AG490: An inhibitor of hepcidin expression in vivo

World Journal of Gastroenterology

Volumn 17, Issue 45, 2011, Pages 5032-5034

  Zhang, Shu Ping ^a   Wang, Zhe ^a   Wang, Li Xin ^a   Liu, Si Jin ^a  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

Author keywords

AG490; Anemia; Hepcidin; Inflammation

Indexed keywords

HEPCIDIN; JANUS KINASE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; RNA; STAT PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANEMIA; BAGG ALBINO MOUSE; HOMEOSTASIS; IN VIVO STUDY; INFLAMMATION; IRON BLOOD LEVEL; LETTER; LIVER; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; SPLEEN;

EID: 83155177082     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i45.5032     Document Type: Letter

References (12)

1. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009; 122: 78-86
2. Roy CN. Anemia of inflammation. Hematology Am Soc Hematol Educ Program 2010; 2010: 276-280
3. Fatih N, Camberlein E, Island ML, Corlu A, Abgueguen E, Détivaud L, Leroyer P, Brissot P, Loréal O. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med (Berl) 2010; 88: 477-486
4. Liu S, Suragani RN, Wang F, Han A, Zhao W, Andrews NC, Chen JJ. The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J Clin Invest 2007; 117: 3296-3305
5. Liu S, Goldstein RH, Scepansky EM, Rosenblatt M. Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 2009; 69: 8742-8751
6. Andrews NC. Forging a field: the golden age of iron biology. Blood 2008; 112: 219-230
7. Liu S, Suragani RN, Han A, Zhao W, Andrews NC, Chen JJ. Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica 2008; 93: 753-756
8. Wessling-Resnick M. Iron homeostasis and the inflammatory response. Annu Rev Nutr 2010; 30: 105-122
9. Poli M, Girelli D, Campostrini N, Maccarinelli F, Finazzi D, Luscieti S, Nai A, Arosio P. Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood 2011; 117: 997-1004
10. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996; 379: 645-648
11. Ferrajoli A, Faderl S, Van Q, Koch P, Harris D, Liu Z, Hazan-Halevy I, Wang Y, Kantarjian HM, Priebe W, Estrov Z. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res 2007; 67: 11291-11299
12. Verstovsek S, Manshouri T, Quintás-Cardama A, Harris D, Cortes J, Giles FJ, Kantarjian H, Priebe W, Estrov Z. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res 2008; 14: 788-796