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Volumn 84, Issue 3, 2014, Pages 594-607

Unbiased approaches to biomarker discovery in neurodegenerative diseases

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN A1; BIOLOGICAL MARKER; DNA; DOPAMINE; DOPAMINE TRANSPORTER; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; MICRORNA; PITTSBURGH COMPOUND B; RNA; TAU PROTEIN; URATE; URIC ACID;

EID: 84912088714     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.10.031     Document Type: Review
Times cited : (48)

References (166)
  • 2
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Albert M.S., DeKosky S.T., Dickson D., Dubois B., Feldman H.H., Fox N.C., Gamst A., Holtzman D.M., Jagust W.J., Petersen R.C., et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:270-279.
    • (2011) Alzheimers Dement. , vol.7 , pp. 270-279
    • Albert, M.S.1    DeKosky, S.T.2    Dickson, D.3    Dubois, B.4    Feldman, H.H.5    Fox, N.C.6    Gamst, A.7    Holtzman, D.M.8    Jagust, W.J.9    Petersen, R.C.10
  • 4
    • 84912077781 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative (2013). Alzheimer's Disease Neuroimaging Initiative. http://www.adni-info.org.
    • (2013)
  • 6
    • 84885632062 scopus 로고    scopus 로고
    • Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes
    • Bajaj N., Hauser R.A., Grachev I.D. Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes. J.Neurol. Neurosurg. Psychiatry 2013, 84:1288-1295.
    • (2013) J.Neurol. Neurosurg. Psychiatry , vol.84 , pp. 1288-1295
    • Bajaj, N.1    Hauser, R.A.2    Grachev, I.D.3
  • 7
    • 64149132942 scopus 로고    scopus 로고
    • MicroRNAs: novel biomarkers for human cancer
    • Bartels C.L., Tsongalis G.J. MicroRNAs: novel biomarkers for human cancer. Clin. Chem. 2009, 55:623-631.
    • (2009) Clin. Chem. , vol.55 , pp. 623-631
    • Bartels, C.L.1    Tsongalis, G.J.2
  • 11
    • 84912143182 scopus 로고    scopus 로고
    • BioFIND Clinical Study (2014). BioFIND Clinical Study. https://www.michaeljfox.org/page.html?biofind-clinical-study.
    • (2014)
  • 12
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 2001, 69:89-95. Biomarkers Definitions Working Group.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 89-95
  • 13
    • 84855975889 scopus 로고    scopus 로고
    • Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease
    • Björkqvist M., Ohlsson M., Minthon L., Hansson O. Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease. PLoS ONE 2012, 7:e29868.
    • (2012) PLoS ONE , vol.7 , pp. e29868
    • Björkqvist, M.1    Ohlsson, M.2    Minthon, L.3    Hansson, O.4
  • 15
    • 84860848068 scopus 로고    scopus 로고
    • Mass spectrometry-based targeted quantitative proteomics: achieving sensitive and reproducible detection of proteins
    • Boja E.S., Rodriguez H. Mass spectrometry-based targeted quantitative proteomics: achieving sensitive and reproducible detection of proteins. Proteomics 2012, 12:1093-1110.
    • (2012) Proteomics , vol.12 , pp. 1093-1110
    • Boja, E.S.1    Rodriguez, H.2
  • 16
    • 38349146444 scopus 로고    scopus 로고
    • Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs
    • Booij J., Kemp P. Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. Eur. J. Nucl. Med. Mol. Imaging 2008, 35:424-438.
    • (2008) Eur. J. Nucl. Med. Mol. Imaging , vol.35 , pp. 424-438
    • Booij, J.1    Kemp, P.2
  • 18
    • 43649106356 scopus 로고    scopus 로고
    • Invited Article: Nervous system pathology in sporadic Parkinson disease
    • Braak H., Del Tredici K. Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 2008, 70:1916-1925.
    • (2008) Neurology , vol.70 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2
  • 20
    • 77950931868 scopus 로고    scopus 로고
    • Imaging approaches to Parkinson disease
    • Brooks D.J. Imaging approaches to Parkinson disease. J.Nucl. Med. 2010, 51:596-609.
    • (2010) J.Nucl. Med. , vol.51 , pp. 596-609
    • Brooks, D.J.1
  • 22
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Comprehensive molecular portraits of human breast tumours. Nature 2012, 490:61-70. Cancer Genome Atlas Network.
    • (2012) Nature , vol.490 , pp. 61-70
  • 23
    • 84884286307 scopus 로고    scopus 로고
    • The impact of the Oncotype Dx breast cancer assay in clinical practice: a systematic review and meta-analysis
    • Carlson J.J., Roth J.A. The impact of the Oncotype Dx breast cancer assay in clinical practice: a systematic review and meta-analysis. Breast Cancer Res. Treat. 2013, 141:13-22.
    • (2013) Breast Cancer Res. Treat. , vol.141 , pp. 13-22
    • Carlson, J.J.1    Roth, J.A.2
  • 27
    • 81055125527 scopus 로고    scopus 로고
    • The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration
    • Cummings J.L., Henchcliffe C., Schaier S., Simuni T., Waxman A., Kemp P. The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration. Brain 2011, 134:3146-3166.
    • (2011) Brain , vol.134 , pp. 3146-3166
    • Cummings, J.L.1    Henchcliffe, C.2    Schaier, S.3    Simuni, T.4    Waxman, A.5    Kemp, P.6
  • 31
    • 84871675217 scopus 로고    scopus 로고
    • Gene expression profiling combined with bioinformatics analysis identify biomarkers for Parkinson disease
    • Diao H., Li X., Hu S., Liu Y. Gene expression profiling combined with bioinformatics analysis identify biomarkers for Parkinson disease. PLoS ONE 2012, 7:e52319.
    • (2012) PLoS ONE , vol.7 , pp. e52319
    • Diao, H.1    Li, X.2    Hu, S.3    Liu, Y.4
  • 34
    • 84879125617 scopus 로고    scopus 로고
    • The coming crisis: obtaining care for the growing burden of neurodegenerative conditions
    • Dorsey E.R., George B.P., Leff B., Willis A.W. The coming crisis: obtaining care for the growing burden of neurodegenerative conditions. Neurology 2013, 80:1989-1996.
    • (2013) Neurology , vol.80 , pp. 1989-1996
    • Dorsey, E.R.1    George, B.P.2    Leff, B.3    Willis, A.W.4
  • 36
    • 28944449088 scopus 로고    scopus 로고
    • Proteomics as a tool for clinically relevant biomarker discovery and validation
    • Duncan M.W., Hunsucker S.W. Proteomics as a tool for clinically relevant biomarker discovery and validation. Exp. Biol. Med. (Maywood) 2005, 230:808-817.
    • (2005) Exp. Biol. Med. (Maywood) , vol.230 , pp. 808-817
    • Duncan, M.W.1    Hunsucker, S.W.2
  • 38
    • 0025074907 scopus 로고
    • Invitro selection of RNA molecules that bind specific ligands
    • Ellington A.D., Szostak J.W. Invitro selection of RNA molecules that bind specific ligands. Nature 1990, 346:818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 39
    • 75749147077 scopus 로고    scopus 로고
    • Antibody-based protein multiplex platforms: technical and operational challenges
    • Ellington A.A., Kullo I.J., Bailey K.R., Klee G.G. Antibody-based protein multiplex platforms: technical and operational challenges. Clin. Chem. 2010, 56:186-193.
    • (2010) Clin. Chem. , vol.56 , pp. 186-193
    • Ellington, A.A.1    Kullo, I.J.2    Bailey, K.R.3    Klee, G.G.4
  • 40
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/β-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    • Fagan A.M., Roe C.M., Xiong C., Mintun M.A., Morris J.C., Holtzman D.M. Cerebrospinal fluid tau/β-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch. Neurol. 2007, 64:343-349.
    • (2007) Arch. Neurol. , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 41
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114:2283-2301.
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 42
    • 81955167983 scopus 로고    scopus 로고
    • Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
    • Foulds P.G., Yokota O., Thurston A., Davidson Y., Ahmed Z., Holton J., Thompson J.C., Akiyama H., Arai T., Hasegawa M., et al. Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies. Neurobiol. Dis. 2012, 45:188-195.
    • (2012) Neurobiol. Dis. , vol.45 , pp. 188-195
    • Foulds, P.G.1    Yokota, O.2    Thurston, A.3    Davidson, Y.4    Ahmed, Z.5    Holton, J.6    Thompson, J.C.7    Akiyama, H.8    Arai, T.9    Hasegawa, M.10
  • 43
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein D.B. Common genetic variation and human traits. N.Engl. J. Med. 2009, 360:1696-1698.
    • (2009) N.Engl. J. Med. , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 46
    • 36849065911 scopus 로고    scopus 로고
    • Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression
    • Gurbel P.A., Kreutz R.P., Bliden K.P., DiChiara J., Tantry U.S. Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. Am. Heart J. 2008, 155:56-61.
    • (2008) Am. Heart J. , vol.155 , pp. 56-61
    • Gurbel, P.A.1    Kreutz, R.P.2    Bliden, K.P.3    DiChiara, J.4    Tantry, U.S.5
  • 50
    • 18344393519 scopus 로고    scopus 로고
    • Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
    • Han X., Gross R.W. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom. Rev. 2005, 24:367-412.
    • (2005) Mass Spectrom. Rev. , vol.24 , pp. 367-412
    • Han, X.1    Gross, R.W.2
  • 51
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    • Hely M.A., Reid W.G., Adena M.A., Halliday G.M., Morris J.G. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 2008, 23:837-844.
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 52
    • 82755192887 scopus 로고    scopus 로고
    • Biomarkers of Parkinson's disease and Dementia with Lewy bodies
    • Henchcliffe C., Dodel R., Beal M.F. Biomarkers of Parkinson's disease and Dementia with Lewy bodies. Prog. Neurobiol. 2011, 95:601-613.
    • (2011) Prog. Neurobiol. , vol.95 , pp. 601-613
    • Henchcliffe, C.1    Dodel, R.2    Beal, M.F.3
  • 54
    • 50249099816 scopus 로고    scopus 로고
    • Metabolic phenotyping in health and disease
    • Holmes E., Wilson I.D., Nicholson J.K. Metabolic phenotyping in health and disease. Cell 2008, 134:714-717.
    • (2008) Cell , vol.134 , pp. 714-717
    • Holmes, E.1    Wilson, I.D.2    Nicholson, J.K.3
  • 56
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes A.J., Daniel S.E., Kilford L., Lees A.J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J.Neurol. Neurosurg. Psychiatry 1992, 55:181-184.
    • (1992) J.Neurol. Neurosurg. Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 57
    • 0035940582 scopus 로고    scopus 로고
    • Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease
    • Hughes A.J., Daniel S.E., Lees A.J. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001, 57:1497-1499.
    • (2001) Neurology , vol.57 , pp. 1497-1499
    • Hughes, A.J.1    Daniel, S.E.2    Lees, A.J.3
  • 58
    • 0034078533 scopus 로고    scopus 로고
    • Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging
    • Hutchinson M., Raff U. Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging. AJNR Am. J. Neuroradiol. 2000, 21:697-701.
    • (2000) AJNR Am. J. Neuroradiol. , vol.21 , pp. 697-701
    • Hutchinson, M.1    Raff, U.2
  • 60
    • 84883174947 scopus 로고    scopus 로고
    • Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
    • Irwin D.J., Lee V.M., Trojanowski J.Q. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat. Rev. Neurosci. 2013, 14:626-636.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 61
    • 84890528022 scopus 로고    scopus 로고
    • Biomarker modeling of Alzheimer's disease
    • Jack C.R., Holtzman D.M. Biomarker modeling of Alzheimer's disease. Neuron 2013, 80:1347-1358.
    • (2013) Neuron , vol.80 , pp. 1347-1358
    • Jack, C.R.1    Holtzman, D.M.2
  • 62
    • 79956076567 scopus 로고    scopus 로고
    • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Jack C.R., Albert M.S., Knopman D.S., McKhann G.M., Sperling R.A., Carrillo M.C., Thies B., Phelps C.H. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:257-262.
    • (2011) Alzheimers Dement. , vol.7 , pp. 257-262
    • Jack, C.R.1    Albert, M.S.2    Knopman, D.S.3    McKhann, G.M.4    Sperling, R.A.5    Carrillo, M.C.6    Thies, B.7    Phelps, C.H.8
  • 63
    • 84862128944 scopus 로고    scopus 로고
    • Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease
    • Kang J.H., Vanderstichele H., Trojanowski J.Q., Shaw L.M. Simultaneous analysis of cerebrospinal fluid biomarkers using microsphere-based xMAP multiplex technology for early detection of Alzheimer's disease. Methods 2012, 56:484-493.
    • (2012) Methods , vol.56 , pp. 484-493
    • Kang, J.H.1    Vanderstichele, H.2    Trojanowski, J.Q.3    Shaw, L.M.4
  • 64
    • 84885699313 scopus 로고    scopus 로고
    • Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease
    • Kang J.H., Irwin D.J., Chen-Plotkin A.S., Siderowf A., Caspell C., Coffey C.S., Waligórska T., Taylor P., Pan S., Frasier M., et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. JAMA Neurol. 2013, 70:1277-1287. Parkinson's Progression Markers Initiative.
    • (2013) JAMA Neurol. , vol.70 , pp. 1277-1287
    • Kang, J.H.1    Irwin, D.J.2    Chen-Plotkin, A.S.3    Siderowf, A.4    Caspell, C.5    Coffey, C.S.6    Waligórska, T.7    Taylor, P.8    Pan, S.9    Frasier, M.10
  • 67
    • 84875543467 scopus 로고    scopus 로고
    • The current and projected economic burden of Parkinson's disease in the United States
    • Kowal S.L., Dall T.M., Chakrabarti R., Storm M.V., Jain A. The current and projected economic burden of Parkinson's disease in the United States. Mov. Disord. 2013, 28:311-318.
    • (2013) Mov. Disord. , vol.28 , pp. 311-318
    • Kowal, S.L.1    Dall, T.M.2    Chakrabarti, R.3    Storm, M.V.4    Jain, A.5
  • 68
    • 84875514732 scopus 로고    scopus 로고
    • Regulatory innovation and drug development for early-stage Alzheimer's disease
    • Kozauer N., Katz R. Regulatory innovation and drug development for early-stage Alzheimer's disease. N.Engl. J. Med. 2013, 368:1169-1171.
    • (2013) N.Engl. J. Med. , vol.368 , pp. 1169-1171
    • Kozauer, N.1    Katz, R.2
  • 69
    • 84908338776 scopus 로고    scopus 로고
    • Mass spectrometry in clinical chemistry: the case of newborn screening
    • Published online April 28, 2014
    • la Marca G. Mass spectrometry in clinical chemistry: the case of newborn screening. J.Pharm. Biomed. Anal. 2014, Published online April 28, 2014. 10.1016/j.jpba.2014.03.047.
    • (2014) J.Pharm. Biomed. Anal.
    • la Marca, G.1
  • 71
    • 0001509014 scopus 로고
    • Paralysis agitans. I. Pathologische anatomie
    • Springer, Berlin
    • Lewy F. Paralysis agitans. I. Pathologische anatomie. Handbuch der Neurologie 1912, 920-933. Springer, Berlin. Volume 3.
    • (1912) Handbuch der Neurologie , pp. 920-933
    • Lewy, F.1
  • 72
    • 84895743899 scopus 로고    scopus 로고
    • Beyond antibodies: new affinity reagents to unlock the proteome
    • Lollo B., Steele F., Gold L. Beyond antibodies: new affinity reagents to unlock the proteome. Proteomics 2014, 14:638-644.
    • (2014) Proteomics , vol.14 , pp. 638-644
    • Lollo, B.1    Steele, F.2    Gold, L.3
  • 73
    • 84885723826 scopus 로고    scopus 로고
    • Moving forward on gait measurement: toward a more refined approach
    • Lord S., Galna B., Rochester L. Moving forward on gait measurement: toward a more refined approach. Mov. Disord. 2013, 28:1534-1543.
    • (2013) Mov. Disord. , vol.28 , pp. 1534-1543
    • Lord, S.1    Galna, B.2    Rochester, L.3
  • 74
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk K.C., Kehm V., Carroll J., Zhang B., O'Brien P., Trojanowski J.Q., Lee V.M. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012, 338:949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 75
    • 84908351208 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
    • Magdalinou N., Lees A.J., Zetterberg H. Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions. J.Neurol. Neurosurg. Psychiatry 2014, 85:1065-1075.
    • (2014) J.Neurol. Neurosurg. Psychiatry , vol.85 , pp. 1065-1075
    • Magdalinou, N.1    Lees, A.J.2    Zetterberg, H.3
  • 76
    • 84904744897 scopus 로고    scopus 로고
    • Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review
    • Malek N., Swallow D., Grosset K.A., Anichtchik O., Spillantini M., Grosset D.G. Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review. Acta Neurol. Scand. 2014, 130:59-72.
    • (2014) Acta Neurol. Scand. , vol.130 , pp. 59-72
    • Malek, N.1    Swallow, D.2    Grosset, K.A.3    Anichtchik, O.4    Spillantini, M.5    Grosset, D.G.6
  • 78
    • 58349108690 scopus 로고    scopus 로고
    • Biomarkers for Parkinson's [corrected] disease: tools to assess Parkinson's disease onset and progression
    • Marek K., Jennings D., Tamagnan G., Seibyl J. Biomarkers for Parkinson's [corrected] disease: tools to assess Parkinson's disease onset and progression. Ann. Neurol. 2008, 64(Suppl 2):S111-S121.
    • (2008) Ann. Neurol. , vol.64 , pp. S111-S121
    • Marek, K.1    Jennings, D.2    Tamagnan, G.3    Seibyl, J.4
  • 80
    • 0036846580 scopus 로고    scopus 로고
    • Predicting motor decline and disability in Parkinson disease: a systematic review
    • Marras C., Rochon P., Lang A.E. Predicting motor decline and disability in Parkinson disease: a systematic review. Arch. Neurol. 2002, 59:1724-1728.
    • (2002) Arch. Neurol. , vol.59 , pp. 1724-1728
    • Marras, C.1    Rochon, P.2    Lang, A.E.3
  • 82
    • 0026751822 scopus 로고
    • A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender
    • Mayeux R., Denaro J., Hemenegildo N., Marder K., Tang M.X., Cote L.J., Stern Y. A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender. Arch. Neurol. 1992, 49:492-497.
    • (1992) Arch. Neurol. , vol.49 , pp. 492-497
    • Mayeux, R.1    Denaro, J.2    Hemenegildo, N.3    Marder, K.4    Tang, M.X.5    Cote, L.J.6    Stern, Y.7
  • 83
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., Klunk W.E., Koroshetz W.J., Manly J.J., Mayeux R., et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:263-269.
    • (2011) Alzheimers Dement. , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3    Hyman, B.T.4    Jack, C.R.5    Kawas, C.H.6    Klunk, W.E.7    Koroshetz, W.J.8    Manly, J.J.9    Mayeux, R.10
  • 85
    • 84927178751 scopus 로고    scopus 로고
    • The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
    • Published online August 20, 2014
    • Molinuevo J.L., Blennow K., Dubois B., Engelborghs S., Lewczuk P., Perret-Liaudet A., Teunissen C.E., Parnetti L. The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement. 2014, Published online August 20, 2014. 10.1016/j.jalz.2014.03.003.
    • (2014) Alzheimers Dement.
    • Molinuevo, J.L.1    Blennow, K.2    Dubois, B.3    Engelborghs, S.4    Lewczuk, P.5    Perret-Liaudet, A.6    Teunissen, C.E.7    Parnetti, L.8
  • 88
    • 84898770196 scopus 로고    scopus 로고
    • What can biomarkers tell us about cognition in Parkinson's disease?
    • Mollenhauer B., Rochester L., Chen-Plotkin A., Brooks D. What can biomarkers tell us about cognition in Parkinson's disease?. Mov. Disord. 2014, 29:622-633.
    • (2014) Mov. Disord. , vol.29 , pp. 622-633
    • Mollenhauer, B.1    Rochester, L.2    Chen-Plotkin, A.3    Brooks, D.4
  • 92
    • 84903954271 scopus 로고    scopus 로고
    • Design and Analysis for Studying microRNAs in Human Disease: A Primer on -Omic Technologies
    • Nair V.S., Pritchard C.C., Tewari M., Ioannidis J.P. Design and Analysis for Studying microRNAs in Human Disease: A Primer on -Omic Technologies. Am. J. Epidemiol. 2014, 180:140-152.
    • (2014) Am. J. Epidemiol. , vol.180 , pp. 140-152
    • Nair, V.S.1    Pritchard, C.C.2    Tewari, M.3    Ioannidis, J.P.4
  • 93
    • 84912121524 scopus 로고    scopus 로고
    • National Cancer Institute (2014). What is Proteomics?. http://proteomics.cancer.gov/whatisproteomics.
    • (2014) What is Proteomics?
  • 94
    • 84912143180 scopus 로고    scopus 로고
    • NIH-NINDS (2014). http://www.commondataelements.ninds.nih.gov/PD.aspx.
    • (2014)
  • 95
    • 84929264851 scopus 로고    scopus 로고
    • Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
    • Published online September 27, 2014
    • O'Bryant S.E., Gupta V., Henriksen K., Edwards M., Jeromin A., Lista S., Bazenet C., Soares H., Lovestone S., Hampel H., et al. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimers Dement. 2014, STAR-B and BBBIG working groups, Published online September 27, 2014. 10.1016/j.jalz.2014.08.099.
    • (2014) Alzheimers Dement.
    • O'Bryant, S.E.1    Gupta, V.2    Henriksen, K.3    Edwards, M.4    Jeromin, A.5    Lista, S.6    Bazenet, C.7    Soares, H.8    Lovestone, S.9    Hampel, H.10
  • 96
    • 58349122472 scopus 로고    scopus 로고
    • Why have we failed to achieve neuroprotection in Parkinson's disease?
    • Olanow C.W., Kieburtz K., Schapira A.H. Why have we failed to achieve neuroprotection in Parkinson's disease?. Ann. Neurol. 2008, 64(Suppl 2):S101-S110.
    • (2008) Ann. Neurol. , vol.64 , pp. S101-S110
    • Olanow, C.W.1    Kieburtz, K.2    Schapira, A.H.3
  • 98
    • 84862916400 scopus 로고    scopus 로고
    • Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease
    • Park M.J., Cheon S.M., Bae H.R., Kim S.H., Kim J.W. Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease. J Clin Neurol 2011, 7:215-222.
    • (2011) J Clin Neurol , vol.7 , pp. 215-222
    • Park, M.J.1    Cheon, S.M.2    Bae, H.R.3    Kim, S.H.4    Kim, J.W.5
  • 100
    • 35148882113 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 2007, 69:1480-1490. Parkinson Study Group PRECEPT Investigators.
    • (2007) Neurology , vol.69 , pp. 1480-1490
  • 101
    • 84912099882 scopus 로고    scopus 로고
    • Parkinson's Disease Biomarkers Program (2014). https://pdbp.ninds.nih.gov.
    • (2014)
  • 102
    • 84912143178 scopus 로고    scopus 로고
    • Parkinson's Progression Markers Initiative (2014). http://www.ppmi-info.org.
    • (2014)
  • 104
    • 83055179759 scopus 로고    scopus 로고
    • Impact of the 21-gene recurrence score assay compared with standard clinicopathologic guidelines in adjuvant therapy selection for node-negative, estrogen receptor-positive breast cancer
    • Partin J.F., Mamounas E.P. Impact of the 21-gene recurrence score assay compared with standard clinicopathologic guidelines in adjuvant therapy selection for node-negative, estrogen receptor-positive breast cancer. Ann. Surg. Oncol. 2011, 18:3399-3406.
    • (2011) Ann. Surg. Oncol. , vol.18 , pp. 3399-3406
    • Partin, J.F.1    Mamounas, E.P.2
  • 107
    • 70350061949 scopus 로고    scopus 로고
    • Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
    • Perrin R.J., Fagan A.M., Holtzman D.M. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009, 461:916-922.
    • (2009) Nature , vol.461 , pp. 916-922
    • Perrin, R.J.1    Fagan, A.M.2    Holtzman, D.M.3
  • 110
    • 0037435524 scopus 로고    scopus 로고
    • The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism
    • Pressley J.C., Louis E.D., Tang M.X., Cote L., Cohen P.D., Glied S., Mayeux R. The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism. Neurology 2003, 60:87-93.
    • (2003) Neurology , vol.60 , pp. 87-93
    • Pressley, J.C.1    Louis, E.D.2    Tang, M.X.3    Cote, L.4    Cohen, P.D.5    Glied, S.6    Mayeux, R.7
  • 113
    • 0025939232 scopus 로고
    • Accuracy of clinical diagnosis in parkinsonism-a prospective study
    • Rajput A.H., Rozdilsky B., Rajput A. Accuracy of clinical diagnosis in parkinsonism-a prospective study. Can. J. Neurol. Sci. 1991, 18:275-278.
    • (1991) Can. J. Neurol. Sci. , vol.18 , pp. 275-278
    • Rajput, A.H.1    Rozdilsky, B.2    Rajput, A.3
  • 114
    • 79954706259 scopus 로고    scopus 로고
    • A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes
    • Rascol O., Fitzer-Attas C.J., Hauser R., Jankovic J., Lang A., Langston J.W., Melamed E., Poewe W., Stocchi F., Tolosa E., et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol. 2011, 10:415-423.
    • (2011) Lancet Neurol. , vol.10 , pp. 415-423
    • Rascol, O.1    Fitzer-Attas, C.J.2    Hauser, R.3    Jankovic, J.4    Lang, A.5    Langston, J.W.6    Melamed, E.7    Poewe, W.8    Stocchi, F.9    Tolosa, E.10
  • 115
    • 79957603259 scopus 로고    scopus 로고
    • Milestones in Parkinson's disease therapeutics
    • Rascol O., Lozano A., Stern M., Poewe W. Milestones in Parkinson's disease therapeutics. Mov. Disord. 2011, 26:1072-1082.
    • (2011) Mov. Disord. , vol.26 , pp. 1072-1082
    • Rascol, O.1    Lozano, A.2    Stern, M.3    Poewe, W.4
  • 119
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • Ross J.S., Hatzis C., Symmans W.F., Pusztai L., Hortobágyi G.N. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist 2008, 13:477-493.
    • (2008) Oncologist , vol.13 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3    Pusztai, L.4    Hortobágyi, G.N.5
  • 120
    • 41649102043 scopus 로고    scopus 로고
    • The cancer biomarker problem
    • Sawyers C.L. The cancer biomarker problem. Nature 2008, 452:548-552.
    • (2008) Nature , vol.452 , pp. 548-552
    • Sawyers, C.L.1
  • 121
    • 0029878953 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder
    • Schenck C.H., Bundlie S.R., Mahowald M.W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996, 46:388-393.
    • (1996) Neurology , vol.46 , pp. 388-393
    • Schenck, C.H.1    Bundlie, S.R.2    Mahowald, M.W.3
  • 123
    • 84890574796 scopus 로고    scopus 로고
    • Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies
    • Schmid A.W., Fauvet B., Moniatte M., Lashuel H.A. Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies. Mol. Cell. Proteomics 2013, 12:3543-3558.
    • (2013) Mol. Cell. Proteomics , vol.12 , pp. 3543-3558
    • Schmid, A.W.1    Fauvet, B.2    Moniatte, M.3    Lashuel, H.A.4
  • 125
    • 33846544538 scopus 로고    scopus 로고
    • Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics
    • Schwenk J.M., Lindberg J., Sundberg M., Uhlén M., Nilsson P. Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics. Mol. Cell. Proteomics 2007, 6:125-132.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 125-132
    • Schwenk, J.M.1    Lindberg, J.2    Sundberg, M.3    Uhlén, M.4    Nilsson, P.5
  • 126
    • 67651108596 scopus 로고    scopus 로고
    • Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    • Seng P., Drancourt M., Gouriet F., La Scola B., Fournier P.E., Rolain J.M., Raoult D. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin. Infect. Dis. 2009, 49:543-551.
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 543-551
    • Seng, P.1    Drancourt, M.2    Gouriet, F.3    La Scola, B.4    Fournier, P.E.5    Rolain, J.M.6    Raoult, D.7
  • 127
    • 84903120463 scopus 로고    scopus 로고
    • Molecular Imaging Insights into Neurodegeneration: Focus on Tau PET Radiotracers
    • Shah M., Catafau A.M. Molecular Imaging Insights into Neurodegeneration: Focus on Tau PET Radiotracers. J.Nucl. Med. 2014, 55:871-874.
    • (2014) J.Nucl. Med. , vol.55 , pp. 871-874
    • Shah, M.1    Catafau, A.M.2
  • 129
    • 77949342573 scopus 로고    scopus 로고
    • SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease
    • Shehadeh L.A., Yu K., Wang L., Guevara A., Singer C., Vance J., Papapetropoulos S. SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. PLoS ONE 2010, 5:e9104.
    • (2010) PLoS ONE , vol.5 , pp. e9104
    • Shehadeh, L.A.1    Yu, K.2    Wang, L.3    Guevara, A.4    Singer, C.5    Vance, J.6    Papapetropoulos, S.7
  • 130
    • 79955034708 scopus 로고    scopus 로고
    • Biomarkers for Parkinson's disease
    • 79ps14
    • Sherer T.B. Biomarkers for Parkinson's disease. Sci. Transl. Med. 2011, 3:79ps14.
    • (2011) Sci. Transl. Med. , vol.3
    • Sherer, T.B.1
  • 134
    • 82355191922 scopus 로고    scopus 로고
    • CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease
    • Sierks M.R., Chatterjee G., McGraw C., Kasturirangan S., Schulz P., Prasad S. CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol (Camb) 2011, 3:1188-1196.
    • (2011) Integr Biol (Camb) , vol.3 , pp. 1188-1196
    • Sierks, M.R.1    Chatterjee, G.2    McGraw, C.3    Kasturirangan, S.4    Schulz, P.5    Prasad, S.6
  • 136
    • 84895770914 scopus 로고    scopus 로고
    • Antibody-based proteomics and biomarker research - current status and limitations
    • Solier C., Langen H. Antibody-based proteomics and biomarker research - current status and limitations. Proteomics 2014, 14:774-783.
    • (2014) Proteomics , vol.14 , pp. 774-783
    • Solier, C.1    Langen, H.2
  • 137
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups ondiagnostic guidelines for Alzheimer's disease
    • Sperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., Iwatsubo T., Jack C.R., Kaye J., Montine T.J., et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups ondiagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:280-292.
    • (2011) Alzheimers Dement. , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6    Iwatsubo, T.7    Jack, C.R.8    Kaye, J.9    Montine, T.J.10
  • 139
    • 79951521421 scopus 로고    scopus 로고
    • Progress and promise of genome-wide association studies for human complex trait genetics
    • Stranger B.E., Stahl E.A., Raj T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics 2011, 187:367-383.
    • (2011) Genetics , vol.187 , pp. 367-383
    • Stranger, B.E.1    Stahl, E.A.2    Raj, T.3
  • 140
    • 33646082990 scopus 로고    scopus 로고
    • Practice Parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Suchowersky O., Reich S., Perlmutter J., Zesiewicz T., Gronseth G., Weiner W.J. Practice Parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006, 66:968-975. Quality Standards Subcommittee of the American Academy of Neurology.
    • (2006) Neurology , vol.66 , pp. 968-975
    • Suchowersky, O.1    Reich, S.2    Perlmutter, J.3    Zesiewicz, T.4    Gronseth, G.5    Weiner, W.J.6
  • 141
    • 84863880556 scopus 로고    scopus 로고
    • Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment
    • Svenningsson P., Westman E., Ballard C., Aarsland D. Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment. Lancet Neurol. 2012, 11:697-707.
    • (2012) Lancet Neurol. , vol.11 , pp. 697-707
    • Svenningsson, P.1    Westman, E.2    Ballard, C.3    Aarsland, D.4
  • 143
  • 144
    • 84865756966 scopus 로고    scopus 로고
    • Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease
    • Tateno F., Sakakibara R., Kawai T., Kishi M., Murano T. Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2012, 26:213-216.
    • (2012) Alzheimer Dis. Assoc. Disord. , vol.26 , pp. 213-216
    • Tateno, F.1    Sakakibara, R.2    Kawai, T.3    Kishi, M.4    Murano, T.5
  • 145
    • 84886888470 scopus 로고    scopus 로고
    • NINDS boosts research for biomarkers in Parkinson's disease
    • NINDS boosts research for biomarkers in Parkinson's disease. Lancet Neurol. 2013, 12:217. The Lancet Neurology.
    • (2013) Lancet Neurol. , vol.12 , pp. 217
  • 146
    • 84855929701 scopus 로고    scopus 로고
    • Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine
    • Tian Q., Price N.D., Hood L. Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine. J.Intern. Med. 2012, 271:111-121.
    • (2012) J.Intern. Med. , vol.271 , pp. 111-121
    • Tian, Q.1    Price, N.D.2    Hood, L.3
  • 150
    • 84881376726 scopus 로고    scopus 로고
    • Advances in the genetics of Parkinson disease
    • Trinh J., Farrer M. Advances in the genetics of Parkinson disease. Nat Rev Neurol 2013, 9:445-454.
    • (2013) Nat Rev Neurol , vol.9 , pp. 445-454
    • Trinh, J.1    Farrer, M.2
  • 151
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C., Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249:505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 152
    • 0242365681 scopus 로고    scopus 로고
    • Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism
    • Uhl G.R. Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. Mov. Disord. 2003, 18(Suppl 7):S71-S80.
    • (2003) Mov. Disord. , vol.18 , pp. S71-S80
    • Uhl, G.R.1
  • 155
    • 84856008210 scopus 로고    scopus 로고
    • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative
    • Vanderstichele H., Bibl M., Engelborghs S., Le Bastard N., Lewczuk P., Molinuevo J.L., Parnetti L., Perret-Liaudet A., Shaw L.M., Teunissen C., et al. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement. 2012, 8:65-73.
    • (2012) Alzheimers Dement. , vol.8 , pp. 65-73
    • Vanderstichele, H.1    Bibl, M.2    Engelborghs, S.3    Le Bastard, N.4    Lewczuk, P.5    Molinuevo, J.L.6    Parnetti, L.7    Perret-Liaudet, A.8    Shaw, L.M.9    Teunissen, C.10
  • 156
    • 43449083749 scopus 로고    scopus 로고
    • A decade of HPLC-MS/MS in the routineclinical laboratory-goals for further developments
    • Vogeser M., Seger C. A decade of HPLC-MS/MS in the routineclinical laboratory-goals for further developments. Clin. Biochem. 2008, 41:649-662.
    • (2008) Clin. Biochem. , vol.41 , pp. 649-662
    • Vogeser, M.1    Seger, C.2
  • 157
    • 20444366879 scopus 로고    scopus 로고
    • Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder
    • Volkow N.D., Wang G.J., Fowler J.S., Ding Y.S. Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol. Psychiatry 2005, 57:1410-1415.
    • (2005) Biol. Psychiatry , vol.57 , pp. 1410-1415
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Ding, Y.S.4
  • 159
    • 84873094123 scopus 로고    scopus 로고
    • Biomarkers of Parkinson's disease: current status and future perspectives
    • Wang J., Hoekstra J.G., Zuo C., Cook T.J., Zhang J. Biomarkers of Parkinson's disease: current status and future perspectives. Drug Discov. Today 2013, 18:155-162.
    • (2013) Drug Discov. Today , vol.18 , pp. 155-162
    • Wang, J.1    Hoekstra, J.G.2    Zuo, C.3    Cook, T.J.4    Zhang, J.5
  • 164
    • 36949065559 scopus 로고
    • Assay of plasma insulin in human subjects by immunological methods
    • Yalow R.S., Berson S.A. Assay of plasma insulin in human subjects by immunological methods. Nature 1959, 184(Suppl 21):1648-1649.
    • (1959) Nature , vol.184 , pp. 1648-1649
    • Yalow, R.S.1    Berson, S.A.2
  • 165
    • 26444505936 scopus 로고    scopus 로고
    • Translational and clinical science-time for a new vision
    • Zerhouni E.A. Translational and clinical science-time for a new vision. N.Engl. J. Med. 2005, 353:1621-1623.
    • (2005) N.Engl. J. Med. , vol.353 , pp. 1621-1623
    • Zerhouni, E.A.1


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