Optical deconstruction of parkinsonian neural circuitry

Science

Volumn 324, Issue 5925, 2009, Pages 354-359

  Gradinaru, Viviana ^a,b   Mogri, Murtaza ^a   Thompson, Kimberly R ^a   Henderson, Jaimie M ^b   Deisseroth, Karl ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASE TREATMENT; INHIBITION; NERVOUS SYSTEM DISORDER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; BRAIN TISSUE; CONTROLLED STUDY; DEPOLARIZATION; EXCITATION; MOTOR CORTEX; NERVE FIBER; NONHUMAN; OPTICS; OPTOGENETICS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBTHALAMIC NUCLEUS;

ACTION POTENTIALS; ANIMALS; ASTROCYTES; AXONS; DEEP BRAIN STIMULATION; FIBER OPTIC TECHNOLOGY; HALORHODOPSINS; LIGHT; MOTOR ACTIVITY; MOTOR CORTEX; NEURAL INHIBITION; NEURONS, AFFERENT; OPTICS AND PHOTONICS; PARKINSONIAN DISORDERS; RATS; RHODOPSIN; SUBTHALAMIC NUCLEUS;

PARKINSONIA; RODENTIA;

EID: 65249150709     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1167093     Document Type: Article

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60. K.D. is supported by the Kinetics Foundation, the William M. Keck Foundation, the Snyder Foundation, the Albert Yu and Mary Bechmann Foundation, and the Wallace Coulter Foundation, as well as by California Institute for Regenerative Medicine, the McKnight Foundation, the Esther A. and Joseph Klingenstein Fund, NSF, National Institute of Mental Health, National Institute on Drug Abuse, and the NIH Pioneer Award. V.G. is supported by SGF and SIGF (Stanford Graduate Fellowships). M.M is supported by Bio-X and SGF Fellowships. K.R.T. is supported by NARSAD. J.M.H is supported by the Coulter Foundation, the John Blume Foundation and the Davis Phinney Foundation. We especially thank A. M. Aravanis for mentoring and advice on animal surgery and in vivo recordings, F. Zhang and H. C. Tsai for assistance with Cre-dependent opsin targeting, L. Meltzer for useful discussion, advice and help on immunohistochemistry, G. Feng and G. Augustine for collaboration on generation of the Thy-1 mice (available at the Jackson Laboratory), and V. Sohal for help with power spectra analysis. We also thank the entire Deisseroth lab for useful discussions. The materials and methods described herein are freely distributed and supported by the authors (www.stanford.edu/group/dlab).