메뉴 건너뛰기




Volumn 13, Issue 6, 2017, Pages 368-380

The immunology of atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; AUTOANTIGEN; CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

EID: 85017184321     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2017.51     Document Type: Review
Times cited : (729)

References (233)
  • 1
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano, R. et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1
  • 2
    • 4644221457 scopus 로고    scopus 로고
    • Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    • Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E. & Hsu, C. Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296-1305 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1296-1305
    • Go, A.S.1    Chertow, G.M.2    Fan, D.3    McCulloch, C.E.4    Hsu, C.Y.5
  • 3
    • 34347350171 scopus 로고    scopus 로고
    • Chronic kidney disease: Effects on the cardiovascular system
    • Schiffrin, E. L., Lipman, M. L. & Mann, J. F. Chronic kidney disease: effects on the cardiovascular system. Circulation 116, 85-97 (2007).
    • (2007) Circulation , vol.116 , pp. 85-97
    • Schiffrin, E.L.1    Lipman, M.L.2    Mann, J.F.3
  • 4
    • 84904546852 scopus 로고    scopus 로고
    • Screening and risk stratification of coronary artery disease in end-stage renal disease
    • Hakeem, A., Bhatti, S. & Chang, S. M. Screening and risk stratification of coronary artery disease in end-stage renal disease. JACC Cardiovasc. Imaging 7, 715-728 (2014).
    • (2014) JACC Cardiovasc. Imaging , vol.7 , pp. 715-728
    • Hakeem, A.1    Bhatti, S.2    Chang, S.M.3
  • 5
    • 0032952901 scopus 로고    scopus 로고
    • Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
    • Stenvinkel, P. et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int. 55, 1899-1911 (1999).
    • (1999) Kidney Int. , vol.55 , pp. 1899-1911
    • Stenvinkel, P.1
  • 6
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson, G. K. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352, 1685-1695 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 7
    • 0037071843 scopus 로고    scopus 로고
    • Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
    • Skalen, K. et al. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 417, 750-754 (2002).
    • (2002) Nature , vol.417 , pp. 750-754
    • Skalen, K.1
  • 8
    • 0029299438 scopus 로고
    • The response-to-retention hypothesis of early atherogenesis
    • Williams, K. J. & Tabas, I. The response-to-retention hypothesis of early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 15, 551-561 (1995).
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 551-561
    • Williams, K.J.1    Tabas, I.2
  • 9
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby, P., Ridker, P. M. & Hansson, G. K. Progress and challenges in translating the biology of atherosclerosis. Nature 473, 317-325 (2011).
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 10
    • 79951669207 scopus 로고    scopus 로고
    • The immune system in atherosclerosis
    • Hansson, G. K. & Hermansson, A. The immune system in atherosclerosis. Nat. Immunol. 12, 204-212 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 204-212
    • Hansson, G.K.1    Hermansson, A.2
  • 11
    • 0029053557 scopus 로고
    • T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein
    • Stemme, S. et al. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc. Natl Acad. Sci. USA 92, 3893-3897 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 3893-3897
    • Stemme, S.1
  • 12
    • 0033048632 scopus 로고    scopus 로고
    • Cytokine expression in advanced human atherosclerotic plaques: Dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines
    • Frostegard, J. et al. Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis 145, 33-43 (1999).
    • (1999) Atherosclerosis , vol.145 , pp. 33-43
    • Frostegard, J.1
  • 14
    • 0001223219 scopus 로고
    • Über Veränderungen der Kaninchen-Aorta bei experimentelle Cholesterolinsteatose
    • (in German)
    • Anitschkoff, N. Über Veränderungen der Kaninchen-Aorta bei experimentelle Cholesterolinsteatose. Beitr. Path. Anat. 56, 379-391 (in German) (1913).
    • (1913) Beitr. Path. Anat. , vol.56 , pp. 379-391
    • Anitschkoff, N.1
  • 15
    • 0020072450 scopus 로고
    • Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction
    • de Beer, F. C. et al. Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br. Heart J. 47, 239-243 (1982).
    • (1982) Br. Heart J. , vol.47 , pp. 239-243
    • De Beer, F.C.1
  • 16
    • 0027933081 scopus 로고
    • The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina
    • Liuzzo, G. et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N. Engl. J. Med. 331, 417-424 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 417-424
    • Liuzzo, G.1
  • 17
    • 0030956673 scopus 로고    scopus 로고
    • Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
    • Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P. & Hennekens, C. H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336, 973-979 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , pp. 973-979
    • Ridker, P.M.1    Cushman, M.2    Stampfer, M.J.3    Tracy, R.P.4    Hennekens, C.H.5
  • 18
    • 20444419422 scopus 로고    scopus 로고
    • Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
    • Hirschfield, G. M. et al. Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice. Proc. Natl Acad. Sci. USA 102, 8309-8314 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 8309-8314
    • Hirschfield, G.M.1
  • 20
    • 0024245610 scopus 로고
    • Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes
    • Morrone, G. et al. Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J. Biol. Chem. 263, 12554-12558 (1988).
    • (1988) J. Biol. Chem. , vol.263 , pp. 12554-12558
    • Morrone, G.1
  • 21
    • 84944681101 scopus 로고    scopus 로고
    • Novel methodologies for biomarker discovery in atherosclerosis
    • Hoefer, I. E. et al. Novel methodologies for biomarker discovery in atherosclerosis. Eur. Heart J. 36, 2635-2642 (2015).
    • (2015) Eur. Heart J. , vol.36 , pp. 2635-2642
    • Hoefer, I.E.1
  • 22
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker, P. M. et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359, 2195-2207 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2195-2207
    • Ridker, P.M.1
  • 23
    • 0035651710 scopus 로고    scopus 로고
    • Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients
    • Qureshi, A. R. et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J. Am. Soc. Nephrol. 13 (Suppl. 1), S28-S36 (2002).
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. S28-S36
    • Qureshi, A.R.1
  • 24
    • 34548848020 scopus 로고    scopus 로고
    • Plasma pentraxin 3 in patients with chronic kidney disease: Associations with renal function, protein-energy wasting, cardiovascular disease, and mortality
    • Tong, M. et al. Plasma pentraxin 3 in patients with chronic kidney disease: associations with renal function, protein-energy wasting, cardiovascular disease, and mortality. Clin. J. Am. Soc. Nephrol. 2, 889-897 (2007).
    • (2007) Clin. J. Am. Soc. Nephrol. , vol.2 , pp. 889-897
    • Tong, M.1
  • 25
    • 77955081427 scopus 로고    scopus 로고
    • The long pentraxin PTX3: A modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases
    • Norata, G. D., Garlanda, C. & Catapano, A. L. The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases. Trends Cardiovasc. Med. 20, 35-40 (2010).
    • (2010) Trends Cardiovasc. Med. , vol.20 , pp. 35-40
    • Norata, G.D.1    Garlanda, C.2    Catapano, A.L.3
  • 26
    • 77949782407 scopus 로고    scopus 로고
    • Regulation of leukocyte recruitment by the long pentraxin PTX3
    • Deban, L. et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat. Immunol. 11, 328-334 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 328-334
    • Deban, L.1
  • 27
    • 69549111120 scopus 로고    scopus 로고
    • Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis
    • Norata, G. D. et al. Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis. Circulation 120, 699-708 (2009).
    • (2009) Circulation , vol.120 , pp. 699-708
    • Norata, G.D.1
  • 28
    • 0032562148 scopus 로고    scopus 로고
    • Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model
    • Muhlestein, J. B. et al. Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97, 633-636 (1998).
    • (1998) Circulation , vol.97 , pp. 633-636
    • Muhlestein, J.B.1
  • 29
    • 0035849579 scopus 로고    scopus 로고
    • Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice
    • Caligiuri, G., Rottenberg, M., Nicoletti, A., Wigzell, H. & Hansson, G. K. Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice. Circulation 103, 2834-2838 (2001).
    • (2001) Circulation , vol.103 , pp. 2834-2838
    • Caligiuri, G.1    Rottenberg, M.2    Nicoletti, A.3    Wigzell, H.4    Hansson, G.K.5
  • 30
    • 0034678402 scopus 로고    scopus 로고
    • Infectious agents are not necessary for murine atherogenesis
    • Wright, S. D. et al. Infectious agents are not necessary for murine atherogenesis. J. Exp. Med. 191, 1437-1442 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1437-1442
    • Wright, S.D.1
  • 31
    • 19644362702 scopus 로고    scopus 로고
    • Effects of antibiotic therapy on outcomes of patients with coronary artery disease: A meta-analysis of randomized controlled trials
    • Andraws, R., Berger, J. S. & Brown, D. L. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA 293, 2641-2647 (2005).
    • (2005) JAMA , vol.293 , pp. 2641-2647
    • Andraws, R.1    Berger, J.S.2    Brown, D.L.3
  • 32
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63 (2011).
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1
  • 33
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 333-338
    • Schunkert, H.1
  • 34
    • 79951473520 scopus 로고    scopus 로고
    • 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response
    • Harismendy, O. et al. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature 470, 264-268 (2011).
    • (2011) Nature , vol.470 , pp. 264-268
    • Harismendy, O.1
  • 35
    • 84861530209 scopus 로고    scopus 로고
    • Genetics of atherosclerosis
    • Lusis, A. J. Genetics of atherosclerosis. Trends Genet. 28, 267-275 (2012).
    • (2012) Trends Genet. , vol.28 , pp. 267-275
    • Lusis, A.J.1
  • 36
    • 84860790053 scopus 로고    scopus 로고
    • A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex
    • Davies, R. W. et al. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ. Cardiovasc. Genet. 5, 217-225 (2012).
    • (2012) Circ. Cardiovasc. Genet. , vol.5 , pp. 217-225
    • Davies, R.W.1
  • 37
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • Swanberg, M. et al. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat. Genet. 37, 486-494 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 486-494
    • Swanberg, M.1
  • 38
    • 77952539046 scopus 로고    scopus 로고
    • Weak associations between human leucocyte antigen genotype and acute myocardial infarction
    • Bjorkbacka, H. et al. Weak associations between human leucocyte antigen genotype and acute myocardial infarction. J. Intern. Med. 268, 50-58 (2010).
    • (2010) J. Intern. Med. , vol.268 , pp. 50-58
    • Bjorkbacka, H.1
  • 39
    • 0034036648 scopus 로고    scopus 로고
    • Modified LDL-trigger of atherosclerosis and inflammation in the arterial intima
    • Pentikainen, M. O., Oorni, K., Ala-Korpela, M. & Kovanen, P. T. Modified LDL-trigger of atherosclerosis and inflammation in the arterial intima. J. Intern. Med. 247, 359-370 (2000).
    • (2000) J. Intern. Med. , vol.247 , pp. 359-370
    • Pentikainen, M.O.1    Oorni, K.2    Ala-Korpela, M.3    Kovanen, P.T.4
  • 40
    • 0025896795 scopus 로고
    • Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
    • Cybulsky, M. I. & Gimbrone, M. A. Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791 (1991).
    • (1991) Science , vol.251 , pp. 788-791
    • Cybulsky, M.I.1    Gimbrone, M.A.2
  • 41
    • 0031806684 scopus 로고    scopus 로고
    • Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse
    • Nakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L. & Ross, R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 18, 842-851 (1998).
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 842-851
    • Nakashima, Y.1    Raines, E.W.2    Plump, A.S.3    Breslow, J.L.4    Ross, R.5
  • 42
    • 84896774884 scopus 로고    scopus 로고
    • High-resolution imaging of intravascular atherogenic inflammation in live mice
    • Chevre, R. et al. High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ. Res. 114, 770-779 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 770-779
    • Chevre, R.1
  • 43
    • 84977641150 scopus 로고    scopus 로고
    • Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis
    • McArdle, S., Mikulski, Z. & Ley, K. Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis. J. Exp. Med. 213, 1117-1131 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 1117-1131
    • McArdle, S.1    Mikulski, Z.2    Ley, K.3
  • 44
    • 0018701365 scopus 로고
    • Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations
    • Fowler, S., Shio, H. & Haley, N. J. Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations. Lab. Invest. 41, 372-378 (1979).
    • (1979) Lab. Invest. , vol.41 , pp. 372-378
    • Fowler, S.1    Shio, H.2    Haley, N.J.3
  • 45
    • 84883800208 scopus 로고    scopus 로고
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis
    • Robbins, C. S. et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat. Med. 19, 1166-1172 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1166-1172
    • Robbins, C.S.1
  • 46
    • 0009627006 scopus 로고
    • Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein, J. L., Ho, Y. K., Basu, S. K. & Brown, M. S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl Acad. Sci. USA 76, 333-337 (1979).
    • (1979) Proc. Natl Acad. Sci. USA , vol.76 , pp. 333-337
    • Goldstein, J.L.1    Ho, Y.K.2    Basu, S.K.3    Brown, M.S.4
  • 47
    • 84886797808 scopus 로고    scopus 로고
    • Macrophages in atherosclerosis: A dynamic balance
    • Moore, K. J., Sheedy, F. J. & Fisher, E. A. Macrophages in atherosclerosis: a dynamic balance. Nat. Rev. Immunol. 13, 709-721 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 709-721
    • Moore, K.J.1    Sheedy, F.J.2    Fisher, E.A.3
  • 48
    • 0346037268 scopus 로고    scopus 로고
    • Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    • Kunjathoor, V. V. et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 277, 49982-49988 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 49982-49988
    • Kunjathoor, V.V.1
  • 49
    • 66449125123 scopus 로고    scopus 로고
    • Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions
    • Buono, C., Anzinger, J. J., Amar, M. & Kruth, H. S. Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions. J. Clin. Invest. 119, 1373-1381 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 1373-1381
    • Buono, C.1    Anzinger, J.J.2    Amar, M.3    Kruth, H.S.4
  • 50
    • 61749103652 scopus 로고    scopus 로고
    • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima
    • Park, Y. M., Febbraio, M. & Silverstein, R. L. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J. Clin. Invest. 119, 136-145 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 136-145
    • Park, Y.M.1    Febbraio, M.2    Silverstein, R.L.3
  • 52
    • 79954802715 scopus 로고    scopus 로고
    • Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways
    • Chinetti-Gbaguidi, G. et al. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways. Circ. Res. 108, 985-995 (2011).
    • (2011) Circ. Res. , vol.108 , pp. 985-995
    • Chinetti-Gbaguidi, G.1
  • 53
    • 77957260181 scopus 로고    scopus 로고
    • Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2
    • Kadl, A. et al. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ. Res. 107, 737-746 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 737-746
    • Kadl, A.1
  • 54
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez, F. O. & Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014).
    • (2014) F1000Prime Rep. , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 55
    • 0344392240 scopus 로고    scopus 로고
    • Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading
    • Rong, J. X., Shapiro, M., Trogan, E. & Fisher, E. A. Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading. Proc. Natl Acad. Sci. USA 100, 13531-13536 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13531-13536
    • Rong, J.X.1    Shapiro, M.2    Trogan, E.3    Fisher, E.A.4
  • 56
    • 84910137512 scopus 로고    scopus 로고
    • Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis
    • Feil, S. et al. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ. Res. 115, 662-667 (2014).
    • (2014) Circ. Res. , vol.115 , pp. 662-667
    • Feil, S.1
  • 57
    • 84930758301 scopus 로고    scopus 로고
    • KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
    • Shankman, L. S. et al. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat. Med. 21, 628-637 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 628-637
    • Shankman, L.S.1
  • 58
    • 84899122698 scopus 로고    scopus 로고
    • Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis
    • Allahverdian, S., Chehroudi, A. C., McManus, B. M., Abraham, T. & Francis, G. A. Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation 129, 1551-1559 (2014).
    • (2014) Circulation , vol.129 , pp. 1551-1559
    • Allahverdian, S.1    Chehroudi, A.C.2    McManus, B.M.3    Abraham, T.4    Francis, G.A.5
  • 59
    • 0022523129 scopus 로고
    • Regional accumulations of T-cells, macrophages, and smooth-muscle cells in the human atherosclerotic plaque
    • Jonasson, L., Holm, J., Skalli, O., Bondjers, G. & Hansson, G. K. Regional accumulations of T-cells, macrophages, and smooth-muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6, 131-138 (1986).
    • (1986) Arteriosclerosis , vol.6 , pp. 131-138
    • Jonasson, L.1    Holm, J.2    Skalli, O.3    Bondjers, G.4    Hansson, G.K.5
  • 60
    • 0024330373 scopus 로고
    • Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
    • Richardson, P. D., Davies, M. J. & Born, G. V. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 2, 941-944 (1989).
    • (1989) Lancet , vol.2 , pp. 941-944
    • Richardson, P.D.1    Davies, M.J.2    Born, G.V.3
  • 61
    • 0141885294 scopus 로고    scopus 로고
    • From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I
    • Naghavi, M. et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 108, 1664-1672 (2003).
    • (2003) Circulation , vol.108 , pp. 1664-1672
    • Naghavi, M.1
  • 62
    • 0028085059 scopus 로고
    • Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology
    • van der Wal, A. C., Becker, A. E., van der Loos, C. M. & Das, P. K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89, 36-44 (1994).
    • (1994) Circulation , vol.89 , pp. 36-44
    • Van Der Wal, A.C.1    Becker, A.E.2    Van Der Loos, C.M.3    Das, P.K.4
  • 63
    • 34548161312 scopus 로고    scopus 로고
    • Assessment of culprit lesion morphology in acute myocardial infarction: Ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy
    • Kubo, T. et al. Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J. Am. Coll. Cardiol. 50, 933-939 (2007).
    • (2007) J. Am. Coll. Cardiol. , vol.50 , pp. 933-939
    • Kubo, T.1
  • 64
    • 0034019601 scopus 로고    scopus 로고
    • Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions
    • Virmani, R., Kolodgie, F. D., Burke, A. P., Farb, A. & Schwartz, S. M. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 20, 1262-1275 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1262-1275
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3    Farb, A.4    Schwartz, S.M.5
  • 65
    • 84983134120 scopus 로고    scopus 로고
    • Requiem for the 'vulnerable plaque'
    • Libby, P. & Pasterkamp, G. Requiem for the 'vulnerable plaque'. Eur. Heart J. 36, 2984-2987 (2015).
    • (2015) Eur. Heart J. , vol.36 , pp. 2984-2987
    • Libby, P.1    Pasterkamp, G.2
  • 66
    • 84901933376 scopus 로고    scopus 로고
    • Time-dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery
    • van Lammeren, G. W. et al. Time-dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery. Circulation 129, 2269-2276 (2014).
    • (2014) Circulation , vol.129 , pp. 2269-2276
    • Van Lammeren, G.W.1
  • 67
    • 0025800329 scopus 로고
    • Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells
    • Amento, E. P., Ehsani, N., Palmer, H. & Libby, P. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler. Thromb. 11, 1223-1230 (1991).
    • (1991) Arterioscler. Thromb. , vol.11 , pp. 1223-1230
    • Amento, E.P.1    Ehsani, N.2    Palmer, H.3    Libby, P.4
  • 68
    • 84911434770 scopus 로고    scopus 로고
    • The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions
    • Ovchinnikova, O. A. et al. The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions. J. Intern. Med. 276, 525-536 (2014).
    • (2014) J. Intern. Med. , vol.276 , pp. 525-536
    • Ovchinnikova, O.A.1
  • 69
    • 0024811224 scopus 로고
    • Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells
    • Hansson, G. K., Hellstrand, M., Rymo, L., Rubbia, L. & Gabbiani, G. Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells. J. Exp. Med. 170, 1595-1608 (1989).
    • (1989) J. Exp. Med. , vol.170 , pp. 1595-1608
    • Hansson, G.K.1    Hellstrand, M.2    Rymo, L.3    Rubbia, L.4    Gabbiani, G.5
  • 72
    • 0029165365 scopus 로고
    • Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction
    • Kovanen, P. T., Kaartinen, M. & Paavonen, T. Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction. Circulation 92, 1084-1088 (1995).
    • (1995) Circulation , vol.92 , pp. 1084-1088
    • Kovanen, P.T.1    Kaartinen, M.2    Paavonen, T.3
  • 73
    • 20844451175 scopus 로고    scopus 로고
    • Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: An intravascular ultrasound study
    • Ehara, S. et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation 110, 3424-3429 (2004).
    • (2004) Circulation , vol.110 , pp. 3424-3429
    • Ehara, S.1
  • 74
    • 0037066041 scopus 로고    scopus 로고
    • Expression of toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation
    • Edfeldt, K., Swedenborg, J., Hansson, G. K. & Yan, Z. Q. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105, 1158-1161 (2002).
    • (2002) Circulation , vol.105 , pp. 1158-1161
    • Edfeldt, K.1    Swedenborg, J.2    Hansson, G.K.3    Yan, Z.Q.4
  • 75
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller, Y. I. et al. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem. 278, 1561-1568 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 1561-1568
    • Miller, Y.I.1
  • 76
    • 78049250350 scopus 로고    scopus 로고
    • Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    • West, X. Z. et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467, 972-976 (2010).
    • (2010) Nature , vol.467 , pp. 972-976
    • West, X.Z.1
  • 77
    • 71949107774 scopus 로고    scopus 로고
    • Innate immune signals in atherosclerosis
    • Lundberg, A. M. & Hansson, G. K. Innate immune signals in atherosclerosis. Clin. Immunol. 134, 5-24 (2010).
    • (2010) Clin. Immunol. , vol.134 , pp. 5-24
    • Lundberg, A.M.1    Hansson, G.K.2
  • 78
    • 3242728901 scopus 로고    scopus 로고
    • Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
    • Bjorkbacka, H. et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. 10, 416-421 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 416-421
    • Bjorkbacka, H.1
  • 80
    • 20044383911 scopus 로고    scopus 로고
    • Effects of long-term Vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial
    • Lonn, E. et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 293, 1338-1347 (2005).
    • (2005) JAMA , vol.293 , pp. 1338-1347
    • Lonn, E.1
  • 81
    • 40849110313 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease-results of the renal Hope-2 study
    • Mann, J. F. et al. Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease-results of the renal Hope-2 study. Nephrol. Dial. Transplant. 23, 645-653 (2008).
    • (2008) Nephrol. Dial. Transplant. , vol.23 , pp. 645-653
    • Mann, J.F.1
  • 82
    • 84899718423 scopus 로고    scopus 로고
    • Darapladib for preventing ischemic events in stable coronary heart disease
    • White, H. D. et al. Darapladib for preventing ischemic events in stable coronary heart disease. N. Engl. J. Med. 370, 1702-1711 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1702-1711
    • White, H.D.1
  • 83
    • 84907007906 scopus 로고    scopus 로고
    • Effect of darapladib on major coronary events after an acute coronary syndrome: The SOLID-TIMI 52 randomized clinical trial
    • O'Donoghue, M. L. et al. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. JAMA 312, 1006-1015 (2014).
    • (2014) JAMA , vol.312 , pp. 1006-1015
    • O'Donoghue, M.L.1
  • 84
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361 (2010).
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 85
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
    • Rajamaki, K. et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE 5, e11765 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e11765
    • Rajamaki, K.1
  • 86
    • 80053644777 scopus 로고    scopus 로고
    • Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: Rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
    • Ridker, P. M., Thuren, T., Zalewski, A. & Libby, P. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am. Heart J. 162, 597-605 (2011).
    • (2011) Am. Heart J. , vol.162 , pp. 597-605
    • Ridker, P.M.1    Thuren, T.2    Zalewski, A.3    Libby, P.4
  • 87
    • 0025216647 scopus 로고
    • Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6
    • Loppnow, H. & Libby, P. Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6. J. Clin. Invest. 85, 731-738 (1990).
    • (1990) J. Clin. Invest. , vol.85 , pp. 731-738
    • Loppnow, H.1    Libby, P.2
  • 88
    • 20144381067 scopus 로고    scopus 로고
    • Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: Locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein
    • Maier, W. et al. Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation 111, 1355-1361 (2005).
    • (2005) Circulation , vol.111 , pp. 1355-1361
    • Maier, W.1
  • 89
    • 0029830113 scopus 로고    scopus 로고
    • Elevated levels of interleukin-6 in unstable angina
    • Biasucci, L. M. et al. Elevated levels of interleukin-6 in unstable angina. Circulation 94, 874-877 (1996).
    • (1996) Circulation , vol.94 , pp. 874-877
    • Biasucci, L.M.1
  • 90
  • 91
    • 1342321659 scopus 로고    scopus 로고
    • CD1d-dependent activation of NKT cells aggravates atherosclerosis
    • Tupin, E. et al. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J. Exp. Med. 199, 417-422 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 417-422
    • Tupin, E.1
  • 92
    • 2942516034 scopus 로고    scopus 로고
    • Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice
    • Whitman, S. C., Rateri, D. L., Szilvassy, S. J., Yokoyama, W. & Daugherty, A. Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Arterioscler. Thromb. Vasc. Biol. 24, 1049-1054 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 1049-1054
    • Whitman, S.C.1    Rateri, D.L.2    Szilvassy, S.J.3    Yokoyama, W.4    Daugherty, A.5
  • 93
    • 70350435777 scopus 로고    scopus 로고
    • Effect of natural killer T cell activation on the initiation of atherosclerosis
    • van Puijvelde, G. H. et al. Effect of natural killer T cell activation on the initiation of atherosclerosis. Thromb. Haemost. 102, 223-230 (2009).
    • (2009) Thromb. Haemost. , vol.102 , pp. 223-230
    • Van Puijvelde, G.H.1
  • 94
    • 84900853070 scopus 로고    scopus 로고
    • Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis
    • Cheng, H. Y., Wu, R. & Hedrick, C. C. Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis. Atherosclerosis 234, 265-269 (2014).
    • (2014) Atherosclerosis , vol.234 , pp. 265-269
    • Cheng, H.Y.1    Wu, R.2    Hedrick, C.C.3
  • 95
    • 9644308103 scopus 로고    scopus 로고
    • Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice
    • Elhage, R. et al. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am. J. Pathol. 165, 2013-2018 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 2013-2018
    • Elhage, R.1
  • 96
    • 0021929537 scopus 로고
    • Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis
    • Jonasson, L., Holm, J., Skalli, O., Gabbiani, G. & Hansson, G. K. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J. Clin. Invest. 76, 125-131 (1985).
    • (1985) J. Clin. Invest. , vol.76 , pp. 125-131
    • Jonasson, L.1    Holm, J.2    Skalli, O.3    Gabbiani, G.4    Hansson, G.K.5
  • 97
    • 0032029256 scopus 로고    scopus 로고
    • Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions
    • Bobryshev, Y. V. & Lord, R. S. Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc. Res. 37, 799-810 (1998).
    • (1998) Cardiovasc. Res. , vol.37 , pp. 799-810
    • Bobryshev, Y.V.1    Lord, R.S.2
  • 98
    • 4143092691 scopus 로고    scopus 로고
    • Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques
    • Llodra, J. et al. Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc. Natl Acad. Sci. USA 101, 11779-11784 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11779-11784
    • Llodra, J.1
  • 99
    • 0004968087 scopus 로고
    • Low density lipoprotein undergoes oxidative modification in vivo
    • Palinski, W. et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl Acad. Sci. USA 86, 1372-1376 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 1372-1376
    • Palinski, W.1
  • 100
    • 0029929276 scopus 로고    scopus 로고
    • Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis
    • Bui, M. N. et al. Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis. Am. Heart J. 131, 663-667 (1996).
    • (1996) Am. Heart J. , vol.131 , pp. 663-667
    • Bui, M.N.1
  • 102
    • 0342939538 scopus 로고    scopus 로고
    • Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
    • Shaw, P. X. et al. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J. Clin. Invest. 105, 1731-1740 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1731-1740
    • Shaw, P.X.1
  • 103
    • 0038222531 scopus 로고    scopus 로고
    • Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease
    • Fredrikson, G. N. et al. Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 23, 872-878 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 872-878
    • Fredrikson, G.N.1
  • 104
    • 0027233751 scopus 로고
    • Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
    • Xu, Q., Kleindienst, R., Waitz, W., Dietrich, H. & Wick, G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J. Clin. Invest. 91, 2693-2702 (1993).
    • (1993) J. Clin. Invest. , vol.91 , pp. 2693-2702
    • Xu, Q.1    Kleindienst, R.2    Waitz, W.3    Dietrich, H.4    Wick, G.5
  • 105
    • 20844460614 scopus 로고    scopus 로고
    • Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques
    • Benagiano, M. et al. Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J. Immunol. 174, 6509-6517 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 6509-6517
    • Benagiano, M.1
  • 106
    • 0034857562 scopus 로고    scopus 로고
    • Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice
    • George, J., Afek, A., Gilburd, B., Shoenfeld, Y. & Harats, D. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. J. Am. Coll. Cardiol. 38, 900-905 (2001).
    • (2001) J. Am. Coll. Cardiol. , vol.38 , pp. 900-905
    • George, J.1    Afek, A.2    Gilburd, B.3    Shoenfeld, Y.4    Harats, D.5
  • 107
    • 0028809489 scopus 로고
    • Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity
    • Schett, G. et al. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J. Clin. Invest. 96, 2569-2577 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 2569-2577
    • Schett, G.1
  • 109
    • 0037167684 scopus 로고    scopus 로고
    • Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice
    • Maron, R. et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106, 1708-1715 (2002).
    • (2002) Circulation , vol.106 , pp. 1708-1715
    • Maron, R.1
  • 111
    • 0034633845 scopus 로고    scopus 로고
    • 2-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice
    • 2-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice. Circulation 102, 1822-1827 (2000).
    • (2000) Circulation , vol.102 , pp. 1822-1827
    • George, J.1
  • 112
    • 79960802275 scopus 로고    scopus 로고
    • -/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis
    • -/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis. Cardiovasc. Res. 91, 528-536 (2011).
    • (2011) Cardiovasc. Res. , vol.91 , pp. 528-536
    • Duner, P.1
  • 113
  • 114
    • 84875873877 scopus 로고    scopus 로고
    • Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
    • Martel, C. et al. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J. Clin. Invest. 123, 1571-1579 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1571-1579
    • Martel, C.1
  • 115
    • 38449083896 scopus 로고    scopus 로고
    • Induction of indoleamine 2, 3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege
    • Cuffy, M. C. et al. Induction of indoleamine 2, 3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. J. Immunol. 179, 5246-5254 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 5246-5254
    • Cuffy, M.C.1
  • 116
    • 33646692002 scopus 로고    scopus 로고
    • Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    • Galkina, E. et al. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J. Exp. Med. 203, 1273-1282 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1273-1282
    • Galkina, E.1
  • 117
    • 41049097862 scopus 로고    scopus 로고
    • Distribution of inflammatory cells in adventitia changed with advancing atherosclerosis of human coronary artery
    • Watanabe, M. et al. Distribution of inflammatory cells in adventitia changed with advancing atherosclerosis of human coronary artery. J. Atheroscler. Thromb. 14, 325-331 (2007).
    • (2007) J. Atheroscler. Thromb. , vol.14 , pp. 325-331
    • Watanabe, M.1
  • 118
    • 84937573919 scopus 로고    scopus 로고
    • Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin beta receptors
    • Hu, D. et al. Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin beta receptors. Immunity 42, 1100-1115 (2015).
    • (2015) Immunity , vol.42 , pp. 1100-1115
    • Hu, D.1
  • 119
    • 84922765476 scopus 로고    scopus 로고
    • + regulatory T cells limits atherosclerosis and tertiary lymphoid organ development
    • + regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. Circulation 131, 560-570 (2015).
    • (2015) Circulation , vol.131 , pp. 560-570
    • Clement, M.1
  • 120
    • 0024416254 scopus 로고
    • Detection of activated T lymphocytes in the human atherosclerotic plaque
    • Hansson, G. K., Holm, J. & Jonasson, L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am. J. Pathol. 135, 169-175 (1989).
    • (1989) Am. J. Pathol. , vol.135 , pp. 169-175
    • Hansson, G.K.1    Holm, J.2    Jonasson, L.3
  • 121
    • 0030017028 scopus 로고    scopus 로고
    • Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice
    • Zhou, X., Stemme, S. & Hansson, G. K. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice. Am. J. Pathol. 149, 359-366 (1996).
    • (1996) Am. J. Pathol. , vol.149 , pp. 359-366
    • Zhou, X.1    Stemme, S.2    Hansson, G.K.3
  • 122
    • 0026561548 scopus 로고
    • T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1
    • Stemme, S., Holm, J. & Hansson, G. K. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler. Thromb. 12, 206-211 (1992).
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 206-211
    • Stemme, S.1    Holm, J.2    Hansson, G.K.3
  • 123
    • 0033958328 scopus 로고    scopus 로고
    • Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice
    • Paulsson, G., Zhou, X., Tornquist, E. & Hansson, G. K. Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 20, 10-17 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 10-17
    • Paulsson, G.1    Zhou, X.2    Tornquist, E.3    Hansson, G.K.4
  • 124
    • 0034642328 scopus 로고    scopus 로고
    • + T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice
    • + T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102, 2919-2922 (2000).
    • (2000) Circulation , vol.102 , pp. 2919-2922
    • Zhou, X.1    Nicoletti, A.2    Elhage, R.3    Hansson, G.K.4
  • 125
    • 33646700957 scopus 로고    scopus 로고
    • Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis
    • Zhou, X., Robertson, A. K., Hjerpe, C. & Hansson, G. K. Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26, 864-870 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 864-870
    • Zhou, X.1    Robertson, A.K.2    Hjerpe, C.3    Hansson, G.K.4
  • 126
    • 0031001972 scopus 로고    scopus 로고
    • T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse
    • Dansky, H. M., Charlton, S. A., Harper, M. M. & Smith, J. D. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc. Natl Acad. Sci. USA 94, 4642-4646 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 4642-4646
    • Dansky, H.M.1    Charlton, S.A.2    Harper, M.M.3    Smith, J.D.4
  • 127
    • 0034952970 scopus 로고    scopus 로고
    • Lymphocytes are important in early atherosclerosis
    • Song, L., Leung, C. & Schindler, C. Lymphocytes are important in early atherosclerosis. J. Clin. Invest. 108, 251-259 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 251-259
    • Song, L.1    Leung, C.2    Schindler, C.3
  • 129
    • 0030017111 scopus 로고    scopus 로고
    • Inhibition of atherosclerosis in CD4 T-cell-ablated and nude (nu/nu) C57BL/6 hyperlipidemic mice
    • Emeson, E. E., Shen, M. L., Bell, C. G. & Qureshi, A. Inhibition of atherosclerosis in CD4 T-cell-ablated and nude (nu/nu) C57BL/6 hyperlipidemic mice. Am. J. Pathol. 149, 675-685 (1996).
    • (1996) Am. J. Pathol. , vol.149 , pp. 675-685
    • Emeson, E.E.1    Shen, M.L.2    Bell, C.G.3    Qureshi, A.4
  • 130
    • 40549112657 scopus 로고    scopus 로고
    • CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
    • Olofsson, P. S. et al. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117, 1292-1301 (2008).
    • (2008) Circulation , vol.117 , pp. 1292-1301
    • Olofsson, P.S.1
  • 131
    • 77952308908 scopus 로고    scopus 로고
    • Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis
    • Hermansson, A. et al. Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis. J. Exp. Med. 207, 1081-1093 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1081-1093
    • Hermansson, A.1
  • 132
    • 15844415074 scopus 로고    scopus 로고
    • Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis
    • Uyemura, K. et al. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J. Clin. Invest. 97, 2130-2138 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2130-2138
    • Uyemura, K.1
  • 133
    • 0030974188 scopus 로고    scopus 로고
    • IFN-gamma potentiates atherosclerosis in ApoE knock-out mice
    • Gupta, S. et al. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J. Clin. Invest. 99, 2752-2761 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2752-2761
    • Gupta, S.1
  • 135
    • 0037341158 scopus 로고    scopus 로고
    • Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse
    • Buono, C. et al. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 23, 454-460 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 454-460
    • Buono, C.1
  • 136
    • 13444250894 scopus 로고    scopus 로고
    • T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses
    • Buono, C. et al. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc. Natl Acad. Sci. USA 102, 1596-1601 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1596-1601
    • Buono, C.1
  • 137
    • 0020519134 scopus 로고
    • Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon
    • Pober, J. S. et al. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J. Exp. Med. 157, 1339-1353 (1983).
    • (1983) J. Exp. Med. , vol.157 , pp. 1339-1353
    • Pober, J.S.1
  • 138
    • 0023809126 scopus 로고
    • Gamma-interferon regulates vascular smooth muscle proliferation and Ia antigen expression in vivo and in vitro
    • Hansson, G. K., Jonasson, L., Holm, J., Clowes, M. M. & Clowes, A. W. Gamma-interferon regulates vascular smooth muscle proliferation and Ia antigen expression in vivo and in vitro. Circ. Res. 63, 712-719 (1988).
    • (1988) Circ. Res. , vol.63 , pp. 712-719
    • Hansson, G.K.1    Jonasson, L.2    Holm, J.3    Clowes, M.M.4    Clowes, A.W.5
  • 139
    • 84958933712 scopus 로고    scopus 로고
    • Gene expression signatures, pathways and networks in carotid atherosclerosis
    • Perisic, L. et al. Gene expression signatures, pathways and networks in carotid atherosclerosis. J. Intern. Med. 279, 293-308 (2016).
    • (2016) J. Intern. Med. , vol.279 , pp. 293-308
    • Perisic, L.1
  • 140
    • 0032522995 scopus 로고    scopus 로고
    • Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice
    • Zhou, X., Paulsson, G., Stemme, S. & Hansson, G. K. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J. Clin. Invest. 101, 1717-1725 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1717-1725
    • Zhou, X.1    Paulsson, G.2    Stemme, S.3    Hansson, G.K.4
  • 141
    • 0042926424 scopus 로고    scopus 로고
    • The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice
    • Davenport, P. & Tipping, P. G. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am. J. Pathol. 163, 1117-1125 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1117-1125
    • Davenport, P.1    Tipping, P.G.2
  • 143
    • 4043152981 scopus 로고    scopus 로고
    • IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    • Binder, C. J. et al. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J. Clin. Invest. 114, 427-437 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 427-437
    • Binder, C.J.1
  • 144
    • 84867043765 scopus 로고    scopus 로고
    • Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype
    • Cardilo-Reis, L. et al. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol. Med. 4, 1072-1086 (2012).
    • (2012) EMBO Mol. Med. , vol.4 , pp. 1072-1086
    • Cardilo-Reis, L.1
  • 145
    • 39549100797 scopus 로고    scopus 로고
    • IL-33 reduces the development of atherosclerosis
    • Miller, A. M. et al. IL-33 reduces the development of atherosclerosis. J. Exp. Med. 205, 339-346 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 339-346
    • Miller, A.M.1
  • 146
    • 80053452394 scopus 로고    scopus 로고
    • Large-scale gene-centric analysis identifies novel variants for coronary artery disease
    • IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet. 7, e1002260 (2011).
    • (2011) PLoS Genet. , vol.7 , pp. e1002260
  • 147
    • 84892467822 scopus 로고    scopus 로고
    • Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo
    • Lim, H. et al. Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity 40, 153-165 (2014).
    • (2014) Immunity , vol.40 , pp. 153-165
    • Lim, H.1
  • 148
    • 64549126102 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    • Eid, R. E. et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation 119, 1424-1432 (2009).
    • (2009) Circulation , vol.119 , pp. 1424-1432
    • Eid, R.E.1
  • 149
    • 76749088486 scopus 로고    scopus 로고
    • Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques
    • de Boer, O. J. et al. Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J. Pathol. 220, 499-508 (2010).
    • (2010) J. Pathol. , vol.220 , pp. 499-508
    • De Boer, O.J.1
  • 150
    • 84856227494 scopus 로고    scopus 로고
    • Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice
    • Danzaki, K. et al. Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 32, 273-280 (2012).
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 273-280
    • Danzaki, K.1
  • 151
    • 84859102455 scopus 로고    scopus 로고
    • Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice
    • Usui, F. et al. Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice. Biochem. Biophys. Res. Commun. 420, 72-77 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.420 , pp. 72-77
    • Usui, F.1
  • 152
    • 79959791502 scopus 로고    scopus 로고
    • Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice
    • Madhur, M. S. et al. Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler. Thromb. Vasc. Biol. 31, 1565-1572 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 1565-1572
    • Madhur, M.S.1
  • 153
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 154
    • 78650637747 scopus 로고    scopus 로고
    • A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice
    • Gao, Q. et al. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J. Immunol. 185, 5820-5827 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 5820-5827
    • Gao, Q.1
  • 155
    • 76249103398 scopus 로고    scopus 로고
    • Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
    • Erbel, C. et al. Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice. J. Immunol. 183, 8167-8175 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 8167-8175
    • Erbel, C.1
  • 156
    • 77951485998 scopus 로고    scopus 로고
    • Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice
    • Smith, E. et al. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 121, 1746-1755 (2010).
    • (2010) Circulation , vol.121 , pp. 1746-1755
    • Smith, E.1
  • 157
    • 70350433833 scopus 로고    scopus 로고
    • Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis
    • Taleb, S. et al. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J. Exp. Med. 206, 2067-2077 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2067-2077
    • Taleb, S.1
  • 158
    • 79953053438 scopus 로고    scopus 로고
    • Inhibition of IL-17A in atherosclerosis
    • Cheng, X. et al. Inhibition of IL-17A in atherosclerosis. Atherosclerosis 215, 471-474 (2011).
    • (2011) Atherosclerosis , vol.215 , pp. 471-474
    • Cheng, X.1
  • 159
    • 84883851219 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway
    • Gistera, A. et al. Transforming growth factor-beta signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Sci. Transl Med. 5, 196ra100 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 196ra100
    • Gistera, A.1
  • 160
    • 40849130955 scopus 로고    scopus 로고
    • The Th17/Treg imbalance in patients with acute coronary syndrome
    • Cheng, X. et al. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin. Immunol. 127, 89-97 (2008).
    • (2008) Clin. Immunol. , vol.127 , pp. 89-97
    • Cheng, X.1
  • 161
    • 84870746974 scopus 로고    scopus 로고
    • Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction
    • Simon, T. et al. Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction. Eur. Heart J. 34, 570-577 (2013).
    • (2013) Eur. Heart J. , vol.34 , pp. 570-577
    • Simon, T.1
  • 162
    • 36348967350 scopus 로고    scopus 로고
    • Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions
    • de Boer, O. J., van der Meer, J. J., Teeling, P., van der Loos, C. M. & van der Wal, A. C. Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS ONE 2, e779 (2007).
    • (2007) PLoS ONE , vol.2 , pp. e779
    • De Boer, O.J.1    Van Der Meer, J.J.2    Teeling, P.3    Van Der Loos, C.M.4    Van Der Wal, A.C.5
  • 163
    • 79960410419 scopus 로고    scopus 로고
    • Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    • Maganto-Garcia, E., Tarrio, M. L., Grabie, N., Bu, D. X. & Lichtman, A. H. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation 124, 185-195 (2011).
    • (2011) Circulation , vol.124 , pp. 185-195
    • Maganto-Garcia, E.1    Tarrio, M.L.2    Grabie, N.3    Bu, D.X.4    Lichtman, A.H.5
  • 164
    • 32244445416 scopus 로고    scopus 로고
    • Natural regulatory T cells control the development of atherosclerosis in mice
    • Ait-Oufella, H. et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat. Med. 12, 178-180 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 178-180
    • Ait-Oufella, H.1
  • 165
    • 84874597449 scopus 로고    scopus 로고
    • Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    • Klingenberg, R. et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J. Clin. Invest. 123, 1323-1334 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1323-1334
    • Klingenberg, R.1
  • 166
    • 34247190299 scopus 로고    scopus 로고
    • Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis
    • Mor, A. et al. Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27, 893-900 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 893-900
    • Mor, A.1
  • 167
    • 84865865387 scopus 로고    scopus 로고
    • Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis
    • Dinh, T. N. et al. Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis. Circulation 126, 1256-1266 (2012).
    • (2012) Circulation , vol.126 , pp. 1256-1266
    • Dinh, T.N.1
  • 168
    • 78650418451 scopus 로고    scopus 로고
    • Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions
    • Takeda, M. et al. Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler. Thromb. Vasc. Biol. 30, 2495-2503 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 2495-2503
    • Takeda, M.1
  • 169
    • 72449195338 scopus 로고    scopus 로고
    • Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice
    • Sasaki, N. et al. Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice. Circulation 120, 1996-2005 (2009).
    • (2009) Circulation , vol.120 , pp. 1996-2005
    • Sasaki, N.1
  • 170
    • 84897013523 scopus 로고    scopus 로고
    • Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice
    • Kita, T. et al. Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice. Cardiovasc. Res. 102, 107-117 (2014).
    • (2014) Cardiovasc. Res. , vol.102 , pp. 107-117
    • Kita, T.1
  • 171
    • 80052261509 scopus 로고    scopus 로고
    • Differential effects of regulatory T cells on the initiation and regression of atherosclerosis
    • Foks, A. C. et al. Differential effects of regulatory T cells on the initiation and regression of atherosclerosis. Atherosclerosis 218, 53-60 (2011).
    • (2011) Atherosclerosis , vol.218 , pp. 53-60
    • Foks, A.C.1
  • 172
    • 77951433369 scopus 로고    scopus 로고
    • Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis
    • Klingenberg, R. et al. Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 30, 946-952 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 946-952
    • Klingenberg, R.1
  • 173
    • 79954576946 scopus 로고    scopus 로고
    • Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine
    • Wigren, M. et al. Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine. J. Intern. Med. 269, 546-556 (2011).
    • (2011) J. Intern. Med. , vol.269 , pp. 546-556
    • Wigren, M.1
  • 174
    • 84857653448 scopus 로고    scopus 로고
    • Regulatory T-cell response to apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice
    • Herbin, O. et al. Regulatory T-cell response to apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 32, 605-612 (2012).
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 605-612
    • Herbin, O.1
  • 175
    • 0033569130 scopus 로고    scopus 로고
    • Protective role of interleukin-10 in atherosclerosis
    • Mallat, Z. et al. Protective role of interleukin-10 in atherosclerosis. Circ. Res. 85, e17-e24 (1999).
    • (1999) Circ. Res. , vol.85 , pp. e17-e24
    • Mallat, Z.1
  • 176
    • 0000614773 scopus 로고    scopus 로고
    • Interleukin-10 blocks atherosclerotic events in vitro and in vivo
    • Pinderski Oslund, L. J. et al. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 19, 2847-2853 (1999).
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2847-2853
    • Pinderski Oslund, L.J.1
  • 177
    • 0038544576 scopus 로고    scopus 로고
    • Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice
    • Caligiuri, G. et al. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol. Med. 9, 10-17 (2003).
    • (2003) Mol. Med. , vol.9 , pp. 10-17
    • Caligiuri, G.1
  • 179
    • 0346726036 scopus 로고    scopus 로고
    • Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
    • Robertson, A. K. et al. Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J. Clin. Invest. 112, 1342-1350 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1342-1350
    • Robertson, A.K.1
  • 180
    • 0035834818 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice
    • Mallat, Z. et al. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ. Res. 89, 930-934 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 930-934
    • Mallat, Z.1
  • 181
    • 0036078307 scopus 로고    scopus 로고
    • Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression
    • Lutgens, E. et al. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler. Thromb. Vasc. Biol. 22, 975-982 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 975-982
    • Lutgens, E.1
  • 182
    • 69849094786 scopus 로고    scopus 로고
    • TGF-β1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice
    • Frutkin, A. D. et al. TGF-β1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice. Arterioscler. Thromb. Vasc. Biol. 29, 1251-1257 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 1251-1257
    • Frutkin, A.D.1
  • 183
    • 84864026952 scopus 로고    scopus 로고
    • Overexpression of TGF-beta1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice
    • Reifenberg, K. et al. Overexpression of TGF-beta1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice. PLoS ONE 7, e40990 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e40990
    • Reifenberg, K.1
  • 185
    • 0032991052 scopus 로고    scopus 로고
    • Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice
    • Zhou, X. & Hansson, G. K. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice. Scand. J. Immunol. 50, 25-30 (1999).
    • (1999) Scand. J. Immunol. , vol.50 , pp. 25-30
    • Zhou, X.1    Hansson, G.K.2
  • 186
    • 0036193513 scopus 로고    scopus 로고
    • Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice
    • Caligiuri, G., Nicoletti, A., Poirier, B. & Hansson, G. K. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J. Clin. Invest. 109, 745-753 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 745-753
    • Caligiuri, G.1    Nicoletti, A.2    Poirier, B.3    Hansson, G.K.4
  • 187
    • 0036847364 scopus 로고    scopus 로고
    • B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice
    • Major, A. S., Fazio, S. & Linton, M. F. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler. Thromb. Vasc. Biol. 22, 1892-1898 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1892-1898
    • Major, A.S.1    Fazio, S.2    Linton, M.F.3
  • 188
    • 84919587816 scopus 로고
    • Splenectomy and subsequent mortality in veterans of the 1939-1945 war
    • Robinette, C. D. & Fraumeni, J. F. Jr. Splenectomy and subsequent mortality in veterans of the 1939-1945 war. Lancet 2, 127-129 (1977).
    • (1977) Lancet , vol.2 , pp. 127-129
    • Robinette, C.D.1    Fraumeni, J.F.2
  • 189
    • 77954914191 scopus 로고    scopus 로고
    • B cell depletion reduces the development of atherosclerosis in mice
    • Ait-Oufella, H. et al. B cell depletion reduces the development of atherosclerosis in mice. J. Exp. Med. 207, 1579-1587 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1579-1587
    • Ait-Oufella, H.1
  • 190
    • 77958125881 scopus 로고    scopus 로고
    • Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis
    • Kyaw, T. et al. Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis. J. Immunol. 185, 4410-4419 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4410-4419
    • Kyaw, T.1
  • 191
    • 67349230306 scopus 로고    scopus 로고
    • Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis
    • Kerekes, G. et al. Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis. Clin. Rheumatol. 28, 705-710 (2009).
    • (2009) Clin. Rheumatol. , vol.28 , pp. 705-710
    • Kerekes, G.1
  • 192
    • 80053574700 scopus 로고    scopus 로고
    • B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions
    • Kyaw, T. et al. B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. Circ. Res. 109, 830-840 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 830-840
    • Kyaw, T.1
  • 193
    • 0038375997 scopus 로고    scopus 로고
    • Pneumococcal vaccination decreases atherosclerotic lesion formation: Molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    • Binder, C. J. et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. 9, 736-743 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 736-743
    • Binder, C.J.1
  • 194
    • 84952636647 scopus 로고    scopus 로고
    • Atherosclerosis susceptibility in mice is independent of the V1 immunoglobulin heavy chain gene
    • Centa, M. et al. Atherosclerosis susceptibility in mice is independent of the V1 immunoglobulin heavy chain gene. Arterioscler. Thromb. Vasc. Biol. 36, 25-36 (2016).
    • (2016) Arterioscler. Thromb. Vasc. Biol. , vol.36 , pp. 25-36
    • Centa, M.1
  • 195
    • 10644293824 scopus 로고    scopus 로고
    • Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory
    • Chang, M. K. et al. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J. Exp. Med. 200, 1359-1370 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1359-1370
    • Chang, M.K.1
  • 196
    • 84928250306 scopus 로고    scopus 로고
    • Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response
    • Grasset, E. K. et al. Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response. Proc. Natl Acad. Sci. USA 112, E2030-E2038 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E2030-E2038
    • Grasset, E.K.1
  • 197
    • 0034837376 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality associated with the metabolic syndrome
    • Isomaa, B. et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24, 683-689 (2001).
    • (2001) Diabetes Care , vol.24 , pp. 683-689
    • Isomaa, B.1
  • 198
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 200
    • 0023916786 scopus 로고
    • Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation
    • Tracey, K. J. et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J. Exp. Med. 167, 1211-1227 (1988).
    • (1988) J. Exp. Med. , vol.167 , pp. 1211-1227
    • Tracey, K.J.1
  • 201
    • 0022485610 scopus 로고
    • Cachectin and tumour necrosis factor as two sides of the same biological coin
    • Beutler, B. & Cerami, A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320, 584-588 (1986).
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 202
    • 3042606551 scopus 로고    scopus 로고
    • Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host
    • Khovidhunkit, W. et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J. Lipid Res. 45, 1169-1196 (2004).
    • (2004) J. Lipid Res. , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1
  • 203
    • 46149098344 scopus 로고    scopus 로고
    • LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    • Bensinger, S. J. et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134, 97-111 (2008).
    • (2008) Cell , vol.134 , pp. 97-111
    • Bensinger, S.J.1
  • 204
    • 78649467528 scopus 로고    scopus 로고
    • Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006
    • Holmqvist, M. E. et al. Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006. J. Intern. Med. 268, 578-585 (2010).
    • (2010) J. Intern. Med. , vol.268 , pp. 578-585
    • Holmqvist, M.E.1
  • 205
    • 69949148371 scopus 로고    scopus 로고
    • Effects of biologics on vascular function and atherosclerosis associated with rheumatoid arthritis
    • Kerekes, G. et al. Effects of biologics on vascular function and atherosclerosis associated with rheumatoid arthritis. Ann. NY Acad. Sci. 1173, 814-821 (2009).
    • (2009) Ann. NY Acad. Sci. , vol.1173 , pp. 814-821
    • Kerekes, G.1
  • 206
    • 22244443784 scopus 로고    scopus 로고
    • Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis
    • Jacobsson, L. T. et al. Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis. J. Rheumatol. 32, 1213-1218 (2005).
    • (2005) J. Rheumatol. , vol.32 , pp. 1213-1218
    • Jacobsson, L.T.1
  • 207
    • 84881068658 scopus 로고    scopus 로고
    • reg cell homeostasis
    • reg cell homeostasis. Science 341, 569-573 (2013).
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 208
    • 84922163095 scopus 로고    scopus 로고
    • Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
    • Park, J. et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 8, 80-93 (2015).
    • (2015) Mucosal Immunol. , vol.8 , pp. 80-93
    • Park, J.1
  • 209
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth, R. A. et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19, 576-585 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 210
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota-masters of host development and physiology
    • Sommer, F. & Backhed, F. The gut microbiota-masters of host development and physiology. Nat. Rev. Microbiol. 11, 227-238 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 211
    • 0024121577 scopus 로고
    • Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury
    • Jonasson, L., Holm, J. & Hansson, G. K. Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury. Proc. Natl Acad. Sci. USA 85, 2303-2306 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 2303-2306
    • Jonasson, L.1    Holm, J.2    Hansson, G.K.3
  • 212
    • 0035928843 scopus 로고    scopus 로고
    • Bench to bedside: The development of rapamycin and its application to stent restenosis
    • Marx, S. O. & Marks, A. R. Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation 104, 852-855 (2001).
    • (2001) Circulation , vol.104 , pp. 852-855
    • Marx, S.O.1    Marks, A.R.2
  • 213
    • 84925880935 scopus 로고    scopus 로고
    • Anti-inflammatory therapies for atherosclerosis
    • Back, M. & Hansson, G. K. Anti-inflammatory therapies for atherosclerosis. Nat. Rev. Cardiol. 12, 199-211 (2015).
    • (2015) Nat. Rev. Cardiol. , vol.12 , pp. 199-211
    • Back, M.1    Hansson, G.K.2
  • 214
    • 0028895573 scopus 로고
    • Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis
    • Palinski, W., Miller, E. & Witztum, J. L. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl Acad. Sci. USA 92, 821-825 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 821-825
    • Palinski, W.1    Miller, E.2    Witztum, J.L.3
  • 215
    • 0029793720 scopus 로고    scopus 로고
    • Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits
    • Ameli, S. et al. Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 16, 1074-1079 (1996).
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 1074-1079
    • Ameli, S.1
  • 216
    • 17444454127 scopus 로고    scopus 로고
    • Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis
    • George, J. et al. Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis. Atherosclerosis 138, 147-152 (1998).
    • (1998) Atherosclerosis , vol.138 , pp. 147-152
    • George, J.1
  • 217
    • 0035170994 scopus 로고    scopus 로고
    • LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis
    • Zhou, X., Caligiuri, G., Hamsten, A., Lefvert, A. K. & Hansson, G. K. LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 21, 108-114 (2001).
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 108-114
    • Zhou, X.1    Caligiuri, G.2    Hamsten, A.3    Lefvert, A.K.4    Hansson, G.K.5
  • 218
    • 0038639407 scopus 로고    scopus 로고
    • Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    • Fredrikson, G. N. et al. Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences. Arterioscler. Thromb. Vasc. Biol. 23, 879-884 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 879-884
    • Fredrikson, G.N.1
  • 219
    • 84892145590 scopus 로고    scopus 로고
    • Atheroprotective vaccination with MHC-II restricted peptides from ApoB-100
    • Tse, K. et al. Atheroprotective vaccination with MHC-II restricted peptides from ApoB-100. Front. Immunol. 4, 493 (2013).
    • (2013) Front. Immunol. , vol.4 , pp. 493
    • Tse, K.1
  • 220
    • 85013116270 scopus 로고    scopus 로고
    • Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis
    • Gistera, A. et al. Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis. J. Intern. Med. 281, 383-397 (2017).
    • (2017) J. Intern. Med. , vol.281 , pp. 383-397
    • Gistera, A.1
  • 221
    • 33750502631 scopus 로고    scopus 로고
    • Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis
    • van Puijvelde, G. H. et al. Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114, 1968-1976 (2006).
    • (2006) Circulation , vol.114 , pp. 1968-1976
    • Van Puijvelde, G.H.1
  • 222
    • 79953037006 scopus 로고    scopus 로고
    • Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice
    • Hermansson, A. et al. Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice. Circulation 123, 1083-1091 (2011).
    • (2011) Circulation , vol.123 , pp. 1083-1091
    • Hermansson, A.1
  • 224
    • 33846859569 scopus 로고    scopus 로고
    • Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events
    • Tsimikas, S. et al. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J. Lipid Res. 48, 425-433 (2007).
    • (2007) J. Lipid Res. , vol.48 , pp. 425-433
    • Tsimikas, S.1
  • 225
    • 84928124939 scopus 로고    scopus 로고
    • FDG-PET imaging for oxidized LDL in stable atherosclerotic disease: A phase II study of safety, tolerability, and anti-inflammatory activity
    • Lehrer-Graiwer, J. et al. FDG-PET imaging for oxidized LDL in stable atherosclerotic disease: a phase II study of safety, tolerability, and anti-inflammatory activity. JACC Cardiovasc. Imaging 8, 493-494 (2015).
    • (2015) JACC Cardiovasc. Imaging , vol.8 , pp. 493-494
    • Lehrer-Graiwer, J.1
  • 226
    • 66349096056 scopus 로고    scopus 로고
    • The role of innate immunity in atherogenesis
    • Hartvigsen, K. et al. The role of innate immunity in atherogenesis. J. Lipid Res. 50 (Suppl.), S388-S393 (2009).
    • (2009) J. Lipid Res. , vol.50 , pp. S388-S393
    • Hartvigsen, K.1
  • 227
    • 0033990553 scopus 로고    scopus 로고
    • Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects
    • Shoji, T. et al. Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis 148, 171-177 (2000).
    • (2000) Atherosclerosis , vol.148 , pp. 171-177
    • Shoji, T.1
  • 228
    • 74249123382 scopus 로고    scopus 로고
    • Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice
    • Habets, K. L. et al. Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice. Cardiovasc. Res. 85, 622-630 (2010).
    • (2010) Cardiovasc. Res. , vol.85 , pp. 622-630
    • Habets, K.L.1
  • 229
    • 0031702543 scopus 로고    scopus 로고
    • Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes
    • Freigang, S., Horkko, S., Miller, E., Witztum, J. L. & Palinski, W. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes. Arterioscler. Thromb. Vasc. Biol. 18, 1972-1982 (1998).
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 1972-1982
    • Freigang, S.1    Horkko, S.2    Miller, E.3    Witztum, J.L.4    Palinski, W.5
  • 230
    • 20844432027 scopus 로고    scopus 로고
    • Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis
    • Schiopu, A. et al. Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis. Circulation 110, 2047-2052 (2004).
    • (2004) Circulation , vol.110 , pp. 2047-2052
    • Schiopu, A.1
  • 231
    • 82355175118 scopus 로고    scopus 로고
    • Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses
    • Ketelhuth, D. F. et al. Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses. Circulation 124, 2433-2443 (2011).
    • (2011) Circulation , vol.124 , pp. 2433-2443
    • Ketelhuth, D.F.1
  • 232
    • 66349100479 scopus 로고    scopus 로고
    • The LDL modification hypothesis of atherogenesis: An update
    • Steinberg, D. The LDL modification hypothesis of atherogenesis: an update. J. Lipid Res. 50 (Suppl.), S376-S381 (2009).
    • (2009) J. Lipid Res. , vol.50 , pp. S376-S381
    • Steinberg, D.1
  • 233
    • 0034998413 scopus 로고    scopus 로고
    • In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses
    • Dongre, A. R. et al. In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. Eur. J. Immunol. 31, 1485-1494 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1485-1494
    • Dongre, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.