Elevated systemic TGF-β impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE -/- mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 2, 2010, Pages

  Buday, Anna ^a   Orsy, Petra ^a   Godó, Mária ^a   Mózes, Miklós ^a   Kökény, Gábor ^a   Lacza, Zsombor ^a   Koller, Ákos ^a,b   Ungvári, Zoltán ^b   Gross, Marie Luise ^c   Benyó, Zoltán ^a   Hamar, Péter ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aorta; Apolipoprotein E deficient mice; Nicotinamide adenine dinucleotide phosphate; Oxidative stress; Transforming growth factor

Indexed keywords

APOCYNIN; APOLIPOPROTEIN E; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; CAPILLARY DENSITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; HYPERLIPOPROTEINEMIA TYPE 3; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; THORACIC AORTA;

ACETOPHENONES; ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOOD PRESSURE; BODY WEIGHT; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; FREE RADICAL SCAVENGERS; HEART DISEASES; HUMANS; HYPERTENSION; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIUM; NADPH OXIDASE; NITRIC OXIDE; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SUPEROXIDE DISMUTASE; SUPEROXIDES; SWINE; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; VASODILATION; VENTRICULAR REMODELING;

EID: 77955434953     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01042.2009     Document Type: Article

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