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Volumn 21, Issue , 2017, Pages S37-S46

Role of hepcidin-ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation

Author keywords

Anemia; inflammation; iron metabolism

Indexed keywords

ERYTHROPOIETIN; FERRITIN; FERROPORTIN; HEMOGLOBIN; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR; TUMOR NECROSIS FACTOR; CATION TRANSPORT PROTEIN; CYTOKINE; IRON; METAL TRANSPORTING PROTEIN 1;

EID: 85016452438     PISSN: 14927535     EISSN: 15424758     Source Type: Journal    
DOI: 10.1111/hdi.12543     Document Type: Review
Times cited : (39)

References (84)
  • 1
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005; 352:1011–1023.
    • (2005) N Engl J Med. , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 2
    • 0018350898 scopus 로고
    • Prevalence and causes of anemia in elderly hospitalized patients
    • Matzner Y, Levy S, Grossowicz N, Izak G, Hershko C. Prevalence and causes of anemia in elderly hospitalized patients. Gerontology. 1979; 25:113–119.
    • (1979) Gerontology. , vol.25 , pp. 113-119
    • Matzner, Y.1    Levy, S.2    Grossowicz, N.3    Izak, G.4    Hershko, C.5
  • 3
    • 84862792124 scopus 로고    scopus 로고
    • Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
    • Sun CC, Vaja V, Babitt JL, Lin HY. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol. 2012; 87:392–400.
    • (2012) Am J Hematol. , vol.87 , pp. 392-400
    • Sun, C.C.1    Vaja, V.2    Babitt, J.L.3    Lin, H.Y.4
  • 4
    • 77956605615 scopus 로고    scopus 로고
    • Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
    • Cohen LA, Gutierrez L, Weiss A, et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood. 2010; 116:1574–1584.
    • (2010) Blood. , vol.116 , pp. 1574-1584
    • Cohen, L.A.1    Gutierrez, L.2    Weiss, A.3
  • 5
    • 0030015099 scopus 로고    scopus 로고
    • Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
    • Cazzola M, Ponchio L, de Benedetti F, et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood. 1996; 87:4824–4830.
    • (1996) Blood. , vol.87 , pp. 4824-4830
    • Cazzola, M.1    Ponchio, L.2    de Benedetti, F.3
  • 6
    • 0026561396 scopus 로고
    • New tools for clinical evaluation of erythron function in man
    • Cazzola M, Beguin Y. New tools for clinical evaluation of erythron function in man. Br J Haematol. 1992; 80:278–284.
    • (1992) Br J Haematol. , vol.80 , pp. 278-284
    • Cazzola, M.1    Beguin, Y.2
  • 7
    • 0025271562 scopus 로고
    • Serum transferrin receptor: A quantitative measure of tissue iron deficiency
    • Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: A quantitative measure of tissue iron deficiency. Blood. 1990; 75:1870–1876.
    • (1990) Blood. , vol.75 , pp. 1870-1876
    • Skikne, B.S.1    Flowers, C.H.2    Cook, J.D.3
  • 8
    • 0034986262 scopus 로고    scopus 로고
    • Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors
    • R'Zik S, Beguin Y. Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors. Exp Hematol. 2001; 29:677–685.
    • (2001) Exp Hematol. , vol.29 , pp. 677-685
    • R'Zik, S.1    Beguin, Y.2
  • 9
    • 84868130107 scopus 로고    scopus 로고
    • Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia. A meta-analysis
    • Infusino I, Braga F, Dolci A, Panteghini M. Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia. A meta-analysis. Am J Clin Pathol. 2012; 138:642–649.
    • (2012) Am J Clin Pathol. , vol.138 , pp. 642-649
    • Infusino, I.1    Braga, F.2    Dolci, A.3    Panteghini, M.4
  • 10
    • 0028908945 scopus 로고
    • Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development
    • Wang CQ, Udupa KB, Lipschitz DA. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol. 1995; 162:134–138.
    • (1995) J Cell Physiol. , vol.162 , pp. 134-138
    • Wang, C.Q.1    Udupa, K.B.2    Lipschitz, D.A.3
  • 11
    • 79958159238 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression
    • Grigorakaki C, Morceau F, Chateauvieux S, Dicato M, Diederich M. Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression. Biochem Pharmacol. 2011; 82:156–166.
    • (2011) Biochem Pharmacol. , vol.82 , pp. 156-166
    • Grigorakaki, C.1    Morceau, F.2    Chateauvieux, S.3    Dicato, M.4    Diederich, M.5
  • 12
    • 0026526803 scopus 로고
    • Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon
    • Means RT Jr, Dessypris EN, Krantz SB. Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon. J Cell Physiol. 1992; 150:59–64.
    • (1992) J Cell Physiol. , vol.150 , pp. 59-64
    • Means, R.T.1    Dessypris, E.N.2    Krantz, S.B.3
  • 13
    • 34247123177 scopus 로고    scopus 로고
    • Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha
    • Krajewski J, Batmunkh C, Jelkmann W, Hellwig-Burgel T. Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha. Cell Mol Life Sci. 2007; 64:989–998.
    • (2007) Cell Mol Life Sci. , vol.64 , pp. 989-998
    • Krajewski, J.1    Batmunkh, C.2    Jelkmann, W.3    Hellwig-Burgel, T.4
  • 14
    • 0031821059 scopus 로고    scopus 로고
    • Proinflammatory cytokines lowering erythropoietin production
    • Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res. 1998; 18:555–559.
    • (1998) J Interferon Cytokine Res. , vol.18 , pp. 555-559
    • Jelkmann, W.1
  • 16
    • 84891903512 scopus 로고    scopus 로고
    • Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells
    • McCranor BJ, Kim MJ, Cruz NM, et al. Interleukin-6 directly impairs the erythroid development of human TF-1 erythroleukemic cells. Blood Cells Mol Dis. 2014; 52:126–133.
    • (2014) Blood Cells Mol Dis. , vol.52 , pp. 126-133
    • McCranor, B.J.1    Kim, M.J.2    Cruz, N.M.3
  • 17
    • 84897911790 scopus 로고    scopus 로고
    • Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus
    • Gardenghi S, Renaud TM, Meloni A, et al. Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood. 2014; 123:1137–1145.
    • (2014) Blood. , vol.123 , pp. 1137-1145
    • Gardenghi, S.1    Renaud, T.M.2    Meloni, A.3
  • 18
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000; 480:147–150.
    • (2000) FEBS Lett. , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3
  • 19
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001; 276:7806–7810.
    • (2001) J Biol Chem. , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 20
    • 14544298717 scopus 로고    scopus 로고
    • Hepcidin–a regulator of intestinal iron absorption and iron recycling by macrophages
    • Ganz T. Hepcidin–a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005; 18:171–182.
    • (2005) Best Pract Res Clin Haematol. , vol.18 , pp. 171-182
    • Ganz, T.1
  • 21
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306:2090–2093.
    • (2004) Science. , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 22
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A, Lima CA, Pinkus JL, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005; 1:191–200.
    • (2005) Cell Metab. , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3
  • 23
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001; 276:7811–7819.
    • (2001) J Biol Chem. , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 24
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004; 113:1271–1276.
    • (2004) J Clin Invest. , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 25
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002; 110:1037–1044.
    • (2002) J Clin Invest. , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 26
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA. 2006; 103:10289–10293.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 27
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007; 117:1933–1939.
    • (2007) J Clin Invest. , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 29
    • 33748370295 scopus 로고    scopus 로고
    • Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera
    • Weizer-Stern O, Adamsky K, Amariglio N, et al. Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol. 2006; 135:129–138.
    • (2006) Br J Haematol. , vol.135 , pp. 129-138
    • Weizer-Stern, O.1    Adamsky, K.2    Amariglio, N.3
  • 30
    • 33745742487 scopus 로고    scopus 로고
    • Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
    • Vokurka M, Krijt J, Sulc K, Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res. 2006; 55:667–674.
    • (2006) Physiol Res. , vol.55 , pp. 667-674
    • Vokurka, M.1    Krijt, J.2    Sulc, K.3    Necas, E.4
  • 32
    • 34447306076 scopus 로고    scopus 로고
    • Liver iron concentrations and urinary hepcidin in beta-thalassemia
    • Origa R, Galanello R, Ganz T, et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007; 92:583–588.
    • (2007) Haematologica. , vol.92 , pp. 583-588
    • Origa, R.1    Galanello, R.2    Ganz, T.3
  • 34
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007; 13:1096–1101.
    • (2007) Nat Med. , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 35
    • 67651043722 scopus 로고    scopus 로고
    • Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    • Tanno T, Porayette P, Sripichai O, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009; 114:181–186.
    • (2009) Blood. , vol.114 , pp. 181-186
    • Tanno, T.1    Porayette, P.2    Sripichai, O.3
  • 36
    • 84903578007 scopus 로고    scopus 로고
    • Identification of erythroferrone as an erythroid regulator of iron metabolism
    • Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014; 46:678–684.
    • (2014) Nat Genet. , vol.46 , pp. 678-684
    • Kautz, L.1    Jung, G.2    Valore, E.V.3    Rivella, S.4    Nemeth, E.5    Ganz, T.6
  • 37
    • 84944930727 scopus 로고    scopus 로고
    • Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia
    • Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015; 126:2031–2037.
    • (2015) Blood. , vol.126 , pp. 2031-2037
    • Kautz, L.1    Jung, G.2    Du, X.3
  • 38
    • 43049132128 scopus 로고    scopus 로고
    • A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    • Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med. 2008; 86:531–540.
    • (2008) J Mol Med. , vol.86 , pp. 531-540
    • Verga Falzacappa, M.V.1    Casanovas, G.2    Hentze, M.W.3    Muckenthaler, M.U.4
  • 39
    • 33846392878 scopus 로고    scopus 로고
    • Hepcidin activation during inflammation: Make it STAT
    • Fleming RE. Hepcidin activation during inflammation: Make it STAT. Gastroenterology. 2007; 132:447–449.
    • (2007) Gastroenterology. , vol.132 , pp. 447-449
    • Fleming, R.E.1
  • 40
    • 65349173063 scopus 로고    scopus 로고
    • Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
    • Huang H, Constante M, Layoun A, Santos MM. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood. 2009; 113:3593–3599.
    • (2009) Blood. , vol.113 , pp. 3593-3599
    • Huang, H.1    Constante, M.2    Layoun, A.3    Santos, M.M.4
  • 41
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005; 2:399–409.
    • (2005) Cell Metab. , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3
  • 42
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006; 38:531–539.
    • (2006) Nat Genet. , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 43
    • 84908144096 scopus 로고    scopus 로고
    • Erythroferrone contributes to recovery from anemia of inflammation
    • Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014; 124:2569–2574.
    • (2014) Blood. , vol.124 , pp. 2569-2574
    • Kautz, L.1    Jung, G.2    Nemeth, E.3    Ganz, T.4
  • 45
    • 84870566647 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
    • Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012; 122:4635–4644.
    • (2012) J Clin Invest. , vol.122 , pp. 4635-4644
    • Liu, Q.1    Davidoff, O.2    Niss, K.3    Haase, V.H.4
  • 46
    • 84862148400 scopus 로고    scopus 로고
    • Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
    • Mastrogiannaki M, Matak P, Mathieu JR, et al. Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis. Haematologica. 2012; 97:827–834.
    • (2012) Haematologica. , vol.97 , pp. 827-834
    • Mastrogiannaki, M.1    Matak, P.2    Mathieu, J.R.3
  • 47
    • 84857617139 scopus 로고    scopus 로고
    • Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
    • Prentice AM, Doherty CP, Abrams SA, et al. Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood. 2012; 119:1922–1928.
    • (2012) Blood. , vol.119 , pp. 1922-1928
    • Prentice, A.M.1    Doherty, C.P.2    Abrams, S.A.3
  • 48
    • 84907378165 scopus 로고    scopus 로고
    • Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats
    • Theurl M, Nairz M, Schroll A, et al. Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats. Haematologica. 2014; 99:1516–1524.
    • (2014) Haematologica. , vol.99 , pp. 1516-1524
    • Theurl, M.1    Nairz, M.2    Schroll, A.3
  • 49
    • 84945536472 scopus 로고    scopus 로고
    • Analysis of inflammatory and anemia-related biomarkers in a randomized, double-blind, placebo-controlled study of siltuximab (anti-IL6 monoclonal antibody) in patients with multicentric castleman disease
    • Casper C, Chaturvedi S, Munshi N, et al. Analysis of inflammatory and anemia-related biomarkers in a randomized, double-blind, placebo-controlled study of siltuximab (anti-IL6 monoclonal antibody) in patients with multicentric castleman disease. Clin Cancer Res. 2015; 21:4294–4304.
    • (2015) Clin Cancer Res. , vol.21 , pp. 4294-4304
    • Casper, C.1    Chaturvedi, S.2    Munshi, N.3
  • 50
    • 84888590842 scopus 로고    scopus 로고
    • Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis
    • Isaacs JD, Harari O, Kobold U, Lee JS, Bernasconi C. Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis. Arthritis Res Ther. 2013; 15:R204
    • (2013) Arthritis Res Ther. , vol.15 , pp. R204
    • Isaacs, J.D.1    Harari, O.2    Kobold, U.3    Lee, J.S.4    Bernasconi, C.5
  • 51
    • 78149324897 scopus 로고    scopus 로고
    • Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
    • Song SN, Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K. Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood. 2010; 116:3627–3634.
    • (2010) Blood. , vol.116 , pp. 3627-3634
    • Song, S.N.1    Tomosugi, N.2    Kawabata, H.3    Ishikawa, T.4    Nishikawa, T.5    Yoshizaki, K.6
  • 52
    • 84884791621 scopus 로고    scopus 로고
    • Comparative evaluation of the effects of treatment with tocilizumab and TNF-alpha inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients
    • Song SN, Iwahashi M, Tomosugi N, et al. Comparative evaluation of the effects of treatment with tocilizumab and TNF-alpha inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients. Arthritis Res Ther. 2013; 15:R141.
    • (2013) Arthritis Res Ther. , vol.15 , pp. R141
    • Song, S.N.1    Iwahashi, M.2    Tomosugi, N.3
  • 53
    • 84879829832 scopus 로고    scopus 로고
    • Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: Results of a phase 1, randomized, open-label trial
    • Doyle MK, Rahman MU, Frederick B, et al. Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: Results of a phase 1, randomized, open-label trial. Rheumatology (Oxford). 2013; 52:1214–1219.
    • (2013) Rheumatology (Oxford). , vol.52 , pp. 1214-1219
    • Doyle, M.K.1    Rahman, M.U.2    Frederick, B.3
  • 54
    • 58849102674 scopus 로고    scopus 로고
    • Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
    • Jiao Y, Wilkinson J, Di X, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009; 113:462–469.
    • (2009) Blood. , vol.113 , pp. 462-469
    • Jiao, Y.1    Wilkinson, J.2    Di, X.3
  • 55
    • 77954563247 scopus 로고    scopus 로고
    • Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form
    • Fatih N, Camberlein E, Island ML, et al. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med. 2010; 88:477–486.
    • (2010) J Mol Med. , vol.88 , pp. 477-486
    • Fatih, N.1    Camberlein, E.2    Island, M.L.3
  • 57
    • 78751696745 scopus 로고    scopus 로고
    • Heparin: A potent inhibitor of hepcidin expression in vitro and in vivo
    • Poli M, Girelli D, Campostrini N, et al. Heparin: A potent inhibitor of hepcidin expression in vitro and in vivo. Blood. 2011; 117:997–1004.
    • (2011) Blood. , vol.117 , pp. 997-1004
    • Poli, M.1    Girelli, D.2    Campostrini, N.3
  • 58
    • 84897504790 scopus 로고    scopus 로고
    • Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo
    • Poli M, Asperti M, Naggi A, et al. Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood. 2014; 123:1564–1573.
    • (2014) Blood. , vol.123 , pp. 1564-1573
    • Poli, M.1    Asperti, M.2    Naggi, A.3
  • 59
    • 84910652964 scopus 로고    scopus 로고
    • Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo
    • Poli M, Asperti M, Ruzzenenti P, et al. Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo. Biochem Pharmacol. 2014; 92:467–475.
    • (2014) Biochem Pharmacol. , vol.92 , pp. 467-475
    • Poli, M.1    Asperti, M.2    Ruzzenenti, P.3
  • 60
    • 84962034386 scopus 로고    scopus 로고
    • High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin
    • Asperti M, Naggi A, Esposito E, et al. High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin. Front Pharmacol. 2015; 6:316.
    • (2015) Front Pharmacol. , vol.6 , pp. 316
    • Asperti, M.1    Naggi, A.2    Esposito, E.3
  • 61
    • 38349194098 scopus 로고    scopus 로고
    • Furin-mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeostasis
    • Silvestri L, Pagani A, Camaschella C. Furin-mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeostasis. Blood. 2008; 111:924–931.
    • (2008) Blood. , vol.111 , pp. 924-931
    • Silvestri, L.1    Pagani, A.2    Camaschella, C.3
  • 62
    • 27144459908 scopus 로고    scopus 로고
    • Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
    • Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005; 106:2884–2889.
    • (2005) Blood. , vol.106 , pp. 2884-2889
    • Lin, L.1    Goldberg, Y.P.2    Ganz, T.3
  • 63
    • 84931564592 scopus 로고    scopus 로고
    • Anti-repulsive guidance molecule C (RGMc) antibodies increases serum iron in rats and cynomolgus monkeys by hepcidin downregulation
    • Boser P, Seemann D, Liguori MJ, et al. Anti-repulsive guidance molecule C (RGMc) antibodies increases serum iron in rats and cynomolgus monkeys by hepcidin downregulation. AAPS J. 2015; 17:930–938.
    • (2015) AAPS J. , vol.17 , pp. 930-938
    • Boser, P.1    Seemann, D.2    Liguori, M.J.3
  • 64
    • 84964788505 scopus 로고    scopus 로고
    • Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels
    • Kovac S, Boser P, Cui Y, et al. Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels. Haematologica. 2016; 101:e173–e176.
    • (2016) Haematologica. , vol.101 , pp. e173-e176
    • Kovac, S.1    Boser, P.2    Cui, Y.3
  • 65
    • 80052647221 scopus 로고    scopus 로고
    • Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
    • Theurl I, Schroll A, Sonnweber T, et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011; 118:4977–4984.
    • (2011) Blood. , vol.118 , pp. 4977-4984
    • Theurl, I.1    Schroll, A.2    Sonnweber, T.3
  • 67
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B Jr, Corradini E, Xia Y, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009; 41:482–487.
    • (2009) Nat Genet. , vol.41 , pp. 482-487
    • Andriopoulos, B.1    Corradini, E.2    Xia, Y.3
  • 68
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu PB, Hong CC, Sachidanandan C, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008; 4:33–41.
    • (2008) Nat Chem Biol. , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3
  • 69
    • 79955980950 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    • Steinbicker AU, Sachidanandan C, Vonner AJ, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011; 117:4915–4923.
    • (2011) Blood. , vol.117 , pp. 4915-4923
    • Steinbicker, A.U.1    Sachidanandan, C.2    Vonner, A.J.3
  • 70
    • 84922191755 scopus 로고    scopus 로고
    • Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation
    • Mayeur C, Kolodziej SA, Wang A, et al. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015; 100:e68–e71.
    • (2015) Haematologica. , vol.100 , pp. e68-e71
    • Mayeur, C.1    Kolodziej, S.A.2    Wang, A.3
  • 71
    • 84884512943 scopus 로고    scopus 로고
    • A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats
    • Sun CC, Vaja V, Chen S, et al. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrol Dial Transplant. 2013; 28:1733–1743.
    • (2013) Nephrol Dial Transplant. , vol.28 , pp. 1733-1743
    • Sun, C.C.1    Vaja, V.2    Chen, S.3
  • 72
    • 84977629965 scopus 로고    scopus 로고
    • ALK2 inhibition via TP-0184 abrogates inflammation-induced hepcidin expression and is a potential therapeutic for anemia of chronic disease
    • Orlando, FL
    • Peterson P, Soh KK, Sol Lee Y, et al. ALK2 inhibition via TP-0184 abrogates inflammation-induced hepcidin expression and is a potential therapeutic for anemia of chronic disease. Annual meeting of the American Society of Hematology, 2015, Orlando, FL.
    • (2015) Annual meeting of the American Society of Hematology
    • Peterson, P.1    Soh, K.K.2    Sol Lee, Y.3
  • 73
    • 84888037689 scopus 로고    scopus 로고
    • IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation
    • Wilkinson N, Pantopoulos K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. Blood. 2013; 122:1658–1668.
    • (2013) Blood. , vol.122 , pp. 1658-1668
    • Wilkinson, N.1    Pantopoulos, K.2
  • 74
    • 84897112787 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain-2 (PHD2) inhibition may be a better therapeutic strategy in renal anemia
    • Soni H. Prolyl hydroxylase domain-2 (PHD2) inhibition may be a better therapeutic strategy in renal anemia. Med Hypotheses. 2014; 82:547–550.
    • (2014) Med Hypotheses. , vol.82 , pp. 547-550
    • Soni, H.1
  • 75
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • Vecchi C, Montosi G, Zhang K, et al. ER stress controls iron metabolism through induction of hepcidin. Science. 2009; 325:877–880.
    • (2009) Science. , vol.325 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3
  • 76
    • 84894730959 scopus 로고    scopus 로고
    • Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
    • Sonnweber T, Nachbaur D, Schroll A, et al. Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB. Gut. 2014; 63:1951–1959.
    • (2014) Gut. , vol.63 , pp. 1951-1959
    • Sonnweber, T.1    Nachbaur, D.2    Schroll, A.3
  • 77
    • 77951745552 scopus 로고    scopus 로고
    • Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
    • Sasu BJ, Cooke KS, Arvedson TL, et al. Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood. 2010; 115:3616–3624.
    • (2010) Blood. , vol.115 , pp. 3616-3624
    • Sasu, B.J.1    Cooke, K.S.2    Arvedson, T.L.3
  • 78
    • 84888219710 scopus 로고    scopus 로고
    • A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates
    • Cooke KS, Hinkle B, Salimi-Moosavi H, et al. A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates. Blood. 2013; 122:3054–3061.
    • (2013) Blood. , vol.122 , pp. 3054-3061
    • Cooke, K.S.1    Hinkle, B.2    Salimi-Moosavi, H.3
  • 79
    • 84901748611 scopus 로고    scopus 로고
    • Engineered human lipocalin as an antibody mimetic: Application to analysis of the small peptide hormone hepcidin
    • Grebenchtchikov N, Geurts-Moespot AJ, Trentmann S, et al. Engineered human lipocalin as an antibody mimetic: Application to analysis of the small peptide hormone hepcidin. Clin Chem. 2014; 60:897–899.
    • (2014) Clin Chem. , vol.60 , pp. 897-899
    • Grebenchtchikov, N.1    Geurts-Moespot, A.J.2    Trentmann, S.3
  • 81
    • 84878425491 scopus 로고    scopus 로고
    • Discovery and preclinical characterization of a novel hepcidin antagonist with tunable PK/PD properties for the treatment of anemia in different patient populations
    • San Diego, CA
    • Hohlbaum AM, Trentman S, Gille H, et al. Discovery and preclinical characterization of a novel hepcidin antagonist with tunable PK/PD properties for the treatment of anemia in different patient populations. Annual meeting of the American Society of Hematology, 2011, San Diego, CA.
    • (2011) Annual meeting of the American Society of Hematology
    • Hohlbaum, A.M.1    Trentman, S.2    Gille, H.3
  • 83
    • 84877930663 scopus 로고    scopus 로고
    • The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys
    • Schwoebel F, van Eijk LT, Zboralski D, et al. The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013; 121:2311–2315.
    • (2013) Blood. , vol.121 , pp. 2311-2315
    • Schwoebel, F.1    van Eijk, L.T.2    Zboralski, D.3
  • 84
    • 84908233244 scopus 로고    scopus 로고
    • Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans
    • van Eijk LT, John AS, Schwoebel F, et al. Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood. 2014; 124:2643–2646.
    • (2014) Blood. , vol.124 , pp. 2643-2646
    • van Eijk, L.T.1    John, A.S.2    Schwoebel, F.3


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