Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis

Atherosclerosis

Volumn 234, Issue 2, 2014, Pages 265-269

  Cheng, Hsin Yuan ^a   Wu, Runpei ^a   Hedrick, Catherine C ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Atherosclerosis; Cholesterol; Gammadelta

Indexed keywords

APOLIPOPROTEIN E; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPROTEIN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; LIPID; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; KNOCKOUT MOUSE; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; AORTA; AORTA DISEASE; BLOOD; DEFICIENCY; DISEASE MODEL; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; RISK FACTOR; T LYMPHOCYTE SUBPOPULATION; TIME; WESTERN DIET;

ANIMALS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CYTOKINES; DIET, WESTERN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; LIPIDS; MALE; MICE, KNOCKOUT; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RISK FACTORS; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 84900853070     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.03.007     Document Type: Article

References (15)

1. Xie J.J., Wang J., Tang T.T., et al. The th17/treg functional imbalance during atherogenesis in apoE(-/-) mice. Cytokine 2010, 49:185-193.
2. Nilsson J., Wigren M., Shah P.K. Regulatory t cells and the control of modified lipoprotein autoimmunity-driven atherosclerosis. Trends Cardiovasc Med 2009, 19:272-276.
3. Lichtman A.H. Adaptive immunity and atherosclerosis: mouse tales in the AJP. Am J Pathol 2013, 182:5-9.
4. Kleindienst R., Xu Q., Willeit J., Waldenberger F.R., Weimann S., Wick G. Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and t lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions. Am J Pathol 1993, 142:1927-1937.
5. Kapsenberg M.L. Gammadelta t cell receptors without a job. Immunity 2009, 31:181-183.
6. Cheng H.Y., Wu R., Gebre A.K., et al. Increased cholesterol content in gammadelta (gammadelta) t lymphocytes differentially regulates their activation. PloS One 2013, 8:e63746.
7. Millonig G., Malcom G.T., Wick G. Early inflammatory-immunological lesions in juvenile atherosclerosis from the pathobiological determinants of atherosclerosis in youth (pday)-study. Atherosclerosis 2002, 160:441-448.
8. Vanderlaan P.A., Reardon C.A. Thematic review series: the immune system and atherogenesis. The unusual suspects:An overview of the minor leukocyte populations in atherosclerosis. JLipid Res 2005, 46:829-838.
9. Jensen K.D., Su X., Shin S., et al. Thymic selection determines gammadelta t cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 2008, 29:90-100.
10. Roark C.L., Simonian P.L., Fontenot A.P., Born W.K., O'Brien R.L. Gammadelta t cells: an important source of il-17. Curr Opin Immunol 2008, 20:353-357.
11. Smith E., Prasad K.M., Butcher M., et al. Blockade of interleukin-17a results in reduced atherosclerosis in apolipoprotein e-deficient mice. Circulation 2010, 121:1746-1755.
12. Kostogrys R.B., Franczyk-Zarow M., Maslak E., et al. Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein e/low-density lipoprotein receptor double knockout mice (apoE/LDLR(-/-)). Atherosclerosis 2012, 223:327-331.
13. Hanna R.N., Shaked I., Hubbeling H.G., et al. Nr4a1 (nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res 2012, 110:416-427.
14. Kones R. Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: Implications of new evidence upon optimizing cardiovascular patient outcomes. Vasc Health Risk Manag 2013, 9:617-670.
15. Elhage R., Gourdy P., Brouchet L., et al. Deleting tcr alpha beta+ or cd4+ t lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein e-deficient mice. Am J Pathol 2004, 165:2013-2018.