Inhibition of atherosclerosis in CD4 T-cell-ablated and nude (nu/nu) C57BL/6 hyperlipidemic mice

American Journal of Pathology

Volumn 149, Issue 2, 1996, Pages 675-685

  Emeson, Eugene E ^a   Shen, Mei Ling ^b   Bell, Clara G H ^a   Qureshi, Asaf ^c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c U States Department of Agriculture   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; OKT 4; OKT 8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENIC DIET; CONTROLLED STUDY; FEMALE; GENOTYPE; HYPERLIPIDEMIA; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; AORTA; ARTERIOSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CHOLESTEROL; CHOLESTEROL, HDL; CYTOTOXICITY, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; HYPERLIPIDEMIAS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; TRIGLYCERIDES;

EID: 0030017111     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Ross R: The pathogenesis of atherosclerosis: an update. N Engl J Med 1986, 314:488-500
2. Munro JM, Cotran RS: The pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest 1988, 58:249-261
3. Jonasson L, Holm J, Skalli O, Bonders G, Hansson GK: Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 1986, 6:131-138
4. Gown AM, Tsukada T, Ross R: Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 1986, 125:191-207
5. Munro JM, van der Walt JD, Munro CS, Chalmers JAC, Vox EL: An immunohistochemical analysis of human aortic fatty streaks: Human Pathol 1987, 18:375-380
6. Emeson EE, Robertson AL: T lymphocytes in aortic and coronary intimas: their potential role in atherogenesis. Am J Pathol 1988, 130:369-376
7. van der Wal AC, Das PK, van de Berg DB, van der Loos CM, Becker AE: Atherosclerotic lesions in human: in situ immunophenotypic analysis suggesting an immune mediated response. Lab Invest 1989, 61:166-170
8. Dartsch PC, Bauriedel G, Schinko I, Wiss H-D, Hoffling B, Betz E: Cell constitution and characteristics of human atherosclerotic plaques selectively removed by percutaneous atherectomy. Atherosclerosis 1989, 80: 149-157
9. Ramshaw AL, Parums DV: Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosis. Histopathology 1990, 17:543-552
10. Xu Q, Oberhuber G, Gruschwitz M, Wick G: Immunology of atherosclerosis: cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens. Clin Immunol Immunopathol 1990, 56:344-359
11. Libby P, Hansson GK: Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest 1991, 64:5-15
12. Libby P, Gallis ZS: Cytokines regulate genes involved in atherogenesis. Ann NY Acad Sci 1995, 748:158-168
13. Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick GJ: Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein. J Clin Invest 1993, 91:2693-2702
14. Wick G, Schett G, Amberger A, Kleindienst R, Xu Q: Is atherosclerosis and immunologically mediated disease. Immunol Today 1995, 16:27-33
15. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK: T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA 1995, 92:3893-3897
16. Palinski W, Miller E, Witztum JL: Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc Natl Acad Sci USA 1995, 92:821-825
17. Emeson EE, Shen M-L: Accelerated atherosclerosis in hyperlipidemic C57BL/6 mice treated with cyclosporin A. Am J Pathol 1993, 142:1906-1915
18. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA: Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 1987, 68:231-240
19. Ishida BY, Paigen B: Atherosclerosis in the mouse. Genetic Factors in Atherosclerosis: Approaches and Model Systems. Edited by AJ Lusis, SR Sparks. Basel, Karger, 1989, pp 189-222
20. Tietz NW: Fundamentals of clinical chemistry. Philadelphia, WB Saunders, 1987, p 473
21. Lopes-Virella MF, Stone P, Ellis S, Colwell JA: Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem 1977, 23:882-884
22. Friedewald WT, Levy RI, Fredrickson DS: Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the ultracentrifuge. Clin Chem 1972, 18:449-502
23. Sokal RR, Rohlf FJ: Biometry. San Francisco, WH Freeman and Co, 1981, pp 226-229
24. Melnick JL, Adams E, DeBakey ME: Human cytomegalovirus and atherogenesis. Frontiers of Virology. Edited by Y Becker, G Darai, E-S Huang. New York, Springer-Verlag, 1993, pp 81-91
25. + mononuclear cells induce cytokine expression, vascular smooth muscle cell proliferation, and arterial occlusion after endothelial injury. Am J Pathol 1994, 145:1008-1014
26. Drew AF, Tipping PG: Cyclosporine treatment reduces early atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis 1995, 116:181-189
27. Ballantyne DM, Podet EJ, Patsch WP, Harati Y, Appel V, Gotto AM Jr, Young JB: Effects of cyclosporine therapy on plasma lipoprotein levels. JAMA 1989, 262: 53-56
28. Lustig S, Stern N, Golub MS, Eggena P, Barrett J, Lee DBN: Experimental cyclosporin hypertension: characterization of the rat model. Transplant Proc 1987, 21: 950-951
29. Zoja C, Furci L, Ghilardi F, Zilio P, Benigini A, Remuzz G: Cyclosporin-induced endothelial cell injury. Lab Invest 1986, 55:455-462
30. Bunchman TE, Brookshire CA: Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells. J Clin Invest 1991, 88:310-314
31. Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK: Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994, 93:1885-1893
32. Marotti KR, Castle CK, Boyle TP, Lin AH, Murray RW, Melchior GW: Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein. Science 1993, 364:73-75
33. Lawn RM, Wade DP, Hammer RE, Chiesa G, Verstuyft JG, Rubin EM: Atherogenesis in transgenic mice expressing human apolipoprotein(a). Nature 1992, 360: 670-672
34. Purcell-Huynh DA, Farese RV Jr, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG: Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J Clin Invest 1995, 95:2246-2257
35. Callow MJ, Verstuyft, Tangirala R, Palinski W, Rubin RM: Atherogenesis in transgenic mice with human apolipoprotein B and lipoprotein(a). J Clin Invest 1995, 96:1639-1646
36. Dueland S, Drisko J, Graf L, Machleder D, Lusis AJ, Davis RA: Effect of dietary cholesterol and taurocholate on cholesterol 7α-hydroxylase and hepatic LDL receptors in inbred mice. J Lipid Res 1993, 34:923-931
37. Garner CM, Mills CO, Elias E, Neuberger JM: The effect of bile salts on human vascular endothelial cells. Biochem Biophys Acta 1991, 1091:41-45
38. Calcamuggi G, Lanzio M, Babini G, Martini S, Anfossi G, Emanuelli G: Sodium taurocholate affects prostacyclin constitutive production by cultured human vascular endothelial cells. J Lab Clin Med 1990, 115:756-760
39. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL: Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992, 71:343-353
40. Zhang SH, Reddick RL, Piedrahita JA, Maeda N: Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992, 258: 468-471
41. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R: ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 1994, 14:133-140
42. Reddick RL, Zhang SH, Maeda N: Atherosclerosis in mice lacking apo E: evaluation of lesional development and progression. Arterioscler Thromb 1994, 14:141-147
43. Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL: Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc Natl Acad Sci USA 1992, 89:421-425
44. + suppressor effector T cell clones from cytotoxic T cell clones by cytokine production and CD45 isoforms, J Immunol 1993, 150:2121-2128
45. + T cells can be primed in vitro to produce IL-4. J Immunol 1992, 148: 1652-1656
46. O'Garra A, Murphy K: T-cell subsets in autoimmunity. Curr Opin Immunol 1993, 5:880-886
47. Mason D, Fowell D: T-cell subsets in autoimmunity. Curr Opin Immunol 1992, 4:728-732
48. + T cells in the pathogenesis of organ-specific autoimmune diseases, Immunol Today 1995, 16:34-38
49. Grainger DJ, Withchell CM, Metcalfe JC: Tamoxifen elevates transforming growth factor-β and suppresses diet-induced formation of lipid lesions in mouse aorta. Nat Med 1995, 1:1067-1073
50. Grainger DJ, Kemp PR, Metcalfe JC, Liu AC, Lawn RM, Williams NR, Grace AA, Schofield PM, Chauhan A: The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis. Nat Med 1995, 1:74-79
51. Hansson GH, Holm J, Holm S, Fotev Z, Hedrich H-J, Fingerle J: T lymphocytes inhibit the vascular response to injury. Proc Natl Acad Sci USA 1991, 88:10530-10534
52. Ferns GAA, Reidy MA, Ross R: Balloon catheter deendothelialization of the nude rat carotid: response to injury in the absence of functional T lymphocytes. Am J Pathol 1991, 138:1045-1057
53. Fyfe Al, Quiano J-H, Lusis AJ: Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 1994, 94:2516-2520
54. MacDonald HR, Blanc C, Lees RK, Sordat B: Abnormal distribution of T cell subsets in athymic mice, J Immunol 1986, 136:4337-4339
55. Lawetzky A, Hunig T: Analysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice. Eur J Immunol 1988, 18:409-416
56. Grusby MJ, Glimcher LH: Immune responses in MHC class II-deficient mice. Annu Rev Immunol 1995, 13: 417-435