Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase: Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184

FEBS Journal

Volumn 272, Issue 18, 2005, Pages 4660-4671

  Khan, Huma ^a   Barna, Terez ^a   Bruce, Neil C ^b   Munro, Andrew W ^a,d   Leys, David ^a,c   Scrutton, Nigel S ^a,c  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Crystallography; Flavoprotein mechanism; Kinetics; Old Yellow Enzyme; PETN reductase

Indexed keywords

FLAVOPROTEIN; HISTIDINE; OXIDOREDUCTASE; PENTAERYTHRITYL TETRANITRATE; PENTAERYTHRITYL TETRANITRATE REDUCTASE; PROGESTERONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; STEROID; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; LIGAND BINDING; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; KINETICS; MUTAGENESIS, SITE-DIRECTED; NADPH DEHYDROGENASE; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROGESTERONE; PROTEIN BINDING; PROTONS; SPECTRUM ANALYSIS; STEROIDS; TYROSINE;

EID: 25444502896     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04875.x     Document Type: Article

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