Trends in the design of nerve guidance channels in peripheral nerve tissue engineering

Progress in Neurobiology

Volumn 131, Issue , 2015, Pages 87-104

  Chiono, Valeria ^a   Tonda Turo, Chiara ^a  

^a POLITECNICO DI TORINO   (Italy)

Author keywords

Biomaterials; Nerve guidance channels; Peripheral nerve tissue engineering; Porosity

Indexed keywords

ELECTROSPINNING; FREEZE DRYING; HUMAN; MUSCLE ATROPHY; NERVE FIBER; NERVE GRAFT; NERVE GUIDANCE CHANNEL; NERVE REGENERATION; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; REVIEW; TISSUE ENGINEERING; ANIMAL; AXON; METABOLISM; PHYSIOLOGY; PROCEDURES; TISSUE REGENERATION;

BIOMATERIAL;

ANIMALS; AXONS; BIOCOMPATIBLE MATERIALS; GUIDED TISSUE REGENERATION; HUMANS; NERVE REGENERATION; PERIPHERAL NERVES; TISSUE ENGINEERING;

EID: 84938286992     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2015.06.001     Document Type: Review

References (124)

1. Ao Q., Wang A.J., Cao W.L., Zhang L., Kong L.J., He Q., Gong Y.D., Zhang X.F. Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro. J. Biomed. Mater. Res., A 2006, 77A:11-18.
2. Balgude A.P., Yu X., Szymanski A., Bellamkonda R.V. Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures. Biomaterials 2001, 22:1077-1084.
3. Battiston B., Raimondo S., Tos P., Gaidano V., Audisio C., Scevola A., Perroteau I., Geuna S. Tissue engineering of peripheral nerves. Int. Rev. Neurobiol. 2009, 87:227-249. (Chapter 11).
4. Bian Y.Z., Wang Y., Aibaidoula G., Chen G.Q., Wu Q. Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration. Biomaterials 2009, 30:217-225.
5. Bini T.B., Gao S.J., Tan T.C., Wang S., Lim A., Hai L.B., Ramakrishna S. Electrospun poly(l-lactide-co-glycolide) biodegradable polymer nanofibre tubes for peripheral nerve regeneration. Nanotechnology 2004, 15:1459-1464.
6. Borschel G.H., Kia K.F., Kuzon W.M., Dennis R.G. Mechanical properties of acellular peripheral nerve. J. Surg. Res. 2003, 114:133-139.
7. Boyle M.D., Gee A.P., Borsos T. Studies on the terminal stages of immune hemolysis. VI. Osmotic blockers of differing Stokes' radii detect complement-induced transmembrane channels of differing size. J. Immunol. 1979, 123:77-82.
8. Bozkurt A., Lassner F., O'Dey D., Deumens R., Bocker A., Schwendt T., Janzen C., Suschek C.V., Tolba R., Kobayashi E., Sellhaus B., Tholl S., Eummelen L., Schugner F., Damink L.O., Weis J., Brook G.A., Pallua N. The role of microstructured and interconnected pore channels in a collagen-based nerve guide on axonal regeneration in peripheral nerves. Biomaterials 2012, 33:1363-1375.
9. Brunelli G.A., Battiston B., Vigasio A., Brunelli G., Marocolo D. Bridging nerve defects with combined skeletal muscle and vein conduits. Microsurgery 1993, 14:247-251.
10. Ceballos D., Navarro X., Dubey N., Wendelschafer-Crabb G., Kennedy W.R., Tranquillo R.T. Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration. Exp. Neurol. 1999, 158:290-300.
11. Chen M.B., Zhang F., Lineaweaver W.C. Luminal fillers in nerve conduits for peripheral nerve repair. Ann. Plast. Surg. 2006, 57:462-471.
12. Chew S.Y., Mi R., Hoke A., Leong K.W. Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv. Funct. Mater. 2007, 17:1288-1296.
13. Chiono V., Ciardelli G., Vozzi G., Cortez J., Barbani N., Gentile P., Giusti P. Enzymatically-modified melt-extruded guides for peripheral nerve repair. Eng. Life Sci. 2008, 8:226-237.
14. Chiono V., Ciardelli G., Vozzi G., Sotgiu M.G., Vinci B., Domenici C., Giusti P. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(epsilon-caprolactone) blends for tissue engineering applications in the form of hollow fibers. J. Biomed. Mater. Res., A 2008, 85A:938-953.
15. Chiono V., Sartori S., Rechichi A., Tonda-Turo C., Vozzi G., Vozzi F., D'Acunto M., Salvadori C., Dini F., Barsotti G., Carlucci F., Burchielli S., Nicolino S., Audisio C., Perroteau I., Giusti P., Ciardelli G. Poly(ester urethane) guides for peripheral nerve regeneration. Macromol. Biosci. 2011, 11:245-256.
16. Chiono V., Tonda-Turo C., Ciardelli G. Artificial scaffolds for peripheral nerve reconstruction. Int. Rev. Neurobiol. 2009, 87:173-198. (Chapter 9).
17. Chiono V., Vozzi G., Vozzi F., Salvadori C., Dini F., Carlucci F., Arispici M., Burchielli S., Di Scipio F., Geuna S., Fornaro M., Tos P., Nicolino S., Audisio C., Perroteau I., Chiaravalloti A., Domenici C., Giusti P., Ciardelli G. Melt-extruded guides for peripheral nerve regeneration. Part I: Poly(epsilon-caprolactone). Biomed. Microdevices 2009, 11:1037-1050.
18. Chung T.W., Yang M.C., Tseng C.C., Sheu S.H., Wang S.S., Huang Y.Y., Chen S.D. Promoting regeneration of peripheral nerves in-vivo using new PCL-NGF/Tirofiban nerve conduits. Biomaterials 2011, 32:734-743.
19. Ciardelli G., Chiono V. Materials for peripheral nerve regeneration. Macromol. Biosci. 2006, 6:13-26.
20. Cordeiro P.G., Seckel B.R., Lipton S.A., Damore P.A., Wagner J., Madison R. Acidic fibroblast growth-factor enhances peripheral-nerve regeneration invivo. Plast. Reconstr. Surg. 1989, 83:1013-1019.
21. Crompton K.E., Goud J.D., Bellamkonda R.V., Gengenbach T.R., Finkelstein D.I., Horne M.K., Forsythe J.S. Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. Biomaterials 2007, 28:441-449.
22. Cui T.K., Yan Y.N., Zhang R.J., Liu L., Xu W., Wang X.H. Rapid prototyping of a double-layer polyurethane-collagen conduit for peripheral nerve regeneration. Tissue Eng., C-Methods 2009, 15:1-9.
23. Daly W., Yao L., Zeugolis D., Windebank A., Pandit A. A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery. J. R. Soc. Interface 2012, 9:202-221.
24. de Ruiter G.C., Malessy M.J., Yaszemski M.J., Windebank A.J., Spinner R.J. Designing ideal conduits for peripheral nerve repair. Neurosurg. Focus 2009, 26:E5.
25. de Ruiter G.C., Spinner R.J., Malessy M.J., Moore M.J., Sorenson E.J., Currier B.L., Yaszemski M.J., Windebank A.J. Accuracy of motor axon regeneration across autograft, single-lumen, and multichannel poly(lactic-co-glycolic acid) nerve tubes. Neurosurgery 2008, 63:144-153. (discussion 153-145).
26. Dellon A.L., Mackinnon S.E. Basic scientific and clinical applications of peripheral nerve regeneration. Surg. Annu. 1988, 20:59-100.
27. Desai E.S., Tang M.Y., Ross A.E., Gemeinhart R.A. Critical factors affecting cell encapsulation in superporous hydrogels. Biomed. Mater. 2012, 7.
28. Deumens R., Bozkurt A., Meek M.F., Marcus M.A., Joosten E.A., Weis J., Brook G.A. Repairing injured peripheral nerves: bridging the gap. Prog. Neurobiol. 2010, 92:245-276.
29. Dodla M.C., Bellamkonda R.V. Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. Biomaterials 2008, 29:33-46.
30. Dumont C.E., Born W. Stimulation of neurite outgrowth in a human nerve scaffold designed for peripheral nerve reconstruction. J. Biomed. Mater. Res., B: Appl. Biomater. 2005, 73:194-202.
31. Galla T.J., Vedecnik S.V., Halbgewachs J., Steinmann S., Friedrich C., Stark G.B. Fibrin/Schwann cell matrix in poly-epsilon-caprolactone conduits enhances guided nerve regeneration. Int. J. Artif. Organs 2004, 27:127-136.
32. Georgiou M., Golding J.P., Loughlin A.J., Kingham P.J., Phillips J.B. Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials 2015, 37:242-251.
33. Gnavi S., di Blasio L., Tonda-Turo C., Mancardi A., Primo L., Ciardelli G., Gambarotta G., Geuna S., Perroteau I. Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering. J. Tissue Eng. Regen. Med. 2014, 1-12.
34. Gopferich A. Mechanisms of polymer degradation and erosion. Biomaterials 1996, 17:103-114.
35. Gu X., Ding F., Yang Y., Liu J. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog. Neurobiol. 2011, 93:204-230.
36. Hammer J., Han L.H., Tong X.M., Yang F. A facile method to fabricate hydrogels with microchannel-like porosity for tissue engineering. Tissue Eng., C-Method 2014, 20:169-176.
37. He L., Zhang Y., Zeng C., Ngiam M., Liao S., Quan D., Zeng Y., Lu J., Ramakrishna S. Manufacture of PLGA multiple-channel conduits with precise hierarchical pore architectures and in vitro/vivo evaluation for spinal cord injury. Tissue Eng., C: Methods 2009, 15:243-255.
38. Homayoni H., Ravandi S.A.H., Valizadeh M. Electrospinning of chitosan nanofibers: processing optimization. Carbohydr. Polym. 2009, 77:656-661.
39. Hsu S.H., Ni H.C. Fabrication of the microgrooved/microporous polylactide substrates as peripheral nerve conduits and in vivo evaluation. Tissue Eng., A 2009, 15:1381-1390.
40. Huang Y.C., Huang Y.Y. Biomaterials and strategies for nerve regeneration. Artif. Organs 2006, 30:514-522.
41. Huang Z.M., Zhang Y.Z., Ramakrishna S., Lim C.T. Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 2004, 45:5361-5368.
42. Ichihara S., Inada Y., Nakada A., Endo K., Azuma T., Nakai R., Tsutsumi S., Kurosawa H., Nakamura T. Development of new nerve guide tube for repair of long nerve defects. Tissue Eng., C: Methods 2009, 15:387-402.
43. Ichihara S., Inada Y., Nakamura T. Artificial nerve tubes and their application for repair of peripheral nerve injury: an update of current concepts. Injury 2008, 39(Suppl. 4):29-39.
44. Jenq C.B., Coggeshall R.E. Nerve regeneration through holey silicone tubes. Brain Res. 1985, 361:233-241.
45. Jha B.S., Colello R.J., Bowman J.R., Sell S.A., Lee K.D., Bigbee J.W., Bowlin G.L., Chow W.N., Mathern B.E., Simpson D.G. Two pole air gap electrospinning: fabrication of highly aligned, three-dimensional scaffolds for nerve reconstruction. Acta Biomater. 2011, 7:203-215.
46. Jiang X., Cao H.Q., Shi L.Y., Ng S.Y., Stanton L.W., Chew S.Y. Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment. Acta Biomater. 2012, 8:1290-1302.
47. Jiang X., Lim S.H., Mao H.Q., Chew S.Y. Current applications and future perspectives of artificial nerve conduits. Exp. Neurol. 2010, 223:86-101.
48. Jin J., Limburg S., Joshi S.K., Landman R., Park M., Zhang Q., Kim H.T., Kuo A.C. Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor. Tissue Eng., A 2013, 19:2138-2146.
49. Johnson E.O., Soucacos P.N. Nerve repair: experimental and clinical evaluation of biodegradable artificial nerve guides. Injury 2008, 39(Suppl. 3):S30-S36.
50. Kanungo B.P., Silva E., Van Vliet K., Gibson L.J. Characterization of mineralized collagen-glycosaminoglycan scaffolds for bone regeneration. Acta Biomater. 2008, 4:490-503.
51. Kehoe S., Zhang X.F., Boyd D. FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury-Int. J. Care Injured 2012, 43:553-572.
52. Ki C.S., Baek D.H., Gang K.D., Lee K.H., Um I.C., Park Y.H. Characterization of gelatin nanofiber prepared from gelatin-formic acid solution. Polymer 2005, 46:5094-5102.
53. Kim H.W., Song J.H., Kim H.E. Nanoriber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Adv. Funct. Mater. 2005, 15:1988-1994.
54. Kokai L.E., Lin Y.C., Oyster N.M., Marra K.G. Diffusion of soluble factors through degradable polymer nerve guides: controlling manufacturing parameters. Acta Biomater. 2009, 5:2540-2550.
55. Lee S.K., Wolfe S.W. Peripheral nerve injury and repair. J. Am. Acad. Orthop. Surg. 2000, 8:243-252.
56. Leong K.F., Cheah C.M., Chua C.K. Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. Biomaterials 2003, 24:2363-2378.
57. Lim S.H., Liu X.Y., Song H.J., Yarema K.J., Mao H.Q. The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells. Biomaterials 2010, 31:9031-9039.
58. Lin Y.C., Marra K.G. Injectable systems and implantable conduits for peripheral nerve repair. Biomed. Mater. 2012, 7:024102.
59. Lu C.M., Chang C.J., Tang C.M., Lin H.C., Hsieh S.C., Liu B.S., Huang W.C. Effects of asymmetric polycaprolactone discs on co-culture nerve conduit model. J. Med. Biol. Eng. 2009, 29:76-82.
60. Lyons J.G., Geever L.M., Nugent M.J., Kennedy J.E., Higginbotham C.L. Development and characterisation of an agar-polyvinyl alcohol blend hydrogel. J. Mech. Behav. Biomed. 2009, 2:485-493.
61. Mackinnon S.E., Dellon A.L., Hudson A.R., Hunter D.A. Chronic nerve compression-an experimental-model in the rat. Ann. Plast. Surg. 1984, 13:112-120.
62. Madison R., Dasilva C.F., Dikkes P., Chiu T.H., Sidman R.L. Increased rate of peripheral-nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp. Neurol. 1985, 88:767-772.
63. Mahoney M.J., Anseth K.S. Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels. Biomaterials 2006, 27:2265-2274.
64. Marquardt L.M., Sakiyama-Elbert S.E. Engineering peripheral nerve repair. Curr. Opin. Biotechnol. 2013, 24:887-892.
65. Martens P.J., Bryant S.J., Anseth K.S. Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering. Biomacromolecules 2003, 4:283-292.
66. Matsumoto K., Ohnishi K., Kiyotani T., Sekine T., Ueda H., Nakamura T., Endo K., Shimizu Y. Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res 2000, 868:315-328.
67. Meek M.F., Varejao A.S., Geuna S. Muscle grafts and alternatives for nerve repair. J. Oral Maxillofac. Surg. 2002, 60:1095-1096. (Author reply 1096).
68. Meena R., Prasad K., Siddhanta A.K. Preparation of genipin-fixed agarose hydrogel. J. Appl. Polym. Sci. 2007, 104:290-296.
69. Nafea E.H., Poole-Warren L.A., Martens P.J. Correlation of macromolecular permeability to network characteristics of multivinyl poly(vinyl alcohol) hydrogels. J. Polym. Sci. Pol. Phys. 2014, 52:63-72.
70. Nakayama K., Takakuda K., Koyama Y., Itoh S., Wang W., Mukai T., Shirahama N. Enhancement of peripheral nerve regeneration using bioabsorbable polymer tubes packed with fibrin gel. Artif. Organs 2007, 31:500-508.
71. Nectow A.R., Marra K.G., Kaplan D.L. Biomaterials for the development of peripheral nerve guidance conduits. Tissue Eng., B: Rev. 2012, 18:40-50.
72. Nichols C.M., Myckatyn T.M., Rickman S.R., Fox I.K., Hadlock T., Mackinnon S.E. Choosing the correct functional assay: a comprehensive assessment of functional tests in the rat. Behav. Brain Res. 2005, 163:143-158.
73. Novajra G., Tonda-Turo C., Vitale-Brovarone C., Ciardelli G., Geuna S., Raimondo S. Novel systems for tailored neurotrophic factor release based on hydrogel and resorbable glass hollow fibers. Mater. Sci. Eng., C: Mater. Biol. Appl. 2014, 36:25-32.
74. Oh S.H., Kim J.H., Song K.S., Jeon B.H., Yoon J.H., Seo T.B., Narngung U., Lee I.W., Lee J.H. Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit. Biomaterials 2008, 29:1601-1609.
75. Okamoto H., Hata K.I., Kagami H., Okada K., Ito Y., Narita Y., Hirata H., Sekiya I., Otsuka T., Ueda M. Recovery process of sciatic nerve defect with novel bioabsorbable collagen tubes packed with collagen filaments in dogs. J. Biomed. Mater. Res., A 2010, 92A:859-868.
76. Oliveira J.T., Bittencourt-Navarrete R.E., de Almeida F.M., Tonda-Turo C., Martinez A.M., Franca J.G. Enhancement of median nerve regeneration by mesenchymal stem cells engraftment in an absorbable conduit: improvement of peripheral nerve morphology with enlargement of somatosensory cortical representation. Front. Neuroanat. 2014, 8:111.
77. Panseri S., Cunha C., Lowery J., Del Carro U., Taraballi F., Amadio S., Vescovi A., Gelain F. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol. 2008, 8:39.
78. Pfister L.A., Papaloizos M., Merkle H.P., Gander B. Hydrogel nerve conduits produced from alginate/chitosan complexes. J. Biomed. Mater. Res., A 2007, 80A:932-937.
79. Pfister L.A., Papaloizos M., Merkle H.P., Gander B. Nerve conduits and growth factor delivery in peripheral nerve repair. J. Peripher. Nerv. Syst. 2007, 12:65-82.
80. Phinney D.G., Isakova I. Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system. Curr. Pharm. Des. 2005, 11:1255-1265.
81. Prabhakaran M.P., Venugopal J.R., Ramakrishna S. Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering. Biomaterials 2009, 30:4996-5003.
82. Radulescu D., Dhar S., Young C.M., Taylor D.W., Trost H.J., Hayes D.J., Evans G.R. Tissue engineering scaffolds for nerve regeneration manufactured by ink-jet technology. Mater. Sci. Eng., C: Biol. Sci. 2007, 27:534-539.
83. Ritfeld G.J., Rauck B.M., Novosat T.L., Park D., Patel P., Roos R.A.C., Wang Y.D., Oudega M. The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. Biomaterials 2014, 35:1924-1931.
84. Rodriguez F.J., Gomez N., Perego G., Navarro X. Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps. Biomaterials 1999, 20:1489-1500.
85. Sakiyama S.E., Schense J.C., Hubbell J.A. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. FASEB J. 1999, 13:2214-2224.
86. Sanghvi A., Murray J., Schmidt C.E. Encyclopedia of Biomaterials and Biomedical Engineering 2004, 1613. Marcel Dekker Inc., New York, NY.
87. Sarazin P., Roy X., Favis B.D. Controlled preparation and properties of porous poly(l-lactide) obtained from a co-continuous blend of two biodegradable polymers. Biomaterials 2004, 25:5965-5978.
88. Schmidt C.E., Leach J.B. Neural tissue engineering: strategies for repair and regeneration. Annu. Rev. Biomed. Eng. 2003, 5:293-347.
89. Schultz S.G., Solomon A.K. Determination of the effective hydrodynamic radii of small molecules by viscometry. J. Gen. Physiol. 1961, 44:1189-1199.
90. Scuteri A., Miloso M., Foudah D., Orciani M., Cavaletti G., Tredici G. Mesenchymal stem cells neuronal differentiation ability: a real perspective for nervous system repair?. Curr. Stem Cell Res. Ther. 2011, 6:82-92.
91. Seckel B.R., Jones D., Hekimian K.J., Wang K.K., Chakalis D.P., Costas P.D. Hyaluronic acid through a new injectable nerve guide delivery system enhances peripheral nerve regeneration in the rat. J. Neurosci. Res. 1995, 40:318-324.
92. Sill T.J., von Recum H.A. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 2008, 29:1989-2006.
93. Song J.H., Kim H.E., Kim H.W. Production of electrospun gelatin nanofiber by water-based co-solvent approach. J. Mater. Sci.-Mater. Med. 2008, 19:95-102.
94. Stokols S., Tuszynski M.H. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials 2004, 25:5839-5846.
95. Subramanian A., Krishnan U.M., Sethuraman S. Fabrication, characterization and in vitro evaluation of aligned PLGA-PCL nanofibers for neural regeneration. Ann. Biomed. Eng. 2012, 40:2098-2110.
96. Sun C., Jin X., Holzwarth J.M., Liu X., Hu J., Gupte M.J., Zhao Y., Ma P.X. Development of channeled nanofibrous scaffolds for oriented tissue engineering. Macromol. Biosci. 2012, 12:761-769.
97. Sundback C., Hadlock T., Cheney M., Vacanti J. Manufacture of porous polymer nerve conduits by a novel low-pressure injection molding process. Biomaterials 2003, 24:819-830.
98. Sunderland S. A classification of peripheral nerve injuries producing loss of function. Brain 1951, 74:491-516. (a journal of neurology).
99. Suri S., Schmidt C.E. Cell-laden hydrogel constructs of hyaluronic acid. Collagen, and laminin for neural tissue engineering. Tissue Eng., A 2010, 16:1703-1716.
100. Taras J.S., Jacoby S.M. Repair of lacerated peripheral nerves with nerve conduits. Tech. Hand Up Extrem. Surg. 2008, 12:100-106.
101. Teo W.E., Kotaki M., Mo X.M., Ramakrishna S. Porous tubular structures with controlled fibre orientation using a modified electrospinning method. Nanotechnology 2005, 16:918-924.
102. Teo W.E., Ramakrishna S. Electrospun fibre bundle made of aligned nanofibres over two fixed points. Nanotechnology 2005, 16:1878-1884.
103. Thompson D.M., Buettner H.M. Schwann cell response to micropatterned laminin surfaces. Tissue Eng. 2001, 7:247-265.
104. Timnak A., Gharebaghi F.Y., Shariati R.P., Bahrami S.H., Javadian S., Emami S.H., Shokrgozar M.A. Fabrication of nano-structured electrospun collagen scaffold intended for nerve tissue engineering. J. Mater. Sci.-Mater. Med. 2011, 22:1555-1567.
105. Tonda-Turo C., Audisio C., Gnavi S., Chiono V., Gentile P., Raimondo S., Geuna S., Perroteau I., Ciardelli G. Porous poly(epsilon-caprolactone) nerve guide filled with porous gelatin matrix for nerve tissue engineering. Adv. Eng. Mater. 2011, 13:B151-B164.
106. Tonda-Turo C., Gentile P., Saracino S., Chiono V., Nandagiri V.K., Muzio G., Canuto R.A., Ciardelli G. Comparative analysis of gelatin scaffolds crosslinked by genipin and silane coupling agent. Int. J. Biol. Macromol. 2011, 49:700-706.
107. Tonda-Turo C., Cipriani E., Gnavi S., Chiono V., Mattu C., Gentile P., Perroteau I., Zanetti M., Ciardelli G. Cross linked gelatin nanofibres: preparation, characterisation and in vitro studies using glial-like cells. Mater. Sci. Eng., C-Mater. 2013, 33:2723-2735.
108. Tonda-Turo C., Gnavi S., Ruini F., Gambarotta G., Gioffredi E., Chiono V., Perroteau I., Ciardelli G. Development and characterization of novel agar and gelatin injectable hydrogel as filler for peripheral nerve guidance channels. J. Tissue Eng. Regen. Med. 2014, 10.1002/term.1902.
109. Vleggeert-Lankamp C.L.A.M., de Ruiter G.C.W., Wolfs J.F.C., Pego A.P., van den Berg R.J., Feirabend H.K.P., Malessy M.J.A., Lakke E.A.J.F. Pores in synthetic nerve conduits are beneficial to regeneration. J. Biomed. Mater. Res., A 2007, 80A:965-982.
110. Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hata Y., Tanaka J. Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. J. Biomed. Mater. Res., A 2008, 84A:557-566.
111. Wang X.D., Hu W., Cao Y., Yao J., Wu J., Gu X.S. Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. Brain 2005, 128:1897-1910.
112. Wang Y.S., Zhou C.W., Yao M., Li Y., Liu Y.G., Zheng W. Biodegradable parallel and porous HSPG/collagen scaffolds for the in vitro culture of NSCs for the spinal cord tissue engineering. J. Porous Mater. 2012, 19:173-180.
113. Wen X.J., Tresco P.A. Fabrication and characterization of permeable degradable poly(dl-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels. Biomaterials 2006, 27:3800-3809.
114. Wiberg M., Terenghi G. Will it be possible to produce peripheral nerves?. Surg. Technol. Int. 2003, 11:303-310.
115. Widmer M.S., Gupta P.K., Lu L.C., Meszlenyi R.K., Evans G.R.D., Brandt K., Savel T., Gurlek A., Patrick C.W., Mikos A.G. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 1998, 19:1945-1955.
116. Williams L.R., Danielsen N., Muller H., Varon S. Exogenous matrix precursors promote functional nerve regeneration across a 15-mm gap within a silicone chamber in the rat. J. Comp. Neurol. 1987, 264:284-290.
117. Wong J.Y., Leach J.B., Brown X.Q. Balance of chemistry, topography, and mechanics at the cell-biomaterial interface: issues and challenges for assessing the role of substrate mechanics on cell response. Surf. Sci. 2004, 570:119-133.
118. Xie J., MacEwan M.R., Schwartz A.G., Xia Y. Electrospun nanofibers for neural tissue engineering. Nanoscale 2010, 2:35-44.
119. Xu H.X., Yan Y.H., Li S.P. PDLLA/chondroitin sulfate/chitosan/NGF conduits for peripheral nerve regeneration. Biomaterials 2011, 32:4506-4516.
120. Yamada A., Niikura F., Ikuta K. A three-dimensional microfabrication system for biodegradable polymers with high resolution and biocompatibility. J. Micromech. Microeng. 2008, 18:1-9.
121. Yannas I.V., Zhang M., Spilker M.H. Standardized criterion to analyze and directly compare various materials and models for peripheral nerve regeneration. J. Biomater. Sci. Polym. Ed. 2007, 18:943-966.
122. Yucel D., Kose G.T., Hasirci V. Polyester based nerve guidance conduit design. Biomaterials 2010, 31:1596-1603.
123. Zeugolis D.I., Khew S.T., Yew E.S.Y., Ekaputra A.K., Tong Y.W., Yung L.Y.L., Hutmacher D.W., Sheppard C., Raghunath M. Electro-spinning of pure collagen nano-fibres-just an expensive way to make gelatin?. Biomaterials 2008, 29:2293-2305.
124. Zhu Y., Wang A., Patel S., Kurpinski K., Diao E., Bao X., Kwong G., Young W., Li S. Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration. Tissue Eng., C: Methods 2011, 17:705-715.