Bioactive polymeric scaffolds for tissue engineering

Bioactive Materials

Volumn 1, Issue 2, 2016, Pages 93-108

  Stratton, Scott ^a,b   Shelke, Namdev B ^a   Hoshino, Kazunori ^b   Rudraiah, Swetha ^c   Kumbar, Sangamesh G ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b University of Connecticut   (United States)

^c UNIVERSITY OF SAINT JOSEPH   (United States)

Author keywords

Bioactive; Biodegradable; Biomaterials; Porosity; Scaffold; Tissue regeneration

Indexed keywords

BONE SIALOPROTEIN; CHITOSAN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 5; HYALURONIC ACID; MACROGOL; NANOFIBER; NANOPARTICLE; NITRIC OXIDE; OSTEOCALCIN; OSTEONECTIN; PLATELET DERIVED GROWTH FACTOR; POLYACRYLIC ACID; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIC ACID; POLYPROPYLENE; SILK; TENASCIN; VASCULOTROPIN;

ACHILLES TENDON; ANALYTIC METHOD; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; BIOCOMPATIBILITY; BIOLOGICAL ACTIVITY; BONE MARROW STROMA CELL; BONE REGENERATION; CELL GROWTH; CENTRAL NERVOUS SYSTEM; DEGRADATION; DRUG DELIVERY SYSTEM; HYDROGEL; LIGAMENT REGENERATION; LITHOGRAPHY; MUSCLE REGENERATION; NERVE REGENERATION; PARTICLE SINTERING; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; SALT LEACHING; STEM CELL; TENDON REGENERATION; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE SCAFFOLD;

EID: 85016468108     PISSN: 2452199X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioactmat.2016.11.001     Document Type: Review

References (200)

1. R. Langer, J.P. Vacanti, Tissue engineering, Science 260 (1993) 920-926.
2. P. Lee, K. Tran, W. Chang, Y.-L. Fang, G. Zhou, R. Junka, et al., Bioactive polymeric scaffolds for osteochondral tissue engineering: in vitro evaluation of the effect of culture media on bone marrow stromal cells, Polym. Adv. Technol. 26 (2015) 1476-1485.
3. P. Lee, K. Tran, G. Zhou, A. Bedi, N.B. Shelke, X. Yu, et al., Guided differentiation of bone marrow stromal cells on co-cultured cartilage and bone scaffolds, Soft Matter 11 (2015) 7648-7655.
4. P. Lee, K. Tran, W. Chang, N.B. Shelke, S.G. Kumbar, X. Yu, Influence of chondroitin sulfate and hyaluronic acid presence in nanofibers and its alignment on the bone marrow stromal cells: cartilage regeneration, J. Biomed. Nanotechnol. 10 (2014) 1469-1479.
5. E. Piskin, Biodegradable polymers as biomaterials, J. Biomater. Sci. Polym. Ed. 6 (1995) 775-795.
6. N. Shelke, R. Nagarale, S. Kumbar, Chapter 7-Polyurethanes, in: S.G. Kumbar, C. Laurencin, M. Meng Deng (Eds.), Natural and Synthetic Biomedical Polymers, 2014, pp. 123-144.
7. N.B. Shelke, R. James, C.T. Laurencin, S.G. Kumbar, Polysaccharide biomaterials for drug delivery and regenerative engineering, Polym. Adv. Technol. 25 (2014) 448-460.
8. B. Dhandayuthapani, Y. Yoshida, T. Maekawa, D.S. Kumar, Polymeric scaffolds in tissue engineering application: a review, Int. J. Polym. Sci. 2011 (2011).
9. F.A. Müller, L. Müller, I. Hofmann, P. Greil, M.M. Wenzel, R. Staudenmaier, Cellulose-based scaffold materials for cartilage tissue engineering, Biomaterials 27 (2006) 3955-3963.
10. G. Narayanan, B.S. Gupta, A.E. Tonelli, Poly(ε-caprolactone) nanowebs functionalized with α- and γ-cyclodextrins, Biomacromolecules 15 (2014) 4122-4133.
11. N.B. Shelke, M. Anderson, S. Idrees, M.J. Nip, S. Donde, X. Yu, et al., Handbook of Polyester Drug Delivery Systems, Pan Stanford, 2016, pp. 595-649.
12. M. Shoichet, R. Wylie, Y. Aizawa, R. Tam, S. Owen, Three dimensional hydrogel scaffolds and applications in the CNS, FASEB J. 29 (2015), 13.12.
13. W. Bonfield, Designing porous scaffolds for tissue engineering, Philos. Trans. R. Soc. Lond. A Math. Phys. Eng. Sci. 364 (2006) 227-232.
14. J. Zeltinger, J.K. Sherwood, D.A. Graham, R. Müeller, L.G. Griffith, Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition, Tissue Eng. 7 (2001) 557-572.
15. F.J. O’Brien, B. Harley, I.V. Yannas, L.J. Gibson, The effect of pore size on cell adhesion in collagen-GAG scaffolds, Biomaterials 26 (2005) 433-441.
16. B. Chan, K. Leong, Scaffolding in tissue engineering: general approaches and tissue-specific considerations, Eur. Spine J. 17 (2008) 467-479.
17. J.M. Holzwarth, P.X. Ma, 3D nanofibrous scaffolds for tissue engineering, J. Mater. Chem. 21 (2011) 10243-10251.
18. X. Liu, J.M. Holzwarth, P.X. Ma, Functionalized synthetic biodegradable polymer scaffolds for tissue engineering, Macromol. Biosci. 12 (2012) 911-919.
19. S. Kumbar, R. James, S. Nukavarapu, C. Laurencin, Electrospun nanofiber scaffolds: engineering soft tissues, Biomed. Mater. 3 (2008) 034002.
20. S.J. Lee, J.J. Yoo, G.J. Lim, A. Atala, J. Stitzel, In vitro evaluation of electrospun nanofiber scaffolds for vascular graft application, J. Biomed. Mater. Res. Part A 83 (2007) 999-1008.
21. J. Zhu, R.E. Marchant, Design properties of hydrogel tissue-engineering scaffolds, Expert Rev. Med. Devices 8 (2011) 607-626.
22. N.B. Shelke, P. Lee, M. Anderson, N. Mistry, R.K. Nagarale, X.M. Ma, et al., Neural tissue engineering: nanofiber-hydrogel based composite scaffolds, Polym. Adv. Technol. 27 (2016) 42-51.
23. D. Chau, K. Agashi, K. Shakesheff, Microparticles as tissue engineering scaffolds:manufacture, modification and manipulation, Mater. Sci. Technol. 24 (2008) 1031-1044.
24. S.K. Sahoo, A.K. Panda, V. Labhasetwar, Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells, Biomacromolecules 6 (2005) 1132-1139.
25. D.M. García Cruz, J.L. Escobar Ivirico, M.M. Gomes, J.L. Gómez Ribelles, M.S. Sánchez, R.L. Reis, et al., Chitosan microparticles as injectable scaffolds for tissue engineering, J. Tissue Eng. Regen. Med. 2 (2008) 378-380.
26. N.B. Shelke, R. Kadam, P. Tyagi, V.R. Rao, U.B. Kompella, Intravitreal poly(llactide) microparticles sustain retinal and choroidal delivery of TG-0054, a hydrophilic drug intended for neovascular diseases, Drug Deliv. Transl. Res. 1 (2011) 76-90.
27. D. Rana, H. Zreiqat, N. Benkirane-Jessel, S. Ramakrishna, M. Ramalingam, Development of decellularized scaffolds for stem cell-driven tissue engineering, J. Tissue Eng. Regen. Med. (2015) 26119160, http://dx.doi.org/10.1002/term.2061.
28. S. Zia, M. Mozafari, G. Natasha, A. Tan, Z. Cui, A.M. Seifalian, Hearts beating through decellularized scaffolds: whole-organ engineering for cardiac regeneration and transplantation, Crit. Rev. Biotechnol. 36 (2016) 705-715.
29. A. Crabbé, Y. Liu, S.F. Sarker, N.R. Bonenfant, J. Barrila, Z.D. Borg, et al., Recellularization of Decellularized Lung Scaffolds Is Enhanced by Dynamic Suspension Culture. 10 (2015) e0126846.
30. H. Rasti, N. Saghiri, J. Baharara, N. Mahdavi-Shahri, M. Marjani, S.H. Alavi, et al., Differentiation of blastema cells in decellularized bladder scaffold in vitro, Zahedan J. Res. Med. Sci. 17 (2015) e960.
31. C.B. Highley, C.B. Rodell, J.A. Burdick, Direct 3D printing of shear-thinning hydrogels into self-healing hydrogels, Adv. Mater. 27 (2015) 5075-5079.
32. Y. Zhang, H. Ouyang, C.T. Lim, S. Ramakrishna, Z.M. Huang, Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds, J. Biomed. Mater. Res. Part B Appl. Biomater. 72 (2005) 156-165.
33. I. Gerçek, R. Tığlı, M. Gümüşderelioğlu, A novel scaffold based on formation and agglomeration of PCL microbeads by freeze-drying, J. Biomed. Mater. Res. Part A 86 (2008) 1012-1022.
34. C. Kazimoğlu, S. Bölükbaşi, U. Kanatli, A. Senköylü, N. Altun, C. Babac, et al., A novel biodegradable PCL film for tendon reconstruction: Achilles tendon defect model in rats, Int. J. Artif. Organs 26 (2003) 804-812.
35. M. Alves da Silva, A. Martins, A. Costa-Pinto, P. Costa, S. Faria, M. Gomes, et al., Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs, Biomacromolecules 11 (2010) 3228-3236.
36. H. Yoshimoto, Y. Shin, H. Terai, J. Vacanti, A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering, Biomaterials 24 (2003) 2077-2082.
37. G. Narayanan, B.S. Gupta, A.E. Tonelli, Enhanced mechanical properties of poly (ε-caprolactone) nanofibers produced by the addition of nonstoichiometric inclusion complexes of poly (ε-caprolactone) and a-cyclodextrin, Polymer 76 (2015) 321-330.
38. A.A. Nada, R. James, N.B. Shelke, M.D. Harmon, H.M. Awad, R.K. Nagarale, et al., A smart methodology to fabricate electrospun chitosan nanofiber matrices for regenerative engineering applications, Polym. Adv. Technol. 25 (2014) 507-515.
39. M.A. Woodruff, D.W. Hutmacher, The return of a forgotten polymerdpolycaprolactone in the 21st century, Prog. Polym. Sci. 35 (2010) 1217-1256.
40. A.J. Domb, J. Kost, D. Wiseman, Handbook of Biodegradable Polymers, vol. 7, CRC Press, 1998.
41. K. Lowry, K. Hamson, L. Bear, Y. Peng, R. Calaluce, M. Evans, et al., Polycaprolactone/ glass bioabsorbable implant in a rabbit humerus fracture model, J. Biomed. Mater. Res. 36 (1997) 536-541.
42. B.D. Ulery, L.S. Nair, C.T. Laurencin, Biomedical applications of biodegradable polymers, J. Polym. Sci. Part B Polym. Phys. 49 (2011) 832-864.
43. R. Chandra, R. Rustgi, Biodegradable polymers, Prog. Polym. Sci. 23 (1998) 1273-1335.
44. M. Okada, Chemical syntheses of biodegradable polymers, Prog. Polym. Sci. 27 (2002) 87-133.
45. L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials, Prog. Polym. Sci. 32 (2007) 762-798.
46. A. Cipitria, A. Skelton, T. Dargaville, P. Dalton, D. Hutmacher, Design, fabrication and characterization of PCL electrospun scaffoldsda review, J. Mater. Chem. 21 (2011) 9419-9453.
47. Z. Cheng, S.-H. Teoh, Surface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen, Biomaterials 25 (2004) 1991-2001.
48. D. Simon, A. Holland, R. Shanks, Poly(caprolactone) thin film preparation, morphology, and surface texture, J. Appl. Polym. Sci. 103 (2007) 1287-1294.
49. G. Narayanan, R. Aguda, M. Hartman, C.-C. Chung, R. Boy, B.S. Gupta, et al., Fabrication and characterization of poly(ε-caprolactone)/a-cyclodextrin pseudorotaxane nanofibers, Biomacromolecules 17 (2016) 271-279.
50. K.Y. Chang, L.H. Hung, I. Chu, C.S. Ko, Y.D. Lee, The application of type II collagen and chondroitin sulfate grafted PCL porous scaffold in cartilage tissue engineering, J. Biomed. Mater. Res. Part A 92 (2010) 712-723.
51. R. Izquierdo, N. Garcia-Giralt, M. Rodriguez, E. Caceres, S. Garcia, J. Gomez Ribelles, et al., Biodegradable PCL scaffolds with an interconnected spherical pore network for tissue engineering, J. Biomed. Mater. Res. Part A 85 (2008) 25-35.
52. R.L. Kronenthal, Polymers in Medicine and Surgery, Springer, 1975, pp. 119-137.
53. R.S. Narins, W.P. Coleman, R.G. Glogau, Recommendations and treatment options for nodules and other filler complications, Dermatol. Surg. 35 (2009) 1667-1671.
54. R.A. Hule, D.J. Pochan, Polymer nanocomposites for biomedical applications, Mrs Bull. 32 (2007) 354-358.
55. C. Shasteen, Y. Choy, Controlling degradation rate of poly(lactic acid) for its biomedical applications, Biomed. Eng. Lett. 1 (2011) 163-167.
56. A.J. Lasprilla, G.A. Martinez, B.H. Lunelli, A.L. Jardini, R. Maciel Filho, Polylactic acid synthesis for application in biomedical devicesda review, Biotechnol. Adv. 30 (2012) 321-328.
57. K. Fukushima, Y. Kimura, An efficient solid-state polycondensation method for synthesizing stereocomplexed poly (lactic acid) s with high molecular weight, J. Polym. Sci. Part A Polym. Chem. 46 (2008) 3714-3722.
58. W. Cui, L. Cheng, C. Hu, H. Li, Y. Zhang, J. Chang, Electrospun poly (L-lactide) fiber with ginsenoside rg3 for inhibiting scar hyperplasia of skin, PloS One 8 (2013) e68771.
59. P. Gentile, V. Chiono, I. Carmagnola, P.V. Hatton, An overview of poly (lacticco- glycolic) acid (PLGA)-based biomaterials for bone tissue engineering, Int. J. Mol. Sci. 15 (2014) 3640-3659.
60. A. Göpferich, Mechanisms of polymer degradation and erosion, Biomaterials 17 (1996) 103-114.
61. F. Danhier, E. Ansorena, J.M. Silva, R. Coco, A. Le Breton, V. Préat, PLGA-based nanoparticles: an overview of biomedical applications, J. Control. Release 161 (2012) 505-522.
62. C. Holy, J. Davies, M. Shoichet, Bone Tissue Engineering on Biodegradable Polymers: Preparation of a Novel Poly (Lactide-co-glycolide) Foam, American Institute of Chemical Engineers, 1997.
63. E.M.E. On, Bone marrow cell colonization of, and extracellular matrix expression on, biodegradable polymers, Cells Mater. 7 (1997) 223-234.
64. S.L. Ishaug, G.M. Crane, M.J. Miller, A.W. Yasko, M.J. Yaszemski, A.G. Mikos, Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds, J. Biomed. Mater. Res. 36 (1997) 17-28.
65. O. Kerimoğlu, E. Alarçin, Poly (lactic-co-glycolic acid) based drug delivery devices for tissue engineering and regenerative medicine, Ankem Derg. 26 (2012) 86-98.
66. M. Houchin, E. Topp, Chemical degradation of peptides and proteins in PLGA:a review of reactions and mechanisms, J. Pharm. Sci. 97 (2008) 2395-2404.
67. E. Locatelli, M. Comes Franchini, Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system, J. Nanopart. Res. 14 (2012) 1-17.
68. N. Faisant, J. Siepmann, J. Benoit, PLGA-based microparticles: elucidation of mechanisms and a new, simple mathematical model quantifying drug release, Eur. J. Pharm. Sci. 15 (2002) 355-366.
69. N.B. Shelke, A.P. Rokhade, T.M. Aminabhavi, Preparation and evaluation of novel blend microspheres of poly(lactic-co-glycolic)acid and pluronic F68/127 for controlled release of repaglinide, J. Appl. Polym. Sci. 116 (2010) 366-372.
70. T. Ren, J. Ren, X. Jia, K. Pan, The bone formation in vitro and mandibular defect repair using PLGA porous scaffolds, J. Biomed. Mater. Res. Part A 74A (2005) 562-569.
71. R.C. Thomson, M.J. Yaszemski, J.M. Powers, A.G. Mikos, Fabrication of biodegradable polymer scaffolds to engineer trabecular bone, J. Biomater. Sci. Polym. Ed. 7 (1996) 23-38.
72. Y. Wang, H.-J. Kim, G. Vunjak-Novakovic, D.L. Kaplan, Stem cell-based tissue engineering with silk biomaterials, Biomaterials 27 (2006) 6064-6082.
73. C. Vepari, D.L. Kaplan, Silk as a biomaterial, Prog. Polym. Sci. 32 (2007) 991-1007.
74. Y. Yang, F. Ding, J. Wu, W. Hu, W. Liu, J. Liu, et al., Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration, Biomaterials 28 (2007) 5526-5535.
75. O. Hakimi, D.P. Knight, F. Vollrath, P. Vadgama, Spider and mulberry silkworm silks as compatible biomaterials, Compos. Part B Eng. 38 (2007) 324-337.
76. O. Etienne, A. Schneider, J.A. Kluge, C. Bellemin-Laponnaz, C. Polidori, G.G. Leisk, et al., Soft tissue augmentation using silk gels: an in vitro and in vivo study, J. Periodontol. 80 (2009) 1852-1858.
77. Y. Wang, D.J. Blasioli, H.-J. Kim, H.S. Kim, D.L. Kaplan, Cartilage tissue engineering with silk scaffolds and human articular chondrocytes, Biomaterials 27 (2006) 4434-4442.
78. T. Kardestuncer, M. McCarthy, V. Karageorgiou, D. Kaplan, G. Gronowicz, RGD-tethered silk substrate stimulates the differentiation of human tendon cells, Clin. Orthop. Relat. Res. 448 (2006) 234-239.
79. Z.-x. Cai, X.-m. Mo, K.-h. Zhang, L.-p. Fan, A.-l. Yin, C.-l. He, et al., Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications, Int. J. Mol. Sci. 11 (2010) 3529-3539.
80. R. Okabayashi, M. Nakamura, T. Okabayashi, Y. Tanaka, A. Nagai, K. Yamashita, Efficacy of polarized hydroxyapatite and silk fibroin composite dressing gel on epidermal recovery from full-thickness skin wounds, J. Biomed. Mater. Res. Part B Appl. Biomater. 90B (2009) 641-646.
81. B.B. Mandal, S.C. Kundu, Cell proliferation and migration in silk fibroin 3D scaffolds, Biomaterials 30 (2009) 2956-2965.
82. M.L. Lovett, C.M. Cannizzaro, G. Vunjak-Novakovic, D.L. Kaplan, Gel spinning of silk tubes for tissue engineering, Biomaterials 29 (2008) 4650-4657.
83. R. Parenteau-Bareil, R. Gauvin, F. Berthod, Collagen-based biomaterials for tissue engineering applications, Materials 3 (2010) 1863-1887.
84. S.M. Oliveira, R.A. Ringshia, R.Z. Legeros, E. Clark, M.J. Yost, L. Terracio, et al., An improved collagen scaffold for skeletal regeneration, J. Biomed. Mater. Res. Part A 94 (2010) 371-379.
85. Y. Pang, H.P. Greisler, Using a type I collagen based system to understand cell-scaffold interactions and to deliver chimeric collagen binding growth factors for vascular tissue engineering, J. Investig. Med. Off. Publ. Am. Fed. Clin. Res. 58 (2010) 845-848.
86. S.M. Vickers, L.S. Squitieri, M. Spector, Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation, Tissue Eng. 12 (2006) 1345-1355.
87. C.P. Barnes, C.W. Pemble IV, D.D. Brand, D.G. Simpson, G.L. Bowlin, Crosslinking electrospun type II collagen tissue engineering scaffolds with carbodiimide in ethanol, Tissue Eng. 13 (2007) 1593-1605.
88. D. Ceballos, X. Navarro, N. Dubey, G. Wendelschafer-Crabb, W.R. Kennedy, R.T. Tranquillo, Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration, Exp. Neurol. 158 (1999) 290-300.
89. A. Aravamudhan, D.M. Ramos, J. Nip, M.D. Harmon, R. James, M. Deng, et al., Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering, J. Biomed. Nanotechnol. 9 (2013) 719-731.
90. Y.K. Lin, D.C. Liu, Comparison of physicalechemical properties of type I collagen from different species, Food Chem. 99 (2006) 244-251.
91. E.C. Chan, S.-M. Kuo, A.M. Kong, W.A. Morrison, G.J. Dusting, G.M. Mitchell, et al., Three dimensional collagen scaffold promotes intrinsic vascularisation for tissue engineering applications, PloS One 11 (2016) e0149799.
92. S. Zhong, W.E. Teo, X. Zhu, R.W. Beuerman, S. Ramakrishna, L.Y.L. Yung, An aligned nanofibrous collagen scaffold by electrospinning and its effects on in vitro fibroblast culture, J. Biomed. Mater. Res. Part A 79 (2006) 456-463.
93. A. Aravamudhan, D. Ramos, N. Jenkins, N. Dyment, M. Sanders, D. Rowe, et al., Collagen nanofibril self-assembly on a natural polymeric material for the osteoinduction of stem cells in vitro and biocompatibility in vivo, RSC Adv. 6 (2016) 80851-80866.
94. E. Sachlos, N. Reis, C. Ainsley, B. Derby, J. Czernuszka, Novel collagen scaffolds with predefined internal morphology made by solid freeform fabrication, Biomaterials 24 (2003) 1487-1497.
95. J. Necas, L. Bartosikova, P. Brauner, J. Kolar, Hyaluronic acid (hyaluronan): a review, Veterinarni Med. 53 (2008) 397-411.
96. S.A. Unterman, M. Gibson, J.H. Lee, J. Crist, T. Chansakul, E.C. Yang, et al., Hyaluronic acid-binding scaffold for articular cartilage repair, Tissue Eng. Part A 18 (2012) 2497-2506.
97. X. Wang, J. He, Y. Wang, F.-Z. Cui, Hyaluronic acid-based scaffold for central neural tissue engineering, Interface Focus (2012) rsfs20120016.
98. J.B. Leach, C.E. Schmidt, Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds, Biomaterials 26 (2005) 125-135.
99. Y. Ji, K. Ghosh, X.Z. Shu, B. Li, J.C. Sokolov, G.D. Prestwich, et al., Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds, Biomaterials 27 (2006) 3782-3792.
100. T.G. Kim, H.J. Chung, T.G. Park, Macroporous and nanofibrous hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles, Acta Biomater. 4 (2008) 1611-1619.
101. I.P. Monteiro, A. Shukla, A.P. Marques, R.L. Reis, P.T. Hammond, Sprayassisted layer-by-layer assembly on hyaluronic acid scaffolds for skin tissue engineering, J. Biomed. Mater. Res. Part A 103 (2015) 330-340.
102. R. Gaetani, D.A. Feyen, V. Verhage, R. Slaats, E. Messina, K.L. Christman, et al., Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/ hyaluronic acid patch preserves cardiac function after myocardial infarction, Biomaterials 61 (2015) 339-348.
103. P.A. Levett, D.W. Hutmacher, J. Malda, T.J. Klein, Hyaluronic acid enhances the mechanical properties of tissue-engineered cartilage constructs, PloS One 9 (2014) e113216.
104. T. Chandy, C.P. Sharma, Chitosan-as a biomaterial, Artif. Cells, Blood Subst. Biotechnol. 18 (1990) 1-24.
105. M. Zhang, S. Jana, Google Patents, 2014.
106. C.T. Laurencin, T. Jiang, S.G. Kumbar, L.S. Nair, Biologically active chitosan systems for tissue engineering and regenerative medicine, Curr. Top. Med. Chem. 8 (2008) 354-364.
107. F. Croisier, C. Jérôme, Chitosan-based biomaterials for tissue engineering, Eur. Polym. J. 49 (2013) 780-792.
108. S. Chopra, S. Mahdi, J. Kaur, Z. Iqbal, S. Talegaonkar, F.J. Ahmad, Advances and potential applications of chitosan derivatives as mucoadhesive biomaterials in modern drug delivery, J. Pharm. Pharmacol. 58 (2006) 1021-1032.
109. M.Z. Albanna, T.H. Bou-Akl, O. Blowytsky, H.L. Walters, H.W. Matthew, Chitosan fibers with improved biological and mechanical properties for tissue engineering applications, J. Mech. Behav. Biomed. Mater. 20 (2013) 217-226.
110. R.A. Muzzarelli, F. Greco, A. Busilacchi, V. Sollazzo, A. Gigante, Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: a review, Carbohydr. Polym. 89 (2012) 723-739.
111. S.C. Neves, L.S.M. Teixeira, L. Moroni, R.L. Reis, C.A. Van Blitterswijk, N.M. Alves, et al., Chitosan/Poly (3-caprolactone) blend scaffolds for cartilage repair, Biomaterials 32 (2011) 1068-1079.
112. W. Xiao, X. Hu, W. Zeng, J. Huang, Y. Zhang, Z. Luo, Rapid sciatic nerve regeneration of rats by a surface modified collagenechitosan scaffold, Injury 44 (2013) 941-946.
113. W. Zeng, M. Rong, X. Hu, W. Xiao, F. Qi, J. Huang, et al., Incorporation of chitosan microspheres into collagen-chitosan scaffolds for the controlled release of nerve growth factor, PloS One 9 (2014) e101300.
114. F. Rengier, A. Mehndiratta, H. von Tengg-Kobligk, C.M. Zechmann, R. Unterhinninghofen, H.-U. Kauczor, et al., 3D printing based on imaging data: review of medical applications, Int. J. Comput. Assist. Radiol. Surg. 5 (2010) 335-341.
115. J.S. Naftulin, E.Y. Kimchi, S.S. Cash, Streamlined, inexpensive 3D printing of the brain and skull, PloS One 10 (2015) e0136198.
116. S.V. Murphy, A. Atala, 3D bioprinting of tissues and organs, Nat. Biotech. 32 (2014) 773-785.
117. C.L. Ventola, Medical applications for 3D printing: current and projected uses, Pharm. Ther. 39 (2014) 704-711.
118. B. Leukers, H. Gülkan, S.H. Irsen, S. Milz, C. Tille, M. Schieker, et al., Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing, J. Mater. Sci. Mater. Med. 16 (2005) 1121-1124.
119. K. Markstedt, A. Mantas, I. Tournier, H. Martínez Ávila, D. Hägg, P. Gatenholm, 3D bioprinting human chondrocytes with nanocelluloseealginate bioink for cartilage tissue engineering applications, Biomacromolecules 16 (2015) 1489-1496.
120. P.H. Warnke, H. Seitz, F. Warnke, S.T. Becker, S. Sivananthan, E. Sherry, et al., Ceramic scaffolds produced by computer-assisted 3D printing and sintering:characterization and biocompatibility investigations, J. Biomed. Mater. Res. Part B Appl. Biomater. 93 (2010) 212-217.
121. M. Lee, B.M. Wu, J.C. Dunn, Effect of scaffold architecture and pore size on smooth muscle cell growth, J. Biomed. Mater. Res. Part A 87 (2008) 1010-1016.
122. C. Liu, Z. Xia, Z. Han, P. Hulley, J. Triffitt, J. Czernuszka, Novel 3D collagen scaffolds fabricated by indirect printing technique for tissue engineering, J. Biomed. Mater. Res. Part B Appl. Biomater. 85 (2008) 519-528.
123. Q.P. Pham, U. Sharma, A.G. Mikos, Electrospinning of polymeric nanofibers for tissue engineering applications: a review, Tissue Eng. 12 (2006) 1197-1211.
124. S.G. Kumbar, L.S. Nair, S. Bhattacharyya, C.T. Laurencin, Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules, J. Nanosci. Nanotechnol. 6 (2006) 2591-2607.
125. Z.-M. Huang, Y.-Z. Zhang, M. Kotaki, S. Ramakrishna, A review on polymer nanofibers by electrospinning and their applications in nanocomposites, Compos. Sci. Technol. 63 (2003) 2223-2253.
126. R. James, U.S. Toti, C.T. Laurencin, S.G. Kumbar, Electrospun nanofibrous scaffolds for engineering soft connective tissues, Biomed. Nanotechnol. Methods Protoc. (2011) 243-258.
127. L.B. Hejazian, B. Esmaeilzade, F.M. Ghoroghi, F. Moradi, M.B. Hejazian, A. Aslani, et al., The role of biodegradable engineered nanofiber scaffolds seeded with hair follicle stem cells for tissue engineering, Iran. Biomed. J. 16 (2012) 193-201.
128. T. Subbiah, G. Bhat, R. Tock, S. Parameswaran, S. Ramkumar, Electrospinning of nanofibers, J. Appl. Polym. Sci. 96 (2005) 557-569.
129. J. Wang, Q.-s. Kang, X.-g. Lv, J. Song, N. Zhan, W.-g. Dong, et al., Simple patterned nanofiber scaffolds and its enhanced performance in immunoassay, PloS One 8 (2013) e82888.
130. E. Hammel, X. Tang, M. Trampert, T. Schmitt, K. Mauthner, A. Eder, et al., Carbon nanofibers for composite applications, Carbon 42 (2004) 1153-1158.
131. D. Li, J. Huang, R.B. Kaner, Polyaniline nanofibers: a unique polymer nanostructure for versatile applications, Acc. Chem. Res. 42 (2008) 135-145.
132. R. Jayakumar, M. Prabaharan, S. Nair, H. Tamura, Novel chitin and chitosan nanofibers in biomedical applications, Biotechnol. Adv. 28 (2010) 142-150.
133. J.A. Matthews, G.E. Wnek, D.G. Simpson, G.L. Bowlin, Electrospinning of collagen nanofibers, Biomacromolecules 3 (2002) 232-238.
134. J.M. Corey, D.Y. Lin, K.B. Mycek, Q. Chen, S. Samuel, E.L. Feldman, et al., Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth, J. Biomed. Mater. Res. Part A 83A (2007) 636-645.
135. J.M. Coburn, M. Gibson, S. Monagle, Z. Patterson, J.H. Elisseeff, Bioinspired nanofibers support chondrogenesis for articular cartilage repair, Proc. Natl. Acad. Sci. 109 (2012) 10012-10017.
136. Z. Chen, P. Wang, B. Wei, X. Mo, F. Cui, Electrospun collagenechitosan nanofiber: a biomimetic extracellular matrix for endothelial cell and smooth muscle cell, Acta Biomater. 6 (2010) 372-382.
137. E. Bat, B.H. Kothman, G.A. Higuera, C.A. van Blitterswijk, J. Feijen, D.W. Grijpma, Ultraviolet light crosslinking of poly (trimethylene carbonate) for elastomeric tissue engineering scaffolds, Biomaterials 31 (2010) 8696-8705.
138. N.N. Fathima, A. Dhathathreyan, T. Ramasami, J. Krägel, R. Miller, Degree of crosslinking of collagen at interfaces: adhesion and shear rheological indicators, Int. J. Biol. Macromol. 48 (2011) 67-73.
139. M.E. Frohbergh, A. Katsman, G.P. Botta, P. Lazarovici, C.L. Schauer, U.G. Wegst, et al., Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering, Biomaterials 33 (2012) 9167-9178.
140. L. Brannon-Peppas, Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery, Int. J. Pharm. 116 (1995) 1-9.
141. Y. Hu, J. Hollinger, K. Marra, Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds, J. Drug Target. 9 (2001) 431-438.
142. T. Yoshii, A.E. Hafeman, J.M. Esparza, A. Okawa, G. Gutierrez, S.A. Guelcher, Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora, J. Tissue Eng. Regen. Med. 8 (2014) 589-595.
143. H.E. Bergna, J.J. Kirkland, Google Patents, 1984.
144. H. Katou, A.J. Wandrey, B. Gander, Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication, Int. J. Pharm. 364 (2008) 45-53.
145. E.N. Antonov, V.N. Bagratashvili, M.J. Whitaker, J.J. Barry, K.M. Shakesheff, A.N. Konovalov, et al., Three-dimensional bioactive and biodegradable scaffolds fabricated by surface-selective laser sintering, Adv. Mater. 17 (2005) 327-330.
146. T. Jiang, W.I. Abdel-Fattah, C.T. Laurencin, In vitro evaluation of chitosan/poly (lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering, Biomaterials 27 (2006) 4894-4903.
147. J.L. Drury, D.J. Mooney, Hydrogels for tissue engineering: scaffold design variables and applications, Biomaterials 24 (2003) 4337-4351.
148. A.S. Hoffman, Hydrogels for biomedical applications, Adv. Drug Deliv. Rev. 64 (2012) 18-23.
149. D. Jaiswal, R. James, N.B. Shelke, M.D. Harmon, J.L. Brown, F. Hussain, et al., Gelatin nanofiber matrices derived from schiff base derivative for tissue engineering applications, J. Biomed. Nanotechnol. 11 (2015) 2067-2080.
150. E. Guadalupe, D. Ramos, N.B. Shelke, R. James, C. Gibney, S.G. Kumbar, Bioactive polymeric nanofiber matrices for skin regeneration, J. Appl. Polym. Sci. 132 (2015) 41879-41889.
151. K.Y. Lee, D.J. Mooney, Hydrogels for tissue engineering, Chem. Rev. 101 (2001) 1869-1880.
152. G.D. Nicodemus, S.J. Bryant, Cell encapsulation in biodegradable hydrogels for tissue engineering applications, Tissue Eng. Part B Rev. 14 (2008) 149-165.
153. R.H. Schmedlen, K.S. Masters, J.L. West, Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering, Biomaterials 23 (2002) 4325-4332.
154. P.J. Horner, F.H. Gage, Regenerating the damaged central nervous system, Nature 407 (2000) 963-970.
155. S.J. Davies, M.T. Fitch, S.P. Memberg, A.K. Hall, G. Raisman, J. Silver, Regeneration of adult axons in white matter tracts of the central nervous system, Nature 390 (1997) 680-683.
156. J. Scheib, A. Hoke, Advances in peripheral nerve regeneration, Nat. Rev. Neurol. 9 (2013) 668-676.
157. V. Chiono, C. Tonda-Turo, Trends in the design of nerve guidance channels in peripheral nerve tissue engineering, Prog. Neurobiol. 131 (2015) 87-104.
158. M. Anderson, N.B. Shelke, O.S. Manoukian, X. Yu, L.D. McCullough, S.G. Kumbar, Peripheral nerve regeneration strategies: electrically stimulating polymer based nerve growth conduits, Crit. Rev.™ Biomed. Eng. 43 (2015) 131-159.
159. T. Yamanaka, H. Hosoi, T. Murai, T. Kobayashi, Y. Inada, T. Nakamura, Regeneration of the nerves in the aerial cavity with an artificial nerve conduit-reconstruction of chorda tympani nerve gaps, PloS One 9 (2014) e92258.
160. J. Xie, M.R. MacEwan, W. Liu, N. Jesuraj, X. Li, D. Hunter, et al., Nerve guidance conduits based on double-layered scaffolds of electrospun nanofibers for repairing the peripheral nervous system, ACS Appl. Mater. Interfaces 6 (2014) 9472-9480.
161. J.D. White, S. Wang, A.S. Weiss, D.L. Kaplan, Silketropoelastin protein films for nerve guidance, Acta Biomater. 14 (2015) 1-10.
162. J. Cao, Z. Xiao, W. Jin, B. Chen, D. Meng, W. Ding, et al., Induction of rat facial nerve regeneration by functional collagen scaffolds, Biomaterials 34 (2013) 1302-1310.
163. T.C. Tseng, L. Tao, F.Y. Hsieh, Y. Wei, I.M. Chiu, S.H. Hsu, An injectable, selfhealing hydrogel to repair the central nervous system, Adv. Mater. (2015) 3518-3524.
164. G. Li, Y. Kong, Y. Zhao, Y. Zhao, L. Zhang, Y. Yang, Fabrication and characterization of polyacrylamide/silk fibroin hydrogels for peripheral nerve regeneration, J. Biomater. Sci. Polym. Ed. 26 (2015) 899-916.
165. N.D. Leipzig, M.S. Shoichet, The effect of substrate stiffness on adult neural stem cell behavior, Biomaterials 30 (2009) 6867-6878.
166. S. Bose, M. Roy, A. Bandyopadhyay, Recent advances in bone tissue engineering scaffolds, Trends Biotechnol. 30 (2012) 546-554.
167. X. Li, L. Wang, Y. Fan, Q. Feng, F.-Z. Cui, F. Watari, Nanostructured scaffolds for bone tissue engineering, J. Biomed. Mater. Res. Part A 101A (2013) 2424-2435.
168. C.J. Damien, J.R. Parsons, Bone graft and bone graft substitutes: a review of current technology and applications, J. Appl. Biomater. 2 (1991) 187-208.
169. J.P. Schmitz, J.O. Hollinger, S.B. Milam, Reconstruction of bone using calcium phosphate bone cements: a critical review, J. Oral Maxillofac. Surg. 57 (1999) 1122-1126.
170. W. Zhang, C. Zhu, D. Ye, L. Xu, X. Zhang, Q. Wu, et al., Porous silk scaffolds for delivery of growth factors and stem cells to enhance bone regeneration, PloS One 9 (2014) e102371.
171. E. Saiz, E.A. Zimmermann, J.S. Lee, U.G. Wegst, A.P. Tomsia, Perspectives on the role of nanotechnology in bone tissue engineering, Dent. Mater. 29 (2013) 103-115.
172. S. Deville, E. Saiz, A.P. Tomsia, Freeze casting of hydroxyapatite scaffolds for bone tissue engineering, Biomaterials 27 (2006) 5480-5489.
173. B.B. Mandal, A. Grinberg, E. Seok Gil, B. Panilaitis, D.L. Kaplan, High-strength silk protein scaffolds for bone repair, Proc. Natl. Acad. Sci. 109 (2012) 7699-7704.
174. Q. Zhang, V.N. Mochalin, I. Neitzel, K. Hazeli, J. Niu, A. Kontsos, et al., Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering, Biomaterials 33 (2012) 5067-5075.
175. Q. Fu, E. Saiz, M.N. Rahaman, A.P. Tomsia, Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives, Mater. Sci. Eng. C 31 (2011) 1245-1256.
176. B. Dabrowski, W. Swieszkowski, D. Godlinski, K.J. Kurzydlowski, Highly porous titanium scaffolds for orthopaedic applications, J. Biomed. Mater. Res. Part B Appl. Biomater. 95 (2010) 53-61.
177. V. Guneta, J.K. Wang, S. Maleksaeedi, Z.M. He, M.T.C. Wong, C. Choong, J. Biomimetics Biomater. Biomed. Eng. 21 (2014) 101-115. Trans Tech Publ.
178. Y. Liu, J. Lim, S.-H. Teoh, Review: development of clinically relevant scaffolds for vascularised bone tissue engineering, Biotechnol. Adv. 31 (2013) 688-705.
179. J. Malda, J. Rouwkema, D.E. Martens, E.P. le Comte, F. Kooy, J. Tramper, et al., Oxygen gradients in tissue-engineered Pegt/Pbt cartilaginous constructs:measurement and modeling, Biotechnol. Bioeng. 86 (2004) 9-18.
180. E. Wernike, M. Montjovent, Y. Liu, D. Wismeijer, E. Hunziker, K. Siebenrock, et al., VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo, Eur. Cell Mater 19 (2010) 30-40.
181. D.H. Kempen, L. Lu, A. Heijink, T.E. Hefferan, L.B. Creemers, A. Maran, et al., Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration, Biomaterials 30 (2009) 2816-2825.
182. S. Ishaug-Riley, G. Crane, A. Gurlek, M. Miller, A. Yasko, M. Yaszemski, et al., Ectopic bone formation by marrow stromal osteoblast transplantation using poly (DL-lactic-co-glycolic acid) foams implanted into the rat mesentery, J. Biomed. Mater. Res. 36 (1997) 1-8.
183. F.A. Sheikh, H.W. Ju, B.M. Moon, O.J. Lee, J.-H. Kim, H.J. Park, et al., Hybrid scaffolds based on PLGA and silk for bone tissue engineering, J. Tissue Eng. Regen. Med. (2015) 209-221.
184. K. Kikuchi, K.D. Poss, Cardiac regenerative capacity and mechanisms, Annu. Rev. Cell Dev. Biol. 28 (2012) 719-741.
185. T. Shimizu, M. Yamato, A. Kikuchi, T. Okano, Cell sheet engineering for myocardial tissue reconstruction, Biomaterials 24 (2003) 2309-2316.
186. M. Shachar, O. Tsur-Gang, T. Dvir, J. Leor, S. Cohen, The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering, Acta Biomater. 7 (2011) 152-162.
187. J. Nikolovski, D.J. Mooney, Smooth muscle cell adhesion to tissue engineering scaffolds, Biomaterials 21 (2000) 2025-2032.
188. J.A. Beamish, P. He, K. Kottke-Marchant, R.E. Marchant, Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering, Tissue Eng. Part B Rev. 16 (2010) 467-491.
189. J. Venugopal, L. Ma, T. Yong, S. Ramakrishna, In vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices, Cell Biol. Int. 29 (2005) 861-867.
190. Y. Elsayed, C. Lekakou, F. Labeed, P. Tomlins, Smooth muscle tissue engineering in crosslinked electrospun gelatin scaffolds, J. Biomed. Mater. Res. Part A (2015) 313-321.
191. S.B. Charge, M.A. Rudnicki, Cellular and molecular regulation of muscle regeneration, Physiol. Rev. 84 (2004) 209-238.
192. C.A. Collins, I. Olsen, P.S. Zammit, L. Heslop, A. Petrie, T.A. Partridge, et al., Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche, Cell 122 (2005) 289-301.
193. T.H. Qazi, D.J. Mooney, M. Pumberger, S. Geißler, G.N. Duda, Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends, Biomaterials 53 (2015) 502-521.
194. E. Serena, M. Flaibani, S. Carnio, L. Boldrin, L. Vitiello, P. De Coppi, et al., Electrophysiologic stimulation improves myogenic potential of muscle precursor cells grown in a 3D collagen scaffold, Neurol. Res. 30 (2008) 207-214.
195. J.T. Shearn, K.R. Kinneberg, N.A. Dyment, M.T. Galloway, K. Kenter, C. Wylie, et al., Tendon tissue engineering: progress, challenges, and translation to the clinic, J. Musculoskelet. Neuronal Interact. 11 (2011) 163-173.
196. N. Juncosa-Melvin, G.P. Boivin, M.T. Galloway, C. Gooch, J.R. West, D.L. Butler, Effects of cell-to-collagen ratio in stem cell-seeded constructs for Achilles tendon repair, Tissue Eng. 12 (2006) 681-689.
197. S. Sahoo, S.L. Toh, J.C. Goh, A bFGF-releasing silk/PLGA-based biohybrid scaffold for ligament/tendon tissue engineering using mesenchymal progenitor cells, Biomaterials 31 (2010) 2990-2998.
198. H.W. Ouyang, J.C. Goh, A. Thambyah, S.H. Teoh, E.H. Lee, Knitted poly-lactideco- glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon, Tissue Eng. 9 (2003) 431-439.
199. C.T. Laurencin, J.W. Freeman, Ligament tissue engineering: an evolutionary materials science approach, Biomaterials 26 (2005) 7530-7536.
200. E.J. Laurilliard, K.L. Lee, J.A. Cooper, Characterization and evaluation of fabricated poly(L-lactic) acid core fibers for ligament fascicle development, in: 2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC), 2015, pp. 1-2, http://dx.doi.org/10.1109/NEBEC.2015.7117108.