Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 27103-27110

  Messiha, Hanan L ^a   Bruce, Neil C ^b   Sattelle, Benedict M ^a   Sutcliffe, Michael J ^a   Munro, Andrew W ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; ENZYME KINETICS; OXIDATION; POTENTIOMETERS (RESISTORS); REDOX REACTIONS; SUBSTRATES;

ACTIVE SITE RESIDUES; RATE-LIMITING STEP; STEADY-STATE KINETIC METHODS;

PROTONS;

2 CYCLOHEXENONE; BACTERIAL MORPHINONE REDUCTASE; MORPHINONE; QUERCETIN; SOLVENT; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POTENTIOMETRY; PRIORITY JOURNAL; PROTON TRANSPORT; RESIDUE ANALYSIS; STEADY STATE;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CYCLOHEXANONES; FLAVINS; KINETICS; MUTATION; NAD; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTONS; RECOMBINANT PROTEINS; SOLVENTS;

EID: 22844450431     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502293200     Document Type: Article

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