400-2407.
-
(2012)
ChemBioChem
, vol.13
, pp. 2400-2407
-
-
Reich, S.1
Hoeffken, H.W.2
Rosche, B.3
Nestl, B.M.4
Hauer, B.5
-
78
-
-
33747764281
-
Stereoselective enone reductions by Saccharomyces carlsbergensis old yellow enzyme
-
Swiderska, M.A. and Stewart, J.D. (2006) Stereoselective enone reductions by Saccharomyces carlsbergensis old yellow enzyme. J. Mol. Catal. B: Enzym., 42, 52-54.
-
(2006)
J. Mol. Catal. B: Enzym.
, vol.42
, pp. 52-54
-
-
Swiderska, M.A.1
Stewart, J.D.2
-
79
-
-
78349285477
-
Asymmetric synthesis of (R)-3-hydroxy-2- methylpropanoate ("Roche ester") and derivatives via biocatalytic C=C bond reduction
-
Stueckler, C., Winkler, C.K., Bonnekessel, M., and Faber, K. (2010) Asymmetric synthesis of (R)-3-hydroxy-2- methylpropanoate ("Roche ester") and derivatives via biocatalytic C=C bond reduction. Adv. Synth. Catal., 352, 2663-2666.
-
(2010)
Adv. Synth. Catal.
, vol.352
, pp. 2663-2666
-
-
Stueckler, C.1
Winkler, C.K.2
Bonnekessel, M.3
Faber, K.4
-
82
-
-
77950570908
-
The flavoprotein-catalyzed reduction of aliphatic nitro-compounds represents a biocatalytic equivalent to the Nef-reaction
-
Durchschein, K., Ferreira-da Silva, B., Wallner, S., Macheroux, P., Kroutil, W., Glueck, S.M., and Faber, K. (2010) The flavoprotein-catalyzed reduction of aliphatic nitro-compounds represents a biocatalytic equivalent to the Nef-reaction. Green Chem., 12, 616-619.
-
(2010)
Green Chem.
, vol.12
, pp. 616-619
-
-
Durchschein, K.1
Ferreira-da Silva, B.2
Wallner, S.3
Macheroux, P.4
Kroutil, W.5
Glueck, S.M.6
Faber, K.7
-
83
-
-
0037077313
-
Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters and nitroaromatic explosives
-
Khan, H., Harris, R.J., Barna, T., Craig, D. H., Bruce, N.C., Munro, A.W., Moody, P.C. E., and Scrutton, N.S. (2002) Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters and nitroaromatic explosives. J. Biol. Chem., 277, 21906-21912.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21906-21912
-
-
Khan, H.1
Harris, R.J.2
Barna, T.3
Craig, D.H.4
Bruce, N.C.5
Munro, A.W.6
Moody, P.C.E.7
Scrutton, N.S.8
-
84
-
-
53849094459
-
Asymmetric bioreduction of activated C=C bonds using Zymomonas mobilis NCR enoate reductase and old yellow enzymes QYE 1-3 from yeasts
-
Hall, M., Stueckler, C., Hauer, B., Stuermer, R., Friedrich, T., Breuer, M., Kroutil,W., and Faber, K. (2008) Asymmetric bioreduction of activated C=C bonds using Zymomonas mobilis NCR enoate reductase and old yellow enzymes QYE 1-3 from yeasts. Eur. J. Org. Chem., 2008 (9), 1511-1516.
-
(2008)
Eur. J. Org. Chem.
, Issue.9
, pp. 1511-1516
-
-
Hall, M.1
Stueckler, C.2
Hauer, B.3
Stuermer, R.4
Friedrich, T.5
Breuer, M.6
Kroutil, W.7
Faber, K.8
-
85
-
-
34548240307
-
Asymmetric alkene reduction by yeast old yellow enzymes and by a novel Zymomonas mobilis reductase
-
Müller, A., Hauer, B., and Rosche, B. (2007) Asymmetric alkene reduction by yeast old yellow enzymes and by a novel Zymomonas mobilis reductase. Biotechnol. Bioeng., 98, 22-29.
-
(2007)
Biotechnol. Bioeng.
, vol.98
, pp. 22-29
-
-
Müller, A.1
Hauer, B.2
Rosche, B.3
-
86
-
-
23044455760
-
The 1.3A crystal structure of the flavoprotein YqjM reveals a novel class of old yellow enzymes
-
Kitzing, K., Fitzpatrick, T.B., Wilken, C., Sawa, J., Bourenkov, G.P., Macheroux, P., and Clausen, T. (2005) The 1.3A crystal structure of the flavoprotein YqjM reveals a novel class of old yellow enzymes. J. Biol. Chem., 280, 27904-27913.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 27904-27913
-
-
Kitzing, K.1
Fitzpatrick, T.B.2
Wilken, C.3
Sawa, J.4
Bourenkov, G.P.5
Macheroux, P.6
Clausen, T.7
-
87
-
-
36749020130
-
Protein engineers turned evolutionists
-
Peisajovich, S.G. and Tawfik, D.S. (2007) Protein engineers turned evolutionists. Nat. Methods, 4, 991-994.
-
(2007)
Nat. Methods
, vol.4
, pp. 991-994
-
-
Peisajovich, S.G.1
Tawfik, D.S.2
-
88
-
-
49349085897
-
The subtle benefits of being promiscuous: adaptive evolution potentiated by enzyme promiscuity
-
DePristo, M.A. (2007) The subtle benefits of being promiscuous: adaptive evolution potentiated by enzyme promiscuity. HFSP J., 1, 94-98.
-
(2007)
HFSP J.
, vol.1
, pp. 94-98
-
-
DePristo, M.A.1
-
89
-
-
0006654299
-
Molecular quasi-species
-
Eigen, M., McCaskill, J., and Schuster, P. (1988) Molecular quasi-species. J. Phys. Chem., 92, 6881-6891.
-
(1988)
J. Phys. Chem.
, vol.92
, pp. 6881-6891
-
-
Eigen, M.1
McCaskill, J.2
Schuster, P.3
-
90
-
-
33746592452
-
Functionally diverging molecular quasi-species evolve by crossing two enzymes
-
Emrén, L.O., Kurtovic, S., Runarsdottir, A., Larsson, A.-K., and Mannervik, B. (2006) Functionally diverging molecular quasi-species evolve by crossing two enzymes. Proc. Nat. Acad. Sci. USA, 103, 10866-10870.
-
(2006)
Proc. Nat. Acad. Sci. USA
, vol.103
, pp. 10866-10870
-
-
Emrén, L.O.1
Kurtovic, S.2
Runarsdottir, A.3
Larsson, A.-K.4
Mannervik, B.5
-
91
-
-
70350077283
-
Identification of emerging quasi-species in directed enzyme evolution
-
Kurtovic, S. and Mannervik, B. (2009) Identification of emerging quasi-species in directed enzyme evolution. Biochemistry, 48, 9330-9339.
-
(2009)
Biochemistry
, vol.48
, pp. 9330-9339
-
-
Kurtovic, S.1
Mannervik, B.2
-
92
-
-
80052135332
-
Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution
-
Kille, S., Zilly, F.E., Acevedo, J.P., and Reetz, M.T. (2011) Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution. Nat. Chem., 3, 738-743.
-
(2011)
Nat. Chem.
, vol.3
, pp. 738-743
-
-
Kille, S.1
Zilly, F.E.2
Acevedo, J.P.3
Reetz, M.T.4
|