Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

Physiological Research

Volumn 55, Issue 6, 2006, Pages 667-674

  Vokurka, M ^a   Krijt, J ^a   Sulc K ^a   Necas E ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Erythropoiesis; Gene expression; Hepcidin; Iron; Liver

Indexed keywords

FERRITIN; FERROPORTIN 1; HEMOJUVELIN; HEPCIDIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PHENYLHYDRAZINE; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN RECEPTOR;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW SUPPRESSION; CONTROLLED STUDY; DRUG EFFECT; ERYTHROPOIESIS; GENE EXPRESSION; HEMATOPOIESIS; HEMOLYSIS; HORMONAL REGULATION; IRON METABOLISM; MALE; MOUSE; NONHUMAN; POLYCYTHEMIA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WHOLE BODY RADIATION;

ANEMIA, HEMOLYTIC; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; ERYTHROPOIESIS; ERYTHROPOIETIN; FERRITINS; GAMMA RAYS; GENE EXPRESSION REGULATION; HEMOLYSIS; IRON COMPOUNDS; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHENYLHYDRAZINES; POLYCYTHEMIA; RECEPTORS, TRANSFERRIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 33745742487     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. ADAMSKY K, WEIZER O, AMARIGLIO N, BREDA L, HARMELIN A, RIVELLA S, RACHMILEWITZ E, RECHAVI G: Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol 124: 123-124, 2004.
2. AHMAD KA, AHMANN JR, MIGAS MC, WAHEED A, BRITTON RS, BACON BR, SLY WS, FLEMING RE: Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 29: 361-366, 2002.
3. AISEN P, ENNS C, WESSLING-RESNICK M: Chemistry and biology of eukaryotic iron metabolism. Int J Biochem Cell Biol 33: 940-959, 2001.
4. BEUTLER E: Cell biology. "Pumping" iron: the proteins. Science 306: 2051-2053, 2004.
5. ERLANDSON ME, WALDEN B, STERN G, HILGARTNER MW, WEHMAN J, SMITH CH: Studies on congenital hemolytic syndromes, IV. Gastrointestinal absorption of iron. Blood 19: 359-378, 1962.
6. FRAZER DM, WILKINS SJ, BECKER EM, VULPE CD, MCKIE AT, TRINDER D, ANDERSON GJ: Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002.
7. FRAZER DM, INGLIS HR, WILKINS SJ, MILLARD KN, STEELE TM, MCLAREN GD, MCKIE AT, VULPE CD, ANDERSON GJ: Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 53: 1509-1515, 2004.
8. GANZ T.: Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 18: 171-182, 2005.
9. KAWABATA H, FLEMING RE, GUI D, MOON SY, SAITOH T, O'KELLY J, UMEHARA Y, WANO Y, SAID JW, KOEFFLER HP: Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 105: 376-381, 2005.
10. KRAUSE A. NEITZ S, MAGERT HJ, SCHULZ A, FORSSMANN WG, SCHULZ-KNAPPE P, ADERMANN K: LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480: 147-150, 2000.
11. KRIJT J, ČMEJLA R, SÝKORA V, VOKURKA M, VYORAL D, NEČAS E: Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. J Hepatol 40: 891-896, 2004a.
12. KRIJT J, VOKURKA M, CHANG KT, NEČAS E: Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 104: 4308-4310, 2004b.
13. LATUNDE-DADA GO, VULPE CD, ANDERSON GJ, SIMPSON RJ, MCKIE AT: Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta 1690: 169-176, 2004.
14. NEČAS E, NEUWIRT J: The role of oxygen supply in the regulation of erythropoiesis in compensated anaemia. Scand J Haematol 6: 179-185, 1969.
15. NEMETH E. VALORE EV, TERRITO M, SCHILLER G, LICHTENSTEIN A, GANZ T: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101: 2461-2463, 2003.
16. NEMETH E., TUTTLE MS, POWELSON J, VAUGHN MB, DONOVAN A, WARD DM, GANZ T, KAPLAN J: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093, 2004.
17. NEMETH E, ROETTO A, GAROZZO G, GANZ T, CAMASCHELLA C: Hepcidin is decreased in TFR2 hemochromatosis. Blood 105: 1803-1806, 2005.
18. NICOLAS G, BENNOUN M, DEVAUX I, BEAUMONT C, GRANDCHAMP B, KAHN A, VAULONT S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98: 8780-8785, 2001.
19. NICOLAS G, CHAUVET C, VIATTE L, DANAN JL, BIGARD X, DEVAUX I, BEAUMONT C, KAHN A, VAULONT S: The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037-1044, 2002a.
20. NICOLAS G, VIATTE L, BENNOUN M, BEAUMONT C, KAHN A, VAULONT S: Hepcidin, a new iron regulatory peptide. Blood Cells Mol Dis 29: 327-335, 2002b.
21. PAPANIKOLAOU G, PANTOPOULOS K: Iron metabolism and toxicity. Toxicol Appl Pharmacol 202: 199-211, 2005.
22. PAPANIKOLAOU G, SAMUELS ME, LUDWIG EH, MACDONALD MLE, FRANCHINI PL, DUBE MP, ANDRES L, MACFARLANE J, SAKELLAROPOULOS N, POLITOU M, NEMETH E, THOMPSON J, RISLER JK, ZABOROWSKA C, BABAKAIFF R, RADOMSKI CC, PAPE TD, DAVIDAS O, CHRISTAKIS J, BRISSOT P, LOCKITCH G, GANZ T, HAYDEN MR, GOLDBERG YP: Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36: 77-82, 2004.
23. PARK CH, VALORE EV, WARING AJ, GANZ T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810, 2001.
24. PIETRANGELO A: Hereditary hemochromatosis - a new look at an old disease. N Engl J Med 350: 2383-2397, 2004.
25. PIGEON C, ILYIN G, COURSELAUD B, LEROYER P, TURLIN B, BRISSOT P, LOREAL O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819, 2001.
26. PONKA P: Cellular iron metabolism. Kidney Int Suppl 69: S2-S11, 1999.
27. 3+) absorption, hypoxia and erythropoiesis in the mouse. Br J Haematol 68: 373-378, 1988.
28. SHARMA N, BUTTERWORTH J, COOPER BT, TSELEPIS C, IQBAL TH: The emerging role of the liver in iron metabolism. Am J Gastroenterol 100: 201-206, 2005.
29. TORRANCE JD, BOTHWELL TH: Tissue iron stores. Methods Hematol 1: 90-115, 1980.
30. WEINSTEIN DA, ROY CN, FLEMING MD, LODA MF, WOLFSDORF JI, ANDREWS NC: Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100: 3776-3781, 2002.