메뉴 건너뛰기




Volumn 14, Issue 12, 2012, Pages

Biodegradable PLGA-b-PEG polymeric nanoparticles: Synthesis, properties, and nanomedical applications as drug delivery system

Author keywords

Nanomedicine; Polyesters; Polymeric nanoparticles

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADABILITY; BIODEGRADABLE POLYMERS; BLOCK COPOLYMERS; BLOOD; MEDICAL NANOTECHNOLOGY; MICELLES; NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; STRESS ANALYSIS; SYNTHESIS (CHEMICAL); TARGETED DRUG DELIVERY;

EID: 84869875871     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-012-1316-4     Document Type: Review
Times cited : (188)

References (82)
  • 1
    • 0017388651 scopus 로고
    • Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
    • Abuchowski A, Van Es T, Palczuk NC, Davis FF (1977) Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. J Biol Chem 252: 3582-358.
    • (1977) J Biol Chem , vol.252 , pp. 3582-4358
    • Abuchowski, A.1    Van Es, T.2    Palczuk, N.C.3    Davis, F.F.4
  • 2
    • 0025110089 scopus 로고
    • Encapsulation of water-soluble drugs by a modified solvent evaporation method: Effect of process and formulation variables on drug entrapment
    • Alex R, Bodmeier R (1989) Encapsulation of water-soluble drugs by a modified solvent evaporation method: effect of process and formulation variables on drug entrapment. J Microencapsul 7: 347-35.
    • (1989) J Microencapsul , vol.7 , pp. 347-435
    • Alex, R.1    Bodmeier, R.2
  • 3
    • 84863319869 scopus 로고    scopus 로고
    • Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for insulin delivery: A physicochemical investigation and determination of CMC values
    • Ashjari M, Khoee S, Mahdavian AR, Rahmatolahzadeh R (2012) Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values. J Mater Sci: Mater Med 23: 943-95.
    • (2012) J Mater Sci: Mater Med , vol.23 , pp. 943-995
    • Ashjari, M.1    Khoee, S.2    Mahdavian, A.R.3    Rahmatolahzadeh, R.4
  • 4
    • 33746052131 scopus 로고    scopus 로고
    • Synthesis and characterization of PLGA nanoparticles
    • Astete CE, Sabliov CM (2006) Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed 17: 247-28.
    • (2006) J Biomater Sci Polym Ed , vol.17 , pp. 247-328
    • Astete, C.E.1    Sabliov, C.M.2
  • 5
    • 0037133087 scopus 로고    scopus 로고
    • PLGA-mPEG nanoparticles of cisplatin: In vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties
    • Avgoustakis K, Beletsi A, Panagi Z, Karydas AG, Klepetsanis P, Ithakissios DS (2002) PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. J Control Release 79: 123-13.
    • (2002) J Control Release , vol.79 , pp. 123-213
    • Avgoustakis, K.1    Beletsi, A.2    Panagi, Z.3    Karydas, A.G.4    Klepetsanis, P.5    Ithakissios, D.S.6
  • 6
    • 0038699633 scopus 로고    scopus 로고
    • Effect of copolymer composition on physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles
    • Avgoustakis K, Beletsi A, Panagi Z, Klepetsanis P, Livaniou E, Evangelatos G, Ithakissios DS (2003) Effect of copolymer composition on physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. Int J Pharm 259: 115-12.
    • (2003) Int J Pharm , vol.259 , pp. 115-212
    • Avgoustakis, K.1    Beletsi, A.2    Panagi, Z.3    Klepetsanis, P.4    Livaniou, E.5    Evangelatos, G.6    Ithakissios, D.S.7
  • 8
    • 0033058717 scopus 로고    scopus 로고
    • Effect of preparative variables on the properties of poly(dl-lactide-co- glycolide)-methoxypoly (ethyleneglycol) copolymers related to their application in controlled drug delivery
    • Beletsi A, Leontiadis L, Klepetsanis P, Ithakissios DS, Avgoustakis K (1999) Effect of preparative variables on the properties of poly(dl-lactide-co- glycolide)-methoxypoly (ethyleneglycol) copolymers related to their application in controlled drug delivery. Int J Pharm 182: 187-19.
    • (1999) Int J Pharm , vol.182 , pp. 187-219
    • Beletsi, A.1    Leontiadis, L.2    Klepetsanis, P.3    Ithakissios, D.S.4    Avgoustakis, K.5
  • 9
    • 20444467972 scopus 로고    scopus 로고
    • Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers
    • Beletsi A, Panagi Z, Avgoustakis K (2005) Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers. Int J Pharm 298: 233-24.
    • (2005) Int J Pharm , vol.298 , pp. 233-324
    • Beletsi, A.1    Panagi, Z.2    Avgoustakis, K.3
  • 12
    • 80053967517 scopus 로고    scopus 로고
    • Enhanced cellular uptake of folic acid-conjugated PLGA-PEG nanoparticles loaded with vincristine sulfate in human breast cancer
    • Chen J, Li S, Shen Q, He H, Zhang Y (2011) Enhanced cellular uptake of folic acid-conjugated PLGA-PEG nanoparticles loaded with vincristine sulfate in human breast cancer. Drug Dev Ind Pharm 37: 1339-134.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 1339-2134
    • Chen, J.1    Li, S.2    Shen, Q.3    He, H.4    Zhang, Y.5
  • 13
    • 84864414984 scopus 로고    scopus 로고
    • Folic acid and cell-penetrating peptide conjugated PLGA-PEG bifunctional nanoparticles for vincristine sulfate delivery
    • Chen J, Li S, Shen Q (2012) Folic acid and cell-penetrating peptide conjugated PLGA-PEG bifunctional nanoparticles for vincristine sulfate delivery. Eur J Pharm Sci 47: 430-443
    • (2012) Eur J Pharm Sci , vol.47 , pp. 430-443
    • Chen, J.1    Li, S.2    Shen, Q.3
  • 15
    • 0035350181 scopus 로고    scopus 로고
    • New polyethylene glycol laxative for treatment of constipation in adults: A randomized, double-blind, placebo- controlled study
    • Cleveland MV, Flavin DP, Ruben RA, Epstein RM, Clark GE (2001) New polyethylene glycol laxative for treatment of constipation in adults: a randomized, double-blind, placebo- controlled study. South Med J 94: 478-48.
    • (2001) South Med J , vol.94 , pp. 478-548
    • Cleveland, M.V.1    Flavin, D.P.2    Ruben, R.A.3    Epstein, R.M.4    Clark, G.E.5
  • 17
    • 78649705762 scopus 로고    scopus 로고
    • Polymeric entrapped thiol-coated gold nanorods: Cytotoxicity and suitability as molecular optoacoustic contrast agent
    • Comes Franchini M, Ponti J, Lemor R, Fournelle M, Broggi F, Locatelli E (2010b) Polymeric entrapped thiol-coated gold nanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent. J Mater Chem 20: 10908-1091.
    • (2010) J Mater Chem , vol.20 , pp. 10908-11091
    • Comes Franchini, M.1    Ponti, J.2    Lemor, R.3    Fournelle, M.4    Broggi, F.5    Locatelli, E.6
  • 19
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    • Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ (2008) Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 105: 17356-1736.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17356-21736
    • Dhar, S.1    Gu, F.X.2    Langer, R.3    Farokhzad, O.C.4    Lippard, S.J.5
  • 20
    • 1042264211 scopus 로고    scopus 로고
    • Methoxy poly(ethylene glycol)- poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs
    • Dong Y, Feng S-S (2004) Methoxy poly(ethylene glycol)- poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials 25: 2843-284.
    • (2004) Biomaterials , vol.25 , pp. 2843-3284
    • Dong, Y.1    Feng, S.-S.2
  • 21
    • 77957057350 scopus 로고    scopus 로고
    • Advances in using chitosanbased nanoparticles for in vitro and in vivo drug and gene delivery
    • Duceppe N, Tabrizian M (2010) Advances in using chitosanbased nanoparticles for in vitro and in vivo drug and gene delivery. Expert Opin Drug Deliv 7: 1191-120.
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 1191-2120
    • Duceppe, N.1    Tabrizian, M.2
  • 22
    • 33748531659 scopus 로고    scopus 로고
    • Polymer therapeutics - Polymers as drugs, drug and protein conjugates and gene delivery systems: Past, present and future opportunities
    • Duncan R, Ringsdorf H, Satchi-Fainaro R (2006) Polymer therapeutics - polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities. Adv Polym Sci 192: 1-8
    • (2006) Adv Polym Sci , vol.192 , pp. 1-8
    • Duncan, R.1    Ringsdorf, H.2    Satchi-Fainaro, R.3
  • 23
    • 0031016078 scopus 로고    scopus 로고
    • In vitro cell interaction and in vivo biodistribution of poly(lactide-co-glycolide) nanospheres surface modified by poloxamer and poloxamine copolymers
    • Dunn SE, Coombes AGA, Garnett MC, Davis SS, Davies MC, Illum L (1997) In vitro cell interaction and in vivo biodistribution of poly(lactide-co-glycolide) nanospheres surface modified by poloxamer and poloxamine copolymers. J Control Release 44: 65-7.
    • (1997) J Control Release , vol.44 , pp. 65-67
    • Dunn, S.E.1    Coombes, A.G.A.2    Garnett, M.C.3    Davis, S.S.4    Davies, M.C.5    Illum, L.6
  • 26
    • 42949164034 scopus 로고    scopus 로고
    • Comparison of the preparation of PLGA-BSA nano- and microparticles by PVA, polaxamer and PVP
    • Feczko T, Toth J, Gyenis J (2008) Comparison of the preparation of PLGA-BSA nano- and microparticles by PVA, polaxamer and PVP. Colloid Surf A 319: 188-19.
    • (2008) Colloid Surf A , vol.319 , pp. 188-219
    • Feczko, T.1    Toth, J.2    Gyenis, J.3
  • 27
    • 80051471387 scopus 로고    scopus 로고
    • Optimization of protein encapsulation in PLGA nanoparticles
    • Feczko T, Toth J, Dosa G, Gyenis J (2011) Optimization of protein encapsulation in PLGA nanoparticles. Chem Eng Process 50: 757-76.
    • (2011) Chem Eng Process , vol.50 , pp. 757-776
    • Feczko, T.1    Toth, J.2    Dosa, G.3    Gyenis, J.4
  • 28
    • 70349694137 scopus 로고    scopus 로고
    • Double phase transfer of gold nanorods for surface functionalization and entrapment into PEG-based nanocarriers
    • Gentili D, Ori G, Comes Franchini M (2009) Double phase transfer of gold nanorods for surface functionalization and entrapment into PEG-based nanocarriers. Chem Comm 39: 5874-587.
    • (2009) Chem Comm , vol.39 , pp. 5874-6587
    • Gentili, D.1    Ori, G.2    Comes Franchini, M.3
  • 29
    • 0018737940 scopus 로고
    • Biodegradable polymers for use in surgery. Polyglycolic/poy(lactic acid) homo- and copolymers
    • Ginlding DK, Reed AM (1979) Biodegradable polymers for use in surgery. Polyglycolic/poy(lactic acid) homo- and copolymers. Polymer 20: 1459-146.
    • (1979) Polymer , vol.20 , pp. 1459-2146
    • Ginlding, D.K.1    Reed, A.M.2
  • 34
    • 79951885378 scopus 로고    scopus 로고
    • Cancer nanotechnology: Methods and protocols
    • Grobmyer SR, Moudgil BM (2010) Cancer nanotechnology: methods and protocols. Method Mol Biol 624: 1-39.
    • (2010) Method Mol Biol , vol.624 , pp. 1-39
    • Grobmyer, S.R.1    Moudgil, B.M.2
  • 36
    • 0036707316 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug delivery and targeting
    • Hans ML, Lowman AM (2002) Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci 6: 319-32.
    • (2002) Curr Opin Solid State Mater Sci , vol.6 , pp. 319-332
    • Hans, M.L.1    Lowman, A.M.2
  • 37
    • 27844449247 scopus 로고    scopus 로고
    • PLGA-PEG block copolymers for drug formulations
    • Huh KM, Cho YW, Park K (2003) PLGA-PEG block copolymers for drug formulations. Drug Dev Deliv 3: 5
    • (2003) Drug Dev Deliv , vol.3 , pp. 5
    • Huh, K.M.1    Cho, Y.W.2    Park, K.3
  • 38
    • 0026536422 scopus 로고
    • Preparation of multi-phase microspheres of poly(lactic acid) and poly(lactic-co-glycolic acid) containing a W: O emulsion by a multiple solvent evaporation technique
    • Iwata M, McGinity JW (1992) Preparation of multi-phase microspheres of poly(lactic acid) and poly(lactic-co-glycolic acid) containing a W: O emulsion by a multiple solvent evaporation technique. J Microencapsul 7: 201-21.
    • (1992) J Microencapsul , vol.7 , pp. 201-221
    • Iwata, M.1    McGinity, J.W.2
  • 39
    • 76949103845 scopus 로고    scopus 로고
    • PEGylated polymers for medicine: From conjugation to self-assembled systems
    • Joralemon MJ, McRae S, Emrick T (2010) PEGylated polymers for medicine: from conjugation to self-assembled systems. Chem Comm 46: 1377-139.
    • (2010) Chem Comm , vol.46 , pp. 1377-2139
    • Joralemon, M.J.1    McRae, S.2    Emrick, T.3
  • 41
    • 77956036859 scopus 로고    scopus 로고
    • Poly(ethylene glycol) in drug delivery: Pros and cons as Wellas potential alternatives
    • Knop K, Hoogenboom R, Fischer D, Schubert US (2010) Poly(ethylene glycol) in drug delivery: pros and cons as Wellas potential alternatives. Angew Chem Int Ed 49: 6288-630.
    • (2010) Angew Chem Int Ed , vol.49 , pp. 6288-6630
    • Knop, K.1    Hoogenboom, R.2    Fischer, D.3    Schubert, U.S.4
  • 43
    • 30444434307 scopus 로고    scopus 로고
    • Nanoparticles as drug delivery systems
    • Kreuter J (2004) Nanoparticles as drug delivery systems. Encycl Nanosci Nanotechnol 7: 161-18.
    • (2004) Encycl Nanosci Nanotechnol , vol.7 , pp. 161-218
    • Kreuter, J.1
  • 46
    • 0032690165 scopus 로고    scopus 로고
    • Influence of crystallinity and stereochemistry on the enzymatic degradation of poly(lactide)s
    • Li S, McCarthy SP (1999) Influence of crystallinity and stereochemistry on the enzymatic degradation of poly(lactide)s. Macromolecules 32: 4454-445.
    • (1999) Macromolecules , vol.32 , pp. 4454-5445
    • Li, S.1    McCarthy, S.P.2
  • 48
    • 79959514159 scopus 로고    scopus 로고
    • Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma
    • Liang C, Yang Y, Ling Y, Huang Y, Li T, Li X (2011) Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma. Bioorganic Med Chem 19: 4057-406.
    • (2011) Bioorganic Med Chem , vol.19 , pp. 4057-4406
    • Liang, C.1    Yang, Y.2    Ling, Y.3    Huang, Y.4    Li, T.5    Li, X.6
  • 49
    • 34247475688 scopus 로고    scopus 로고
    • Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles
    • Liu Y, Miyoshi H, Nakamura M (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer 120: 2527-253.
    • (2007) Int J Cancer , vol.120 , pp. 2527-3253
    • Liu, Y.1    Miyoshi, H.2    Nakamura, M.3
  • 51
    • 84870399000 scopus 로고    scopus 로고
    • Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma
    • Locatelli E, Broggi F, Ponti J, Marmorato P, Franchini F, Lena S, Comes Franchini M (2012) Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma. Adv Healthcare Mater 1: 342-34.
    • (2012) Adv Healthcare Mater , vol.1 , pp. 342-434
    • Locatelli, E.1    Broggi, F.2    Ponti, J.3    Marmorato, P.4    Franchini, F.5    Lena, S.6    Comes Franchini, M.7
  • 53
    • 72149086003 scopus 로고    scopus 로고
    • LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors
    • Luo G, Yu X, Jin C, Yang F, Fu D, Long J, Xu J, Zhan C, LuW (2010) LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors. Int J Pharm 385: 150-15.
    • (2010) Int J Pharm , vol.385 , pp. 150-215
    • Luo, G.1    Yu, X.2    Jin, C.3    Yang, F.4    Fu, D.5    Long, J.6    Xu, J.7    Zhan, C.8    Lu, W.9
  • 54
    • 0025738052 scopus 로고
    • Nanoparticle characterization: A comprehensive physicochemical approach
    • Magenheim B, Benita S (1991) Nanoparticle characterization : a comprehensive physicochemical approach. S.T.P. Pharma Sci 1: 221-24.
    • (1991) S.T.P. Pharma Sci , vol.1 , pp. 221-224
    • Magenheim, B.1    Benita, S.2
  • 55
    • 0027319288 scopus 로고
    • A new in vitro technique for the evaluation of drug release profiles from colloidal carriers-ultrafiltration technique at low pressure
    • Magenheim B, Levy MY, Benita S (1993) A new in vitro technique for the evaluation of drug release profiles from colloidal carriers-ultrafiltration technique at low pressure. Int J Pharm 94: 115-12.
    • (1993) Int J Pharm , vol.94 , pp. 115-212
    • Magenheim, B.1    Levy, M.Y.2    Benita, S.3
  • 57
    • 84870252557 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • doi: 10.1016/j.addr.2012.09.021
    • Mehnert W, Mäder K (2012) Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. doi: 10.1016/j.addr.2012. 09.021
    • (2012) Adv Drug Deliv Rev
    • Mehnert, W.1    Mäder, K.2
  • 58
    • 0025778796 scopus 로고
    • Non phagocytic uptake of intravenously injected microspheres in rat spleen-influence of particles-size and hydrophilic coating
    • Moghimi SM, Porter CJH, Muir IS, Illum L, Davis SS (1991) Non phagocytic uptake of intravenously injected microspheres in rat spleen-influence of particles-size and hydrophilic coating. Biochem Biophys Res Commun 177: 861-86.
    • (1991) Biochem Biophys Res Commun , vol.177 , pp. 861-886
    • Moghimi, S.M.1    Porter, C.J.H.2    Muir, I.S.3    Illum, L.4    Davis, S.S.5
  • 61
    • 77953468519 scopus 로고    scopus 로고
    • Nanoparticles based on PLGA and its copolymer: An overview
    • Muthu MS (2009) Nanoparticles based on PLGA and its copolymer: an overview. Asian J Pharm 3: 266-27.
    • (2009) Asian J Pharm , vol.3 , pp. 266-327
    • Muthu, M.S.1
  • 62
    • 79957451657 scopus 로고    scopus 로고
    • Polylactide (PLA)-based amphiphilic block copolymers: Synthesis, self-assembly, and biomedical applications
    • Oh JK (2011) Polylactide (PLA)-based amphiphilic block copolymers: synthesis, self-assembly, and biomedical applications. Soft Matter 7: 5096-510.
    • (2011) Soft Matter , vol.7 , pp. 5096-5510
    • Oh, J.K.1
  • 63
    • 0036225362 scopus 로고    scopus 로고
    • Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
    • Oupicky D, Ogris M, Howard KA, Dash PR, Ulbrich K, Seymour LW (2002) Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther 5: 463-47.
    • (2002) Mol Ther , vol.5 , pp. 463-547
    • Oupicky, D.1    Ogris, M.2    Howard, K.A.3    Dash, P.R.4    Ulbrich, K.5    Seymour, L.W.6
  • 64
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens DE III, Peppas NA (2006) Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 307: 93-10.
    • (2006) Int J Pharm , vol.307 , pp. 93-10
    • Owens Iii, D.E.1    Peppas, N.A.2
  • 65
    • 0028319146 scopus 로고
    • Degradation of poly(D, L-lactic acid) microspheres: Effect of molecular weight
    • Park TG (1994) Degradation of poly(D, L-lactic acid) microspheres: effect of molecular weight. J Control Release 30: 538-54.
    • (1994) J Control Release , vol.30 , pp. 538-554
    • Park, T.G.1
  • 67
    • 0030948510 scopus 로고    scopus 로고
    • PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics
    • Peracchia MT, Gref R, Minamitake Y, Domb A, Lotan N, Langer R (1997) PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: investigation of their drug encapsulation and release characteristics. J Control Release 46: 23-22.
    • (1997) J Control Release , vol.46 , pp. 23-22
    • Peracchia, M.T.1    Gref, R.2    Minamitake, Y.3    Domb, A.4    Lotan, N.5    Langer, R.6
  • 68
    • 0035936975 scopus 로고    scopus 로고
    • Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterisation and in vivo evaluation
    • Redhead HM, Davis SS, Illum L (2001) Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 70: 353-36.
    • (2001) J Control Release , vol.70 , pp. 353-436
    • Redhead, H.M.1    Davis, S.S.2    Illum, L.3
  • 69
    • 33751520245 scopus 로고    scopus 로고
    • Thermo- and pH-responsive polymers in drug delivery
    • Schmaljohann D (2006) Thermo- and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev 58: 1655-167.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1655-2167
    • Schmaljohann, D.1
  • 70
    • 79951926863 scopus 로고    scopus 로고
    • Nanoprecipitation and nanoformulation of polymers: From history to powerful possibilities beyond poly(lactic acid)
    • Schubert S, Delaney JT, Schubert US (2011) Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly(lactic acid). Soft Matter 7: 1581-158.
    • (2011) Soft Matter , vol.7 , pp. 1581-2158
    • Schubert, S.1    Delaney, J.T.2    Schubert, U.S.3
  • 72
    • 0037122745 scopus 로고    scopus 로고
    • Nanosized cationic hydrogels for drug delivery: Preparation, properties and interactions with cells
    • Vinagradov SV, Bronich TK, Kabanov AV (2002) Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev 54: 223-23.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 223-323
    • Vinagradov, S.V.1    Bronich, T.K.2    Kabanov, A.V.3
  • 73
  • 74
    • 77953683770 scopus 로고    scopus 로고
    • Targeting nanoparticles to cancer
    • Wanga M, ThanouaM(2010) Targeting nanoparticles to cancer. Pharmacol Res 62: 90-9.
    • (2010) Pharmacol Res , vol.62 , pp. 90-99
    • Wanga, M.1    Thanoua, M.2
  • 75
    • 0025020415 scopus 로고
    • Drug release from micro disperse system. A critical review
    • Washington C (1990) Drug release from micro disperse system. A critical review. Int J Pharm 58: 1-1.
    • (1990) Int J Pharm , vol.58 , pp. 1-1
    • Washington, C.1
  • 76
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Win KY, Feng SS (2005) Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26: 2713-272.
    • (2005) Biomaterials , vol.26 , pp. 2713-3272
    • Win, K.Y.1    Feng, S.S.2
  • 77
    • 0035966546 scopus 로고    scopus 로고
    • Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer
    • Yoo HS, Park TG (2001) Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Release 70: 63-7.
    • (2001) J Control Release , vol.70 , pp. 63-67
    • Yoo, H.S.1    Park, T.G.2
  • 78
    • 0032767088 scopus 로고    scopus 로고
    • Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release
    • Yoo HS, Oh JE, Lee KH, Park TG (1999) Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release. Pharm Res 16: 1114-111.
    • (1999) Pharm Res , vol.16 , pp. 1114-2111
    • Yoo, H.S.1    Oh, J.E.2    Lee, K.H.3    Park, T.G.4
  • 80
    • 0032472391 scopus 로고    scopus 로고
    • Influence of experimental parameters on the characteristic of poly(lactic acid) nanoparticles prepared by a double emulsion method
    • Zambaux MF, Bonneaux F, Gref R, Maincent P, Dellacherie E, Alonso MJ, Labrude P (1998) Influence of experimental parameters on the characteristic of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Control Release 50: 31-4.
    • (1998) J Control Release , vol.50 , pp. 31-34
    • Zambaux, M.F.1    Bonneaux, F.2    Gref, R.3    Maincent, P.4    Dellacherie, E.5    Alonso, M.J.6    Labrude, P.7
  • 81
    • 37349053715 scopus 로고    scopus 로고
    • Selectivity of folate conjugated polymer micelles against different tumor cells
    • Zhao H, Yung LYL (2007) Selectivity of folate conjugated polymer micelles against different tumor cells. Int J Pharm 349: 256-26.
    • (2007) Int J Pharm , vol.349 , pp. 256-326
    • Zhao, H.1    Yung, L.Y.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.