Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

Journal of Clinical Investigation

Volumn 109, Issue 6, 2002, Pages 745-753

  Caligiuri, Giuseppina ^a   Nicoletti, Antonino ^a,b   Poirierand, Bruno ^b   Hansson, Göran K ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HÔPITAL BROUSSAIS   (France)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CD4 ANTIGEN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ATHEROSCLEROSIS; B LYMPHOCYTE; BLOOD VESSEL INJURY; CELL PROLIFERATION; CELL TRANSFER; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERCHOLESTEROLEMIA; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOMAGNETIC SEPARATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLENECTOMY; T LYMPHOCYTE SUBPOPULATION;

EID: 0036193513     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7272     Document Type: Article

References (44)

1. Atherosclerosis: An inflammatory disease
2. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atheroscleroric plaque
3. T lymphocytes from human atherosclerotic plaques recognize oxidized LDL
4. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL
5. Autoantibody against oxidised LDL and progression of carotid atherosclerosis
6. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis
7. Serological, evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction
8. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
9. Severe hypercholescerotemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
10. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse
11. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice
12. Requirement for CD 154 in the progression of atherosclerosis
13. Transfer of CD4+ T cells aggravates atherosclerosis in immunodeficient apoE knockout mice
14. Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice
15. Reduction of atherosclerosis in mice by inhibition of CD40 signalling
16. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis
17. Immunization with homologous oxidized low density lipoprotein reduces neointimal formation after balloon injury in hypercholesterolemic rabbits
18. Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis
19. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes
20. Protection against atherosclerosis by LDL immunization is associated with T cell dependent IgG antibodies in apoE-deFicient mice
21. Protective role of interleukin-10 in atherosclerosis
22. Interleukin-10 blocks atherosclerotic events in vitro and in vivo
23. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: Evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells
24. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins From apoIipoprorein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
25. Immunological functions of splenic B-lymphocytes
26. Immunogenicity of lipid-conjugated antigens. II. Anti-complementary activity and antigen trapping in the spleen
27. Functions of the spleen in host defense against infection
28. Immune response after splenectomy
29. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice
30. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice
31. ELISA of IgG antibody to oxidized low-density lipoprotein: Effects of blocking buffer and method of data expression
32. Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes
33. Visualizing the generation of memory CD4 T cells in the whole body
34. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
35. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
36. Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations (beta)VLDL catabolism, and atherosclerosis
37. Altered immune responses in apolipoprotein E-deficient mice
38. Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA
39. Anti-idiotype and immunosuppressant treatment of murine lupus
40. Immunomodulation of autoimmune disease with normal polyspecific immunoglobulin G (intravenous immunoglobulin)
41. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
42. Myelin basic protein-specific T lymphocytes induce chronic relapsing experimental autoimmune encephalomyelitis in lymphocyte-deficient (SCID) mice
43. Cross-regulatory roles of inteleukin (IL)-12 and IL-10 in atherosclerosis
44. In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice