Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

Biochemical Pharmacology

Volumn 82, Issue 2, 2011, Pages 156-166

  Grigorakaki, Christine ^a   Morceau, Franck ^a   Chateauvieux, Sébastien ^a   Dicato, Mario ^a   Diederich, Marc ^a  

^a LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

Author keywords

Anemia; GATA 1; GATA 2; Inflammation; PU.1; TNF

Indexed keywords

ERYTHROPOIETIN RECEPTOR; GLOBIN; GLYCOPHORIN A; HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD34 SELECTION; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GIEMSA STAIN; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; UMBILICAL CORD BLOOD;

CELLS, CULTURED; ERYTHROID CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; GATA1 TRANSCRIPTION FACTOR; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958159238     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.03.030     Document Type: Article

References (60)

1. A. Sica, and V. Bronte Altered macrophage differentiation and immune dysfunction in tumor development J Clin Invest 117 2007 1155 1166 (Pubitemid 46718400)
2. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
3. E. Pikarsky, R.M. Porat, I. Stein, R. Abramovitch, S. Amit, and S. Kasem NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 431 2004 461 466 (Pubitemid 39329586)
4. H. Friess, X.Z. Guo, B.C. Nan, O. Kleeff, and M.W. Buchler Growth factors and cytokines in pancreatic carcinogenesis Ann N Y Acad Sci 880 1999 110 121 (Pubitemid 29349119)
5. F. Balkwill Cancer and the chemokine network Nat Rev Cancer 4 2004 540 550 (Pubitemid 38868623)
6. R.J. Moore, D.M. Owens, G. Stamp, C. Arnott, F. Burke, and N. East Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis Nat Med 5 1999 828 831 (Pubitemid 29318619)
7. K. Knight, S. Wade, and L. Balducci Prevalence and outcomes of anemia in cancer: a systematic review of the literature Am J Med 2004 11S 26S 116 Suppl 7A:
8. R.A. Johnson, T.A. Waddelow, J. Caro, A. Oliff, and G.D. Roodman Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice Blood 74 1989 130 138 (Pubitemid 19187420)
9. H.A. Papadaki, H.D. Kritikos, V. Valatas, D.T. Boumpas, and G.D. Eliopoulos Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy Blood 100 2002 474 482 (Pubitemid 34761109)
10. W. Xiao, K. Koizumi, M. Nishio, T. Endo, M. Osawa, and K. Fujimoto Tumor necrosis factor-alpha inhibits generation of glycophorin A+ cells by CD34+ cells Exp Hematol 30 2002 1238 1247 (Pubitemid 35287576)
11. C. Dufour, A. Corcione, J. Svahn, R. Haupt, V. Poggi, and A.N. Beka'ssy TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro Blood 102 2003 2053 2059 (Pubitemid 37122379)
12. S. Dubey, P. Shukla, and S. Nityanand Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia Ann Hematol 84 2005 572 577 (Pubitemid 41194543)
13. I. Buck, F. Morceau, S. Cristofanon, C. Heintz, S. Chateauvieux, and S. Reuter Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway GATA-1 and FOG-1 downregulation and GATA-2 upregulation Biochem Pharmacol 76 2008 1229 1239
14. I. Buck, F. Morceau, S. Cristofanon, S. Reuter, M. Dicato, and M. Diederich The inhibitory effect of the proinflammatory cytokine TNFalpha on erythroid differentiation involves erythroid transcription factor modulation Int J Oncol 34 2009 853 860
15. F. Morceau, M. Schnekenburger, R. Blasius, I. Buck, M. Dicato, and M. Diederich Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1 Cancer Lett 240 2006 203 212 (Pubitemid 44093822)
16. B. Haraoui Differentiating the efficacy of tumor necrosis factor inhibitors J Rheumatol Suppl 74 2005 3 7 (Pubitemid 40365773)
17. J. Vilcek, and M. Feldmann Historical review: cytokines as therapeutics and targets of therapeutics Trends Pharmacol Sci 25 2004 201 209 (Pubitemid 38519911)
18. L. Yan, G.M. Anderson, M. DeWitte, and M.T. Nakada Therapeutic potential of cytokine and chemokine antagonists in cancer therapy Eur J Cancer 42 2006 793 802
19. N. Scheinfeld A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab J Dermatol Treat 15 2004 280 294 (Pubitemid 39423287)
20. J.L. Spivak The anaemia of cancer: death by a thousand cuts Nat Rev Cancer 5 2005 543 555 (Pubitemid 40942830)
21. A. Engert Recombinant human erythropoietin in oncology: current status and further developments Ann Oncol 16 2005 1584 1595 (Pubitemid 41510131)
22. J.D. Rizzo, M.R. Somerfield, K.L. Hagerty, J. Seidenfeld, J. Bohlius, and C.L. Bennett Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update Blood 111 2008 25 41
23. J. Bohlius, K. Schmidlin, C. Brillant, G. Schwarzer, S. Trelle, and J. Seidenfeld Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials Lancet 373 2009 1532 1542
24. M. Tonelli, B. Hemmelgarn, T. Reiman, B. Manns, M.N. Reaume, and A. Lloyd Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis CMAJ 180 2009 E62 E71
25. J. Fandrey Erythropoietin receptors on tumor cells: what do they mean? Oncologist 13 Suppl. 3 2008 16 20
26. Y. Yasuda, Y. Fujita, T. Matsuo, S. Koinuma, S. Hara, and A. Tazaki Erythropoietin regulates tumour growth of human malignancies Carcinogenesis 24 2003 1021 1029 (Pubitemid 36833185)
27. A.C. Cooper, A. Mikhail, M.W. Lethbridge, D.M. Kemeny, and I.C. Macdougall Increased expression of erythropoiesis inhibiting cytokines (IFN-gamma, TNF-alpha IL-10, and IL-13) by T cells in patients exhibiting a poor response to erythropoietin therapy. J Am Soc Nephrol 14 2003 1776 1784 (Pubitemid 36750473)
28. I.C. Macdougall, and A.C. Cooper Hyporesponsiveness to erythropoietic therapy due to chronic inflammation Eur J Clin Invest 35Suppl3 2005 32 35 (Pubitemid 41783602)
29. C.C. Tan, K.U. Eckardt, J.D. Firth, and P.J. Ratcliffe Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia Am J Physiol 263 1992 F474 F481
30. B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, and O. Miura JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell 74 1993 227 236 (Pubitemid 23221699)
31. M. Socolovsky, H. Nam, M.D. Fleming, V.H. Haase, C. Brugnara, and H.F. Lodish Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
32. D. Bouscary, F. Pene, Y.E. Claessens, O. Muller, S. Chretien, and M. Fontenay-Roupie Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Blood 101 2003 3436 3443 (Pubitemid 36857926)
33. J.H. Myklebust, H.K. Blomhoff, L.S. Rusten, T. Stokke, and E.B. Smeland Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells Exp Hematol 30 2002 990 1000 (Pubitemid 35286615)
34. M.P. Carroll, J.L. Spivak, M. McMahon, N. Weich, U.R. Rapp, and W.S. May Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation J Biol Chem 266 1991 14964 14969 (Pubitemid 21907604)
35. S.H. Orkin, L.I. Zon, and Hematopoiesis: an evolving paradigm for stem cell biology Cell 132 2008 631 644 (Pubitemid 351260057)
36. A.D. Friedman Transcriptional control of granulocyte and monocyte development Oncogene 26 2007 6816 6828 (Pubitemid 47585105)
37. F. Morceau, M. Schnekenburger, M. Dicato, and M. Diederich GATA-1: friends brothers coworkers Ann N Y Acad Sci 1030 2004 537 554
38. L. Pevny, M.C. Simon, E. Robertson, W.H. Klein, S.F. Tsai, and V. D'Agati Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 Nature 349 1991 257 260 (Pubitemid 21912061)
39. Y. Fujiwara, C.P. Browne, K. Cunniff, S.C. Goff, and S.H. Orkin Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1 Proc Natl Acad Sci U S A 93 1996 12355 12358 (Pubitemid 26367147)
40. F.Y. Tsai, and S.H. Orkin Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation Blood 89 1997 3636 3643 (Pubitemid 27227086)
41. F.Y. Tsai, G. Keller, F.C. Kuo, M. Weiss, J. Chen, and M. Rosenblatt An early haematopoietic defect in mice lacking the transcription factor GATA-2 Nature 371 1994 221 226 (Pubitemid 24293019)
42. R. Ferreira, K. Ohneda, M. Yamamoto, and S. Philipsen GATA1 function, a paradigm for transcription factors in hematopoiesis Mol Cell Biol 25 2005 1215 1227 (Pubitemid 40204902)
43. K. Ohneda, and M. Yamamoto Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage Acta Haematol 108 2002 237 245 (Pubitemid 35356700)
44. M. Leonard, M. Brice, J.D. Engel, and T. Papayannopoulou Dynamics of GATA transcription factor expression during erythroid differentiation Blood 82 1993 1071 1079 (Pubitemid 23253977)
45. D.G. Tenen Disruption of differentiation in human cancer: AML shows the way Nat Rev Cancer 3 2003 89 101 (Pubitemid 37328876)
46. P. Zhang, X. Zhang, A. Iwama, C. Yu, K.A. Smith, and B.U. Mueller PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding Blood 96 2000 2641 2648
47. G.A. Blobel, T. Nakajima, R. Eckner, M. Montminy, and S.H. Orkin CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation Proc Natl Acad Sci U S A 95 1998 2061 2066 (Pubitemid 28145894)
48. L. Collavin, M. Gostissa, F. Avolio, P. Secco, A. Ronchi, and C. Santoro Modification of the erythroid transcription factor GATA-1 by SUMO-1 Proc Natl Acad Sci U S A 101 2004 8870 8875 (Pubitemid 38781578)
49. C.K. Liew, R.J. Simpson, A.H. Kwan, L.A. Crofts, F.E. Loughlin, and J.M. Matthews Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction Proc Natl Acad Sci U S A 102 2005 583 588 (Pubitemid 40282708)
50. I. Buck, F. Morceau, C. Grigorakaki, M. Dicato, and M. Diederich Linking anemia to inflammation and cancer: the crucial role of TNFalpha Biochem Pharmacol 77 2009 1572 1579
51. R. Ferreira, A. Wai, R. Shimizu, N. Gillemans, R. Rottier, and M. von Lindern Dynamic regulation of Gata factor levels is more important than their identity Blood 109 2007 5481 5490 (Pubitemid 46890573)
52. J.A. Grass, M.E. Boyer, S. Pal, J. Wu, M.J. Weiss, and E.H. Bresnick GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling Proc Natl Acad Sci U S A 100 2003 8811 8816 (Pubitemid 36899180)
53. P. Ikonomi, C.E. Rivera, M. Riordan, G. Washington, A.N. Schechter, and C.T. Noguchi Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation Exp Hematol 28 2000 1423 1431 (Pubitemid 32012544)
54. D. Whyatt, F. Lindeboom, A. Karis, R. Ferreira, E. Milot, and R. Hendriks An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells Nature 406 2000 519 524 (Pubitemid 30625736)
55. D.J. Whyatt, A. Karis, I.C. Harkes, A. Verkerk, N. Gillemans, and A.G. Elefanty The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery Genes Funct 1 1997 11 24
56. K. La Ferla, C. Reimann, W. Jelkmann, and T. Hellwig-Burgel Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB FASEB J 16 2002 1811 1813
57. T. Stopka, D.F. Amanatullah, M. Papetti, and A.I. Skoultchi PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure EMBO J 24 2005 3712 3723 (Pubitemid 41581688)
58. R.P. DeKoter, and H. Singh Regulation of B lymphocyte and macrophage development by graded expression of PU.1 Science 288 2000 1439 1441
59. T. Ito, C. Nishiyama, M. Nishiyama, H. Matsuda, K. Maeda, and Y. Akizawa Mast cells acquire monocyte-specific gene expression and monocyte-like morphology by overproduction of PU.1 J Immunol 174 2005 376 383 (Pubitemid 40007425)
60. M.J. Weiss, G. Keller, and S.H. Orkin Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells Genes Dev 8 1994 1184 1197 (Pubitemid 24163446)