Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 16, Issue 8, 1996, Pages 1074-1079

  Ameli, Sean ^a   Hultgårdh Nilsson, Anna ^b   Regnström, Jan ^c   Calara, Federico ^a   Yano, Juliana ^a   Cercek, Bojan ^a   Shah, Prediman K ^a   Nilsson, Jan ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

atherosclerosis; autoimmunity; lipoproteins; oxidation

Indexed keywords

LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; AUTOIMMUNITY; HYPERCHOLESTEROLEMIA; IMMUNE RESPONSE; IMMUNIZATION; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT;

EID: 0029793720     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.16.8.1074     Document Type: Article

References (31)

1. Jonasson L, Holm J, Skalli O, Bondjers G, Hansson GK. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis. 1986;6:131-138.
2. Gown AM, Tsukada T, ROSS R. Human atherosclerosis, II: immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol. 1986;125:191-207.
3. Emeson EE, Robertson AL. T lymphocytes in aortic and coronary intimas: their potential role in atherogenesis. Am J Pathol. 1988;130:369-376.
4. Hansson G, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989;135:169-175.
5. Stemme S, Holm J, Hansson GK. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler Thromb. 1992;12:206-211.
6. Minick CR, Murphy GE. Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet, II: effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet. Am J Pathol. 1973;73:265-292.
7. Xu Q, Dietrich H, Steiner HJ, Gown AM, Shoel B, Mikuz G, Kaufmann S, Wick G. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65, Arterioscler Thromb. 1992;12:789-799.
8. Roselaar SE, Schonfeld G, Daugherty A. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. J Clin Invest. 1995;96:1389-1394.
9. Hansson G, Holm J, Holm S, Fotev Z, Hedric HJ, Fingerle J. T lymphocytes inhibit the vascular response to injury. Proc Natl Acad Sci U S A. 1991;88:10530-10534.
10. Stemme S, Faber B, Holm J, Wiklund O, Witztum J, Hansson GK. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein, Proc Natl Acad Sci USA. 1995;92:3893-3897.
11. Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
12. Salonen JT, Ylä-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssönen K, Palinski W, Witztum J. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet. 1992;339:883-887.
13. Palinski W, Ord V, Plump AS, Breslow JL, Steinberg D, Witztum J. Apoprotein E-deficient mice are a model for lipoprotein oxidation in atherogenesis: demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb. 1994;14:605-616.
14. Maggi E, Chiesa R, Melissano G, Castellano R, Astore D, Grossi A, Finardi G, Bellomo G. LDL oxidation markers in patients with severe carotid atherosclerosis: a study of in vitro and in vivo oxidation markers. Arterioscler Thromb. 1994;14:1892-1899.
15. Ylä-Herttuala S, Palinsky W, Butler S, Picard S, Steinberg D, Witztum J. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized low density lipoprotein. Arterioscler Thromb. 1994;14:32-40.
16. Frostegård J, Wu R, Giscombe R, Holm G, Lefvert AK, Nilsson J. Induction of T cell activation by oxidized low density lipoprotein. Arterioscler Thromb. 1992;12:461-467.
17. Cathcart MK, McNally AK, Morel DW, Chisholm GM, Superoxide anion participation in human monocyte-mediated oxidation of low density lipoprotein and conversion of low density lipoprotein to a cytotoxin. J Immunol. 1989;142:1963-1969.
18. Chisholm GM, Ma G, Irwin KC, Martin LL, Gunderson KG, Linberg LF, Morel DW, DiCorleto PE. 7β-Hydroperoxycholset-5-en3β-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein. Proc Natl Acad Sci USA. 1994;91:11452-11456.
19. Regnström J, Nilsson J. Lipid oxidation and inflammatory-induced intimal fibrosis in coronary heart disease. J Lab Clin Med. 1994;124:162-168.
20. Palinski W, Miller E, Witztum J. Immunization of low density lipoprotein (LDL) receptor deficient rabbits with homologous malondialdehyde-modified LDL reduces atherosclerosis. Proc Natl Acad Sci USA. 1995;92:821-825.
21. Redgrave TG, Roberts DCK, West CE. Separation of plasma lipoproteins by density gradient ultracentrifugation. Anal Biochem. 1975;65:42-49.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
23. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94:2493-2503.
24. Ameli S, Hultgårdh-Niisson A, Cercek B, Shah PK, Forrester JS, Ageland H, Nilsson J. Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits. Circulation. 1994;90:1935-1941.
25. Libby P, Hansson GK. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-15.
26. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA. 1984;81:3883-3887.
27. Chisholm G. Cytotoxicity of oxidized lipoproteins. Curr Opin Lipidol 1991;2:311-316.
28. Liao F, Andalibi A, Lusis AJ, Fogelman AM. Genetic control of the inflammatory response induced by oxidized lipids. Am J Cardiol. 1995;75:65B-66B.
29. Fyfe AI, Qiao JH, Lusis AJ. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest. 1994;94:2516-2520.
30. Roth RI, Gaubatz JW, Gotto AM, Patsch JR. Effect of cholesterol feeding on the distribution of plasma lipoproteins and on the metabolism of apolipoprotein E in the rabbit. J Lipid Res. 1983;24:1-11.
31. Miyazawa T, Fujimoto K, Oikawa S. Determination of lipid hydroperoxides in low density lipoprotein from human plasma using high performance liquid chromatography with chemiluminescence. Biochem Chromatogr. 1990;4:131-134.