Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease

Cell Stem Cell

Volumn 19, Issue 6, 2016, Pages 709-724

  Hsieh, Chung Han ^a   Shaltouki, Atossa ^a   Gonzalez, Ashley E ^a   Bettencourt da Cruz, Alexandre ^a   Burbulla, Lena F ^b   St Lawrence, Erica ^a   Schüle, Birgitt ^c   Krainc, Dimitri ^b   Palmer, Theo D ^a   Wang, Xinnan ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c PARKINSON S INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LEUCINE RICH REPEAT KINASE 2; MIRO PROTEIN; MITOCHONDRIAL PROTEIN; OUTER MEMBRANE PROTEIN; PARKIN; PROTEIN; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG; LRRK2 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOT1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; BRAIN MITOCHONDRION; CELL MOTILITY; CELL PROTECTION; CELL STRESS; CLINICAL FEATURE; COMPLEX FORMATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; FAMILIAL PARKINSON DISEASE; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MITOCHONDRIAL STRESS; MITOPHAGY; MOLECULAR PATHOLOGY; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPORADIC PARKINSON DISEASE; ANIMAL; AXON; CELL LINE; COMPLICATION; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; MITOCHONDRION; MOTOR ACTIVITY; MUTATION; PATHOLOGY; PHYSIOLOGICAL STRESS; RNA INTERFERENCE;

ANIMALS; AXONS; CELL LINE; DOPAMINERGIC NEURONS; DROSOPHILA MELANOGASTER; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LEUCINE-RICH REPEAT SERINE-THREONINE PROTEIN KINASE-2; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; MOTOR ACTIVITY; MUTATION; NERVE DEGENERATION; NEUROPROTECTION; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN KINASES; PROTEOLYSIS; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 84994834600     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.08.002     Document Type: Article

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