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Volumn 113, Issue 15, 2009, Pages 3593-3599

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEPCIDIN; IRON; LIPOPOLYSACCHARIDE; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STAT3 PROTEIN;

EID: 65349173063     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-08-173641     Document Type: Article
Times cited : (139)

References (42)
  • 1
    • 0033120009 scopus 로고    scopus 로고
    • Aisen P, Wessling-Resnick M, Leibold EA. Iron metabolism. CurrOpin Chem Biol. 1999;3:200-206.
    • Aisen P, Wessling-Resnick M, Leibold EA. Iron metabolism. CurrOpin Chem Biol. 1999;3:200-206.
  • 2
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch C. Regulators of iron balance in humans. Blood. 1994;84:1697-1702.
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, C.1
  • 3
    • 0023603577 scopus 로고
    • Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia
    • Osterloh KR, Simpson RJ, Snape S, Peters TJ. Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia. Blut. 1987;55:421-431.
    • (1987) Blut , vol.55 , pp. 421-431
    • Osterloh, K.R.1    Simpson, R.J.2    Snape, S.3    Peters, T.J.4
  • 4
    • 0016240473 scopus 로고    scopus 로고
    • Hershko C, Cook JD, Finch CA. Storage iron kinetics, VI: the effect of inflammation on iron exchange in the rat. Br J Haematol. 1974;28:67-75.
    • Hershko C, Cook JD, Finch CA. Storage iron kinetics, VI: the effect of inflammation on iron exchange in the rat. Br J Haematol. 1974;28:67-75.
  • 5
    • 0023897841 scopus 로고
    • In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse
    • Raja KB, Simpson RJ, Pippard MJ, Peters TJ. In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse. Br J Haematol. 1988;68:373-378.
    • (1988) Br J Haematol , vol.68 , pp. 373-378
    • Raja, K.B.1    Simpson, R.J.2    Pippard, M.J.3    Peters, T.J.4
  • 6
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert H-J, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480:147-150.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.-J.3
  • 7
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 8
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 9
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 11
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 14
    • 0031836302 scopus 로고    scopus 로고
    • Classification and diagnosis of iron overload
    • Piperno A. Classification and diagnosis of iron overload. Haematologica. 1998;83:447-455.
    • (1998) Haematologica , vol.83 , pp. 447-455
    • Piperno, A.1
  • 15
    • 33745743014 scopus 로고    scopus 로고
    • Hepcidin and iron-loading anemias
    • Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica. 2006;91:727-732.
    • (2006) Haematologica , vol.91 , pp. 727-732
    • Nemeth, E.1    Ganz, T.2
  • 16
    • 33748370295 scopus 로고    scopus 로고
    • Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera
    • Weizer-Stern O, Adamsky K, Amariglio N, et al. Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol. 2006;135:129-138.
    • (2006) Br J Haematol , vol.135 , pp. 129-138
    • Weizer-Stern, O.1    Adamsky, K.2    Amariglio, N.3
  • 17
    • 0029809511 scopus 로고    scopus 로고
    • Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man
    • Santos M, Schilham MW, Rademakers LH, Marx JJ, de Sousa M, Clevers H. Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man. J Exp Med. 1996;184:1975-1985.
    • (1996) J Exp Med , vol.184 , pp. 1975-1985
    • Santos, M.1    Schilham, M.W.2    Rademakers, L.H.3    Marx, J.J.4    de Sousa, M.5    Clevers, H.6
  • 18
    • 24344468431 scopus 로고    scopus 로고
    • Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading
    • Makui H, Soares RJ, Jiang W, Constante M, Santos MM. Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood. 2005;106:2189-2195.
    • (2005) Blood , vol.106 , pp. 2189-2195
    • Makui, H.1    Soares, R.J.2    Jiang, W.3    Constante, M.4    Santos, M.M.5
  • 19
    • 10244225221 scopus 로고    scopus 로고
    • Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin
    • Krijt J, Vokurka M, Chang K-T, Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood. 2004;104:4308-4310.
    • (2004) Blood , vol.104 , pp. 4308-4310
    • Krijt, J.1    Vokurka, M.2    Chang, K.-T.3    Necas, E.4
  • 20
    • 0030015514 scopus 로고    scopus 로고
    • Dietary iron levels and hypoxia independently affect iron absorption in mice
    • Simpson RJ. Dietary iron levels and hypoxia independently affect iron absorption in mice. J Nutr. 1996;126:1858-1864.
    • (1996) J Nutr , vol.126 , pp. 1858-1864
    • Simpson, R.J.1
  • 22
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremiaof inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremiaof inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 23
    • 58749110142 scopus 로고    scopus 로고
    • Erythropoietin reduces lipopolysaccharide-induced cell damage and midkine secretion in U937 human histiocytic lymphoma cells
    • Yazihan N, Karakurt O, Ataoglu H. Erythropoietin reduces lipopolysaccharide-induced cell damage and midkine secretion in U937 human histiocytic lymphoma cells. Adv Ther. 2008;25:502-514.
    • (2008) Adv Ther , vol.25 , pp. 502-514
    • Yazihan, N.1    Karakurt, O.2    Ataoglu, H.3
  • 24
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 26
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38:531-539.
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 27
    • 33748902441 scopus 로고    scopus 로고
    • Hypoxia-induced erythropoietin production: A paradigm for oxygen-regulated gene expression
    • Stockmann C, Fandrey J. Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol. 2006;33:968-979.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 968-979
    • Stockmann, C.1    Fandrey, J.2
  • 28
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115:2180-2186.
    • (2005) J Clin Invest , vol.115 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 29
    • 34548024901 scopus 로고    scopus 로고
    • Molecular regulation of hepatic expression of iron regulatory hormone hepcidin
    • Oates PS, Ahmed U. Molecular regulation of hepatic expression of iron regulatory hormone hepcidin. J Gastroenterol Hepatol. 2007;22:1378-1387.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1378-1387
    • Oates, P.S.1    Ahmed, U.2
  • 31
    • 33846212344 scopus 로고    scopus 로고
    • STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    • Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294-300.
    • (2007) Gastroenterology , vol.132 , pp. 294-300
    • Pietrangelo, A.1    Dierssen, U.2    Valli, L.3
  • 32
    • 0037064261 scopus 로고    scopus 로고
    • Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
    • Agnello D, Bigini P, Villa P, et al. Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res. 2002;952:128-134.
    • (2002) Brain Res , vol.952 , pp. 128-134
    • Agnello, D.1    Bigini, P.2    Villa, P.3
  • 33
    • 12344335260 scopus 로고    scopus 로고
    • Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1
    • Rui T, Feng Q, Lei M, et al. Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res. 2005;65:719-727.
    • (2005) Cardiovasc Res , vol.65 , pp. 719-727
    • Rui, T.1    Feng, Q.2    Lei, M.3
  • 34
    • 33751568137 scopus 로고    scopus 로고
    • Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure
    • Li Y, Takemura G, Okada H, et al. Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure. Cardiovasc Res. 2006;71:684-694.
    • (2006) Cardiovasc Res , vol.71 , pp. 684-694
    • Li, Y.1    Takemura, G.2    Okada, H.3
  • 35
    • 33645210680 scopus 로고    scopus 로고
    • Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion
    • Liu X, Xie W, Liu P, et al. Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion. Life Sci. 2006;78:2255-2264.
    • (2006) Life Sci , vol.78 , pp. 2255-2264
    • Liu, X.1    Xie, W.2    Liu, P.3
  • 36
    • 37249010753 scopus 로고    scopus 로고
    • Dorso-morphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu PB, Hong CC, Sachidanandan C, et al. Dorso-morphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008;4:33-41.
    • (2008) Nat Chem Biol , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3
  • 37
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP{alpha}
    • Pinto JP, Ribeiro S, Pontes H, et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP{alpha}. Blood. 2008;111:5727-5733.
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3
  • 38
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108:3730-3735.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 39
    • 33745742487 scopus 로고    scopus 로고
    • Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
    • Vokurka M, Krijt J, Sulc K, Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res. 2006;55:667-674.
    • (2006) Physiol Res , vol.55 , pp. 667-674
    • Vokurka, M.1    Krijt, J.2    Sulc, K.3    Necas, E.4
  • 41
    • 34447306076 scopus 로고    scopus 로고
    • Liver iron concentrations and urinary hepcidin in {beta}-thalassemia
    • Origa R, Galanello R, Ganz T, et al. Liver iron concentrations and urinary hepcidin in {beta}-thalassemia. Haematologica. 2007;92:583-588.
    • (2007) Haematologica , vol.92 , pp. 583-588
    • Origa, R.1    Galanello, R.2    Ganz, T.3
  • 42
    • 54549087621 scopus 로고    scopus 로고
    • Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways
    • Kartikasari AE, Roelofs R, Schaeps RM, et al. Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways. Biochim Biophys Acta. 2008;1784:2029-2037.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 2029-2037
    • Kartikasari, A.E.1    Roelofs, R.2    Schaeps, R.M.3


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