From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I

Circulation

Volumn 108, Issue 14, 2003, Pages 1664-1672

  Naghavi, Morteza ^an   Libby, Peter ^a   Falk, Erling ^b   Casscells, S Ward ^ao   Litovsky, Silvio ^ao   Rumberger, John ^ao   Badimon, Juan Jose ^ao   Stefanadis, Christodoulos ^k   Moreno, Pedro ^e   Pasterkamp, Gerard ^c   Fayad, Zahi ^d   Stone, Peter H ^a   Waxman, Sergio ^f   Raggi, Paolo ^g   Madjid, Mohammad ^ao   Zarrabi, Alireza ^ao   Burke, Allen ^h   Yuan, Chun ⁱ   Fitzgerald, Peter J ^j   Siscovick, David S ⁱ   De Korte, Chris L ^l   Aikawa, Masanori ^a   Airaksinen, K E Juhani ^m   Assmann, Gerd ⁿ   Becker, Christoph R ^o   Chesebro, James H ^p   Farb, Andrew ^ao   Galis, Zorina S ^q   Jackson, Chris ^r   Jang, Ik Kyung ^s   Koenig, Wolfgang ^t   Lodder, Robert A ^e   March, Keith ^u   Demirovic, Jasenka ^v   Navab, Mohamad ^w   Priori, Silvia G ^x   Rekhter, Mark D ^y   Bahr, Raymond ^z   Grundy, Scott M ^ao   Mehran, Roxana ^aa   Colombo, Antonio ^ab   Boerwinkle, Eric ^ac   Ballantyne, Christie ^ad   Insull Jr , William ^ad   Schwartz, Robert S ^ae   Vogel, Robert ^af   Serruys, Patrick W ^ao   Hansson, Goran K ^ag   Faxon, David P ^ah   Kaul, Sanjay ^ai   Drexler, Helmut ^aj   Greenland, Philip ^ak   Muller, James E ^s   Virmani, Renu ^ao   Ridker, Paul M ^am   Zipes, Douglas P ^ao   Shah, Prediman K ^al   Willerson, James T ^ao   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d MOUNT SINAI MEDICAL CENTER   (United States)

^e UNIVERSITY OF KENTUCKY   (United States)

^f TUFTS MEDICAL CENTER   (United States)

^g TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^k UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^l ERASMUS MEDICAL CENTER   (Netherlands)

^m UNIVERSITY OF TURKU   (Finland)

ⁿ UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^o UNIVERSITY OF MÜNSTER   (Germany)

^p MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^q EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r UNIVERSITY OF BRISTOL   (United Kingdom)

^s MASSACHUSETTS GENERAL HOSPITAL   (United States)

^t UNIVERSITY OF ULM   (Germany)

^u VETERANS AFFAIRS MEDICAL CENTER   (United States)

^v UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x UNIVERSITY OF PAVIA   (Italy)

^y PFIZER INC   (United States)

^z Paul Dudley White Coronary Care System   (United States)

^aa LENOX HILL HOSPITAL   (United States)

^ab EMO GVM CENTRO CUORE COLUMBUS   (Italy)

^ac UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^ad BAYLOR COLLEGE OF MEDICINE   (United States)

^ae MINNEAPOLIS HEART INSTITUTE FOUNDATION   (United States)

^af UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^ag KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^ah UNIVERSITY OF CHICAGO   (United States)

^ai CEDARS SINAI MEDICAL CENTER   (United States)

^aj LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^ak NORTHWESTERN UNIVERSITY   (United States)

^al UNIVERSITY OF CALIFORNIA   (United States)

^am BRIGHAM AND WOMEN S HOSPITAL   (United States)

^an Association for Eradication of Heart Attack   (United States)

^ao Assoc Eradication of Heart Attack ^*

more..

Author keywords

Atherosclerosis; Coronary disease; Death, sudden; Myocardial infarction; Plaque

Indexed keywords

MYELOPEROXIDASE;

ACUTE HEART INFARCTION; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CAUSE OF DEATH; COMPUTER ASSISTED TOMOGRAPHY; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HEART DEATH; HISTOPATHOLOGY; HUMAN; INTRAVASCULAR ULTRASOUND; ISCHEMIC HEART DISEASE; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SUDDEN DEATH; THROMBOCYTE AGGREGATION; THROMBOSIS;

ACUTE DISEASE; ARTERIOSCLEROSIS; CONSENSUS; CORONARY DISEASE; DEATH, SUDDEN, CARDIAC; DISEASE PROGRESSION; HUMANS; MODELS, CARDIOVASCULAR; RISK ASSESSMENT; SYNDROME; TERMINOLOGY;

EID: 0141885294     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000087480.94275.97     Document Type: Review

References (95)

1. Yusuf S, Reddy S, Ounpuu S, et al. Global burden of cardiovascular diseases, I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104:2746-2753.
2. American Heart Association. 2002 Heart and Stroke Statistical Update. Dallas, Tex: American Heart Association: 2002.
3. Myerburg RJ, Interian A Jr, Mitrani RM, et al. Frequency of sudden cardiac death and profiles of risk. Am J Cardiol. 1997;80:10F-19F.
4. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334-2351.
5. Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
6. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657-671.
7. Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease. Circulation. 1990;82 (suppl II):II-38-II-46.
8. Kolodgie FD, Burke AP, Farb A, et al. The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol. 2001;16:285-292.
9. Farb A, Burke AP, Tang AL, et al. Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death. Circulation. 1996;93:1354-1363.
10. Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol. 1988;12:56-62.
11. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 1983;50:127-134.
12. Friedman M, Van den Bovenkamp GJ. Role of thrombus in plaque formation in the human diseased coronary artery. Br J Exp Pathol. 1966;47:550-557.
13. Constantinides P. Pathogenesis of cerebral artery thrombosis in man. Arch Pathol. 1967;83:422-428.
14. Chapman I. Relationships of recent coronary artery occlusion and acute myocardial infarction. J Mt Sinai Hosp N Y. 1968;35:149-154.
15. Davies MJ, Thomas AC. Plaque fissuring: the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J. 1985;53:363-373.
16. Deleted in proof.
17. Willerson JT, Campbell WB, Winniford MD, et al. Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. Am J Cardiol. 1984;54:1349-1354.
18. Muller J, Tofler G, Stone P. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989;79:733-743.
19. Muller JE, Abela GS, Nesto RW, et al. Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier. J Am Coll Cardiol. 1994;23:809-813.
20. Vulnerable. In: Merriam-Webster's Collegiate Dictionary & Thesaurus. 11th ed (e-book). Springfield, Mass: Merriam-Webster, Inc; 2003.
21. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis. American Heart Association. Circulation. 1995;92:1355-1374.
22. Mann J, Davies MJ. Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart. 1999;82:265-268.
23. Burke AP, Farb A, Malcom GT, et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276-1282.
24. Goldstein JA, Demetriou D, Grines CL, et al. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med. 2000;343:915-922.
25. Nissen SE. Who is at risk for atherosclerotic disease? Lessons from intravascular ultrasound. Am J Med. 2002;112(suppl 8A):27S-33S.
26. Rioufol G, Finet G, Ginon I, et al. Multiple atherosclerotic plaque rupture in acute coronary syndrome. Circulation. 2002;106:804-808.
27. Buffon A, Biasucci LM, Liuzzo G, et al. Widespread coronary inflammation in unstable angina. N Engl J Med. 2002;347:5-12.
28. Casscells W, Naghavi M, Willerson JT. Vulnerable atherosclerotic plaque: a multifocal disease. Circulation. 2003;107:2072-2075.
29. Maseri A, Fuster V. Is there a vulnerable plaque? Circulation. 2003;107:2068-2071.
30. Kereiakes DJ. The emperor's clothes: in search of the vulnerable plaque. Circulation. 2003;107:2076-2077.
31. Davies MJ. Pathology of arterial thrombosis. Br Med Bull. 1994;50:789-802.
32. Burke AP, Kolodgie FD, Farb A, et al. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation. 2001;103:934-940.
33. Vallabhajosula S, Fuster V. Atherosclerosis: imaging techniques and the evolving role of nuclear medicine. J Nucl Med. 1997;38:1788-1796.
34. Fayad ZA, Fuster V. Clinical imaging of the high-risk or vulnerable atherosclerotic plaque. Circ Res. 2001;89:305-316.
35. Naghavi M, Madjid M, Khan MR, et al. New developments in the detection of vulnerable plaque. Curr Atheroscler Rep. 2001;3:125-135.
36. Stefanadis C, Diamantopoulos L, Vlachopoulos C, et al. Thermal heterogeneity within human atherosclerotic coronary arteries detected in vivo: a new method of detection by application of a special thermography catheter. Circulation. 1999;99:1965-1971.
37. Stefanadis C, Toutouzas K, Tsiamis E, et al. Thermal heterogeneity in stable human coronary atherosclerotic plaques is underestimated in vivo: the "cooling effect" of blood flow. J Am Coll Cardiol. 2003;41:403-408.
38. Schmitz SA, Coupland SE, Gust R, et al. Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits. Invest Radiol. 2000;35:460-471.
39. Ruehm SG, Corot C, Vogt P, et al. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation. 2001;103:415-422.
40. Lederman RJ, Raylman RR, Fisher SJ, et al. Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nucl Med Commun. 2001;22:747-753.
41. Ciavolella M, Tavolaro R, Taurino M, et al. Immunoscintigraphy of atherosclerotic uncomplicated lesions in vivo with a monoclonal antibody against D-dimers of insoluble fibrin. Atherosclerosis. 1999;143:171-175.
42. Tearney GJ, Yabushita H, Houser SL, et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation. 2003;107:113-119.
43. Krinsky GA, Freedberg R, Lee VS, et al. Innominate artery atheroma: a lesion seen with gadolinium-enhanced MR angiography and often missed by transesophageal echocardiography. Clin Imaging. 2001;25:251-257.
44. Bonk RT, Schmiedl UP, Yuan C, et al. Time-of-flight MR angiography with Gd-DTPA hexamethylene diamine co-polymer blood pool contrast agent: comparison of enhanced MRA and conventional angiography for arterial stenosis induced in rabbits. J Magn Reson Imaging. 2000;11:638-646.
45. Yuan C, Kerwin WS, Ferguson MS, et al. Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization. J Magn Reson Imaging. 2002;15:62-67.
46. Patwari P, Weissman NJ, Boppart SA, et al. Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound. Am J Cardiol. 2000;85:641-644.
47. Jang I-K, Bouma BE, Kang D-H, et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol. 2002;39:604-609.
48. Nissen SE. Clinical images from intravascular ultrasound: coronary disease, plaque rupture, and intervention-the inside view. Am J Cardiol. 2001;88:16-18.
49. Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation. 2001;103:604-616.
50. de Korte CL, Cespedes EI, van der Steen AF, et al. Intravascular ultrasound elastography: assessment and imaging of elastic properties of diseased arteries and vulnerable plaque. Eur J Ultrasound. 1998;7:219-224.
51. de Korte CL, Sierevogel MJ, Mastik F, et al. Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study. Circulation. 2002;105:1627-1630.
52. Corti R, Osende JI, Fuster V, et al. Artery dissection and arterial thrombus aging: the role of noninvasive magnetic resonance imaging. Circulation. 2001;103:2420-2421.
53. Takano M, Mizuno K, Okamatsu K, et al. Mechanical and structural characteristics of vulnerable plaques: analysis by coronary angioscopy and intravascular ultrasound. J Am Coll Cardiol. 2001;38:99-104.
54. Cassis LA, Lodder RA. Near-IR imaging of atheromas in living arterial tissue. Anal Chem. 1993;65:1247-1256.
55. Moreno PR, Lodder RA, Purushothaman KR, et al. Detection of lipid pool, thin fibrous cap, and inflammatory cells in human aortic atherosclerotic plaques by near-infrared spectroscopy. Circulation. 2002;105:923-927.
56. Wang J, Geng YJ, Guo B, et al. Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques. J Am Coll Cardiol. 2002;39:1305-1313.
57. Jeremias A, Kolz ML, Ikonen TS, et al. Feasibility of in vivo intravascular ultrasound tissue characterization in the detection of early vascular transplant rejection. Circulation. 1999;100:2127-2130.
58. Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200-2206.
59. Helft G, Worthley SG, Fuster V, et al. Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging. Circulation. 2002;105:993-998.
60. Hatsukami TS, Ross R, Polissar NL, et al. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation. 2000;102:959-964.
61. Yuan C, Mitsumori LM, Ferguson MS, et al. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation. 2001;104:2051-2056.
62. Yuan C, Zhang S-X, Polissar NL, et al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation. 2002;105:181-185.
63. Uchida Y, Nakamura F, Tomaru T, et al. Prediction of acute coronary syndromes by percutaneous coronary angioscopy in patients with stable angina. Am Heart J. 1995;130:195-203.
64. Flacke S, Fischer S, Scott MJ, et al. Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation. 2001;104:1280-1285.
65. Corti R, Osende JI, Fayad ZA, et al. In vivo noninvasive detection and age definition of arterial thrombus by MRI. J Am Coll Cardiol. 2002;39:1366-1373.
66. Asakura M, Ueda Y, Yamaguchi O, et al. Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study. J Am Coll Cardiol. 2001;37:1284-1288.
67. Nieman K, Oudkerk M, Rensing BJ, et al. Coronary angiography with multi-slice computed tomography. Lancet. 2001;357:599-603.
68. Giesler TBU, Ropers D, Ulzheimer S, et al. Noninvasive visualization of coronary arteries using contrast-enhanced multidetector CT: influence of heart rate on image quality and stenosis detection. AJR Am J Roentgenol. 2002;179:911-916.
69. Duerinckx AJ. Imaging of coronary artery disease: MR. J Thorac Imaging. 2001;16:25-34.
70. Hecht HS. New developments in atherosclerosis imaging: electron beam tomography. Curr Atheroscler Rep. 2001;3:417-424.
71. Corti R, Fayad ZA, Fuster V, et al. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation. 2001;104:249-252.
72. Rumberger JA. Tomographic (plaque) imaging: state of the art. Am. J Cardiol. 2001;88:66E-69E.
73. Achenbach S, Ropers D, Regenfus M, et al. Noninvasive coronary angiography by magnetic resonance imaging, electron-beam computed tomography, and multislice computed tomography. Am J Cardiol. 2001;88:70E-73E.
74. Kodama K, Asakura M, Ueda Y, et al. The role of plaque rupture in the development of acute coronary syndrome evaluated by the coronary angioscope. Intern Med. 2000;39:333-335.
75. Lehmann KG, van Suylen RJ, Stibbe J, et al. Composition of human thrombus assessed by quantitative colorimetric angioscopic analysis. Circulation. 1997;96:3030-3041.
76. Moulton KS. Plaque angiogenesis and atherosclerosis. Curr Atheroscler Rep. 2001;3:225-233.
77. Nasu K, Kawamoto A, Sasaki Y, et al. Measurement of vascular tissue blood flow of the atherosclerotic aorta in Watanabe heritable hypercholesterolemic (WHHL) rabbit by using laser Doppler flowmeter-equipped balloon catheter. Am J Cardiol. 1999;84:84P.
78. Drexler H, Zeiher AM, Wollschlager H, et al. Flow-dependent coronary artery dilatation in humans. Circulation. 1989;80:466-474.
79. Vogel RA, Brachial artery ultrasound: a noninvasive tool in the assessment of triglyceride-rich lipoproteins. Clin Cardiol. 1999(6 suppl);22:II34-II39.
80. Varnava AM, Mills PG, Davies MJ. Relationship between coronary artery remodeling and plaque vulnerability. Circulation. 2002;105:939-943.
81. Smits PC, Pasterkamp G, Quarles van Ufford MA et al. Coronary artery disease: arterial remodelling and clinical presentation. Heart. 1999;82:461-464.
82. Kim WY, Stuber M, Bornert P, et al. Three-dimensional black-blood cardiac magnetic resonance coronary vessel wall imaging detects positive arterial remodeling in patients with nonsignificant coronary artery disease. Circulation. 2002;106:296-299.
83. Naghavi M, Madjid M, Gul K, et al. Thermography basket catheter: in vivo measurement of the temperature of atherosclerotic plaques for detection of vulnerable plaques. Catheter Cardiovasc Interv. 2003;59:52-59.
84. Wissler RW, Strong JP. Risk factors and progression of atherosclerosis in youth. PDAY Research Group. Pathological Determinants of Atherosclerosis in Youth. Am J Pathol. 1998;153:1023-1033.
85. Tuzcu EM, Kapadia SR, Tutar E, et al. High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation. 2001;103:2705-2710.
86. Pasterkamp G, Schoneveld AH, van der Wal AC, et al. Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol. 1998;32:655-662.
87. Becker CR, Nikolaou K, Muders M, et al. Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT. Eur Radiol. 2003;12:12.
88. Vogel RA. Heads and hearts: the endothelial connection. Circulation. 2003;107:2766-2768.
89. Targonski PV, Bonetti PO, Pumper GM, et al. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation. 2003;107:2805-2809.
90. Cusack MR, Marber MS, Lambiase PD, et al. Systemic inflammation in unstable angina is the result of myocardial necrosis. J Am Coll Cardiol. 2002;39:1917-1923.
91. Yamamoto H, Uemura S, Tomoda Y, et al. Transcardiac gradient of soluble adhesion molecules predicts progression of coronary artery disease. Int J Cardiol. 2002;84:249-257.
92. Moreno PR, Purushothaman KR, Fuster V, et al. Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability. Circulation. 2002;105:2504-2511.
93. Friedman M, Van den Borenkamp G.J. The pathogenesis of a coronary thrombus. Am J Pathol. 1966;48:19-44.
94. Friedman M. The pathogenesis of coronary plaques, thromboses, and hemorrhages: an evaluative review. Circulation. 1975;52(suppl III): III34-III40.
95. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial function. Circulation. 2002;106:653-658.