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Volumn 3, Issue , 2017, Pages 1-21

Parkinson disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BIOLOGICAL MARKER; CATECHOL METHYLTRANSFERASE INHIBITOR; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; ANTIPARKINSON AGENT;

EID: 85016139358     PISSN: None     EISSN: 2056676X     Source Type: Journal    
DOI: 10.1038/nrdp.2017.13     Document Type: Article
Times cited : (2280)

References (277)
  • 1
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence studies of Parkinson's disease
    • Twelves, D., Perkins, K. S. & Counsell, C. Systematic review of incidence studies of Parkinson's disease. Mov. Disord. 18, 19-31 (2003).
    • (2003) Mov. Disord. , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.S.2    Counsell, C.3
  • 2
    • 84880302934 scopus 로고    scopus 로고
    • Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism
    • Savica, R., Grossardt, B. R., Bower, J. H., Ahlskog, J. E. & Rocca, W. A. Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism. JAMA Neurol. 70, 859-866 (2013).
    • (2013) JAMA Neurol. , vol.70 , pp. 859-866
    • Savica, R.1    Grossardt, B.R.2    Bower, J.H.3    Ahlskog, J.E.4    Rocca, W.A.5
  • 3
    • 0037675042 scopus 로고    scopus 로고
    • Incidence of Parkinson's disease: Variation by age, gender, and race/ethnicity
    • Van Den Eeden, S. K. et al. Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am. J. Epidemiol. 157, 1015-1022 (2003).
    • (2003) Am. J. Epidemiol. , vol.157 , pp. 1015-1022
    • Van Den Eeden, S.K.1
  • 4
    • 84911423174 scopus 로고    scopus 로고
    • The prevalence of Parkinson's disease: A systematic review and meta-analysis
    • Pringsheim, T., Jette, N., Frolkis, A. & Steeves, T. D. The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov. Disord. 29, 1583-1590 (2014).
    • (2014) Mov. Disord. , vol.29 , pp. 1583-1590
    • Pringsheim, T.1    Jette, N.2    Frolkis, A.3    Steeves, T.D.4
  • 5
    • 84922266292 scopus 로고    scopus 로고
    • Mortality in Parkinson's disease: A 38-year follow-up study
    • Pinter, B. et al. Mortality in Parkinson's disease: a 38-year follow-up study. Mov. Disord. 30, 266-269 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 266-269
    • Pinter, B.1
  • 6
    • 77950231728 scopus 로고    scopus 로고
    • Socioeconomic variations in the prevalence and incidence of Parkinson's disease: A population-based analysis
    • Lix, L. M. et al. Socioeconomic variations in the prevalence and incidence of Parkinson's disease: a population-based analysis. J. Epidemiol. Community Health 64, 335-340 (2010).
    • (2010) J. Epidemiol. Community Health , vol.64 , pp. 335-340
    • Lix, L.M.1
  • 7
    • 33846572874 scopus 로고    scopus 로고
    • Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
    • Dorsey, E. R. et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68, 384-386 (2007).
    • (2007) Neurology , vol.68 , pp. 384-386
    • Dorsey, E.R.1
  • 8
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Vos, T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2163-2196 (2012).
    • (2012) Lancet , vol.380 , pp. 2163-2196
    • Vos, T.1
  • 9
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Murray, C. J. et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223 (2012).
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.1
  • 10
    • 33845214966 scopus 로고    scopus 로고
    • Direct medical costs associated with Parkinson's disease: A population-based study
    • Leibson, C. L. et al. Direct medical costs associated with Parkinson's disease: a population-based study. Mov. Disord. 21, 1864-1871 (2006).
    • (2006) Mov. Disord. , vol.21 , pp. 1864-1871
    • Leibson, C.L.1
  • 11
    • 0034649437 scopus 로고    scopus 로고
    • Parkinson's disease and parkinsonism in a longitudinal study: Two-fold higher incidence in men
    • ILSA Working Group. Italian Longitudinal Study on Aging
    • Baldereschi, M. et al. Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging. Neurology 55, 1358-1363 (2000).
    • (2000) Neurology , vol.55 , pp. 1358-1363
    • Baldereschi, M.1
  • 12
    • 0029945762 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease in Yonago City Japan: Comparison with a study carried out 12 years ago
    • Kusumi, M., Nakashima, K., Harada, H., Nakayama, H. & Takahashi, K. Epidemiology of Parkinson's disease in Yonago City, Japan: comparison with a study carried out 12 years ago. Neuroepidemiology 15, 201-207 (1996).
    • (1996) Neuroepidemiology , vol.15 , pp. 201-207
    • Kusumi, M.1    Nakashima, K.2    Harada, H.3    Nakayama, H.4    Takahashi, K.5
  • 13
    • 79958232053 scopus 로고    scopus 로고
    • Use of a refined drug tracer algorithm to estimate prevalence and incidence of Parkinson's disease in a large Israeli population
    • Chillag-Talmor, O. et al. Use of a refined drug tracer algorithm to estimate prevalence and incidence of Parkinson's disease in a large Israeli population. J. Parkinsons Dis. 1, 35-47 (2011).
    • (2011) J. Parkinsons Dis. , vol.1 , pp. 35-47
    • Chillag-Talmor, O.1
  • 14
    • 84866599978 scopus 로고    scopus 로고
    • Parkinson's disease among American Indians and Alaska natives: A nationwide prevalence study
    • Gordon, P. H., Mehal, J. M., Holman, R. C., Rowland, A. S. & Cheek, J. E. Parkinson's disease among American Indians and Alaska natives: a nationwide prevalence study. Mov. Disord. 27, 1456-1459 (2012).
    • (2012) Mov. Disord. , vol.27 , pp. 1456-1459
    • Gordon, P.H.1    Mehal, J.M.2    Holman, R.C.3    Rowland, A.S.4    Cheek, J.E.5
  • 15
    • 0029935219 scopus 로고    scopus 로고
    • Epidemiologic observations on Parkinson's disease: Incidence and mortality in a prospective study of middle-aged men
    • Morens, D. M. et al. Epidemiologic observations on Parkinson's disease: incidence and mortality in a prospective study of middle-aged men. Neurology 46, 1044-1050 (1996).
    • (1996) Neurology , vol.46 , pp. 1044-1050
    • Morens, D.M.1
  • 16
    • 84992198065 scopus 로고    scopus 로고
    • The epidemiology of Parkinson's disease: Risk factors and prevention
    • Ascherio, A. & Schwarzschild, M. A. The epidemiology of Parkinson's disease: risk factors and prevention. Lancet Neurol. 15, 1257-1272 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 1257-1272
    • Ascherio, A.1    Schwarzschild, M.A.2
  • 17
    • 71849092190 scopus 로고    scopus 로고
    • Neuropathological assessment of Parkinson's disease: Refining the diagnostic criteria
    • Dickson, D. W. et al. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol. 8, 1150-1157 (2009).
    • (2009) Lancet Neurol. , vol.8 , pp. 1150-1157
    • Dickson, D.W.1
  • 18
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday, G. M., Holton, J. L., Revesz, T. & Dickson, D. W. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol. 122, 187-204 (2011).
    • (2011) Acta Neuropathol. , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 19
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • Fearnley, J. M. & Lees, A. J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114, 2283-2301 (1991).
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 20
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier, P., Hirsch, E. C., Agid, Y. & Graybiel, A. M. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 122, 1437-1448 (1999).
    • (1999) Brain , vol.122 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 21
    • 84908897412 scopus 로고    scopus 로고
    • Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
    • Dijkstra, A. A. et al. Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease. Mov. Disord. 29, 1244-1251 (2014).
    • (2014) Mov. Disord. , vol.29 , pp. 1244-1251
    • Dijkstra, A.A.1
  • 22
    • 84946923292 scopus 로고    scopus 로고
    • Parkinson disease and incidental Lewy body disease: Just a question of time?
    • Iacono, D. et al. Parkinson disease and incidental Lewy body disease: just a question of time? Neurology 85, 1670-1679 (2015).
    • (2015) Neurology , vol.85 , pp. 1670-1679
    • Iacono, D.1
  • 23
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 24
    • 84939599004 scopus 로고    scopus 로고
    • Large-scale meta-analysis of genomewide association data identifies six new risk loci for Parkinson's disease
    • Nalls, M. A. et al. Large-scale meta-analysis of genomewide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46, 989-993 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 989-993
    • Nalls, M.A.1
  • 26
    • 84971238775 scopus 로고    scopus 로고
    • Parkinson-associated risk variant in distal enhancer of alpha-synuclein modulates target gene expression
    • Soldner, F. et al. Parkinson-associated risk variant in distal enhancer of alpha-synuclein modulates target gene expression. Nature 533, 95-99 (2016).
    • (2016) Nature , vol.533 , pp. 95-99
    • Soldner, F.1
  • 27
    • 84898735649 scopus 로고    scopus 로고
    • Limelight on alpha-synuclein: Pathological and mechanistic implications in neurodegeneration
    • Wales, P., Pinho, R., Lazaro, D. F. & Outeiro, T. F. Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration. J. Parkinsons Dis. 3, 415-459 (2013).
    • (2013) J. Parkinsons Dis. , vol.3 , pp. 415-459
    • Wales, P.1    Pinho, R.2    Lazaro, D.F.3    Outeiro, T.F.4
  • 28
    • 84952645933 scopus 로고    scopus 로고
    • The synaptic function of alpha-synuclein
    • Burre, J. The synaptic function of alpha-synuclein. J. Parkinsons Dis. 5, 699-713 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 699-713
    • Burre, J.1
  • 29
    • 54749104651 scopus 로고    scopus 로고
    • Controlling the mass action of alpha-synuclein in Parkinson's disease
    • Kim, C. & Lee, S. J. Controlling the mass action of alpha-synuclein in Parkinson's disease. J. Neurochem. 107, 303-316 (2008).
    • (2008) J. Neurochem. , vol.107 , pp. 303-316
    • Kim, C.1    Lee, S.J.2
  • 30
    • 84930509257 scopus 로고    scopus 로고
    • Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases
    • Melki, R. Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases. J. Parkinsons Dis. 5, 217-227 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 217-227
    • Melki, R.1
  • 31
    • 84949559900 scopus 로고    scopus 로고
    • Proteostasis and aging
    • Kaushik, S. & Cuervo, A. M. Proteostasis and aging. Nat. Med. 21, 1406-1415 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1406-1415
    • Kaushik, S.1    Cuervo, A.M.2
  • 32
    • 84879606955 scopus 로고    scopus 로고
    • Alphasynuclein and protein degradation systems: A reciprocal relationship
    • Xilouri, M., Brekk, O. R. & Stefanis, L. Alphasynuclein and protein degradation systems: a reciprocal relationship. Mol. Neurobiol. 47, 537-551 (2013).
    • (2013) Mol. Neurobiol. , vol.47 , pp. 537-551
    • Xilouri, M.1    Brekk, O.R.2    Stefanis, L.3
  • 33
    • 52449117926 scopus 로고    scopus 로고
    • Research in motion: The enigma of Parkinson's disease pathology spread
    • Brundin, P., Li, J. Y., Holton, J. L., Lindvall, O. & Revesz, T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat. Rev. Neurosci. 9, 741-745 (2008).
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 741-745
    • Brundin, P.1    Li, J.Y.2    Holton, J.L.3    Lindvall, O.4    Revesz, T.5
  • 34
    • 65849127844 scopus 로고    scopus 로고
    • Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperonemediated autophagy
    • Xilouri, M., Vogiatzi, T., Vekrellis, K., Park, D. & Stefanis, L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperonemediated autophagy. PLoS ONE 4, e5515 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5515
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Park, D.4    Stefanis, L.5
  • 35
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Chu, Y. & Kordower, J. H. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease? Neurobiol. Dis. 25, 134-149 (2007).
    • (2007) Neurobiol. Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 36
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A. & Rubinsztein, D. C. Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 282, 5641-5652 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 37
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence studies of Parkinson's disease
    • Twelves, D., Perkins, K. S. & Counsell, C. Systematic review of incidence studies of Parkinson's disease. Mov. Disord. 18, 19-31 (2003).
    • (2003) Mov. Disord. , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.S.2    Counsell, C.3
  • 38
    • 84880302934 scopus 로고    scopus 로고
    • Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism
    • Savica, R., Grossardt, B. R., Bower, J. H., Ahlskog, J. E. & Rocca, W. A. Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism. JAMA Neurol. 70, 859-866 (2013).
    • (2013) JAMA Neurol. , vol.70 , pp. 859-866
    • Savica, R.1    Grossardt, B.R.2    Bower, J.H.3    Ahlskog, J.E.4    Rocca, W.A.5
  • 39
    • 0037675042 scopus 로고    scopus 로고
    • Incidence of Parkinson's disease: Variation by age, gender, and race/ethnicity
    • Van Den Eeden, S. K. et al. Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am. J. Epidemiol. 157, 1015-1022 (2003).
    • (2003) Am. J. Epidemiol. , vol.157 , pp. 1015-1022
    • Van Den Eeden, S.K.1
  • 40
    • 84911423174 scopus 로고    scopus 로고
    • The prevalence of Parkinson's disease: A systematic review and meta-analysis
    • Pringsheim, T., Jette, N., Frolkis, A. & Steeves, T. D. The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov. Disord. 29, 1583-1590 (2014).
    • (2014) Mov. Disord. , vol.29 , pp. 1583-1590
    • Pringsheim, T.1    Jette, N.2    Frolkis, A.3    Steeves, T.D.4
  • 41
    • 84922266292 scopus 로고    scopus 로고
    • Mortality in Parkinson's disease: A 38-year follow-up study
    • Pinter, B. et al. Mortality in Parkinson's disease: a 38-year follow-up study. Mov. Disord. 30, 266-269 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 266-269
    • Pinter, B.1
  • 42
    • 77950231728 scopus 로고    scopus 로고
    • Socioeconomic variations in the prevalence and incidence of Parkinson's disease: A population-based analysis
    • Lix, L. M. et al. Socioeconomic variations in the prevalence and incidence of Parkinson's disease: a population-based analysis. J. Epidemiol. Community Health 64, 335-340 (2010).
    • (2010) J. Epidemiol. Community Health , vol.64 , pp. 335-340
    • Lix, L.M.1
  • 43
    • 33846572874 scopus 로고    scopus 로고
    • Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
    • Dorsey, E. R. et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68, 384-386 (2007).
    • (2007) Neurology , vol.68 , pp. 384-386
    • Dorsey, E.R.1
  • 44
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Vos, T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2163-2196 (2012).
    • (2012) Lancet , vol.380 , pp. 2163-2196
    • Vos, T.1
  • 45
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Murray, C. J. et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223 (2012).
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.1
  • 46
    • 33845214966 scopus 로고    scopus 로고
    • Direct medical costs associated with Parkinson's disease: A population-based study
    • Leibson, C. L. et al. Direct medical costs associated with Parkinson's disease: a population-based study. Mov. Disord. 21, 1864-1871 (2006).
    • (2006) Mov. Disord. , vol.21 , pp. 1864-1871
    • Leibson, C.L.1
  • 47
    • 0034649437 scopus 로고    scopus 로고
    • Parkinson's disease and parkinsonism in a longitudinal study: Two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging
    • Baldereschi, M. et al. Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging. Neurology 55, 1358-1363 (2000).
    • (2000) Neurology , vol.55 , pp. 1358-1363
    • Baldereschi, M.1
  • 48
    • 0029945762 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease in Yonago City, Japan: Comparison with a study carried out 12 years ago
    • Kusumi, M., Nakashima, K., Harada, H., Nakayama, H. & Takahashi, K. Epidemiology of Parkinson's disease in Yonago City, Japan: comparison with a study carried out 12 years ago. Neuroepidemiology 15, 201-207 (1996).
    • (1996) Neuroepidemiology , vol.15 , pp. 201-207
    • Kusumi, M.1    Nakashima, K.2    Harada, H.3    Nakayama, H.4    Takahashi, K.5
  • 49
    • 79958232053 scopus 로고    scopus 로고
    • Use of a refined drug tracer algorithm to estimate prevalence and incidence of Parkinson's disease in a large Israeli population
    • Chillag-Talmor, O. et al. Use of a refined drug tracer algorithm to estimate prevalence and incidence of Parkinson's disease in a large Israeli population. J. Parkinsons Dis. 1, 35-47 (2011).
    • (2011) J. Parkinsons Dis. , vol.1 , pp. 35-47
    • Chillag-Talmor, O.1
  • 50
    • 84866599978 scopus 로고    scopus 로고
    • Parkinson's disease among American Indians and Alaska natives: A nationwide prevalence study
    • Gordon, P. H., Mehal, J. M., Holman, R. C., Rowland, A. S. & Cheek, J. E. Parkinson's disease among American Indians and Alaska natives: a nationwide prevalence study. Mov. Disord. 27, 1456-1459 (2012).
    • (2012) Mov. Disord. , vol.27 , pp. 1456-1459
    • Gordon, P.H.1    Mehal, J.M.2    Holman, R.C.3    Rowland, A.S.4    Cheek, J.E.5
  • 51
    • 0029935219 scopus 로고    scopus 로고
    • Epidemiologic observations on Parkinson's disease: Incidence and mortality in a prospective study of middle-aged men
    • Morens, D. M. et al. Epidemiologic observations on Parkinson's disease: incidence and mortality in a prospective study of middle-aged men. Neurology 46, 1044-1050 (1996).
    • (1996) Neurology , vol.46 , pp. 1044-1050
    • Morens, D.M.1
  • 52
    • 84992198065 scopus 로고    scopus 로고
    • The epidemiology of Parkinson's disease: Risk factors and prevention
    • Ascherio, A. & Schwarzschild, M. A. The epidemiology of Parkinson's disease: risk factors and prevention. Lancet Neurol. 15, 1257-1272 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 1257-1272
    • Ascherio, A.1    Schwarzschild, M.A.2
  • 53
    • 71849092190 scopus 로고    scopus 로고
    • Neuropathological assessment of Parkinson's disease: Refining the diagnostic criteria
    • Dickson, D. W. et al. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol. 8, 1150-1157 (2009).
    • (2009) Lancet Neurol. , vol.8 , pp. 1150-1157
    • Dickson, D.W.1
  • 54
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday, G. M., Holton, J. L., Revesz, T. & Dickson, D. W. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol. 122, 187-204 (2011).
    • (2011) Acta Neuropathol. , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 55
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • Fearnley, J. M. & Lees, A. J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114, 2283-2301 (1991).
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 56
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier, P., Hirsch, E. C., Agid, Y. & Graybiel, A. M. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 122, 1437-1448 (1999).
    • (1999) Brain , vol.122 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 57
    • 84908897412 scopus 로고    scopus 로고
    • Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
    • Dijkstra, A. A. et al. Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease. Mov. Disord. 29, 1244-1251 (2014).
    • (2014) Mov. Disord. , vol.29 , pp. 1244-1251
    • Dijkstra, A.A.1
  • 58
    • 84946923292 scopus 로고    scopus 로고
    • Parkinson disease and incidental Lewy body disease: Just a question of time?
    • Iacono, D. et al. Parkinson disease and incidental Lewy body disease: just a question of time? Neurology 85, 1670-1679 (2015).
    • (2015) Neurology , vol.85 , pp. 1670-1679
    • Iacono, D.1
  • 59
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 60
    • 84939599004 scopus 로고    scopus 로고
    • Large-scale meta-analysis of genomewide association data identifies six new risk loci for Parkinson's disease
    • Nalls, M. A. et al. Large-scale meta-analysis of genomewide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46, 989-993 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 989-993
    • Nalls, M.A.1
  • 62
    • 84971238775 scopus 로고    scopus 로고
    • Parkinson-associated risk variant in distal enhancer of alpha-synuclein modulates target gene expression
    • Soldner, F. et al. Parkinson-associated risk variant in distal enhancer of alpha-synuclein modulates target gene expression. Nature 533, 95-99 (2016).
    • (2016) Nature , vol.533 , pp. 95-99
    • Soldner, F.1
  • 63
    • 84898735649 scopus 로고    scopus 로고
    • Limelight on alpha-synuclein: Pathological and mechanistic implications in neurodegeneration
    • Wales, P., Pinho, R., Lazaro, D. F. & Outeiro, T. F. Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration. J. Parkinsons Dis. 3, 415-459 (2013).
    • (2013) J. Parkinsons Dis. , vol.3 , pp. 415-459
    • Wales, P.1    Pinho, R.2    Lazaro, D.F.3    Outeiro, T.F.4
  • 64
    • 84952645933 scopus 로고    scopus 로고
    • The synaptic function of alpha-synuclein
    • Burre, J. The synaptic function of alpha-synuclein. J. Parkinsons Dis. 5, 699-713 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 699-713
    • Burre, J.1
  • 65
    • 54749104651 scopus 로고    scopus 로고
    • Controlling the mass action of alpha-synuclein in Parkinson's disease
    • Kim, C. & Lee, S. J. Controlling the mass action of alpha-synuclein in Parkinson's disease. J. Neurochem. 107, 303-316 (2008).
    • (2008) J. Neurochem. , vol.107 , pp. 303-316
    • Kim, C.1    Lee, S.J.2
  • 66
    • 84930509257 scopus 로고    scopus 로고
    • Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases
    • Melki, R. Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases. J. Parkinsons Dis. 5, 217-227 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 217-227
    • Melki, R.1
  • 67
    • 84949559900 scopus 로고    scopus 로고
    • Proteostasis and aging
    • Kaushik, S. & Cuervo, A. M. Proteostasis and aging. Nat. Med. 21, 1406-1415 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1406-1415
    • Kaushik, S.1    Cuervo, A.M.2
  • 68
    • 84879606955 scopus 로고    scopus 로고
    • Alphasynuclein and protein degradation systems: A reciprocal relationship
    • Xilouri, M., Brekk, O. R. & Stefanis, L. Alphasynuclein and protein degradation systems: a reciprocal relationship. Mol. Neurobiol. 47, 537-551 (2013).
    • (2013) Mol. Neurobiol. , vol.47 , pp. 537-551
    • Xilouri, M.1    Brekk, O.R.2    Stefanis, L.3
  • 69
    • 52449117926 scopus 로고    scopus 로고
    • Research in motion: The enigma of Parkinson's disease pathology spread
    • Brundin, P., Li, J. Y., Holton, J. L., Lindvall, O. & Revesz, T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat. Rev. Neurosci. 9, 741-745 (2008).
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 741-745
    • Brundin, P.1    Li, J.Y.2    Holton, J.L.3    Lindvall, O.4    Revesz, T.5
  • 70
    • 65849127844 scopus 로고    scopus 로고
    • Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperonemediated autophagy
    • Xilouri, M., Vogiatzi, T., Vekrellis, K., Park, D. & Stefanis, L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperonemediated autophagy. PLoS ONE 4, e5515 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5515
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Park, D.4    Stefanis, L.5
  • 71
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Chu, Y. & Kordower, J. H. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease? Neurobiol. Dis. 25, 134-149 (2007).
    • (2007) Neurobiol. Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 72
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A. & Rubinsztein, D. C. Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 282, 5641-5652 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 73
    • 84881158430 scopus 로고    scopus 로고
    • Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain
    • Steele, J. W. et al. Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain. Mol. Psychiatry 18, 882-888 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 882-888
    • Steele, J.W.1
  • 74
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
    • Chu, Y., Dodiya, H., Aebischer, P., Olanow, C. W. & Kordower, J. H. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol. Dis. 35, 385-398 (2009).
    • (2009) Neurobiol. Dis. , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya, H.2    Aebischer, P.3    Olanow, C.W.4    Kordower, J.H.5
  • 75
    • 78149469728 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy markers in Parkinson disease brains
    • Alvarez-Erviti, L. et al. Chaperone-mediated autophagy markers in Parkinson disease brains. Arch. Neurol. 67, 1464-1472 (2010).
    • (2010) Arch. Neurol. , vol.67 , pp. 1464-1472
    • Alvarez-Erviti, L.1
  • 76
    • 0031036896 scopus 로고    scopus 로고
    • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
    • Anglade, P. et al. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31 (1997).
    • (1997) Histol. Histopathol. , vol.12 , pp. 25-31
    • Anglade, P.1
  • 77
    • 77951976610 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    • Emmanouilidou, E., Stefanis, L. & Vekrellis, K. Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol. Aging 31, 953-968 (2010).
    • (2010) Neurobiol. Aging , vol.31 , pp. 953-968
    • Emmanouilidou, E.1    Stefanis, L.2    Vekrellis, K.3
  • 78
    • 77957189194 scopus 로고    scopus 로고
    • Alpha-synuclein impairs macroautophagy: Implications for Parkinson's disease
    • Winslow, A. R. et al. Alpha-synuclein impairs macroautophagy: implications for Parkinson's disease. J. Cell Biol. 190, 1023-1037 (2010).
    • (2010) J. Cell Biol. , vol.190 , pp. 1023-1037
    • Winslow, A.R.1
  • 79
    • 84878230429 scopus 로고    scopus 로고
    • Lewy body-like alphasynuclein aggregates resist degradation and impair macroautophagy
    • Tanik, S. A., Schultheiss, C. E., Volpicelli-Daley, L. A., Brunden, K. R. & Lee, V. M. Lewy body-like alphasynuclein aggregates resist degradation and impair macroautophagy. J. Biol. Chem. 288, 15194-15210 (2013).
    • (2013) J. Biol. Chem. , Issue.288 , pp. 15194-15210
    • Tanik, S.A.1    Schultheiss, C.E.2    Volpicelli-Daley, L.A.3    Brunden, K.R.4    Lee, V.M.5
  • 80
    • 38849174979 scopus 로고    scopus 로고
    • Dopamine-modified alphasynuclein blocks chaperone-mediated autophagy
    • Martinez-Vicente, M. et al. Dopamine-modified alphasynuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777-788 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 777-788
    • Martinez-Vicente, M.1
  • 81
    • 84978841976 scopus 로고    scopus 로고
    • G2019S-LRRK2 expression augments alpha-synuclein sequestration into inclusions in neurons
    • Volpicelli-Daley, L. A. et al. G2019S-LRRK2 expression augments alpha-synuclein sequestration into inclusions in neurons. J. Neurosci. 36, 7415-7427 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 7415-7427
    • Volpicelli-Daley, L.A.1
  • 82
    • 70350319531 scopus 로고    scopus 로고
    • Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
    • Sidransky, E. et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N. Engl. J. Med. 361, 1651-1661 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1651-1661
    • Sidransky, E.1
  • 83
    • 84960803232 scopus 로고    scopus 로고
    • ER stress and autophagic perturbations lead to elevated extracellular alphasynuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons
    • Fernandes, H. J. et al. ER stress and autophagic perturbations lead to elevated extracellular alphasynuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons. Stem Cell Reports 6, 342-356 (2016).
    • (2016) Stem Cell Reports , vol.6 , pp. 342-356
    • Fernandes, H.J.1
  • 84
    • 84929870936 scopus 로고    scopus 로고
    • Progressive decline of glucocerebrosidase in aging and Parkinson's disease
    • Rocha, E. M. et al. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Ann. Clin. Transl Neurol. 2, 433-438 (2015).
    • (2015) Ann. Clin. Transl Neurol. , vol.2 , pp. 433-438
    • Rocha, E.M.1
  • 85
    • 84990249645 scopus 로고    scopus 로고
    • Survival and dementia in GBAassociated Parkinson's disease: The mutation matters
    • Cilia, R. et al. Survival and dementia in GBAassociated Parkinson's disease: the mutation matters. Ann. Neurol. 80, 662-673 (2016).
    • (2016) Ann. Neurol. , vol.80 , pp. 662-673
    • Cilia, R.1
  • 86
    • 84995745476 scopus 로고    scopus 로고
    • Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
    • Liu, G. et al. Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's. Ann. Neurol. 80, 674-685 (2016).
    • (2016) Ann. Neurol. , vol.80 , pp. 674-685
    • Liu, G.1
  • 87
    • 79960009804 scopus 로고    scopus 로고
    • Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies
    • Mazzulli, J. R. et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 146, 37-52 (2011).
    • (2011) Cell , vol.146 , pp. 37-52
    • Mazzulli, J.R.1
  • 88
    • 84874487118 scopus 로고    scopus 로고
    • Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
    • Sardi, S. P. et al. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. Proc. Natl Acad. Sci. USA 110, 3537-3542 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 3537-3542
    • Sardi, S.P.1
  • 89
    • 80051488602 scopus 로고    scopus 로고
    • VPS35 mutations in Parkinson disease
    • Vilarino-Guell, C. et al. VPS35 mutations in Parkinson disease. Am. J. Hum. Genet. 89, 162-167 (2011).
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 162-167
    • Vilarino-Guell, C.1
  • 90
    • 80051534540 scopus 로고    scopus 로고
    • A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
    • Zimprich, A. et al. A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am. J. Hum. Genet. 89, 168-175 (2011).
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 168-175
    • Zimprich, A.1
  • 91
    • 84940544945 scopus 로고    scopus 로고
    • Analysis of the retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease
    • Seaman, M. & Freeman, C. L. Analysis of the retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease. Commun. Integr. Biol. 7, e29483 (2014).
    • (2014) Commun. Integr. Biol. , vol.7 , pp. e29483
    • Seaman, M.1    Freeman, C.L.2
  • 92
    • 84937677490 scopus 로고    scopus 로고
    • VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease
    • Tang, F. L. et al. VPS35 in dopamine neurons is required for endosome-to-golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson's disease. J. Neurosci. 35, 10613-10628 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 10613-10628
    • Tang, F.L.1
  • 93
    • 84920740324 scopus 로고    scopus 로고
    • Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein
    • Dhungel, N. et al. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein. Neuron 85, 76-87 (2015).
    • (2015) Neuron , vol.85 , pp. 76-87
    • Dhungel, N.1
  • 94
    • 33749133430 scopus 로고    scopus 로고
    • Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
    • Ramirez, A. et al. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat. Genet. 38, 1184-1191 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 1184-1191
    • Ramirez, A.1
  • 95
    • 84866529985 scopus 로고    scopus 로고
    • Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
    • Dehay, B. et al. Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove. Autophagy 8, 1389-1391 (2012).
    • (2012) Autophagy , vol.8 , pp. 1389-1391
    • Dehay, B.1
  • 96
    • 85016046155 scopus 로고    scopus 로고
    • Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: Evidence for oligogenic inheritance
    • Lubbe, S. J. et al. Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. Hum. Mol. Genet. 25, 5483-5489 (2016).
    • (2016) Hum. Mol. Genet. , vol.25 , pp. 5483-5489
    • Lubbe, S.J.1
  • 98
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin, P., Melki, R. & Kopito, R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat. Rev. Mol. Cell Biol. 11, 301-307 (2010).
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 99
    • 85028261236 scopus 로고    scopus 로고
    • Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology
    • Tyson, T., Steiner, J. A. & Brundin, P. Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology. J. Neurochem. 139 (Suppl. 1), 275-289 (2016).
    • (2016) J. Neurochem. , vol.139 , Issue.SUPPL. 1 , pp. 275-289
    • Tyson, T.1    Steiner, J.A.2    Brundin, P.3
  • 100
    • 84989172537 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiated by binding lymphocyteactivation gene 3
    • Mao, X. et al. Pathological alpha-synuclein transmission initiated by binding lymphocyteactivation gene 3. Science 353, aah3374 (2016).
    • (2016) Science , vol.353 , pp. aah3374
    • Mao, X.1
  • 101
    • 84944460691 scopus 로고    scopus 로고
    • MDS research criteria for prodromal Parkinson's disease
    • Berg D. et al. MDS research criteria for prodromal Parkinson's disease. Mov. Disord. 30, 1600-1611 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1600-1611
    • Berg, D.1
  • 102
    • 84952683160 scopus 로고    scopus 로고
    • The concept of prodromal Parkinson's disease
    • Mahlknecht, P., Seppi, K. & Poewe, W. The concept of prodromal Parkinson's disease. J. Parkinsons Dis. 5, 681-697 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 681-697
    • Mahlknecht, P.1    Seppi, K.2    Poewe, W.3
  • 104
    • 34250716407 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • Schapira, A. H. Mitochondrial dysfunction in Parkinson's disease. Cell Death Differ. 14, 1261-1266 (2007).
    • (2007) Cell Death Differ. , vol.14 , pp. 1261-1266
    • Schapira, A.H.1
  • 105
    • 85027917509 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • Bose, A. & Beal, M. F. Mitochondrial dysfunction in Parkinson's disease. J. Neurochem. 139 (Suppl. 1), 216-231 (2016).
    • (2016) J. Neurochem. , vol.139 , Issue.SUPPL. 1 , pp. 216-231
    • Bose, A.1    Beal, M.F.2
  • 106
    • 77958072667 scopus 로고    scopus 로고
    • PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease
    • Zheng, B. et al. PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Sci. Transl Med. 2, 52ra73 (2010).
    • (2010) Sci. Transl Med. , vol.2 , pp. 52ra73
    • Zheng, B.1
  • 107
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alphasynuclein impair complex i in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G. & Anandatheerthavarada, H. K. Mitochondrial import and accumulation of alphasynuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem. 283, 9089-9100 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 108
    • 84920920653 scopus 로고    scopus 로고
    • Mutual exacerbation of peroxisome proliferator-activated receptor gamma coactivator 1alpha deregulation and alpha-synuclein oligomerization
    • Eschbach, J. et al. Mutual exacerbation of peroxisome proliferator-activated receptor gamma coactivator 1alpha deregulation and alpha-synuclein oligomerization. Ann. Neurol. 77, 15-32 (2015).
    • (2015) Ann. Neurol. , vol.77 , pp. 15-32
    • Eschbach, J.1
  • 109
    • 33846636481 scopus 로고    scopus 로고
    • Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
    • Ekstrand, M. I. et al. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc. Natl Acad. Sci. USA 104, 1325-1330 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 1325-1330
    • Ekstrand, M.I.1
  • 110
    • 84908409010 scopus 로고    scopus 로고
    • Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease
    • Nordstrom, U. et al. Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiol. Dis. 73, 70-82 (2015).
    • (2015) Neurobiol. Dis. , vol.73 , pp. 70-82
    • Nordstrom, U.1
  • 111
    • 3843057052 scopus 로고    scopus 로고
    • Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: Their relation to disease-compensatory mechanisms
    • Sossi, V. et al. Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms. J. Cereb. Blood Flow Metab. 24, 869-876 (2004).
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 869-876
    • Sossi, V.1
  • 112
    • 78650209340 scopus 로고    scopus 로고
    • Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
    • Sossi, V. et al. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov. Disord. 25, 2717-2723 (2010).
    • (2010) Mov. Disord. , vol.25 , pp. 2717-2723
    • Sossi, V.1
  • 113
    • 84880932230 scopus 로고    scopus 로고
    • Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
    • Kordower, J. H. et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 136, 2419-2431 (2013).
    • (2013) Brain , vol.136 , pp. 2419-2431
    • Kordower, J.H.1
  • 114
    • 84927598926 scopus 로고    scopus 로고
    • Spreading of alpha-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis
    • Lamberts, J. T., Hildebrandt, E. N. & Brundin, P. Spreading of alpha-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis. Neurobiol. Dis. 77, 276-283 (2015).
    • (2015) Neurobiol. Dis. , vol.77 , pp. 276-283
    • Lamberts, J.T.1    Hildebrandt, E.N.2    Brundin, P.3
  • 115
    • 84921369563 scopus 로고    scopus 로고
    • The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease
    • Pickrell, A. M. & Youle, R. J. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron 85, 257-273 (2015).
    • (2015) Neuron , vol.85 , pp. 257-273
    • Pickrell, A.M.1    Youle, R.J.2
  • 116
    • 84994834600 scopus 로고    scopus 로고
    • Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson's sisease
    • Hsieh, C. H. et al. Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic Parkinson's sisease. Cell Stem Cell 19, 709-724 (2016).
    • (2016) Cell Stem Cell , vol.19 , pp. 709-724
    • Hsieh, C.H.1
  • 117
    • 84891645843 scopus 로고    scopus 로고
    • The role of oxidative stress in Parkinson's disease
    • Dias, V., Junn, E. & Mouradian, M. M. The role of oxidative stress in Parkinson's disease. J. Parkinsons Dis. 3, 461-491 (2013).
    • (2013) J. Parkinsons Dis. , vol.3 , pp. 461-491
    • Dias, V.1    Junn, E.2    Mouradian, M.M.3
  • 118
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati, V. et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259 (2003).
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1
  • 119
    • 84990853711 scopus 로고    scopus 로고
    • DJ-1 modulates mitochondrial response to oxidative stress: Clues from a novel diagnosis of PARK7
    • Di Nottia, M. et al. DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7. Clin. Genet. http://dx.doi.org/ 10.1111/cge.12841 (2016).
    • (2016) Clin. Genet.
    • Di Nottia, M.1
  • 120
    • 78649866553 scopus 로고    scopus 로고
    • Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
    • Guzman, J. N. et al. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468, 696-700 (2010).
    • (2010) Nature , vol.468 , pp. 696-700
    • Guzman, J.N.1
  • 121
    • 84867745060 scopus 로고    scopus 로고
    • Living on the edge with too many mouths to feed: Why dopamine neurons die
    • Bolam, J. P. & Pissadaki, E. K. Living on the edge with too many mouths to feed: why dopamine neurons die. Mov. Disord. 27, 1478-1483 (2012).
    • (2012) Mov. Disord. , vol.27 , pp. 1478-1483
    • Bolam, J.P.1    Pissadaki, E.K.2
  • 122
    • 84874435362 scopus 로고    scopus 로고
    • The energy cost of action potential propagation in dopamine neurons: Clues to susceptibility in Parkinson's disease
    • Pissadaki, E. K. & Bolam, J. P. The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease. Front. Comput. Neurosci. 7, 13 (2013).
    • (2013) Front. Comput. Neurosci. , vol.7 , pp. 13
    • Pissadaki, E.K.1    Bolam, J.P.2
  • 123
    • 81255149611 scopus 로고    scopus 로고
    • The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease
    • Surmeier, D. J., Guzman, J. N., Sanchez-Padilla, J. & Schumacker, P. T. The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease. Neuroscience 198, 221-231 (2011).
    • (2011) Neuroscience , vol.198 , pp. 221-231
    • Surmeier, D.J.1    Guzman, J.N.2    Sanchez-Padilla, J.3    Schumacker, P.T.4
  • 124
    • 84995470098 scopus 로고    scopus 로고
    • Calcium and Parkinson's disease
    • Surmeier, D. J. et al. Calcium and Parkinson's disease. Biochem. Biophys. Res. Commun. 483, 1013-1019 (2017).
    • (2017) Biochem. Biophys. Res. Commun. , vol.483 , pp. 1013-1019
    • Surmeier, D.J.1
  • 125
    • 65249180086 scopus 로고    scopus 로고
    • Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons
    • Mosharov, E. V. et al. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron 62, 218-229 (2009).
    • (2009) Neuron , vol.62 , pp. 218-229
    • Mosharov, E.V.1
  • 126
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
    • Lotharius, J. & Brundin, P. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat. Rev. Neurosci. 3, 932-942 (2002).
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 127
    • 77956855813 scopus 로고    scopus 로고
    • Pathogenic lysosomal depletion in Parkinson's disease
    • Dehay, B. et al. Pathogenic lysosomal depletion in Parkinson's disease. J. Neurosci. 30, 12535-12544 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 12535-12544
    • Dehay, B.1
  • 128
    • 84938292218 scopus 로고    scopus 로고
    • M1 and M2 immune activation in Parkinson's disease: Foe and ally?
    • Moehle, M. S. & West, A. B. M1 and M2 immune activation in Parkinson's disease: foe and ally? Neuroscience 302, 59-73 (2015).
    • (2015) Neuroscience , vol.302 , pp. 59-73
    • Moehle, M.S.1    West, A.B.2
  • 129
    • 84983071295 scopus 로고    scopus 로고
    • How neuroinflammation contributes to neurodegeneration
    • Ransohoff, R. M. How neuroinflammation contributes to neurodegeneration. Science 353, 777-783 (2016).
    • (2016) Science , vol.353 , pp. 777-783
    • Ransohoff, R.M.1
  • 130
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotection?
    • Hirsch, E. C. & Hunot, S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8, 382-397 (2009).
    • (2009) Lancet Neurol. , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 131
    • 84898783826 scopus 로고    scopus 로고
    • MHC-I expression renders catecholaminergic neurons susceptible to T-cellmediated degeneration
    • Cebrian, C. et al. MHC-I expression renders catecholaminergic neurons susceptible to T-cellmediated degeneration. Nat. Commun. 5, 3633 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3633
    • Cebrian, C.1
  • 132
    • 84902163498 scopus 로고    scopus 로고
    • Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
    • Schapansky, J., Nardozzi, J. D., Felizia, F. & LaVoie, M. J. Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. Hum. Mol. Genet. 23, 4201-4214 (2014).
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 4201-4214
    • Schapansky, J.1    Nardozzi, J.D.2    Felizia, F.3    LaVoie, M.J.4
  • 133
    • 85014314456 scopus 로고    scopus 로고
    • LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways
    • Ma, B. et al. LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways. Hum. Mol. Genet. 25, 3515-3523 (2016).
    • (2016) Hum. Mol. Genet. , vol.25 , pp. 3515-3523
    • Ma, B.1
  • 134
    • 50549085408 scopus 로고    scopus 로고
    • Neuroinflammation and oxidation/ nitration of alpha-synuclein linked to dopaminergic neurodegeneration
    • Gao, H. M. et al. Neuroinflammation and oxidation/ nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J. Neurosci. 28, 7687-7698 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 7687-7698
    • Gao, H.M.1
  • 135
    • 84888394934 scopus 로고    scopus 로고
    • Inflammation and alphasynuclein's prion-like behavior in Parkinson's disease -is there a link?
    • Lema Tome, C. M. et al. Inflammation and alphasynuclein's prion-like behavior in Parkinson's disease -is there a link? Mol. Neurobiol. 47, 561-574 (2013).
    • (2013) Mol. Neurobiol. , vol.47 , pp. 561-574
    • Lema Tome, C.M.1
  • 136
    • 85001930733 scopus 로고    scopus 로고
    • Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
    • Sampson, T. R. et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. Cell 167, 1469-1480.e12 (2016).
    • (2016) Cell , vol.167 , pp. 1469-1469e12
    • Sampson, T.R.1
  • 137
    • 84941779114 scopus 로고    scopus 로고
    • Immunotherapy in Parkinson's disease: Micromanaging alpha-synuclein aggregation
    • George, S. & Brundin, P. Immunotherapy in Parkinson's disease: micromanaging alpha-synuclein aggregation. J. Parkinsons Dis. 5, 413-424 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 413-424
    • George, S.1    Brundin, P.2
  • 138
    • 0025613142 scopus 로고
    • Basal ganglia-thalamocortical circuits: Parallel substrates for motor oculomotor "prefrontal" and "limbic" functions
    • Alexander, G., Crutcher, M. D. & DeLong, M. R. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog. Brain Res. 85, 119-146 (1990).
    • (1990) Prog. Brain Res. , vol.85 , pp. 119-146
    • Alexander, G.1    Crutcher, M.D.2    DeLong, M.R.3
  • 139
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking basal ganglia and cortex
    • Alexander, G. D., DeLong, M. R. & Strick, P. L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357-381 (1986).
    • (1986) Annu. Rev. Neurosci. , vol.9 , pp. 357-381
    • Alexander, G.D.1    DeLong, M.R.2    Strick, P.L.3
  • 140
    • 0025169590 scopus 로고
    • Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
    • Bergman, H., Wichmann, T. & DeLong, M. R. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 249, 1436-1438 (1990).
    • (1990) Science , vol.249 , pp. 1436-1438
    • Bergman, H.1    Wichmann, T.2    DeLong, M.R.3
  • 141
    • 0026536547 scopus 로고
    • Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease
    • Laitinen, L. V., Bergenheim, A. T. & Hariz, M. I. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J. Neurosurg. 76, 53-61 (1992).
    • (1992) J. Neurosurg. , vol.76 , pp. 53-61
    • Laitinen, L.V.1    Bergenheim, A.T.2    Hariz, M.I.3
  • 142
    • 0033623794 scopus 로고    scopus 로고
    • Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey
    • Nambu, A. et al. Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. J. Neurophysiol. 84, 289-300 (2000).
    • (2000) J. Neurophysiol. , vol.84 , pp. 289-300
    • Nambu, A.1
  • 143
    • 36348930802 scopus 로고    scopus 로고
    • Hold your horses: Impulsivity, deep brain stimulation, and medication in parkinsonism
    • Frank, M. J., Samanta, J., Moustafa, A. A. & Sherman, S. J. Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism. Science 318, 1309-1312 (2007).
    • (2007) Science , vol.318 , pp. 1309-1312
    • Frank, M.J.1    Samanta, J.2    Moustafa, A.A.3    Sherman, S.J.4
  • 145
    • 84872732898 scopus 로고    scopus 로고
    • Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex
    • Li, Q. et al. Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex. Neuron 76, 1030-1041 (2012).
    • (2012) Neuron , vol.76 , pp. 1030-1041
    • Li, Q.1
  • 146
    • 46749086642 scopus 로고    scopus 로고
    • High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance
    • Kuhn, A. A. et al. High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance. J. Neurosci. 28, 6165-6173 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 6165-6173
    • Kuhn, A.A.1
  • 147
    • 33645459845 scopus 로고    scopus 로고
    • Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
    • Kuhn, A. A., Kupsch, A., Schneider, G. H. & Brown, P. Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease. Eur. J. Neurosci. 23, 1956-1960 (2006).
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 1956-1960
    • Kuhn, A.A.1    Kupsch, A.2    Schneider, G.H.3    Brown, P.4
  • 148
    • 33646191848 scopus 로고    scopus 로고
    • Oscillatory pallidal local field potential activity correlates with involuntary EMG in dystonia
    • Chen, C. C. et al. Oscillatory pallidal local field potential activity correlates with involuntary EMG in dystonia. Neurology 66, 418-420 (2006).
    • (2006) Neurology , vol.66 , pp. 418-420
    • Chen, C.C.1
  • 149
    • 84966479947 scopus 로고    scopus 로고
    • The cerebral network of Parkinson's tremor: An effective connectivity fMRI study
    • Dirkx, M. F. et al. The cerebral network of Parkinson's tremor: an effective connectivity fMRI study. J. Neurosci. 36, 5362-5372 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 5362-5372
    • Dirkx, M.F.1
  • 150
    • 84929661086 scopus 로고    scopus 로고
    • Where and what is the PPN and what is its role in locomotion?
    • Windels, F., Thevathasan, W., Silburn, P. & Sah, P. Where and what is the PPN and what is its role in locomotion? Brain 138, 1133-1134 (2015).
    • (2015) Brain , vol.138 , pp. 1133-1134
    • Windels, F.1    Thevathasan, W.2    Silburn, P.3    Sah, P.4
  • 151
    • 84940956493 scopus 로고    scopus 로고
    • Parkinson's disease
    • Kalia, L. V. & Lang, A. E. Parkinson's disease. Lancet 386, 896-912 (2015).
    • (2015) Lancet , vol.386 , pp. 896-912
    • Kalia, L.V.1    Lang, A.E.2
  • 152
    • 29044435205 scopus 로고    scopus 로고
    • The diagnosis of Parkinson's disease
    • Tolosa, E., Wenning, G. & Poewe, W. The diagnosis of Parkinson's disease. Lancet Neurol. 5, 75-86 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 75-86
    • Tolosa, E.1    Wenning, G.2    Poewe, W.3
  • 153
    • 0023898945 scopus 로고
    • The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease
    • Gibb, W. R. & Lees, A. J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 51, 745-752 (1988).
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , pp. 745-752
    • Gibb, W.R.1    Lees, A.J.2
  • 154
    • 84944452191 scopus 로고    scopus 로고
    • MDS clinical diagnostic criteria for Parkinson's disease
    • Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 30, 1591-1601 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1591-1601
    • Postuma, R.B.1
  • 155
    • 77957043835 scopus 로고    scopus 로고
    • Frequency of known mutations in early-onset Parkinson disease: Implication for genetic counseling: The consortium on risk for early onset Parkinson disease study
    • Alcalay, R. N. et al. Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch. Neurol. 67, 1116-1122 (2010).
    • (2010) Arch. Neurol. , vol.67 , pp. 1116-1122
    • Alcalay, R.N.1
  • 156
    • 77953633735 scopus 로고    scopus 로고
    • Predictors of parkin mutations in early-onset Parkinson disease: The consortium on risk for early-onset Parkinson disease study
    • Marder, K. S. et al. Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study. Arch. Neurol. 67, 731-738 (2010).
    • (2010) Arch. Neurol. , vol.67 , pp. 731-738
    • Marder, K.S.1
  • 157
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
    • Chaudhuri, K. R. & Schapira, A. H. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 8, 464-474 (2009).
    • (2009) Lancet Neurol. , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 158
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • Hely, M. A., Reid, W. G., Adena, M. A., Halliday, G. M. & Morris, J. G. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23, 837-844 (2008).
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 159
    • 61449165975 scopus 로고    scopus 로고
    • Movement Disorder Societysponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results
    • Goetz, C. G. et al. Movement Disorder Societysponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. 23, 2129-2170 (2008).
    • (2008) Mov. Disord. , vol.23 , pp. 2129-2170
    • Goetz, C.G.1
  • 160
    • 84977556275 scopus 로고    scopus 로고
    • A review of disease progression models of Parkinson's disease and applications in clinical trials
    • Venuto, C. S., Potter, N. B., Ray Dorsey, E. & Kieburtz, K. A review of disease progression models of Parkinson's disease and applications in clinical trials. Mov. Disord. 31, 947-956 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 947-956
    • Venuto, C.S.1    Potter, N.B.2    Ray Dorsey, E.3    Kieburtz, K.4
  • 161
    • 84957837117 scopus 로고    scopus 로고
    • Accuracy of clinical diagnosis of Parkinson disease: A systematic review and metaanalysis
    • Rizzo, G. et al. Accuracy of clinical diagnosis of Parkinson disease: a systematic review and metaanalysis. Neurology 86, 566-576 (2016).
    • (2016) Neurology , vol.86 , pp. 566-576
    • Rizzo, G.1
  • 162
    • 0021083984 scopus 로고
    • Dopamine visualized in the basal ganglia of living man
    • Garnett, E. S., Firnau, G. & Nahmias, C. Dopamine visualized in the basal ganglia of living man. Nature 305, 137-138 (1983).
    • (1983) Nature , vol.305 , pp. 137-138
    • Garnett, E.S.1    Firnau, G.2    Nahmias, C.3
  • 163
    • 84906318591 scopus 로고    scopus 로고
    • Imaging insights into basal ganglia function. Parkinson's disease, and dystonia
    • Stoessl, A. J., Lehericy, S. & Strafella, A. P. Imaging insights into basal ganglia function, Parkinson's disease, and dystonia. Lancet 384, 532-544 (2014).
    • (2014) Lancet , vol.384 , pp. 532-544
    • Stoessl, A.J.1    Lehericy, S.2    Strafella, A.P.3
  • 164
    • 84927173773 scopus 로고    scopus 로고
    • Neuroimaging in Parkinson disease: From research setting to clinical practice
    • Politis, M. Neuroimaging in Parkinson disease: from research setting to clinical practice. Nat. Rev. Neurol. 10, 708-722 (2014).
    • (2014) Nat. Rev. Neurol. , vol.10 , pp. 708-722
    • Politis, M.1
  • 165
    • 77954250857 scopus 로고    scopus 로고
    • Significance of MRI in diagnosis and differential diagnosis of Parkinson's disease
    • Mahlknecht, P. et al. Significance of MRI in diagnosis and differential diagnosis of Parkinson's disease. Neurodegener. Dis. 7, 300-318 (2010).
    • (2010) Neurodegener. Dis. , vol.7 , pp. 300-318
    • Mahlknecht, P.1
  • 166
    • 84962890414 scopus 로고    scopus 로고
    • Diagnostic potential of automated subcortical volume segmentation in atypical parkinsonism
    • Scherfler, C. et al. Diagnostic potential of automated subcortical volume segmentation in atypical parkinsonism. Neurology 86, 1242-1249 (2016).
    • (2016) Neurology , vol.86 , pp. 1242-1249
    • Scherfler, C.1
  • 167
    • 84969915674 scopus 로고    scopus 로고
    • Magnetic resonance imaging as a potential biomarker for Parkinson's disease
    • Tuite, P. Magnetic resonance imaging as a potential biomarker for Parkinson's disease. Transl Res. 175, 4-16 (2016).
    • (2016) Transl Res. , vol.175 , pp. 4-16
    • Tuite, P.1
  • 168
    • 84858707220 scopus 로고    scopus 로고
    • MIBG scintigraphy in differential diagnosis of Parkinsonism: A meta-analysis
    • Treglia, G. et al. MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis. Clin. Auton. Res. 22, 43-55 (2012).
    • (2012) Clin. Auton. Res. , vol.22 , pp. 43-55
    • Treglia, G.1
  • 169
    • 84963550642 scopus 로고    scopus 로고
    • Nomenclature of genetic movement disorders: Recommendations of the International Parkinson and Movement Disorder Society Task Force
    • Marras, C. et al. Nomenclature of genetic movement disorders: recommendations of the International Parkinson and Movement Disorder Society Task Force. Mov. Disord. 31, 436-457 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 436-457
    • Marras, C.1
  • 170
    • 84997497966 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Lill, C. M. Genetics of Parkinson's disease. Mol. Cell. Probes 30, 386-396 (2016).
    • (2016) Mol. Cell. Probes , vol.30 , pp. 386-396
    • Lill, C.M.1
  • 171
    • 84941599000 scopus 로고    scopus 로고
    • Basic science breaks through: New therapeutic advances in Parkinson's disease
    • Brundin, P., Atkin, G. & Lamberts, J. T. Basic science breaks through: new therapeutic advances in Parkinson's disease. Mov. Disord. 30, 1521-1527 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1521-1527
    • Brundin, P.1    Atkin, G.2    Lamberts, J.T.3
  • 172
    • 84912088714 scopus 로고    scopus 로고
    • Unbiased approaches to biomarker discovery in neurodegenerative diseases
    • Chen-Plotkin, A. S. Unbiased approaches to biomarker discovery in neurodegenerative diseases. Neuron 84, 594-607 (2014).
    • (2014) Neuron , vol.84 , pp. 594-607
    • Chen-Plotkin, A.S.1
  • 173
    • 84944510700 scopus 로고    scopus 로고
    • Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients
    • Swanson, C. R. et al. Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients. Mov. Disord. 30, 1648-1656 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1648-1656
    • Swanson, C.R.1
  • 174
    • 84855925916 scopus 로고    scopus 로고
    • Toward a redefinition of Parkinson's disease
    • Stern, M. B., Lang, A. & Poewe, W. Toward a redefinition of Parkinson's disease. Mov. Disord. 27, 54-60 (2012).
    • (2012) Mov. Disord. , vol.27 , pp. 54-60
    • Stern, M.B.1    Lang, A.2    Poewe, W.3
  • 175
    • 84961193036 scopus 로고    scopus 로고
    • Challenges of modifying disease progression in prediagnostic Parkinson's disease
    • Salat, D., Noyce, A. J., Schrag, A. & Tolosa, E. Challenges of modifying disease progression in prediagnostic Parkinson's disease. Lancet Neurol. 15, 637-648 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 637-648
    • Salat, D.1    Noyce, A.J.2    Schrag, A.3    Tolosa, E.4
  • 176
    • 84985911015 scopus 로고    scopus 로고
    • Technology in Parkinson's disease: Challenges and opportunities
    • Espay, A. J. et al. Technology in Parkinson's disease: challenges and opportunities. Mov. Disord. 31, 1272-1282 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 1272-1282
    • Espay, A.J.1
  • 177
    • 84922268526 scopus 로고    scopus 로고
    • The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study)
    • Pont-Sunyer, C. et al. The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study). Mov. Disord. 30, 229-237 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 229-237
    • Pont-Sunyer, C.1
  • 178
    • 84960486366 scopus 로고    scopus 로고
    • Idiopathic rapid eye movement sleep behaviour disorder: Diagnosis, management, and the need for neuroprotective interventions
    • Iranzo, A., Santamaria, J. & Tolosa, E. Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol. 15, 405-419 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 405-419
    • Iranzo, A.1    Santamaria, J.2    Tolosa, E.3
  • 179
    • 84922226466 scopus 로고    scopus 로고
    • Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study
    • Jennings, D. et al. Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology 83, 1739-1746 (2014).
    • (2014) Neurology , vol.83 , pp. 1739-1746
    • Jennings, D.1
  • 180
    • 84923253769 scopus 로고    scopus 로고
    • Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD
    • Mahlknecht, P. et al. Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD. Neurology 84, 654-658 (2015).
    • (2015) Neurology , vol.84 , pp. 654-658
    • Mahlknecht, P.1
  • 181
    • 84985930523 scopus 로고    scopus 로고
    • Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community
    • Mahlknecht, P. et al. Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community. Mov. Disord. 31, 1405-1408 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 1405-1408
    • Mahlknecht, P.1
  • 182
    • 84908345308 scopus 로고    scopus 로고
    • Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): A large, open-label, pragmatic randomised trial
    • PD Med Collaborative Group et al. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet 384, 1196-1205 (2014).
    • (2014) Lancet , vol.384 , pp. 1196-1205
    • Med Collaborative Group, P.D.1
  • 183
    • 84982156297 scopus 로고    scopus 로고
    • Levodopa therapy for Parkinson disease: A look backward and forward
    • LeWitt, P. A. & Fahn, S. Levodopa therapy for Parkinson disease: a look backward and forward. Neurology 86, S3-S12 (2016).
    • (2016) Neurology , vol.86 , pp. S3-S12
    • LeWitt, P.A.1    Fahn, S.2
  • 184
    • 33746105694 scopus 로고    scopus 로고
    • Continuous dopamine-receptor treatment of Parkinson's disease: Scientific rationale and clinical implications
    • Olanow, C. W., Obeso, J. A. & Stocchi, F. Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications. Lancet Neurol. 5, 677-687 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 677-687
    • Olanow, C.W.1    Obeso, J.A.2    Stocchi, F.3
  • 185
    • 84910617976 scopus 로고    scopus 로고
    • Presynaptic mechanisms of l-DOPAinduced dyskinesia: The findings, the debate, and the therapeutic implications
    • Cenci, M. A. Presynaptic mechanisms of l-DOPAinduced dyskinesia: the findings, the debate, and the therapeutic implications. Front. Neurol. 5, 242 (2014).
    • (2014) Front. Neurol. , vol.5 , pp. 242
    • Cenci, M.A.1
  • 186
    • 84920927713 scopus 로고    scopus 로고
    • Novel formulations and modes of delivery of levodopa
    • Poewe, W. & Antonini, A. Novel formulations and modes of delivery of levodopa. Mov. Disord. 30, 114-120 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 114-120
    • Poewe, W.1    Antonini, A.2
  • 187
    • 84958211503 scopus 로고    scopus 로고
    • Effect of levodopa-carbidopa intestinal gel on dyskinesia in advanced Parkinson's disease patients
    • Antonini, A. et al. Effect of levodopa-carbidopa intestinal gel on dyskinesia in advanced Parkinson's disease patients. Mov. Disord. 31, 530-537 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 530-537
    • Antonini, A.1
  • 188
    • 84925483019 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibitors in Parkinson's disease
    • Muller, T. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Drugs 75, 157-174 (2015).
    • (2015) Drugs , vol.75 , pp. 157-174
    • Muller, T.1
  • 189
    • 80055083817 scopus 로고    scopus 로고
    • The Movement Disorder Society evidence-based medicine review update: Treatments for the motor symptoms of Parkinson's disease
    • Fox, S. H. et al. The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease. Mov. Disord. 26, S2-S41 (2011).
    • (2011) Mov. Disord. , vol.26 , pp. S2-S41
    • Fox, S.H.1
  • 190
    • 84955282612 scopus 로고    scopus 로고
    • Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: A randomised, doubleblind, controlled trial
    • Ferreira, J. J. et al. Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, doubleblind, controlled trial. Lancet Neurol. 15, 154-165 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 154-165
    • Ferreira, J.J.1
  • 191
    • 82555196455 scopus 로고    scopus 로고
    • Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: A review of symptomatic and potential disease-modifying effects
    • Schapira, A. H. Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: a review of symptomatic and potential disease-modifying effects. CNS Drugs 25, 1061-1071 (2011).
    • (2011) CNS Drugs , vol.25 , pp. 1061-1071
    • Schapira, A.H.1
  • 192
    • 0017345412 scopus 로고
    • Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study
    • Birkmayer, W., Riederer, P., Ambrozi, L. & Youdim, M. B. Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study. Lancet 1, 439-443 (1977).
    • (1977) Lancet , vol.1 , pp. 439-443
    • Birkmayer, W.1    Riederer, P.2    Ambrozi, L.3    Youdim, M.B.4
  • 193
    • 85014652761 scopus 로고    scopus 로고
    • Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: A randomized clinical trial
    • Schapira, A. H. et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 74, 216-224 (2017).
    • (2017) JAMA Neurol. , vol.74 , pp. 216-224
    • Schapira, A.H.1
  • 194
    • 84898775157 scopus 로고    scopus 로고
    • Pharmacological treatment of Parkinson disease: A review
    • Connolly, B. S. & Lang, A. E. Pharmacological treatment of Parkinson disease: a review. JAMA 311, 1670-1683 (2014).
    • (2014) JAMA , vol.311 , pp. 1670-1683
    • Connolly, B.S.1    Lang, A.E.2
  • 195
    • 84863728773 scopus 로고    scopus 로고
    • Therapies in Parkinson's disease
    • Jankovic, J. & Poewe, W. Therapies in Parkinson's disease. Curr. Opin. Neurol. 25, 433-447 (2012).
    • (2012) Curr. Opin. Neurol. , vol.25 , pp. 433-447
    • Jankovic, J.1    Poewe, W.2
  • 196
    • 79960785470 scopus 로고    scopus 로고
    • Impulse control disorders in Parkinson's disease: Recent advances
    • Voon, V., Mehta, A. R. & Hallett, M. Impulse control disorders in Parkinson's disease: recent advances. Curr. Opin. Neurol. 24, 324-330 (2011).
    • (2011) Curr. Opin. Neurol. , vol.24 , pp. 324-330
    • Voon, V.1    Mehta, A.R.2    Hallett, M.3
  • 198
    • 20144366287 scopus 로고    scopus 로고
    • Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single-dose challenges
    • Katzenschlager, R. et al. Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: a prospective study using single-dose challenges. Mov. Disord. 20, 151-157 (2005).
    • (2005) Mov. Disord. , vol.20 , pp. 151-157
    • Katzenschlager, R.1
  • 199
    • 84985919964 scopus 로고    scopus 로고
    • Sublingual apomorphine (APL-130277) for the acute conversion of off to on in Parkinson's disease
    • Hauser, R. A. et al. Sublingual apomorphine (APL-130277) for the acute conversion of OFF to ON in Parkinson's disease. Mov. Disord. 31, 1366-1372 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 1366-1372
    • Hauser, R.A.1
  • 200
    • 84876328040 scopus 로고    scopus 로고
    • Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications
    • Storch, A. et al. Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications. Neurology 80, 800-809 (2013).
    • (2013) Neurology , vol.80 , pp. 800-809
    • Storch, A.1
  • 201
    • 60549085946 scopus 로고    scopus 로고
    • Overview of the extranigral aspects of Parkinson disease
    • Lim, S. Y., Fox, S. H. & Lang, A. E. Overview of the extranigral aspects of Parkinson disease. Arch. Neurol. 66, 167-172 (2009).
    • (2009) Arch. Neurol. , vol.66 , pp. 167-172
    • Lim, S.Y.1    Fox, S.H.2    Lang, A.E.3
  • 202
    • 84874216826 scopus 로고    scopus 로고
    • Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials
    • Kalia, L. V., Brotchie, J. M. & Fox, S. H. Novel nondopaminergic targets for motor features of Parkinson's disease: review of recent trials. Mov. Disord. 28, 131-144 (2013).
    • (2013) Mov. Disord. , vol.28 , pp. 131-144
    • Kalia, L.V.1    Brotchie, J.M.2    Fox, S.H.3
  • 203
    • 80051500137 scopus 로고    scopus 로고
    • The Movement Disorder Society evidence-based medicine review update: Treatments for the non-motor symptoms of Parkinson's disease
    • Seppi, K. et al. The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson's disease. Mov. Disord. 26, S42-S80 (2011).
    • (2011) Mov. Disord. , vol.26 , pp. S42-S80
    • Seppi, K.1
  • 204
    • 84893110875 scopus 로고    scopus 로고
    • Treatment of cognitive, psychiatric, and affective disorders associated with Parkinson's disease
    • Connolly, B. & Fox, S. H. Treatment of cognitive, psychiatric, and affective disorders associated with Parkinson's disease. Neurotherapeutics 11, 78-91 (2014).
    • (2014) Neurotherapeutics , vol.11 , pp. 78-91
    • Connolly, B.1    Fox, S.H.2
  • 205
    • 84895904524 scopus 로고    scopus 로고
    • Pimavanserin for patients with Parkinson's disease psychosis: A randomised, placebo-controlled phase 3 trial
    • Cummings, J. et al. Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet 383, 533-540 (2014).
    • (2014) Lancet , vol.383 , pp. 533-540
    • Cummings, J.1
  • 206
    • 79957590886 scopus 로고    scopus 로고
    • Parkinson's disease: The quintessential neuropsychiatric disorder
    • Weintraub, D. & Burn, D. J. Parkinson's disease: the quintessential neuropsychiatric disorder. Mov. Disord. 26, 1022-1031 (2011).
    • (2011) Mov. Disord. , vol.26 , pp. 1022-1031
    • Weintraub, D.1    Burn, D.J.2
  • 208
    • 0028796071 scopus 로고
    • Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation
    • Limousin, P. et al. Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 345, 91-95 (1995).
    • (1995) Lancet , vol.345 , pp. 91-95
    • Limousin, P.1
  • 209
    • 79951526730 scopus 로고    scopus 로고
    • Deep brain stimulation for Parkinson disease: An expert consensus and review of key issues
    • Bronstein, J. M. et al. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch. Neurol. 68, 165 (2011).
    • (2011) Arch. Neurol. , vol.68 , pp. 165
    • Bronstein, J.M.1
  • 210
    • 84884161075 scopus 로고    scopus 로고
    • Subthalamic neurostimulation for Parkinson's disease with early fluctuations: Balancing the risks and benefits
    • Deuschl, G. & Agid, Y. Subthalamic neurostimulation for Parkinson's disease with early fluctuations: balancing the risks and benefits. Lancet Neurol. 12, 1025-1034 (2013). This review summarizes the evidence base for the efficacy and safety of DBS in Parkinson disease.
    • (2013) Lancet Neurol. , vol.12 , pp. 1025-1034
    • Deuschl, G.1    Agid, Y.2
  • 211
    • 84870831762 scopus 로고    scopus 로고
    • Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): A randomised controlled trial
    • Odekerken, V. J. et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 12, 37-44 (2013).
    • (2013) Lancet Neurol. , vol.12 , pp. 37-44
    • Odekerken, V.J.1
  • 212
    • 84873682179 scopus 로고    scopus 로고
    • Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes; Turning tables: Should GPi become the preferred DBS target for Parkinson disease? Author response
    • Stern, M. B., Follett, K. A. & Weaver, F. M. Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes; turning tables: should GPi become the preferred DBS target for Parkinson disease? Author response. Neurology 80, 225 (2013).
    • (2013) Neurology , vol.80 , pp. 225
    • Stern, M.B.1    Follett, K.A.2    Weaver, F.M.3
  • 213
    • 84959238046 scopus 로고    scopus 로고
    • GPi versus STN deep brain stimulation for Parkinson disease: Three-year follow-up
    • Odekerken, V. J. et al. GPi versus STN deep brain stimulation for Parkinson disease: three-year follow-up. Neurology 86, 755-761 (2016).
    • (2016) Neurology , vol.86 , pp. 755-761
    • Odekerken, V.J.1
  • 214
    • 34548037454 scopus 로고    scopus 로고
    • Thirty days complication rate following surgery performed for deep-brain-stimulation
    • Voges, J. et al. Thirty days complication rate following surgery performed for deep-brain-stimulation. Mov. Disord. 22, 1486-1489 (2007).
    • (2007) Mov. Disord. , vol.22 , pp. 1486-1489
    • Voges, J.1
  • 215
    • 77956343472 scopus 로고    scopus 로고
    • Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease
    • Volkmann, J., Daniels, C. & Witt, K. Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease. Nat. Rev. Neurol. 6, 487-498 (2010).
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 487-498
    • Volkmann, J.1    Daniels, C.2    Witt, K.3
  • 216
    • 84994187976 scopus 로고    scopus 로고
    • Innovations in deep brain stimulation methodology
    • Kuhn, A. A. & Volkmann, J. Innovations in deep brain stimulation methodology. Mov. Disord. 32, 11-19 (2017).
    • (2017) Mov. Disord. , vol.32 , pp. 11-19
    • Kuhn, A.A.1    Volkmann, J.2
  • 217
    • 61449171278 scopus 로고    scopus 로고
    • Physical therapy in Parkinson's disease: Evolution and future challenges
    • Keus, S. H., Munneke, M., Nijkrake, M. J., Kwakkel, G. & Bloem, B. R. Physical therapy in Parkinson's disease: evolution and future challenges. Mov. Disord. 24, 1-14 (2009).
    • (2009) Mov. Disord. , vol.24 , pp. 1-14
    • Keus, S.H.1    Munneke, M.2    Nijkrake, M.J.3    Kwakkel, G.4    Bloem, B.R.5
  • 218
    • 84941600942 scopus 로고    scopus 로고
    • Nonpharmacological treatments for patients with Parkinson's disease
    • Bloem, B. R., de Vries, N. M. & Ebersbach, G. Nonpharmacological treatments for patients with Parkinson's disease. Mov. Disord. 30, 1504-1520 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1504-1520
    • Bloem, B.R.1    De Vries, N.M.2    Ebersbach, G.3
  • 219
    • 80051534189 scopus 로고    scopus 로고
    • Does vigorous exercise have a neuroprotective effect in Parkinson disease?
    • Ahlskog, J. E. Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology 77, 288-294 (2011).
    • (2011) Neurology , vol.77 , pp. 288-294
    • Ahlskog, J.E.1
  • 220
    • 84922385846 scopus 로고    scopus 로고
    • Physical activity and risk of Parkinson's disease in the Swedish National March Cohort
    • Yang, F. et al. Physical activity and risk of Parkinson's disease in the Swedish National March Cohort. Brain 138, 269-275 (2015).
    • (2015) Brain , vol.138 , pp. 269-275
    • Yang, F.1
  • 221
    • 77955161623 scopus 로고    scopus 로고
    • Physical activities and future risk of Parkinson disease
    • Xu, Q. et al. Physical activities and future risk of Parkinson disease. Neurology 75, 341-348 (2010).
    • (2010) Neurology , vol.75 , pp. 341-348
    • Xu, Q.1
  • 222
    • 84856964952 scopus 로고    scopus 로고
    • Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?
    • Hinnell, C. et al. Nonmotor versus motor symptoms: how much do they matter to health status in Parkinson's disease? Mov. Disord. 27, 236-241 (2012).
    • (2012) Mov. Disord. , vol.27 , pp. 236-241
    • Hinnell, C.1
  • 223
    • 0033875826 scopus 로고    scopus 로고
    • What contributes to quality of life in patients with Parkinson's disease?
    • Schrag, A., Jahanshahi, M. & Quinn, N. What contributes to quality of life in patients with Parkinson's disease? J. Neurol. Neurosurg. Psychiatry 69, 308-312 (2000).
    • (2000) J. Neurol. Neurosurg. Psychiatry , vol.69 , pp. 308-312
    • Schrag, A.1    Jahanshahi, M.2    Quinn, N.3
  • 224
    • 84941564260 scopus 로고    scopus 로고
    • New clinical trials for nonmotor manifestations of Parkinson's disease
    • Schrag, A., Sauerbier, A. & Chaudhuri, K. R. New clinical trials for nonmotor manifestations of Parkinson's disease. Mov. Disord. 30, 1490-1504 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 1490-1504
    • Schrag, A.1    Sauerbier, A.2    Chaudhuri, K.R.3
  • 225
    • 84963650298 scopus 로고    scopus 로고
    • Cognitive decline and quality of life in incident Parkinson's disease: The role of attention
    • Lawson, R. A. et al. Cognitive decline and quality of life in incident Parkinson's disease: the role of attention. Parkinsonism Relat. Disord. 27, 47-53 (2016).
    • (2016) Parkinsonism Relat. Disord. , vol.27 , pp. 47-53
    • Lawson, R.A.1
  • 226
    • 84885642822 scopus 로고    scopus 로고
    • Nonmotor symptoms in nursing home residents with Parkinson's disease: Prevalence and effect on quality of life
    • Weerkamp, N. J. et al. Nonmotor symptoms in nursing home residents with Parkinson's disease: prevalence and effect on quality of life. J. Am. Geriatr. Soc. 61, 1714-1721 (2013).
    • (2013) J. Am. Geriatr. Soc. , vol.61 , pp. 1714-1721
    • Weerkamp, N.J.1
  • 227
    • 84877920475 scopus 로고    scopus 로고
    • Effectiveness of multidisciplinary care for Parkinson's disease: A randomized, controlled trial
    • van der Marck, M. A. et al. Effectiveness of multidisciplinary care for Parkinson's disease: a randomized, controlled trial. Mov. Disord. 28, 605-611 (2013).
    • (2013) Mov. Disord. , vol.28 , pp. 605-611
    • Van Der Marck, M.A.1
  • 228
    • 84918585360 scopus 로고    scopus 로고
    • Predictors of the psychosocial impact of being a carer of people living with Parkinson's disease: A systematic review
    • Greenwell, K., Gray, W. K., van Wersch, A., van Schaik, P. & Walker, R. Predictors of the psychosocial impact of being a carer of people living with Parkinson's disease: a systematic review. Parkinsonism Relat. Disord. 21, 1-11 (2015).
    • (2015) Parkinsonism Relat. Disord. , vol.21 , pp. 1-11
    • Greenwell, K.1    Gray, W.K.2    Van Wersch, A.3    Van Schaik, P.4    Walker, R.5
  • 229
    • 29844453238 scopus 로고    scopus 로고
    • Caregiver-burden in Parkinson's disease is closely associated with psychiatric symptoms, falls, and disability
    • Schrag, A., Hovris, A., Morley, D., Quinn, N. & Jahanshahi, M. Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disability. Parkinsonism Relat. Disord. 12, 35-41 (2006).
    • (2006) Parkinsonism Relat. Disord. , vol.12 , pp. 35-41
    • Schrag, A.1    Hovris, A.2    Morley, D.3    Quinn, N.4    Jahanshahi, M.5
  • 231
    • 84942500662 scopus 로고    scopus 로고
    • Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: A population-based modelling study
    • Nalls, M. A. et al. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 14, 1002-1009 (2015).
    • (2015) Lancet Neurol. , vol.14 , pp. 1002-1009
    • Nalls, M.A.1
  • 232
    • 85050577489 scopus 로고    scopus 로고
    • Can microbiota research change our understanding of neurodegenerative diseases?
    • Scheperjans, F. Can microbiota research change our understanding of neurodegenerative diseases? Neurodegener. Dis. Manag. 6, 81-85 (2016).
    • (2016) Neurodegener. Dis. Manag. , vol.6 , pp. 81-85
    • Scheperjans, F.1
  • 234
    • 84982958055 scopus 로고    scopus 로고
    • The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease
    • Gibbons, C. H., Garcia, J., Wang, N., Shih, L. C. & Freeman, R. The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology 87, 505-512 (2016).
    • (2016) Neurology , vol.87 , pp. 505-512
    • Gibbons, C.H.1    Garcia, J.2    Wang, N.3    Shih, L.C.4    Freeman, R.5
  • 235
    • 84903821570 scopus 로고    scopus 로고
    • Cutaneous neuropathy in Parkinson's disease: A window into brain pathology
    • Doppler, K. et al. Cutaneous neuropathy in Parkinson's disease: a window into brain pathology. Acta Neuropathol. 128, 99-109 (2014).
    • (2014) Acta Neuropathol. , vol.128 , pp. 99-109
    • Doppler, K.1
  • 236
    • 84947428180 scopus 로고    scopus 로고
    • Enteric nervous system alphasynuclein immunoreactivity in idiopathic REM sleep behavior disorder
    • Sprenger, F. S. et al. Enteric nervous system alphasynuclein immunoreactivity in idiopathic REM sleep behavior disorder. Neurology 85, 1761-1768 (2015).
    • (2015) Neurology , vol.85 , pp. 1761-1768
    • Sprenger, F.S.1
  • 237
    • 84962118986 scopus 로고    scopus 로고
    • Assessment of alpha-synuclein in submandibular glands of patients with idiopathic rapideye-movement sleep behaviour disorder: A case-control study
    • Vilas, D. et al. Assessment of alpha-synuclein in submandibular glands of patients with idiopathic rapideye-movement sleep behaviour disorder: a case-control study. Lancet Neurol. 15, 708-718 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 708-718
    • Vilas, D.1
  • 238
    • 84873445906 scopus 로고    scopus 로고
    • Trophic factor gene therapy for Parkinson's disease
    • Kordower, J. H. & Bjorklund, A. Trophic factor gene therapy for Parkinson's disease. Mov. Disord. 28, 96-109 (2013).
    • (2013) Mov. Disord. , vol.28 , pp. 96-109
    • Kordower, J.H.1    Bjorklund, A.2
  • 239
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell linederived neurotrophic factor in Parkinson disease
    • Gill, S. S. et al. Direct brain infusion of glial cell linederived neurotrophic factor in Parkinson disease. Nat. Med. 9, 589-595 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 589-595
    • Gill, S.S.1
  • 240
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang, A. E. et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol. 59, 459-466 (2006).
    • (2006) Ann. Neurol. , vol.59 , pp. 459-466
    • Lang, A.E.1
  • 241
    • 33845993229 scopus 로고    scopus 로고
    • Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
    • Kordower, J. H. et al. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann. Neurol. 60, 706-715 (2006).
    • (2006) Ann. Neurol. , vol.60 , pp. 706-715
    • Kordower, J.H.1
  • 242
    • 84964612393 scopus 로고    scopus 로고
    • Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?
    • Bartus, R. T. & Johnson, E. M. Jr. Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: where have we been and what have we learned? Neurobiol. Dis. 97, 156-168 (2017).
    • (2017) Neurobiol. Dis. , vol.97 , pp. 156-168
    • Bartus, R.T.1    Johnson, E.M.2
  • 243
    • 84964613704 scopus 로고    scopus 로고
    • Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?
    • Bartus, R. T. & Johnson, E. M. Jr. Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: where do we stand and where must we go next? Neurobiol. Dis. 97, 169-178 (2017).
    • (2017) Neurobiol. Dis. , vol.97 , pp. 169-178
    • Bartus, R.T.1    Johnson, E.M.2
  • 244
    • 84860130544 scopus 로고    scopus 로고
    • Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease
    • Mittermeyer, G. et al. Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease. Hum. Gene Ther. 23, 377-381 (2012).
    • (2012) Hum. Gene Ther. , vol.23 , pp. 377-381
    • Mittermeyer, G.1
  • 245
    • 84897076939 scopus 로고    scopus 로고
    • Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: A dose escalation, open-label, phase 1/2 trial
    • Palfi, S. et al. Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet 383, 1138-1146 (2014).
    • (2014) Lancet , vol.383 , pp. 1138-1146
    • Palfi, S.1
  • 246
    • 76949092638 scopus 로고    scopus 로고
    • Gene therapy for dopamine replacement in Parkinson's disease
    • Bjorklund, A., Bjorklund, T. & Kirik, D. Gene therapy for dopamine replacement in Parkinson's disease. Sci. Transl Med. 1, 2ps2 (2009).
    • (2009) Sci. Transl Med. , vol.1 , pp. 2ps2
    • Bjorklund, A.1    Bjorklund, T.2    Kirik, D.3
  • 247
    • 15044365742 scopus 로고    scopus 로고
    • Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
    • Carlsson, T. et al. Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain 128, 559-569 (2005).
    • (2005) Brain , vol.128 , pp. 559-569
    • Carlsson, T.1
  • 248
    • 79952740079 scopus 로고    scopus 로고
    • AAV2-GAD gene therapy for advanced Parkinson's disease: A double-blind, shamsurgery controlled, randomised trial
    • LeWitt, P. A. et al. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, shamsurgery controlled, randomised trial. Lancet Neurol. 10, 309-319 (2011).
    • (2011) Lancet Neurol. , vol.10 , pp. 309-319
    • LeWitt, P.A.1
  • 249
    • 0025058215 scopus 로고
    • Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease
    • Lindvall, O. et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247, 574-577 (1990).
    • (1990) Science , vol.247 , pp. 574-577
    • Lindvall, O.1
  • 250
    • 0033491121 scopus 로고    scopus 로고
    • Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
    • Piccini, P. et al. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat. Neurosci. 2, 1137-1140 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 1137-1140
    • Piccini, P.1
  • 251
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed, C. R. et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344, 710-719 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 710-719
    • Freed, C.R.1
  • 252
    • 0042837887 scopus 로고    scopus 로고
    • A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    • Olanow, C. W. et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 54, 403-414 (2003).
    • (2003) Ann. Neurol. , vol.54 , pp. 403-414
    • Olanow, C.W.1
  • 253
    • 0036307190 scopus 로고    scopus 로고
    • Dyskinesias following neural transplantation in Parkinson's disease
    • Hagell, P. et al. Dyskinesias following neural transplantation in Parkinson's disease. Nat. Neurosci. 5, 627-628 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 627-628
    • Hagell, P.1
  • 254
    • 77953394342 scopus 로고    scopus 로고
    • Role of serotonin neurons in the induction of levodopa-and graft-induced dyskinesias in Parkinson's disease
    • Carta, M., Carlsson, T., Munoz, A., Kirik, D. & Bjorklund, A. Role of serotonin neurons in the induction of levodopa-and graft-induced dyskinesias in Parkinson's disease. Mov. Disord. 25, S174-S179 (2010).
    • (2010) Mov. Disord. , vol.25 , pp. S174-S179
    • Carta, M.1    Carlsson, T.2    Munoz, A.3    Kirik, D.4    Bjorklund, A.5
  • 255
    • 68549099660 scopus 로고    scopus 로고
    • Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamineinduced dyskinesia in grafted rats
    • Lane, E. L., Vercammen, L., Cenci, M. A. & Brundin, P. Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamineinduced dyskinesia in grafted rats. Exp. Neurol. 219, 355-358 (2009).
    • (2009) Exp. Neurol. , vol.219 , pp. 355-358
    • Lane, E.L.1    Vercammen, L.2    Cenci, M.A.3    Brundin, P.4
  • 256
    • 84870269243 scopus 로고    scopus 로고
    • Neuropathology in transplants in Parkinson's disease: Implications for disease pathogenesis and the future of cell therapy
    • Brundin, P. & Kordower, J. H. Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy. Prog. Brain Res. 200, 221-241 (2012).
    • (2012) Prog. Brain Res. , vol.200 , pp. 221-241
    • Brundin, P.1    Kordower, J.H.2
  • 257
    • 84892394291 scopus 로고    scopus 로고
    • Long-term clinical outcome of fetal cell transplantation for Parkinson disease: Two case reports
    • Kefalopoulou, Z. et al. Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports. JAMA Neurol. 71, 83-87 (2014).
    • (2014) JAMA Neurol. , vol.71 , pp. 83-87
    • Kefalopoulou, Z.1
  • 258
    • 84941022742 scopus 로고    scopus 로고
    • Cell-based therapies for Parkinson disease-past insights and future potential
    • Barker, R. A., Drouin-Ouellet, J. & Parmar, M. Cell-based therapies for Parkinson disease-past insights and future potential. Nat. Rev. Neurol. 11, 492-503 (2015).
    • (2015) Nat. Rev. Neurol. , vol.11 , pp. 492-503
    • Barker, R.A.1    Drouin-Ouellet, J.2    Parmar, M.3
  • 259
    • 84892519509 scopus 로고    scopus 로고
    • The future of cell therapies and brain repair: Parkinson's disease leads the way
    • Petit, G. H., Olsson, T. T. & Brundin, P. The future of cell therapies and brain repair: Parkinson's disease leads the way. Neuropathol. Appl. Neurobiol. 40, 60-70 (2014).
    • (2014) Neuropathol. Appl. Neurobiol. , vol.40 , pp. 60-70
    • Petit, G.H.1    Olsson, T.T.2    Brundin, P.3
  • 260
    • 84963773053 scopus 로고    scopus 로고
    • Are stem cell-based therapies for Parkinson's disease ready for the clinic in 2016?
    • Barker, R. A. et al. Are stem cell-based therapies for Parkinson's disease ready for the clinic in 2016? J. Parkinsons Dis. 6, 57-63 (2016).
    • (2016) J. Parkinsons Dis. , vol.6 , pp. 57-63
    • Barker, R.A.1
  • 261
    • 84966565073 scopus 로고    scopus 로고
    • New ISSCR guidelines: Clinical translation of stem cell research
    • Kimmelman, J. et al. New ISSCR guidelines: clinical translation of stem cell research. Lancet 387, 1979-1981 (2016).
    • (2016) Lancet , vol.387 , pp. 1979-1981
    • Kimmelman, J.1
  • 262
    • 84901682081 scopus 로고    scopus 로고
    • Next-generation active immunization approach for synucleinopathies: Implications for Parkinson's disease clinical trials
    • Mandler, M. et al. Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials. Acta Neuropathol. 127, 861-879 (2014).
    • (2014) Acta Neuropathol. , vol.127 , pp. 861-879
    • Mandler, M.1
  • 264
    • 84952700538 scopus 로고    scopus 로고
    • Development of passive immunotherapies for synucleinopathies
    • Bergstrom, A. L., Kallunki, P. & Fog, K. Development of passive immunotherapies for synucleinopathies. Mov. Disord. 31, 203-213 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 203-213
    • Bergstrom, A.L.1    Kallunki, P.2    Fog, K.3
  • 265
    • 85005931200 scopus 로고    scopus 로고
    • First-in-human assessment of PRX002, an anti-a-synuclein monoclonal antibody, in healthy volunteers
    • Schenk, D. B. et al. First-in-human assessment of PRX002, an anti-a-synuclein monoclonal antibody, in healthy volunteers. Mov. Disord. 32, 211-218 (2017).
    • (2017) Mov. Disord. , vol.32 , pp. 211-218
    • Schenk, D.B.1
  • 266
    • 85014852643 scopus 로고    scopus 로고
    • A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease
    • Wrasidlo, W. M. et al. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain 139, 3217-3236 (2016).
    • (2016) Brain , vol.139 , pp. 3217-3236
    • Wrasidlo, W.M.1
  • 267
    • 84904126994 scopus 로고    scopus 로고
    • Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease
    • Aviles-Olmos, I. et al. Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease. J. Parkinsons Dis. 4, 337-344 (2014).
    • (2014) J. Parkinsons Dis. , vol.4 , pp. 337-344
    • Aviles-Olmos, I.1
  • 268
    • 84893841038 scopus 로고    scopus 로고
    • Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: A randomized clinical trial
    • Parkinson Study Group SURE-PD Investigators et al.
    • Parkinson Study Group SURE-PD Investigators et al. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 71, 141-150 (2014).
    • (2014) JAMA Neurol. , vol.71 , pp. 141-150
  • 269
    • 84995802014 scopus 로고    scopus 로고
    • Ambroxol effects in glucocerebrosidase and alpha-synuclein transgenic mice
    • Migdalska-Richards, A., Daly, L., Bezard, E. & Schapira, A. H. Ambroxol effects in glucocerebrosidase and alpha-synuclein transgenic mice. Ann. Neurol. 80, 766-775 (2016).
    • (2016) Ann. Neurol. , vol.80 , pp. 766-775
    • Migdalska-Richards, A.1    Daly, L.2    Bezard, E.3    Schapira, A.H.4
  • 270
    • 84887625913 scopus 로고    scopus 로고
    • Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD)
    • Parkinson Study Group
    • Parkinson Study Group. Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD). Mov. Disord. 28, 1823-1831 (2013).
    • (2013) Mov. Disord. , vol.28 , pp. 1823-1831
  • 271
    • 84964213291 scopus 로고    scopus 로고
    • The incidence of Parkinson's disease: A systematic review and meta-analysis
    • Hirsch, L., Jette, N., Frolkis, A., Steeves, T. & Pringsheim, T. The incidence of Parkinson's disease: a systematic review and meta-analysis. Neuroepidemiology 46, 292-300 (2016).
    • (2016) Neuroepidemiology , vol.46 , pp. 292-300
    • Hirsch, L.1    Jette, N.2    Frolkis, A.3    Steeves, T.4    Pringsheim, T.5
  • 272
    • 77949897463 scopus 로고    scopus 로고
    • The progression of pathology in Parkinson's disease
    • Halliday, G. M. & McCann, H. The progression of pathology in Parkinson's disease. Ann. NY Acad. Sci. 1184, 188-195 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1184 , pp. 188-195
    • Halliday, G.M.1    McCann, H.2
  • 273
    • 84924794709 scopus 로고    scopus 로고
    • Dorsolateral nigral hyperintensity on 3.0T susceptibility-weighted imaging in neurodegenerative Parkinsonism
    • Reiter, E. et al. Dorsolateral nigral hyperintensity on 3.0T susceptibility-weighted imaging in neurodegenerative Parkinsonism. Mov Disord. 30, 1068-1076 (2015).
    • (2015) Mov Disord. , vol.30 , pp. 1068-1076
    • Reiter, E.1
  • 274
    • 84876412536 scopus 로고    scopus 로고
    • Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging
    • Ohtsuka, C. et al. Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging. Neurosci. Lett. 541, 93-98 (2013).
    • (2013) Neurosci. Lett. , vol.541 , pp. 93-98
    • Ohtsuka, C.1
  • 275
    • 25444444501 scopus 로고    scopus 로고
    • Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome
    • Schmidauer, C. et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann. Neurol. 58, 630-634 (2005).
    • (2005) Ann. Neurol. , vol.58 , pp. 630-634
    • Schmidauer, C.1
  • 276
    • 84976285813 scopus 로고    scopus 로고
    • Identification of TMEM230 mutations in familial Parkinson's disease
    • Deng, H. X. et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nat. Genet. 48, 733-739 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 733-739
    • Deng, H.X.1
  • 277
    • 84965025445 scopus 로고    scopus 로고
    • Launching the movement disorders society genetic mutation database (MDSGene)
    • Lill, C. M. et al. Launching the Movement Disorders Society Genetic Mutation Database (MDSGene). Mov. Disord. 31, 607-609 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 607-609
    • Lill, C.M.1


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