메뉴 건너뛰기




Volumn 39, Issue 12, 2016, Pages 847-854

Cancer metabolism: Fueling more than just growth

Author keywords

Cancer; Immune evasion; Metabolism; Metabolites; Tumor Microenvironment

Indexed keywords

AEROBIC GLYCOLYSIS; CANCER STEM CELL; CANCER THERAPY; CELL METABOLISM; CELL PROLIFERATION; CELL SUBPOPULATION; CELL SURVIVAL; HUMAN; IMMUNE EVASION; IMMUNE SYSTEM; METABOLITE; NUCLEOTIDE METABOLISM; TUMOR MICROENVIRONMENT; ANIMAL; METABOLISM; NEOPLASM; PATHOLOGY;

EID: 85015733199     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2016.0310     Document Type: Review
Times cited : (88)

References (86)
  • 2
    • 84888385324 scopus 로고    scopus 로고
    • Immunity, inflammation and cancer: A leading role for adenosine
    • Antonioli, L., Blandizzi, C., Pacher, P., and Hasko, G. (2013). Immunity, inflammation and cancer: a leading role for adenosine. Nat. Rev. Cancer 13, 842-857.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 842-857
    • Antonioli, L.1    Blandizzi, C.2    Pacher, P.3    Hasko, G.4
  • 3
    • 84891007206 scopus 로고    scopus 로고
    • Adult intestinal stem cells: Critical drivers of epithelial homeostasis and regeneration
    • Barker, N. (2014). Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat. Rev. Mol. Cell Biol. 15, 19-33.
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 19-33
    • Barker, N.1
  • 4
    • 0031156985 scopus 로고    scopus 로고
    • Adenosine inhibits neutrophil degranulation in activated human whole blood: Involvement of adenosine A2 and A3 receptors
    • Bouma, M.G., Jeunhomme, T.M., Boyle, D.L., Dentener, M.A., Voitenok, N.N., van den Wildenberg, F. A., and Buurman, W.A. (1997). Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 158, 5400-5408.
    • (1997) J. Immunol , vol.158 , pp. 5400-5408
    • Bouma, M.G.1    Jeunhomme, T.M.2    Boyle, D.L.3    Dentener, M.A.4    Voitenok, N.N.5    Van Den Wildenberg, F.A.6    Buurman, W.A.7
  • 8
    • 84881453720 scopus 로고    scopus 로고
    • Understanding and targeting cancer stem cells: Therapeutic implications and challenges. Acta Pharmacol
    • Chen, K., Huang, Y.H., and Chen, J.L. (2013). Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol. Sin. 34, 732-740.
    • (2013) Sin , vol.34 , pp. 732-740
    • Chen, K.1    Huang, Y.H.2    Chen, J.L.3
  • 9
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche, J., Brahimi-Horn, M.C., and Pouyssegur, J. (2010). Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J. Cell Mol. Med. 14, 771-794.
    • (2010) J. Cell Mol. Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 14
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J., and Pollard, J.W. (2006). Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 16
    • 84975045692 scopus 로고    scopus 로고
    • Metabolic modification in gastrointestinal cancer stem cells: Characteristics and therapeutic approaches
    • Di Francesco, A.M., Toesca, A., Cenciarelli, C., Giordano, A., Gasbarrini, A., and Puglisi, M.A. (2016). Metabolic modification in gastrointestinal cancer stem cells: characteristics and therapeutic approaches. J. Cell Physiol. 231, 2081-2087.
    • (2016) J. Cell Physiol , vol.231 , pp. 2081-2087
    • Di Francesco, A.M.1    Toesca, A.2    Cenciarelli, C.3    Giordano, A.4    Gasbarrini, A.5    Puglisi, M.A.6
  • 17
    • 0024792675 scopus 로고
    • Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis
    • Eppell, B.A., Newell, A.M., and Brown, E.J. (1989). Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis. J. Immunol. 143, 4141-4145.
    • (1989) J. Immunol , vol.143 , pp. 4141-4145
    • Eppell, B.A.1    Newell, A.M.2    Brown, E.J.3
  • 20
    • 84902332213 scopus 로고    scopus 로고
    • Quantitative flux analysis reveals folatedependent NADPH production
    • Fan, J., Ye, J., Kamphorst, J.J., Shlomi, T., Thompson, C.B., and Rabinowitz, J.D. (2014). Quantitative flux analysis reveals folatedependent NADPH production. Nature 510, 298-302.
    • (2014) Nature , vol.510 , pp. 298-302
    • Fan, J.1    Ye, J.2    Kamphorst, J.J.3    Shlomi, T.4    Thompson, C.B.5    Rabinowitz, J.D.6
  • 21
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
    • Farber, S., and Diamond, L.K. (1948). Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl. J. Med. 238, 787-793.
    • (1948) N Engl. J. Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2
  • 22
    • 84965032167 scopus 로고    scopus 로고
    • Cancer immunotherapy: The beginning of the end of cancer?
    • Farkona, S., Diamandis, E.P., and Blasutig, I.M. (2016). Cancer immunotherapy: the beginning of the end of cancer? BMC Med. 14, 73.
    • (2016) BMC Med , vol.14 , pp. 73
    • Farkona, S.1    Diamandis, E.P.2    Blasutig, I.M.3
  • 24
    • 27744519400 scopus 로고    scopus 로고
    • Fuel feeds function: Energy metabolism and the T-cell response
    • Fox, C.J., Hammerman, P.S., and Thompson, C.B. (2005). Fuel feeds function: energy metabolism and the T-cell response. Nat. Rev. Immunol. 5, 844-852.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 844-852
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 25
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment. Nat
    • Gajewski, T.F., Schreiber, H., and Fu, Y.X. (2013). Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014-1022.
    • (2013) Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 27
  • 28
    • 79960029992 scopus 로고    scopus 로고
    • Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
    • Goetze, K., Walenta, S., Ksiazkiewicz, M., Kunz-Schughart, L.A., and Mueller-Klieser, W. (2011). Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int. J. Oncol. 39, 453-463.
    • (2011) Int. J. Oncol , vol.39 , pp. 453-463
    • Goetze, K.1    Walenta, S.2    Ksiazkiewicz, M.3    Kunz-Schughart, L.A.4    Mueller-Klieser, W.5
  • 30
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., and Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 31
    • 0030588630 scopus 로고    scopus 로고
    • Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice
    • Hasko, G., Szabo, C., Nemeth, Z.H., Kvetan, V., Pastores, S.M., and Vizi, E.S. (1996). Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol. 157, 4634-4640.
    • (1996) J. Immunol , vol.157 , pp. 4634-4640
    • Hasko, G.1    Szabo, C.2    Nemeth, Z.H.3    Kvetan, V.4    Pastores, S.M.5    Vizi, E.S.6
  • 32
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases. Nat
    • Hasko, G., Linden, J., Cronstein, B., and Pacher, P. (2008). Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7, 759-770.
    • (2008) Rev. Drug Discov , vol.7 , pp. 759-770
    • Hasko, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 33
    • 80054109170 scopus 로고    scopus 로고
    • Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol
    • Hausler, S.F., Montalban del Barrio, I., Strohschein, J., Chandran, P.A., Engel, J.B., Honig, A., Ossadnik, M., Horn, E., Fischer, B., Krockenberger, M., et al. (2011). Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol. Immunother. 60, 1405-1418.
    • (2011) Immunother , vol.60 , pp. 1405-1418
    • Hausler, S.F.1    Montalban Del Barrio, I.2    Strohschein, J.3    Chandran, P.A.4    Engel, J.B.5    Honig, A.6    Ossadnik, M.7    Horn, E.8    Fischer, B.9    Krockenberger, M.10
  • 35
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu, P.P., and Sabatini, D.M. (2008). Cancer cell metabolism: Warburg and beyond. Cell 134, 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 37
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
    • Isaacs, J.S., Jung, Y.J., Mole, D.R., Lee, S., Torres-Cabala, C., Chung, Y.L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. (2005). HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8, 143-153.
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6    Merino, M.7    Trepel, J.8    Zbar, B.9    Toro, J.10
  • 39
    • 84925545003 scopus 로고    scopus 로고
    • Metabolism in embryonic and cancer stemness
    • Jang, H., Yang, J., Lee, E., and Cheong, J.H. (2015). Metabolism in embryonic and cancer stemness. Arch. Pharm. Res. 38, 381-388.
    • (2015) Arch. Pharm. Res , vol.38 , pp. 381-388
    • Jang, H.1    Yang, J.2    Lee, E.3    Cheong, J.H.4
  • 40
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelialmesenchymal transition
    • Kalluri, R., and Weinberg, R.A. (2009). The basics of epithelialmesenchymal transition. J. Clin. Invest. 119, 1420-1428.
    • (2009) J. Clin. Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 41
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J.W., Tchernyshyov, I., Semenza, G.L., and Dang, C.V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 43
    • 84940467312 scopus 로고    scopus 로고
    • Core pluripotency factors directly regulate metabolism in embryonic stem cell to maintain pluripotency
    • Kim, H., Jang, H., Kim, T.W., Kang, B.H., Lee, S.E., Jeon, Y.K., Chung, D.H., Choi, J., Shin, J., Cho, E.J., et al. (2015b). Core pluripotency factors directly regulate metabolism in embryonic stem cell to maintain pluripotency. Stem Cells 33, 2699-2711.
    • (2015) Stem Cells , vol.33 , pp. 2699-2711
    • Kim, H.1    Jang, H.2    Kim, T.W.3    Kang, B.H.4    Lee, S.E.5    Jeon, Y.K.6    Chung, D.H.7    Choi, J.8    Shin, J.9    Cho, E.J.10
  • 44
    • 40949126440 scopus 로고    scopus 로고
    • Mitochondrial complex III regulates hypoxic activation of HIF
    • Klimova, T., and Chandel, N.S. (2008). Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ. 15, 660-666.
    • (2008) Cell Death Differ , vol.15 , pp. 660-666
    • Klimova, T.1    Chandel, N.S.2
  • 50
    • 0344708478 scopus 로고    scopus 로고
    • Anticancer antifolates: Current status and future directions
    • McGuire, J.J. (2003). Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9, 2593-2613.
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2593-2613
    • McGuire, J.J.1
  • 51
    • 84873160542 scopus 로고    scopus 로고
    • Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells
    • Mimeault, M., and Batra, S.K. (2013). Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells. J. Cell Mol. Med. 17, 30-54.
    • (2013) J. Cell Mol. Med , vol.17 , pp. 30-54
    • Mimeault, M.1    Batra, S.K.2
  • 52
    • 78349252704 scopus 로고    scopus 로고
    • Quiescent, slow-cycling stem cell populations in cancer: A review of the evidence and discussion of significance
    • Moore, N., and Lyle, S. (2011). Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J. Oncol. 2011. pii: 396076
    • (2011) J. Oncol
    • Moore, N.1    Lyle, S.2
  • 53
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn, D.H., and Mellor, A.L. (2007). Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117, 1147-1154.
    • (2007) J. Clin. Invest , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 55
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou, I., Cairns, R.A., Fontana, L., Lim, A.L., and Denko, N.C. (2006). HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 56
    • 78649659788 scopus 로고    scopus 로고
    • PH control mechanisms of tumor survival and growth
    • Parks, S.K., Chiche, J., and Pouyssegur, J. (2011). pH control mechanisms of tumor survival and growth. J. Cell Physiol. 226, 299-308.
    • (2011) J. Cell Physiol , vol.226 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 57
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce, E.L., and Pearce, E.J. (2013). Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633-643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 62
    • 84969951574 scopus 로고    scopus 로고
    • Hallmarks of cancer stem cell metabolism
    • Sancho, P., Barneda, D., and Heeschen, C. (2016). Hallmarks of cancer stem cell metabolism. Br. J. Cancer 114, 1305-1312.
    • (2016) Br. J. Cancer , vol.114 , pp. 1305-1312
    • Sancho, P.1    Barneda, D.2    Heeschen, C.3
  • 65
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza, G.L. (2012). Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci. 33, 207-214.
    • (2012) Trends Pharmacol. Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 68
    • 78649833819 scopus 로고    scopus 로고
    • The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
    • Siemann, D.W. (2011). The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. 37, 63-74.
    • (2011) Cancer Treat. Rev , vol.37 , pp. 63-74
    • Siemann, D.W.1
  • 69
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • Stagg, J., and Smyth, M. J. (2010). Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29, 5346-5358.
    • (2010) Oncogene , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 70
    • 78649423015 scopus 로고    scopus 로고
    • Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats
    • Takahashi, T., Otsuguro, K., Ohta, T., and Ito, S. (2010). Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br. J. Pharmacol. 161, 1806-1816.
    • (2010) Br. J. Pharmacol , vol.161 , pp. 1806-1816
    • Takahashi, T.1    Otsuguro, K.2    Ohta, T.3    Ito, S.4
  • 72
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M.G., Cantley, L.C., and Thompson, C.B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 73
    • 84958567892 scopus 로고    scopus 로고
    • Hypoxia-driven adenosine accumulation: A crucial microenvironmental factor promoting tumor progression
    • Vaupel, P., and Mayer, A. (2016). Hypoxia-driven adenosine accumulation: a crucial microenvironmental factor promoting tumor progression. Adv. Exp. Med. Biol. 876, 177-183.
    • (2016) Adv. Exp. Med. Biol , vol.876 , pp. 177-183
    • Vaupel, P.1    Mayer, A.2
  • 75
    • 84859450097 scopus 로고    scopus 로고
    • Cancer stem cells and drug resistance: The potential of nanomedicine
    • Vinogradov, S., and Wei, X. (2012). Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine 7, 597-615.
    • (2012) Nanomedicine , vol.7 , pp. 597-615
    • Vinogradov, S.1    Wei, X.2
  • 78
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. (1956). On the origin of cancer cells. Science 123, 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 79
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward, P.S., Patel, J., Wise, D.R., Abdel-Wahab, O., Bennett, B.D., Coller, H.A., Fantin, V.R., Hedvat, C.V., Perl, A.E., Rabinowitz, J.D., et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6    Fantin, V.R.7    Hedvat, C.V.8    Perl, A.E.9    Rabinowitz, J.D.10
  • 80
  • 81
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012). Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338.
    • (2012) Genes Dev , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10
  • 82
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutaratedependent dioxygenases
    • Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.H., Ito, S., Yang, C., Wang, P., Xiao, M.T., et al. (2011). Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutaratedependent dioxygenases. Cancer Cell 19, 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6    Ito, S.7    Yang, C.8    Wang, P.9    Xiao, M.T.10
  • 83
    • 84883513587 scopus 로고    scopus 로고
    • Oncometabolites: Linking altered metabolism with cancer
    • Yang, M., Soga, T., and Pollard, P.J. (2013). Oncometabolites: linking altered metabolism with cancer. J. Clin. Invest. 123, 3652-3658.
    • (2013) J. Clin. Invest , vol.123 , pp. 3652-3658
    • Yang, M.1    Soga, T.2    Pollard, P.J.3
  • 84
    • 84988431514 scopus 로고    scopus 로고
    • Serine and one-carbon metabolism in cancer
    • Yang, M., and Vousden, K.H. (2016). Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16, 650-662.
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 650-662
    • Yang, M.1    Vousden, K.H.2
  • 86
    • 84856087055 scopus 로고    scopus 로고
    • Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    • Zhang, W.C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B.S., Sun, L.L., Tai, B.C., Nga, M.E., et al. (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-272.
    • (2012) Cell , vol.148 , pp. 259-272
    • Zhang, W.C.1    Shyh-Chang, N.2    Yang, H.3    Rai, A.4    Umashankar, S.5    Ma, S.6    Soh, B.S.7    Sun, L.L.8    Tai, B.C.9    Nga, M.E.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.