The return of a forgotten polymer - Polycaprolactone in the 21st century

Progress in Polymer Science (Oxford)

Volumn 35, Issue 10, 2010, Pages 1217-1256

  Woodruff, Maria Ann ^a   Hutmacher, Dietmar Werner ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Bone; Polycaprolactone; Polymer; Resorbable; Scaffold; Tissue engineering

Indexed keywords

BIOMEDICAL EQUIPMENT; BONE; CONTROLLED DRUG DELIVERY; DEGRADATION; POLYMERIC IMPLANTS; POLYMERS; SCAFFOLDS; SCAFFOLDS (BIOLOGY); TARGETED DRUG DELIVERY; TISSUE; TISSUE ENGINEERING; VISCOELASTICITY;

ALIPHATIC POLYESTER; DEGRADATION KINETICS; DRUG DELIVERY DEVICES; MEDICAL DEVICES; PRODUCTION ROUTE; RESORBABLE; VISCOELASTIC PROPERTIES;

POLYCAPROLACTONE;

EID: 77957588918     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2010.04.002     Document Type: Review

References (217)

1. F.J. Van Natta, J.W. Hill, and W.H. Carruthers Polymerization and ring formation, ε-caprolactone and its polymers J Am Chem Soc 56 1934 455 459
2. S. Huang Biodegradable polymers F. Mark, N. Bikales, C. Overberger, G. Menges, J. Kroshwitz, Encyclopedia of polymer science and engineering. 1985 John Wiley and Sons New York 220 243
3. C.G. Pitt Poly-ε-caprolactone and its copolymers M. Chasin, R. Langer, biodegradable polymers as drug delivery systems 1990 Marcel Dekker New York 71 120
4. R. Chandra, and R. Rustgi Biodegradable polymers Progr Polym Sci 23 1998 1273 1335
5. M. Okada Chemical syntheses of biodegradable polymers Progr Polym Sci 27 2002 87 133
6. L.S. Nair, and C.T. Laurencin Biodegradable polymers as biomaterials Progr Polym Sci 32 2007 762 798
7. A. Luciani, V. Coccoli, S. Orsi, L. Ambrosio, and P.A. Netti PCL microspheres based functional scaffolds by bottom-up approach with predefined microstructural properties and release profiles Biomaterials 29 2008 4800 4807
8. K.H. Lee, H.Y. Kim, M.S. Khil, Y.M. Ra, and D.R. Lee Characterization of nano-structured poly(epsilon-caprolactone) nonwoven mats via electrospinning Polymer 44 2003 1287 1294
9. C. Marrazzo, E. Di Maio, and S. Iannace Conventional and nanometric nucleating agents in poly(epsilon-caprolactone) foaming: crystals vs. bubbles nucleation Polym Eng Sci 48 2008 336 344
10. H. Huang, S. Oizumi, N. Kojima, T. Niino, and Y. Sakai Avidin-biotin binding-based cell seeding and perfusion culture of liver-derived cells in a porous scaffold with a three-dimensional interconnected flow-channel network Biomaterials 28 2007 3815 3823
11. I. Zein, D.W. Hutmacher, K.C. Tan, and S.H. Teoh Fused deposition modeling of novel scaffold architectures for tissue engineering applications Biomaterials 23 2002 1169 1185
12. R.F. Storey, and A.E. Taylor Effect of stannous octoate concentration on the ethylene glycol-initiated polymerization of epsilon-caprolactone Abstr Pap Am Chem Soc 211 1996 114 120
13. T. Hayashi Biodegradable polymers for biomedical uses Progr Polym Sci 19 1994 663 702
14. O. Coulembier, P. Degee, J.L. Hedrick, and P. Dubois From controlled ring-opening polymerization to biodegradable aliphatic polyester: especially poly(beta-malic acid) derivatives Progr Polym Sci 31 2006 723 747
15. J. Koleske Blends containing poly(e-caprolactone) and related polymers D. Paul, S. Newman, Polymer blends 1978 Academic Press Inc. New York 369 389
16. I. Engelberg, and J. Kohn Physico-mechanical properties of degradable polymers used in medical applications a comparative study Biomaterials 12 1991 292 304
17. M. Vert, S.M. Li, G. Spenlehauer, and P. Guerin Bioresorbability and biocompatibility of aliphatic polyesters J Mater Sci Mater Med 3 1992 432 446
18. M. Vert Degradable and bioresorbable polymers in surgery and in pharmacology: beliefs and facts J Mater Sci Mater Med 20 2009 437 446
19. R. Ginde, and R. Gupta In vitro chemical degradation of poly(glycolic acid) pellets and fibers J Appl Polym Sci 33 1987 2411 2429
20. A. Gopferich, D. Karydas, and R. Langer Predicting drug-release from cylindric polyanhydride matrix discs Eur J Pharm Biopharm 41 1995 81 87
21. J.E. Bergsma, W.C. de Bruijn, F.R. Rozema, R.R.M. Bos, and G. Boering Late degradation tissue response to poly(-lactide) bone plates and screws Biomaterials 16 1995 25 31
22. O. Bostman, E. Hirvensalo, J. Makinen, and P. Rokkanen Foreign-body reactions to fracture fixation implants of biodegradable synthetic polymers J Bone Joint Surg Br 72-B 1990 592 596
23. S.J. Holland, and B.J. Tighe Biodegradable polymers D. Ganderton, T.J. Jones, Advances in pharmaceutical science vol. 6 1992 Academic Press Inc. London 101 164
24. J.C. Middleton, and A.J. Tipton Synthetic biodegradable polymers as orthopedic devices Biomaterials 21 2000 2335 2346
25. P.A. Gunatillake, and R. Adhikari Biodegradable synthetic polymers for tissue engineering Eur Cells Mater 5 2003 1 16
26. C.X.F. Lam, D.W. Hutmacher, J.-T. Schantz, M.A. Woodruff, and S.H. Teoh Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo J Biomed Mater Res Part A 90 2008 906 919
27. C.G. Pitt, F.I. Chasalow, Y.M. Hibionada, D.M. Klimas, and A. Schindler Aliphatic polyesters. I. The degradation of poly(epsilon-caprolactone) in vivo J Appl Polym Sci 26 1981 3779 3787
28. H. Sun, L. Mei, C. Song, X. Cui, and P. Wang The in vivo degradation, absorption and excretion of PCL-based implant Biomaterials 27 2006 1735 1740
29. S.C. Woodward, P.S. Brewer, F. Moatamed, A. Schindler, and C.G. Pitt The intracellular degradation of poly-epsilon-caprolactone J Biomed Mater Res 19 1985 437 444
30. S.A.M. Ali, S.P. Zhong, P.J. Doherty, and D.F. Williams Mechanisms of polymer degradation in implantable devices. 1. Poly(caprolactone) Biomaterials 14 1993 648 656
31. D.R. Chen, J.Z. Bei, and S.G. Wang Polycaprolactone microparticles and their biodegradation Polym Degrad Stab 67 2000 455 459
32. O. Persenaire, M. Alexandre, P. Degee, and P. Dubois Mechanisms and kinetics of thermal degradation of poly(epsilon-caprolactone) Biomacromolecules 2 2001 288 294
33. G. Sivalingam, and G. Madras Thermal degradation of poly(epsilon- caprolactone) Polym Degrad Stab 80 2003 11 16
34. G. Sivalingam, S.P. Vijayalakshmi, and G. Madras Enzymatic and thermal degradation of poly(epsilon-caprolactone), poly(d,l-lactide), and their blends Ind Eng Chem Res 43 2004 7702 7709
35. C.G. Pitt, M.M. Gratzl, G.L. Kimmel, J. Surles, and A. Schindler Aliphatic poly esters 2. The degradation of poly-d,l lactide poly-epsilon capro lactone and their co polymers in-vivo Biomaterials 2 1981 215 220
36. W.P. Ye, F.S. Du, W.H. Jin, J.Y. Yang, and Y. Xu In vitro degradation of poly(caprolactone), poly(lactide) and their block copolymers: influence of composition, temperature and morphology React Funct Polym 32 1997 161 168
37. M.H. Huang, S.M. Li, D.W. Hutmacher, J. Coudane, and M. Vert Degradation characteristics of poly(epsilon-caprolactone)-based copolymers and blends J Appl Polym Sci 102 2006 1681 1687
38. D.W. Hutmacher Scaffold design and fabrication technologies for engineering tissues - state of the art and future perspectives J Biomater Sci Polym Ed 12 2001 107 124
39. A.C. Albertsson, and S. Karlsson Controlled degradation by artificial and biological processes K. Hatada, T. Kitayama, O. Vogl, Macromolecular design of polymeric materials 1997 Marcel Dekker Inc. New York/Basel/Hong Kong 739 780
40. C.G. Pitt, and A. Schinder Capronor - a biodegradable delivery system for levonorgestrel G.L. Zatachini, A. Goldsmith, J.D. Shelton, J.J. Sciarra, Long-acting contraceptives 1984 Harper and Row Philadelphia, PA 63 84
41. M. Pulkkinen, M. Malin, J. Bohm, T. Tarvainen, T. Wirth, and J. Seppalal Erratum to "In vivo implantation of 2,2′-bis(oxazoline)-linked poly-epsilon-caprolactone: proof for enzyme sensitive surface erosion and biocompatibility" [vol 36, pg 310, 2009] Eur J Pharm Sci 37 2009 183
42. C.X.F. Lam, M.M. Savalani, S.H. Teoh, and D.W. Hutmacher Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions Biomed Mater 3 2008 1 15
43. A. Pego, M. Van Luyn, L. Brouwer, P. van Wachem, A. Poot, and D. Grijpma In vivo behaviour of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with d,l-lactide or epsilon-caprolactone: degradation and time response J Biomed Mater Res A 67 2003 1044 1054
44. D.F. Williams Revisiting the definition of biocompatibility Med Dev Technol 14 8 2003 10 13
45. D.F. Williams On the mechanisms of biocompatibility Biomaterials 29 2008 2941 2953
46. M. Vert Polymeric biomaterials: strategies of the past vs. strategies of the future Progr Polym Sci 32 2007 755 761
47. P. Menci, A. Crouc, V. Daniel, B. Pouplard, and J. Benoit Fate and biocompatibility of three types of microspheres implanted into brain J Biomed Mater Res 28 1994 1079 1085
48. J. Jackson, L. Liang, W. Hunter, M. Reynolds, J. Sandberg, and C. Springate The encapsulation of ribozymes in biodegradable polymeric matrices Int J Pharm 243 2002 1731 1735
49. R. Gutwald, H. Pistner, J. Reuther, and J. Muhling Biodegradation and tissue-reaction in a long-term implantation study of poly(l-lactide) J Mater Sci Mater Med 5 1994 485 490
50. H. Pistner, D.R. Bendix, J. Muhling, and J.F. Reuther Poly(l-lactide) - a long-term degradation study in vivo. 3. Analytical characterization Biomaterials 14 1993 291 298
51. H. Pistner, R. Gutwald, R. Ordung, J. Reuther, and J. Muhling Poly(l-lactide) - a long-term degradation study in-vivo. 1. Biological results Biomaterials 14 1993 671 677
52. M.F. Meek, and K. Jansen Two years after in vivo implantation of poly(dl-lactide-epsilon-caprolactone) nerve guides: has the material finally resorbed? J Biomed Mater Res Part A 89 2009 734 738
53. C.X.F. Lam, S.H. Teoh, and D.W. Hutmacher Comparison of the degradation of polycaprolactone and polycaprolactone-(beta-tricalcium phosphate) scaffolds in alkaline medium Polym Int 56 2007 718 728
54. A.A. Sawyer, S.J. Song, E. Susanto, P. Chuan, C.X.F. Lam, and M.A. Woodruff The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2 Biomaterials 30 2009 2479 2488
55. J.T. Schantz, D.W. Hutmacher, C.X.F. Lam, M. Brinkmann, K.M. Wong, and T.C. Lim Repair of calvarial defects with customised tissue-engineered bone grafts - II. Evaluation of cellular efficiency and efficacy in vivo Tissue Eng 9 2003 127 139
56. D.W. Hutmacher, and M.A. Woodruff Fabrication and characterisation of scaffolds via solid free form fabrication techniques P.K. Chu, X. Liu, Handbook of fabrication and processing of biomaterials 2008 CRC Press/Taylor and Francis Group Boca Raton 45 68
57. A. Merkli, C. Tabatabay, R. Gurny, and J. Heller Biodegradable polymers for the controlled release of ocular drugs Progr Polym Sci 23 1998 563 580
58. S. Freiberg, and X. Zhu Polymer microspheres for controlled drug release Int J Pharm 282 2004 1 18
59. V.R. Sinha, K. Bansal, R. Kaushik, R. Kumria, and A. Trehan Poly-epsilon-caprolactone microspheres and nanospheres: an overview Int J Pharm 278 2004 1 23
60. G. Gaucher, M.H. Dufresne, V.P. Sant, N. Kang, D. Maysinger, and J.C. Leroux Block copolymer micelles: preparation, characterization and application in drug delivery J Control Release 109 2005 169 188
61. Y. Lemmouchi, E. Schacht, P. Kageruka, R. De Deken, B. Diarra, and O. Diall Biodegradable polyesters for controlled release of trypanocidal drugs: in vitro and in vivo studies Biomaterials 19 1998 1827 1837
62. D.M.O. Kiminta, G. Braithwaite, and P.F. Luckham Colloidal dispersions, nanogels J.C. Salamone, Polymer materials encyclopedia vol. 1 1996 CRC Press Boca Raton 1298 1309
63. F. Candau Microemulsion polymerization H.F. Mark, N.M. Bikales, C.G. Overberger, G. Menges, J.I. Kroschwitz, Encyclopedia of polymer science and engineering 2nd ed. 1985 John Wiley and Sons New York 719 723
64. I. Piirma Colloids H.F. Mark, N.M. Bikales, C.G. Overberger, G. Menges, J.I. Kroschwitz, Encyclopedia of polymer science and engineering 2nd ed. 1985 John Wiley and Sons New York 125 130
65. J.M. Weissman, H.B. Sunkara, A.S. Tee, and S.A. Asher Thermally switchable periodicities and diffraction from mesoscopically ordered materials Science 274 1996 959 965
66. H.D.H. Strover, and K. Li Dispersion polymerization J.C. Salamone, Polymer materials encyclopedia vol. 1 1996 CRC Press Boca Raton 1900 1905
67. B. Grignard, F. Stassin, C. Calberg, R. Jerome, and C. Jerome Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide Biomacromolecules 9 2008 3141 3149
68. S. Kwon, K. Lee, H. Kim, Y.W. Lee, and W. Bae Synthesis of biocompatible and biodegradable polymer particles in supercritical carbon dioxide Colloid Polym Sci 286 2008 1181 1191
69. J.K. Vasir, K. Tambwekar, and S. Garg Bioadhesive microspheres as a controlled drug delivery system Int J Pharm 255 2003 13 32
70. X.L. Bai, Y.Y. Yang, T.S. Chung, S. Ng, and J. Heller Effect of polymer compositions on the fabrication of poly(ortho-ester) microspheres for controlled release of protein J Appl Polym Sci 80 2001 1630 1642
71. Y.Y. Yang, T.S. Chung, X.L. Bai, and W.K. Chan Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method Chem Eng Sci 55 2000 2223 2236
72. S. Zhang, and H. Uludag Nanoparticulate systems for growth factor delivery Pharm Res 26 2009 1561 1580
73. P. Calvo, J.L. VilaJato, and M.J. Alonso Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules, and nanoemulsions, as ocular drug carriers J Pharm Sci 85 1996 530 536
74. R. Gref, M. Lück, P. Quellec, M. Marchand, E. Dellacherie, and S. Harnisch 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption Colloids Surf B: Biointerface 18 2000 301 313
75. A. Saez, M. Guzman, J. Molpeceres, and M.R. Aberturas Freeze-drying of polycaprolactone and poly(d,l-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs Eur J Pharm Biopharm 50 2000 379 387
76. J. Marty, R. Oppenheim, and P. Speiser Nanoparticles - a new colloidal drug delivery system Pharm Acta Helv 53 1978 17 23
77. H. Fessi, F. Puisieux, J.P. Devissaguet, N. Ammoury, and S. Benita Nanocapsule formation by interfacial polymer deposition following solvent displacement Int J Pharm 55 1989 R1 R4
78. C. Muller, S. Schaffazick, A. Pohlmann, F. DeLucca, N. Pesce Da Silveira, and T. Dalla Costa Spray-dried diclofenac-loaded poly(e-caprolactone) nanocapsules and nanospheres: preparation and physiochemical characterisation Pharmazie 56 2001 864 867 (Pubitemid 33081720)
79. S. Kim, Y. Lee, H. Shin, and J. Kang Indomethacin loaded methoxypoly(ethylene glycol)/poly(e-caprolactone) diblock copolymer nanospheres: pharmacokinetic characteristics of indimethacin in normal Sprague Dawley rats Biomaterials 22 2001 2049 2056
80. G. Birrenbach, and P. Speiser Polymer micelles and their use as adjutants in immunology J Pharm Sci 65 1976 1763 1766
81. P. Calvo, M.J. Alonso, J.L. VilaJato, and J.R. Robinson Improved ocular bioavailability of indomethacin by novel ocular drug carriers J Pharm Pharm 48 1996 1147 1152
82. P. Calvo, A. Sanchez, J. Martinez, M.I. Lopez, M. Calonge, and J.C. Pastor Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A Pharm Res 13 1996 311 315
83. L. Marchal-Heussler, D. Sirbat, M. Hoffman, and P. Maincent Poly(epsilon-capralactone) nanocapsule in cartelol ophthalmic delivery Pharm Res 10 1993 386 390
84. F. Gamisans, F. Lacoulonche, A. Chauvet, M. Espina, M.L. Garcia, and M.A. Egea Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods Int J Pharm 179 1999 37 48
85. F. Lacoulonche, F. Gamisans, A. Chauvet, M.L. Garcia, M. Espina, and M.A. Egea Stability and in vitro drug release of flurbiprofen-loaded poly-epsilon-caprolactone nanospheres Drug Dev Ind Pharm 25 1999 983 993
86. M.J. Alonso, M.L. Garcia, M. Epsina, O. Valls, and M.A. Egea Aclofenac-loaded poly-ε-caprolactone nanocapsules. Effects of coadjuvants on morphological properties and drug entrapment Boll Cheim Farm 139 2000 114 119
87. I. Yenice, M.C. Mocan, E. Palaska, A. Bochot, E. Bilensoy, and I. Vural Hyaluronic acid coated poly-epsilon-caprolactone nanospheres deliver high concentrations of cyclosporine A into the cornea Exp Eye Res 87 2008 162 167
88. C. Losa, M.J. Alonso, J.L. Vila, F. Orallo, J. Martinez, and J.A. Saavedra Reduction of cardiovascular side effects associated with ocular administration of metipranolol by inclusion in polymeric nanocapsules J Ocul Pharmacol 8 1992 191 198
89. C. Losa, L. Marchal-Heussler, F. Orallo, J.L. Vila Jato, and M.J. Alonso Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol Pharm Res 10 1993 80 87
90. M. Leroueil-Le Verger, L. Fluckiger, Y.I. Kim, M. Hoffman, and P. Maincent Preparation and characterization of nanoparticles containing an antihypertensive agent Eur J Pharm Biopharm 46 1998 137 143
91. S.Y. Kim, S.H. Cho, Y.M. Lee, and L.Y. Chu Biotin-conjugated block copolymeric nanoparticles as tumor-targeted drug delivery systems Macromol Res 15 2007 646 655
92. D.B. Shenoy, and M.A. Amiji Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer Int J Pharm 293 2005 261 270
93. E. Frazza, and E. Schmitt A new absorbable suture J Biomed Mater Res Symp 1 1971 43 58
94. C.G. Pitt, and Z.W. Gu Modification of the rates of chain cleavage of poly-epsilon-caprolactone and related polyesters in the solid state J Control Release 4 1987 283 292
95. Y. Cha, and C.G. Pitt The biodegradability of polyester blends Biomaterials 11 1990 108 112
96. Y. Cha, and C.G. Pitt A one-week subdermal delivery system for l methadone based on biodegradable microcapsules J Control Release 7 1988 69 78
97. K.W. Ng, H.N. Achuth, S. Moochhala, T.C. Lim, and D.W. Hutmacher In vivo evaluation of an ultra-thin polycaprolactone film as a wound dressing J Biomater Appl Polym Ed 18 2007 925 938
98. N.J. Medlicott, D.S. Jones, I.G. Tucker, and D. Holborow Preliminary release studies of chlorhexidine (base and diacetate) from poly(epsilon- caprolactone) films prepared by solvent evaporation Int J Pharm 84 1992 85 89
99. D.S. Jones, J. Djokic, C.P. McCoy, and S.P. Gorman Poly(epsilon- caprolactone) and poly(epsilon-caprolactone)-polyvinylpyrrolidone-iodine blends as ureteral biomaterials: characterisation of mechanical and surface properties, degradation and resistance to encrustation in vitro Biomaterials 23 2002 4449 4458
100. M.D. Dhanaraju, D. Gopinath, M.R. Ahmed, R. Jayakumar, and C. Vamsadhara Characterization of polymeric poly(epsilon-caprolactone) injectable implant delivery system for the controlled delivery of contraceptive steroids J Biomed Mater Res Part A 76 2006 63 72
101. M.D. Dhanaraju, R. Jayakumar, and C. Vamsadhara Influence of manufacturing parameters on development of contraceptive steroid loaded injectable microspheres Chem Pharm Bull 52 2004 976 979
102. M.D. Dhanaraju, K. Vema, R. Jayakumar, and C. Vamsadhara Preparation and characterization of injectable microspheres of contraceptive hormones Int J Pharm 268 2003 23 29
103. G. Ma, C. Song, H. Sun, J. Yang, and X. Leng A biodegradable levonorgestrel-releasing implant made of PCL/F68 compound as tested in rats and dogs Contraception 74 2006 141 147
104. A.M. Zalfen, D. Nizet, C. Jérôme, R. Jérôme, F. Frankenne, and J.M. Foidart Controlled release of drugs from multi-component biomaterials Acta Biomater 4 2008 1788 1796
105. R. Kulkarni, E. Moore, A. Hegyeli, and F. Leonard Biodegradable poly(lactic acid) polymers J Biomed Mater Res 5 1971 169 181
106. R. Kulkarni, K. Pani, C. Neuman, and F. Leonard Polylactic acid for surgical implants Arch Surg 93 1966 839 843
107. D. Cutright, J. Beasley, and B. Perez Histological comparison of polylactic acid sutures Oral Surg 32 1971 165 173
108. D. Cutright, and E. Hunsuck The repair of fractures of the orbital floor using biodegradable polylactic acid Oral Surg Oral Med Oral Pathol 33 1972 28 34
109. K.J. Lowry, K.R. Hamson, L. Bear, Y.B. Peng, R. Calaluce, and M.L. Evans Polycaprolactone/glass bioabsorbable implant in a rabbit humerus fracture model J Biomed Mater Res Part A 36 1997 536 541
110. C.M. Agrawal, and R.B. Ray Biodegradable polymeric scaffolds for musculoskeletal tissue engineering J Biomed Mater Res 55 2001 141 150
111. T.J. Corden, I.A. Jones, C.D. Rudd, P. Christian, S. Downes, and K.E. McDougall Physical and biocompatibility properties of poly-epsilon-caprolactone produced using in situ polymerisation: a novel manufacturing technique for long-fibre composite materials Biomaterials 21 2000 713 724
112. L. Onal, S. Cozien-Cazuc, I.A. Jones, and C.D. Rudd Water absorption properties of phosphate glass fiber-reinforced poly-epsilon-caprolactone composites for craniofacial bone repair J Appl Polym Sci 107 2008 3750 3755
113. I. Ahmed, A.J. Parsons, G. Palmer, J.C. Knowles, G.S. Walkers, and C.D. Rudd Weight loss, ion release and initial mechanical properties of a binary calcium phosphate glass fibre/PCL composite Acta Biomaterialia 4 2008 1307 1314
114. J.E. Gough, P. Christian, C.A. Scotchford, C.D. Rudd, and I.A. Jones Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair J Biomed Mater Res 59 2002 481 489
115. J.E. Gough, P. Christian, J. Unsworth, M.P. Evans, C.A. Scotchford, and I.A. Jones Controlled degradation and macrophage responses of a fluoride-treated polycaprolactone J Biomed Mater Res Part A 69 2004 17 25
116. A. Alani, J.C. Knowles, W. Chrzanowski, Y.L. Ng, and K. Gulabivala Ion release characteristics, precipitate formation and sealing ability of a phosphate glass-polycaprolactone-based composite for use as a root canal obturation material Dent Mater 25 2009 400 410
117. M.R. Miner, D.W. Berzins, and J.K. Bahcall A comparison of thermal properties between gutta-percha and a synthetic polymer based root canal filling material (resilon) J Endodontics 31 2006 723 747
118. D.W. Hutmacher Scaffolds in tissue engineering bone and cartilage Biomaterials 21 2000 2529 2543
119. B. Rai, M.E. Oest, K.M. Dupont, K.H. Ho, S.H. Teoh, and R.E. Guldberg Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair J Biomed Mater Res Part A 81 2007 888 899
120. K.H. Schuckert, S. Jopp, and S.H. Teoh Mandibular defect reconstruction using three-dimensional polycaprolactone scaffold in combination with platelet-rich plasma and recombinant human bone morphogenetic protein-2: de novo synthesis of bone in a single case Tissue Eng Part A 15 2009 493 499
121. R. Langer, and J.P. Vacanti Tissue engineering Science 260 1993 920 926
122. P.D. Dalton, T. Woodfield, and D.W. Hutmacher Publisher's note: Erratum to: "SnapShot: polymer scaffolds for tissue engineering" [30/4 (2009) 701-702] Biomaterials 30 2009 2420
123. 2 in the fabrication of polymer systems for drug delivery and tissue engineering Adv Drug Deliv Rev 60 2008 373 387
124. 2 injection system for the production of polymer/mammalian cell composites J Supercrit Fluids 43 2008 535 541
125. L.J. White, S.M. Howdle, and K.M. Shakesheff Controlling the architecture and mechanical properties of supercritical fluid foamed poly d,l-lactic acid scaffolds Tissue Eng Part A 14 2008 831 1831
126. R. Schmelzeisen, R. Schimming, and M. Sittinger Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation - a preliminary report J Cranio-Maxillofac Surg 31 2003 34 39
127. M. Wagner, N. Kiapur, M. Wiedmann-Al-Ahmad, U. Hubner, A. Al-Ahmad, and R. Schon Comparative in vitro study of the cell proliferation of ovine and human osteoblast-like cells on conventionally and rapid prototyping produced scaffolds tailored for application as potential bone replacement material J Biomed Mater Res Part A 83 2007 1154 1164
128. Y.T. Kim, V.K. Haftel, S. Kumar, and R.V. Bellamkonda The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps Biomaterials 29 2008 3117 3127
129. M. Van Lieshout, G. Peters, M. Rutten, and F. Baaijens A knitted, fibrin-covered polycaprolactone scaffold for tissue engineering of the aortic valve Tissue Eng 12 2006 481 487 (Pubitemid 43673453)
130. J.S. Choi, S.J. Lee, G.J. Christ, A. Atala, and J.J. Yoo The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes Biomaterials 29 2008 2899 2906
131. F.P.W. Melchels, J. Feijen, and D.W. Grijpma A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography Biomaterials 30 2009 3801 3809
132. S.R. Khetani, and S.N. Bhatia Engineering tissues for in vitro applications Curr Opin Biotechnol 15 2006 524 531
133. R.A. Giordano, B.M. Wu, S.W. Borland, L.G. Cima, E.M. Sachs, and M.J. Cima Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing J Biomater Appl Polym Ed 8 1996 63 75
134. V. Mironov, R.P. Visconti, V. Kasyanov, G. Forgacs, C.J. Drake, and R.R. Markwald Organ printing: tissue spheroids as building blocks Biomaterials 30 2009 2164 2174
135. P.G. Campbell, and L.E. Weiss Tissue engineering with the aid of inkjet printers Expert Opin Biol Ther 7 2007 1123 1127
136. N.E. Fedorovich, I. Swennen, J. Girones, L. Moroni, C.A. van Blitterswijk, and E. Schacht Evaluation of photocrosslinked lutrol hydrogel for tissue printing applications Biomacromolecules 10 2009 1689 1696
137. G.M. Gratson, M.J. Xu, and J.A. Lewis Microperiodic structures - direct writing of three-dimensional webs Nature 428 2004 386
138. R. Landers, U. Hubner, R. Schmelzeisen, and R. Mulhaupt Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering Biomaterials 23 2002 4437 4447
139. S.H. Park, T.G. Kim, H.C. Kim, D.Y. Yang, and T.G. Park Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration Acta Biomater 4 2008 1198 1207
140. L. Shor, S. Guceri, X.J. Wen, M. Gandhi, and W. Sun Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro Biomaterials 28 2007 5291 5297
141. D.W. Hutmacher, J.T. Schantz, C.X.F. Lam, K.C. Tan, and T.C. Lim State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective J Tissue Eng Regen Med 1 2007 245 260
142. A. Kurella, and N.B. Dahotre Surface modification for bioimplants: the role of laser surface engineering J Biomater Appl 20 2005 5 50
143. W.-W. Hu, Y. Elkasabi, H.-Y. Chen, Y. Zhang, J. Lahann, and S.J. Hollister The use of reactive polymer coatings to facilitate gene delivery from poly([var epsilon]-caprolactone) scaffolds Biomaterials 30 2009 5785 5792
144. E. Kim, J. Yang, J. Choi, J.S. Suh, Y.M. Huh, and S. Haam Synthesis of gold nanorod-embedded polymeric nanoparticles by a nanoprecipitation method for use as photothermal agents Nanotechnology 20 2009 1 8
145. M.-C. Serrano, R. Pagani, M. Vallet-Regí, J. Peña, J.-V. Comas, and M.-T. Portolés Nitric oxide production by endothelial cells derived from blood progenitors cultured on NaOH-treated polycaprolactone films: a biofunctionality study Acta Biomater 5 2009 2045 2053
146. A. Oyane, M. Uchida, C. Choong, J. Triffitt, J. Jones, and A. Ito Simple surface modification of poly([epsilon]-caprolactone) for apatite deposition from simulated body fluid Biomaterials 26 2005 2407 2413
147. H.S. Yu, J.H. Jang, T.I. Kim, H.H. Lee, and H.W. Kim Apatite-mineralized polycaprolactone nanofibrous web as a bone tissue regeneration substrate J Biomed Mater Res Part A 88 2009 747 754
148. H.N. Zhang, C.Y. Lin, and S.J. Hollister The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds Biomaterials 30 2009 4063 4069
149. M.S.K. Chong, J. Chan, M. Choolani, C.N. Lee, and S.H. Teoh Development of cell-selective films for layered co-culturing of vascular progenitor cells Biomaterials 30 2009 2241 2251
150. Y. Lu, H.L. Jiang, K.H. Tu, and L.Q. Wang Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning Acta Biomater 5 2009 1562 1574
151. V. Thomas, M.V. Jose, S. Chowdhury, J.F. Sullivan, D.R. Dean, and Y.K. Vohra Mechano-morphological studies of aligned nanofibrous scaffolds of polycaprolactone fabricated by electrospinning J Biomater Sci Polym Ed 17 2006 969 984
152. C. Kazimoglu, S. Bolukabsi, U. Kanatli, A. Senkoylu, N.S. Altun, and C. Babac A novel biodegradable PCL film for tendon reconstruction: achilles tendon defect model in rats Int J Artif Organs 26 2003 804 812
153. S.H. Oh, I.K. Park, J.M. Kim, and J.H. Lee In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method Biomaterials 28 2007 1664 1671
154. V. Guarino, F. Causa, P. Taddei, M. di Foggia, G. Ciapetti, and D. Martini Polylactic acid fibre-reinforced polycaprolactone scaffolds for bone tissue engineering Biomaterials 29 2008 3662 3670
155. S.A. Abbah, C.X.L. Lam, D.W. Hutmacher, J.C.H. Goh, and H.-K. Wong Biological performance of a polycaprolactone-based scaffold used as fusion cage device in a large animal model of spinal reconstructive surgery Biomaterials 30 2009 5086 5093
156. J.T. Schantz, T.C. Lim, C. Ning, S.H. Teoh, K.C. Tan, and S.C. Wang Cranioplasty after trephination using a novel biodegradable burr hole cover: technical case report Neurosurgery 58 2006 ONS-E176
157. J.T. Schantz, S.H. Teoh, T.C. Lim, M. Endres, C.X.F. Lam, and D.W. Hutmacher Repair of calvarial defects with customized tissue-engineered bone grafts. I. Evaluation of osteogenesis in a three-dimensional culture system Tissue Eng 2003 S113 S126
158. ® CMC Spacer LG 2009 www.totalsmallbone.com/products/artelon.html
159. R. Tuli, W.J. Li, and R.S. Tuan Current state of cartilage tissue engineering Arthritis Res Ther 5 2003 235 238
160. Q. Huang, D.W. Hutmacher, and E.H. Lee In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor beta 1 and the potential for in situ chondrogenesis Tissue Eng 8 2002 469 482
161. W.J. Li, J.A. Cooper, R.L. Mauck, and R.S. Tuan Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications Acta Biomater 2 2006 377 385
162. W.J. Li, R. Tuli, C. Okafor, A. Derfoul, K.G. Danielson, and D.J. Hall A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells Biomaterials 26 2005 599 609 (Pubitemid 38988302)
163. W.J. Li, K.G. Danielson, P.G. Alexander, and R.S. Tuan Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds J Biomed Mater Res Part A 67 2003 1105 1114
164. J.K. Wise, A.L. Yarin, C.M. Megaridis, and M. Cho Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds: engineering the superficial zone of articular cartilage Tissue Eng Part A 15 2009 913 921
165. X.X. Shao, J.C.H. Goh, D.W. Hutmacher, E.H. Lee, and Z.G. Ge Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model Tissue Eng 12 2006 1539 1551
166. W.J. Li, H. Chiang, T.F. Kuo, H.S. Lee, C.C. Jiang, and R.S. Tuan Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study J Tissue Eng Regen Med 3 2009 1 10
167. C.H. Lin, J.M. Su, and S.H. Hsu Evaluation of type II collagen scaffolds reinforced by poly(epsilon-caprolactone) as tissue-engineered trachea Tissue Eng Part C 14 2008 69 77
168. E. Kon, C. Chiari, M. Marcacci, M. Delcogliano, D.M. Salter, and I. Martin Tissue engineering for total meniscal substitution: animal study in sheep model Tissue Eng Part A 14 2008 1067 1080
169. L.S. Klopp, B.J. Simon, J.M. Bush, R.M. Enns, and A.S. Turner Comparison of a caprolactone/lactide film (Mesofol) to two polylactide film products as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model Spine 33 2008 1518 1526
170. M.I. Van Lieshout, C.M. Vaz, M.C.M. Rutten, G.W.M. Peters, and F.P.T. Baaijens Electrospinning versus knitting: two scaffolds for tissue engineering of the aortic valve J Biomater Appl Polym Ed 17 2006 77 89
171. Van Lieshout MI. Tissue engineered aortic valves based on a knitted scaffold. PhD dissertation. Eindhoven: Technische Universiteit Eindhoven; 2005. p. 1-93.
172. Z.R. Wang, L.G. Chen, C.M. Wan, Y. Qu, G. Cornelissen, and F. Halberg In vitro circadian ANP secretion by gene transferring cells encapsulated in polycaprolactone tubes: gene chronotherapy Peptides 25 2004 1259 1267
173. A. Balguid, A. Mol, M.H. van Marion, R.A. Bank, C.V.C. Bouten, and F.P.T. Baaijens Tailoring fiber diameter in electrospun poly(epsilon-caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering Tissue Eng Part A 15 2009 437 444
174. S.H. Ajili, N.G. Ebrahimi, and M. Soleimani Polyurethane/polycaprolactane blend with shape memory effect as a proposed material for cardiovascular implants Acta Biomater 5 2009 1519 1530
175. X.L. Lu, Z.J. Sun, W. Cai, and Z.Y. Gao Study on the shape memory effects of poly(l-lactide-co-epsilon-caprolactone) biodegradable polymers J Mater Sci Mater Med 19 2008 395 399
176. S.H. Lee, B.S. Kim, S.H. Kim, S.W. Choi, S.I. Jeong, and I.K. Kwon Elastic biodegradable poly(glycolide-co-caprolactone) scaffold for tissue engineering J Biomed Mater Res Part A 66 2003 29 37
177. S.I. Jeong, B.S. Kim, S.W. Kang, J.H. Kwon, Y.M. Lee, and S.H. Kim In vivo biocompatibilty and degradation behavior of elastic poly(l-lactide-co- epsilon-caprolactone) scaffolds Biomaterials 25 2004 5939 5946
178. K. Sang-Heon, J. Youngmee, K. Soo Hyun, and H.K. Young Mechano-active tissue engineering T. Tateishi, Biomaterials in Asia 2007 World Scientific Singapore 98 115
179. M.J. Qu, B. Liu, H.Q. Wang, Z.Q. Yan, B.R. Shen, and Z.L. Jiang Frequency-dependent phenotype modulation of vascular smooth muscle cells under cyclic mechanical strain J Vasc Res 44 2007 345 353
180. G.R. Houtchens, M.D. Foster, T.A. Desai, E.F. Morgan, and J.Y. Wong Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation J Biomech 41 2008 762 769
181. B.S. Kim, and D.J. Mooney Scaffolds for engineering smooth muscle under cyclic mechanical strain conditions J Biomech Eng-Trans ASME 122 2000 210 215
182. S.I. Jeong, S.H. Kim, Y.H. Kim, Y. Jung, J.H. Kwon, and B.S. Kim Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering J Biomater Appl Polym Ed 15 2004 645 660 (Pubitemid 38842405)
183. S.I. Jeong, J.H. Kwon, J.I. Lim, S.W. Cho, Y.M. Jung, and W.J. Sung Mechano-active tissue engineering of vascular smooth muscle using pulsatile perfusion bioreactors and elastic PLCL scaffolds Biomaterials 26 2005 1405 1411
184. B.S. Kim, S.I. Jeong, S.W. Cho, J. Nikolovski, D.J. Mooney, and S.H. Lee Tissue engineering of smooth muscle under a mechanically dynamic condition J Microbiol Biotechnol 13 2003 841 845
185. Y. Jung, S.H. Kim, H.J. You, Y.H. Kim, and B.G. Min Application of an elastic biodegradable poly(l-lactide-co-epsilon-caprolactone) scaffold for cartilage tissue regeneration J Biomater Appl Polym Ed 19 2008 1073 1085
186. S.H. Kim, J.H. Kwon, M.S. Chung, E. Chung, Y. Jung, and Y.H. Kim Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering J Biomater Appl Polym Ed 17 2006 1359 1374
187. Y. Jung, S.H. Kim, Y.H. Kim, J. Xie, T. Matsuda, and B.G. Min Cartilaginous tissue formation using a mechano-active scaffold and dynamic compressive stimulation J Biomater Appl Polym Ed 19 2008 61 74
188. J. Xie, M. Ihara, Y.M. Jung, I.K. Kwon, S.H. Kim, and Y.H. Kim Mechano-active scaffold design based on microporous poly(l-lactide-co-epsilon- caprolactone) for articular cartilage tissue engineering: dependence of porosity on compression force-applied mechanical behaviors Tissue Eng 12 2006 449 458
189. J. Xie, Z.Y. Han, S.H. Kim, Y.H. Kim, and T. Matsuda Mechanical loading-dependence of mRNA expressions of extracellular matrices of chondrocytes inoculated into elastomeric microporous poly(l-lactide-co-epsilon-caprolactone) scaffold Tissue Eng 13 2007 29 40
190. K. Iwasaki, K. Kojima, S. Kodama, A.C. Paz, M. Chambers, and M. Umezu Bioengineered three-layered robust and elastic artery using hemodynamically- equivalent pulsatile bioreactor Circulation 118 2008 S52 S57
191. A. Bregy, S. Bogni, V.J.P. Bernau, I. Vajtai, F. Vollbach, and A. Petri-Fink Solder doped polycaprolactone scaffold enables reproducible laser tissue soldering Lasers Surg Med 40 2008 716 725
192. D. Cohn, and G. Lando Tailoring lactide/caprolactone co-oligomers as tissue adhesives Biomaterials 25 2004 5875 5884
193. M.P. Brennan, A. Dardik, N. Hibino, J.D. Roh, G.N. Nelson, and X. Papademitris Tissue-engineered vascular grafts demonstrate evidence of growth and development when implanted in a juvenile animal model Ann Surg 248 2008 370 376
194. C.M. Vaz, S. van Tuijl, C.V.C. Bouten, and F.P.T. Baaijens Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique Acta Biomater 1 2005 575 582
195. E. Pektok, B. Nottelet, J.C. Tille, R. Gurny, A. Kalangos, and M. Moeller Degradation and healing characteristics of small-diameter poly(epsilon- caprolactone) vascular grafts in the rat systemic arterial circulation Circulation 118 2008 2563 2570
196. B.W. Tillman, S.K. Yazdani, S.J. Lee, R.L. Geary, A. Atala, and J.J. Yoo The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction Biomaterials 30 2009 583 588
197. J.J. Stankus, J.J. Guan, K. Fujimoto, and W.R. Wagner Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix Biomaterials 27 2006 735 744
198. H.M. Powell, and S.T. Boyce Engineered human skin fabricated using electrospun collagen-PCL blends: morphogenesis and mechanical properties Tissue Eng Part A 15 2009 2177 2187
199. N.T. Dai, M.R. Williamson, N. Khammo, E.F. Adams, and A.G.A. Coombes Composite cell support membranes based on collagen and polycaprolactone for tissue engineering of skin Biomaterials 25 2004 4263 4271
200. N.-T. Dai, M.-K. Yeh, C.-H. Chiang, K.-C. Chen, T.-H. Liu, and A.-C. Feng Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer Biochem Biophys Res Commun 386 2009 21 25
201. C.R. Reed, L. Han, A. Andrady, M. Caballero, M.C. Jack, and J.B. Collins Composite tissue engineering on polycaprolactone nanofiber scaffolds Ann Plastic Surg 62 2009 505 512
202. M. Chen, H. Michaud, and S. Bhowmick Controlled vacuum seeding as a means of generating uniform cellular distribution in electrospun polycaprolactone (PCL) scaffolds J Biomech Eng-Trans ASME 131 2009 074521/1-8
203. M. Ananta, C.E. Aulin, J. Hilborn, D. Aibibu, S. Houis, and R.A. Brown A poly(lactic acid-co-caprolactone)-collagen hybrid for tissue engineering applications Tissue Eng Part A 15 2009 1667 1675
204. W.F.A. Dendunnen, J.M. Schakenraad, G.J. Zondervan, A.J. Pennings, B. Vanderlei, and P.H. Robinson A new PLLA PCL copolymer for nerve regeneration J Mater Sci-Mater Med 4 1993 521 525
205. W.F.A. DenDunnen, B. VanderLei, J.M. Schakenraad, I. Stokroos, E. Blaauw, and H. Bartels Poly(dl-lactide-epsilon-caprolactone) nerve guides perform better than autologous nerve grafts Microsurgery 17 1996 348 357
206. M.F. Meek, W.F.A. Den Dunnen, J.M. Schakenraad, and P.H. Robinson Long-term evaluation of functional nerve recovery after reconstruction with a thin-walled biodegradable poly(dl-lactide-epsilon-caprolactone) nerve guide, using walking track analysis and electrostimulation tests Microsurgery 19 1999 247 253
207. D.R. Nisbet, A.E. Rodda, M.K. Horne, J.S. Forsythe, and D.I. Finkelstein Neurite infiltration and cellular response to electrospun polycaprolactone scaffolds implanted into the brain Biomaterials 30 2009 4573 4580
208. E. Schnell, K. Klinkhammer, S. Balzer, G. Brook, D. Klee, and P. Dalton Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-epsilon-caprolactone and a collagen/poly-epsilon-caprolactone blend Biomaterials 28 2007 3012 3025
209. M. Bertleff, M.F. Meek, and J.P.A. Nicolai A prospective clinical evaluation of biodegradable neurolac nerve guides for sensory nerve repair in the hand J Hand Surg Am Vol 30A 2005 513 518
210. K.A. Athanasiou, G.G. Niederauer, and C.M. Agrawal Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid polyglycolic acid copolymers Biomaterials 17 1996 93 102
211. R. Jain, N.H. Shah, A.W. Malick, and C.T. Rhodes Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches Drug Dev Ind Pharm 24 1998 703 727
212. E. Cottam, D.W.L. Hukins, K. Lee, C. Hewitt, and M.J. Jenkins Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material Med Eng Phys 31 2009 221 226
213. B. Rai, S.H. Teoh, K.H. Ho, D.W. Hutmacher, T. Cao, and F. Chen The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds Biomaterials 25 2004 5499 5506 (Pubitemid 38610188)
214. J.T. Schantz, A. Brandwood, D.W. Hutmacher, H.L. Khor, and K. Bittner Osteogenic differentiation of mesenchymal progenitor cells in computer designed fibrin-polymer-ceramic scaffolds manufactured by fused deposition modeling J Mater Sci Mater Med 16 2005 807 819
215. Y.F. Zhou, D.W. Hutmacher, S.L. Varawan, and T.M. Lim In vitro bone engineering based on polycaprolactone and polycaprolactone-tricalcium phosphate composites Polym Int 56 2007 333 342
216. D. Rohner, D.W. Hutmacher, T.K. Cheng, M. Oberholzer, and B. Hammer In vivo efficacy of bone-marrow-coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig J Biomed Mater Res Part B 66 2003 574 580
217. B. Rai, S.H. Teoh, D.W. Hutmacher, T. Cao, and K.H. Ho Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2 Biomaterials 26 2005 3739 3748