-
1
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou, D., Poulogiannis, G., Asara, J.M., Boxer, M.B., Jiang, J.K., Shen, M., Bellinger, G., Sasaki, A.T., Locasale, J.W., Auld, D.S., et al. (2011). Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334, 1278-1283.
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
-
2
-
-
84888385324
-
Immunity, inflammation and cancer: A leading role for adenosine
-
Antonioli, L., Blandizzi, C., Pacher, P., and Hasko, G. (2013). Immunity, inflammation and cancer: a leading role for adenosine. Nat. Rev. Cancer 13, 842-857.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 842-857
-
-
Antonioli, L.1
Blandizzi, C.2
Pacher, P.3
Hasko, G.4
-
3
-
-
84891007206
-
Adult intestinal stem cells: Critical drivers of epithelial homeostasis and regeneration
-
Barker, N. (2014). Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat. Rev. Mol. Cell Biol. 15, 19-33.
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 19-33
-
-
Barker, N.1
-
4
-
-
0031156985
-
Adenosine inhibits neutrophil degranulation in activated human whole blood: Involvement of adenosine A2 and A3 receptors
-
Bouma, M.G., Jeunhomme, T.M., Boyle, D.L., Dentener, M.A., Voitenok, N.N., van den Wildenberg, F. A., and Buurman, W.A. (1997). Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 158, 5400-5408.
-
(1997)
J. Immunol
, vol.158
, pp. 5400-5408
-
-
Bouma, M.G.1
Jeunhomme, T.M.2
Boyle, D.L.3
Dentener, M.A.4
Voitenok, N.N.5
Van Den Wildenberg, F.A.6
Buurman, W.A.7
-
5
-
-
84994592466
-
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK cells
-
Brand, A., Singer, K., Koehl, G. E., Kolitzus, M., Schoenhammer, G., Thiel, A., Matos, C., Bruss, C., Klobuch, S., Peter, K., et al. (2016). LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK cells. Cell Metab. 24, 657-671.
-
(2016)
Cell Metab
, vol.24
, pp. 657-671
-
-
Brand, A.1
Singer, K.2
Koehl, G.E.3
Kolitzus, M.4
Schoenhammer, G.5
Thiel, A.6
Matos, C.7
Bruss, C.8
Klobuch, S.9
Peter, K.10
-
6
-
-
84888311642
-
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
-
Carmona-Fontaine, C., Bucci, V., Akkari, L., Deforet, M., Joyce, J.A., and Xavier, J.B. (2013). Emergence of spatial structure in the tumor microenvironment due to the Warburg effect. Proc. Natl. Acad. Sci. USA, 110, 19402-19407.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 19402-19407
-
-
Carmona-Fontaine, C.1
Bucci, V.2
Akkari, L.3
Deforet, M.4
Joyce, J.A.5
Xavier, J.B.6
-
7
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C., Maddocks, O. D., Chokkathukalam, A., Coyle, J.E., Jankevics, A., Holding, F.P., Vousden, K.H., et al. (2012). Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491, 458-462.
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
-
8
-
-
84881453720
-
Understanding and targeting cancer stem cells: Therapeutic implications and challenges. Acta Pharmacol
-
Chen, K., Huang, Y.H., and Chen, J.L. (2013). Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol. Sin. 34, 732-740.
-
(2013)
Sin
, vol.34
, pp. 732-740
-
-
Chen, K.1
Huang, Y.H.2
Chen, J.L.3
-
9
-
-
77953935500
-
Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
-
Chiche, J., Brahimi-Horn, M.C., and Pouyssegur, J. (2010). Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J. Cell Mol. Med. 14, 771-794.
-
(2010)
J. Cell Mol. Med
, vol.14
, pp. 771-794
-
-
Chiche, J.1
Brahimi-Horn, M.C.2
Pouyssegur, J.3
-
10
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury, R., Yeoh, K.K., Tian, Y.M., Hillringhaus, L., Bagg, E.A., Rose, N.R., Leung, I.K., Li, X.S., Woon, E.C., Yang, M., et al. (2011). The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463-469.
-
(2011)
EMBO Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
Leung, I.K.7
Li, X.S.8
Woon, E.C.9
Yang, M.10
-
11
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk, H.R., Vander Heiden, M.G., Harris, M.H., Ramanathan, A., Gerszten, R.E., Wei, R., Fleming, M.D., Schreiber, S.L., and Cantley, L.C. (2008). The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
12
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosinebinding protein
-
Christofk, H.R., Vander Heiden, M.G., Wu, N., Asara, J.M., and Cantley, L.C. (2008). Pyruvate kinase M2 is a phosphotyrosinebinding protein. Nature 452, 181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
13
-
-
84907223092
-
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
-
Colegio, O.R., Chu, N.Q., Szabo, A.L., Chu, T., Rhebergen, A.M., Jairam, V., Cyrus, N., Brokowski, C.E., Eisenbarth, S.C., Phillips, G.M., et al. (2014). Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513, 559-563.
-
(2014)
Nature
, vol.513
, pp. 559-563
-
-
Colegio, O.R.1
Chu, N.Q.2
Szabo, A.L.3
Chu, T.4
Rhebergen, A.M.5
Jairam, V.6
Cyrus, N.7
Brokowski, C.E.8
Eisenbarth, S.C.9
Phillips, G.M.10
-
14
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis, J., and Pollard, J.W. (2006). Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266.
-
(2006)
Cell
, vol.124
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
15
-
-
84878557557
-
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
-
De Medina, P., Paillasse, M.R., Segala, G., Voisin, M., Mhamdi, L., Dalenc, F., Lacroix-Triki, M., Filleron, T., Pont, F., Saati, T.A., et al. (2013). Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Nat. Commun. 4, 1840.
-
(2013)
Nat. Commun
, vol.4
, pp. 1840
-
-
De Medina, P.1
Paillasse, M.R.2
Segala, G.3
Voisin, M.4
Mhamdi, L.5
Dalenc, F.6
Lacroix-Triki, M.7
Filleron, T.8
Pont, F.9
Saati, T.A.10
-
16
-
-
84975045692
-
Metabolic modification in gastrointestinal cancer stem cells: Characteristics and therapeutic approaches
-
Di Francesco, A.M., Toesca, A., Cenciarelli, C., Giordano, A., Gasbarrini, A., and Puglisi, M.A. (2016). Metabolic modification in gastrointestinal cancer stem cells: characteristics and therapeutic approaches. J. Cell Physiol. 231, 2081-2087.
-
(2016)
J. Cell Physiol
, vol.231
, pp. 2081-2087
-
-
Di Francesco, A.M.1
Toesca, A.2
Cenciarelli, C.3
Giordano, A.4
Gasbarrini, A.5
Puglisi, M.A.6
-
17
-
-
0024792675
-
Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis
-
Eppell, B.A., Newell, A.M., and Brown, E.J. (1989). Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis. J. Immunol. 143, 4141-4145.
-
(1989)
J. Immunol
, vol.143
, pp. 4141-4145
-
-
Eppell, B.A.1
Newell, A.M.2
Brown, E.J.3
-
18
-
-
0036790338
-
T cell apoptosis by tryptophan catabolism
-
Fallarino, F., Grohmann, U., Vacca, C., Bianchi, R., Orabona, C., Spreca, A., Fioretti, M.C., and Puccetti, P. (2002). T cell apoptosis by tryptophan catabolism. Cell Death Differ. 9, 1069-1077.
-
(2002)
Cell Death Differ
, vol.9
, pp. 1069-1077
-
-
Fallarino, F.1
Grohmann, U.2
Vacca, C.3
Bianchi, R.4
Orabona, C.5
Spreca, A.6
Fioretti, M.C.7
Puccetti, P.8
-
19
-
-
1042291130
-
T cell apoptosis by kynurenines
-
Fallarino, F., Grohmann, U., Vacca, C., Orabona, C., Spreca, A., Fioretti, M.C., and Puccetti, P. (2003). T cell apoptosis by kynurenines. Adv. Exp. Med. Biol. 527, 183-190.
-
(2003)
Adv. Exp. Med. Biol
, vol.527
, pp. 183-190
-
-
Fallarino, F.1
Grohmann, U.2
Vacca, C.3
Orabona, C.4
Spreca, A.5
Fioretti, M.C.6
Puccetti, P.7
-
20
-
-
84902332213
-
Quantitative flux analysis reveals folatedependent NADPH production
-
Fan, J., Ye, J., Kamphorst, J.J., Shlomi, T., Thompson, C.B., and Rabinowitz, J.D. (2014). Quantitative flux analysis reveals folatedependent NADPH production. Nature 510, 298-302.
-
(2014)
Nature
, vol.510
, pp. 298-302
-
-
Fan, J.1
Ye, J.2
Kamphorst, J.J.3
Shlomi, T.4
Thompson, C.B.5
Rabinowitz, J.D.6
-
21
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
-
Farber, S., and Diamond, L.K. (1948). Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl. J. Med. 238, 787-793.
-
(1948)
N Engl. J. Med
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.K.2
-
22
-
-
84965032167
-
Cancer immunotherapy: The beginning of the end of cancer?
-
Farkona, S., Diamandis, E.P., and Blasutig, I.M. (2016). Cancer immunotherapy: the beginning of the end of cancer? BMC Med. 14, 73.
-
(2016)
BMC Med
, vol.14
, pp. 73
-
-
Farkona, S.1
Diamandis, E.P.2
Blasutig, I.M.3
-
23
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007). Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819.
-
(2007)
Blood
, vol.109
, pp. 3812-3819
-
-
Fischer, K.1
Hoffmann, P.2
Voelkl, S.3
Meidenbauer, N.4
Ammer, J.5
Edinger, M.6
Gottfried, E.7
Schwarz, S.8
Rothe, G.9
Hoves, S.10
-
24
-
-
27744519400
-
Fuel feeds function: Energy metabolism and the T-cell response
-
Fox, C.J., Hammerman, P.S., and Thompson, C.B. (2005). Fuel feeds function: energy metabolism and the T-cell response. Nat. Rev. Immunol. 5, 844-852.
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
25
-
-
84886698315
-
Innate and adaptive immune cells in the tumor microenvironment. Nat
-
Gajewski, T.F., Schreiber, H., and Fu, Y.X. (2013). Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014-1022.
-
(2013)
Immunol
, vol.14
, pp. 1014-1022
-
-
Gajewski, T.F.1
Schreiber, H.2
Fu, Y.X.3
-
26
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pages, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006). Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964.
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
Tosolini, M.7
Camus, M.8
Berger, A.9
Wind, P.10
-
27
-
-
79957532451
-
Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness
-
Gimenez-
-
Giannoni, E., Bianchini, F., Calorini, L., and Chiarugi, P. (2011). Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid. Redox. Signal. 14, 2361-2371. Gimenez-Roqueplo, A.P., Favier, J., Rustin, P., Rieubland, C., Crespin, M., Nau, V., Khau Van Kien, P., Corvol, P., Plouin, P.F., Jeunemaitre, X., et al. (2003). Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res. 63, 5615-5621.
-
(2011)
Antioxid. Redox. Signal
, vol.14
, pp. 2361-2371
-
-
Giannoni, E.1
Bianchini, F.2
Calorini, L.3
Chiarugi, P.4
Roqueplo, A.P.5
Favier, J.6
Rustin, P.7
Rieubland, C.8
Crespin, M.9
Nau, V.10
Khau Van Kien, P.11
Corvol, P.12
Plouin, P.F.13
Jeunemaitre, X.14
-
28
-
-
79960029992
-
Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
-
Goetze, K., Walenta, S., Ksiazkiewicz, M., Kunz-Schughart, L.A., and Mueller-Klieser, W. (2011). Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int. J. Oncol. 39, 453-463.
-
(2011)
Int. J. Oncol
, vol.39
, pp. 453-463
-
-
Goetze, K.1
Walenta, S.2
Ksiazkiewicz, M.3
Kunz-Schughart, L.A.4
Mueller-Klieser, W.5
-
29
-
-
33344467760
-
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
-
Gottfried, E., Kunz-Schughart, L. A., Ebner, S., Mueller-Klieser, W., Hoves, S., Andreesen, R., Mackensen, A., and Kreutz, M. (2006). Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107, 2013-2021.
-
(2006)
Blood
, vol.107
, pp. 2013-2021
-
-
Gottfried, E.1
Kunz-Schughart, L.A.2
Ebner, S.3
Mueller-Klieser, W.4
Hoves, S.5
Reesen, R.6
Mackensen, A.7
Kreutz, M.8
-
30
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D., and Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
31
-
-
0030588630
-
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice
-
Hasko, G., Szabo, C., Nemeth, Z.H., Kvetan, V., Pastores, S.M., and Vizi, E.S. (1996). Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol. 157, 4634-4640.
-
(1996)
J. Immunol
, vol.157
, pp. 4634-4640
-
-
Hasko, G.1
Szabo, C.2
Nemeth, Z.H.3
Kvetan, V.4
Pastores, S.M.5
Vizi, E.S.6
-
32
-
-
51049101334
-
Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases. Nat
-
Hasko, G., Linden, J., Cronstein, B., and Pacher, P. (2008). Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug Discov. 7, 759-770.
-
(2008)
Rev. Drug Discov
, vol.7
, pp. 759-770
-
-
Hasko, G.1
Linden, J.2
Cronstein, B.3
Pacher, P.4
-
33
-
-
80054109170
-
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol
-
Hausler, S.F., Montalban del Barrio, I., Strohschein, J., Chandran, P.A., Engel, J.B., Honig, A., Ossadnik, M., Horn, E., Fischer, B., Krockenberger, M., et al. (2011). Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol. Immunother. 60, 1405-1418.
-
(2011)
Immunother
, vol.60
, pp. 1405-1418
-
-
Hausler, S.F.1
Montalban Del Barrio, I.2
Strohschein, J.3
Chandran, P.A.4
Engel, J.B.5
Honig, A.6
Ossadnik, M.7
Horn, E.8
Fischer, B.9
Krockenberger, M.10
-
34
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
-
Ho, P.C., Bihuniak, J.D., Macintyre, A.N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.C., Cui, G., Micevic, G., Perales, J.C., et al. (2015). Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 162, 1217-1228.
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
Bihuniak, J.D.2
Macintyre, A.N.3
Staron, M.4
Liu, X.5
Amezquita, R.6
Tsui, Y.C.7
Cui, G.8
Micevic, G.9
Perales, J.C.10
-
35
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu, P.P., and Sabatini, D.M. (2008). Cancer cell metabolism: Warburg and beyond. Cell 134, 703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
36
-
-
84938568011
-
Hypoxia induces production of L-2-hydroxyglutarate
-
Intlekofer, A.M., Dematteo, R.G., Venneti, S., Finley, L.W., Lu, C., Judkins, A.R., Rustenburg, A.S., Grinaway, P.B., Chodera, J.D., Cross, J.R., et al. (2015). Hypoxia induces production of L-2-hydroxyglutarate. Cell Metab. 22, 304-311.
-
(2015)
Cell Metab
, vol.22
, pp. 304-311
-
-
Intlekofer, A.M.1
Dematteo, R.G.2
Venneti, S.3
Finley, L.W.4
Lu, C.5
Judkins, A.R.6
Rustenburg, A.S.7
Grinaway, P.B.8
Chodera, J.D.9
Cross, J.R.10
-
37
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs, J.S., Jung, Y.J., Mole, D.R., Lee, S., Torres-Cabala, C., Chung, Y.L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. (2005). HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8, 143-153.
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
-
38
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A.L., Kafri, R., Kirschner, M.W., Clish, C.B., and Mootha, V.K. (2012). Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 1040-1044.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
39
-
-
84925545003
-
Metabolism in embryonic and cancer stemness
-
Jang, H., Yang, J., Lee, E., and Cheong, J.H. (2015). Metabolism in embryonic and cancer stemness. Arch. Pharm. Res. 38, 381-388.
-
(2015)
Arch. Pharm. Res
, vol.38
, pp. 381-388
-
-
Jang, H.1
Yang, J.2
Lee, E.3
Cheong, J.H.4
-
40
-
-
67650999875
-
The basics of epithelialmesenchymal transition
-
Kalluri, R., and Weinberg, R.A. (2009). The basics of epithelialmesenchymal transition. J. Clin. Invest. 119, 1420-1428.
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
41
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim, J.W., Tchernyshyov, I., Semenza, G.L., and Dang, C.V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177-185.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
42
-
-
84928395993
-
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
-
Kim, D., Fiske, B.P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R.L., Chudnovsky, Y., Pacold, M.E., Chen, W.W., Cantor, J.R., et al. (2015a). SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520, 363-367.
-
(2015)
Nature
, vol.520
, pp. 363-367
-
-
Kim, D.1
Fiske, B.P.2
Birsoy, K.3
Freinkman, E.4
Kami, K.5
Possemato, R.L.6
Chudnovsky, Y.7
Pacold, M.E.8
Chen, W.W.9
Cantor, J.R.10
-
43
-
-
84940467312
-
Core pluripotency factors directly regulate metabolism in embryonic stem cell to maintain pluripotency
-
Kim, H., Jang, H., Kim, T.W., Kang, B.H., Lee, S.E., Jeon, Y.K., Chung, D.H., Choi, J., Shin, J., Cho, E.J., et al. (2015b). Core pluripotency factors directly regulate metabolism in embryonic stem cell to maintain pluripotency. Stem Cells 33, 2699-2711.
-
(2015)
Stem Cells
, vol.33
, pp. 2699-2711
-
-
Kim, H.1
Jang, H.2
Kim, T.W.3
Kang, B.H.4
Lee, S.E.5
Jeon, Y.K.6
Chung, D.H.7
Choi, J.8
Shin, J.9
Cho, E.J.10
-
44
-
-
40949126440
-
Mitochondrial complex III regulates hypoxic activation of HIF
-
Klimova, T., and Chandel, N.S. (2008). Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ. 15, 660-666.
-
(2008)
Cell Death Differ
, vol.15
, pp. 660-666
-
-
Klimova, T.1
Chandel, N.S.2
-
45
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen, P., Lee, S., Duncan, C.G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J.A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012). Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483, 484-488.
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
Lopez, G.4
Lu, G.5
Ramkissoon, S.6
Losman, J.A.7
Joensuu, P.8
Bergmann, U.9
Gross, S.10
-
46
-
-
84878969599
-
SDH mutations establish a hypermethylator phenotype in paraganglioma
-
Letouze, E., Martinelli, C., Loriot, C., Burnichon, N., Abermil, N., Ottolenghi, C., Janin, M., Menara, M., Nguyen, A.T., Benit, P., et al. (2013). SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell 23, 739-752.
-
(2013)
Cancer Cell
, vol.23
, pp. 739-752
-
-
Letouze, E.1
Martinelli, C.2
Loriot, C.3
Burnichon, N.4
Abermil, N.5
Ottolenghi, C.6
Janin, M.7
Menara, M.8
Nguyen, A.T.9
Benit, P.10
-
47
-
-
84875496294
-
(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman, J.A., Looper, R.E., Koivunen, P., Lee, S., Schneider, R.K., McMahon, C., Cowley, G.S., Root, D.E., Ebert, B.L., and Kaelin, W.G. Jr. (2013). (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339, 1621-1625.
-
(2013)
Science
, vol.339
, pp. 1621-1625
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
Lee, S.4
Schneider, R.K.5
McMahon, C.6
Cowley, G.S.7
Root, D.E.8
Ebert, B.L.9
Kaelin, W.G.10
-
48
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu, C., Ward, P.S., Kapoor, G.S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C.R., Khanin, R., Figueroa, M.E., Melnick, A., et al. (2012). IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474-478.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
Edwards, C.R.7
Khanin, R.8
Figueroa, M.E.9
Melnick, A.10
-
49
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R.N., Pandey, A., and Semenza, G.L. (2011). Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145, 732-744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
50
-
-
0344708478
-
Anticancer antifolates: Current status and future directions
-
McGuire, J.J. (2003). Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9, 2593-2613.
-
(2003)
Curr. Pharm. Des.
, vol.9
, pp. 2593-2613
-
-
McGuire, J.J.1
-
51
-
-
84873160542
-
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells
-
Mimeault, M., and Batra, S.K. (2013). Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells. J. Cell Mol. Med. 17, 30-54.
-
(2013)
J. Cell Mol. Med
, vol.17
, pp. 30-54
-
-
Mimeault, M.1
Batra, S.K.2
-
52
-
-
78349252704
-
Quiescent, slow-cycling stem cell populations in cancer: A review of the evidence and discussion of significance
-
Moore, N., and Lyle, S. (2011). Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J. Oncol. 2011. pii: 396076
-
(2011)
J. Oncol
-
-
Moore, N.1
Lyle, S.2
-
53
-
-
34248173331
-
Indoleamine 2,3-dioxygenase and tumor-induced tolerance
-
Munn, D.H., and Mellor, A.L. (2007). Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117, 1147-1154.
-
(2007)
J. Clin. Invest
, vol.117
, pp. 1147-1154
-
-
Munn, D.H.1
Mellor, A.L.2
-
54
-
-
4143105824
-
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations
-
Neumann, H.P., Pawlu, C., Peczkowska, M., Bausch, B., McWhinney, S.R., Muresan, M., Buchta, M., Franke, G., Klisch, J., Bley, T.A., et al. (2004). Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA 292, 943-951.
-
(2004)
JAMA
, vol.292
, pp. 943-951
-
-
Neumann, H.P.1
Pawlu, C.2
Peczkowska, M.3
Bausch, B.4
McWhinney, S.R.5
Muresan, M.6
Buchta, M.7
Franke, G.8
Klisch, J.9
Bley, T.A.10
-
55
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou, I., Cairns, R.A., Fontana, L., Lim, A.L., and Denko, N.C. (2006). HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187-197.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
56
-
-
78649659788
-
PH control mechanisms of tumor survival and growth
-
Parks, S.K., Chiche, J., and Pouyssegur, J. (2011). pH control mechanisms of tumor survival and growth. J. Cell Physiol. 226, 299-308.
-
(2011)
J. Cell Physiol
, vol.226
, pp. 299-308
-
-
Parks, S.K.1
Chiche, J.2
Pouyssegur, J.3
-
57
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce, E.L., and Pearce, E.J. (2013). Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633-643.
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
58
-
-
84857136779
-
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
-
Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolusic, E., Frederick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B., et al. (2012). Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc. Natl. Acad. Sci. USA 109, 2497-2502.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 2497-2502
-
-
Pilotte, L.1
Larrieu, P.2
Stroobant, V.3
Colau, D.4
Dolusic, E.5
Frederick, R.6
De Plaen, E.7
Uyttenhove, C.8
Wouters, J.9
Masereel, B.10
-
59
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R., Marks, K.M., Shaul, Y.D., Pacold, M.E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.K., Jang, H.G., Jha, A.K., et al. (2011). Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
60
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., Tsoi, J., Clark, O., Oldrini, B., Komisopoulou, E., et al. (2013). An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630.
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
Tsoi, J.7
Clark, O.8
Oldrini, B.9
Komisopoulou, E.10
-
61
-
-
82755162136
-
Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
-
Ryzhov, S., Novitskiy, S.V., Goldstein, A.E., Biktasova, A., Blackburn, M. R., Biaggioni, I., Dikov, M.M., and Feoktistov, I. (2011). Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J. Immunol. 187, 6120-6129.
-
(2011)
J. Immunol
, vol.187
, pp. 6120-6129
-
-
Ryzhov, S.1
Novitskiy, S.V.2
Goldstein, A.E.3
Biktasova, A.4
Blackburn, M.R.5
Biaggioni, I.6
Dikov, M.M.7
Feoktistov, I.8
-
62
-
-
84969951574
-
Hallmarks of cancer stem cell metabolism
-
Sancho, P., Barneda, D., and Heeschen, C. (2016). Hallmarks of cancer stem cell metabolism. Br. J. Cancer 114, 1305-1312.
-
(2016)
Br. J. Cancer
, vol.114
, pp. 1305-1312
-
-
Sancho, P.1
Barneda, D.2
Heeschen, C.3
-
63
-
-
84989159124
-
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
-
Sciacovelli, M., Goncalves, E., Johnson, T.I., Zecchini, V.R., da Costa, A.S., Gaude, E., Drubbel, A.V., Theobald, S.J., Abbo, S.R., Tran, M.G., et al. (2016). Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 537, 544-547.
-
(2016)
Nature
, vol.537
, pp. 544-547
-
-
Sciacovelli, M.1
Goncalves, E.2
Johnson, T.I.3
Zecchini, V.R.4
Da Costa, A.S.5
Gaude, E.6
Drubbel, A.V.7
Theobald, S.J.8
Abbo, S.R.9
Tran, M.G.10
-
64
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak, M.A., Armour, S.M., MacKenzie, E.D., Boulahbel, H., Watson, D.G., Mansfield, K.D., Pan, Y., Simon, M.C., Thompson, C.B., and Gottlieb E. (2005). Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7, 77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
Mackenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
65
-
-
84859445000
-
Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
-
Semenza, G.L. (2012). Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci. 33, 207-214.
-
(2012)
Trends Pharmacol. Sci
, vol.33
, pp. 207-214
-
-
Semenza, G.L.1
-
66
-
-
84907302546
-
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
-
Shaul, Y.D., Freinkman, E., Comb, W.C., Cantor, J.R., Tam, W.L., Thiru, P., Kim D, Kanarek, N., Pacold, M.E., Chen, W.W., et al. (2014). Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 158, 1094-1109.
-
(2014)
Cell
, vol.158
, pp. 1094-1109
-
-
Shaul, Y.D.1
Freinkman, E.2
Comb, W.C.3
Cantor, J.R.4
Tam, W.L.5
Thiru, P.6
Kim, D.7
Kanarek, N.8
Pacold, M.E.9
Chen, W.W.10
-
67
-
-
84976902804
-
MERAV: A tool for comparing gene expression across human tissues and cell types
-
Shaul, Y.D., Yuan, B., Thiru, P., Nutter-Upham, A., McCallum, S., Lanzkron, C., Bell, G.W., and Sabatini, D.M. (2016). MERAV: a tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res. 44, D560-566.
-
(2016)
Nucleic Acids Res
, vol.44
, pp. D560-D566
-
-
Shaul, Y.D.1
Yuan, B.2
Thiru, P.3
Nutter-Upham, A.4
McCallum, S.5
Lanzkron, C.6
Bell, G.W.7
Sabatini, D.M.8
-
68
-
-
78649833819
-
The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
-
Siemann, D.W. (2011). The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. 37, 63-74.
-
(2011)
Cancer Treat. Rev
, vol.37
, pp. 63-74
-
-
Siemann, D.W.1
-
69
-
-
77957564570
-
Extracellular adenosine triphosphate and adenosine in cancer
-
Stagg, J., and Smyth, M. J. (2010). Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29, 5346-5358.
-
(2010)
Oncogene
, vol.29
, pp. 5346-5358
-
-
Stagg, J.1
Smyth, M.J.2
-
70
-
-
78649423015
-
Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats
-
Takahashi, T., Otsuguro, K., Ohta, T., and Ito, S. (2010). Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br. J. Pharmacol. 161, 1806-1816.
-
(2010)
Br. J. Pharmacol
, vol.161
, pp. 1806-1816
-
-
Takahashi, T.1
Otsuguro, K.2
Ohta, T.3
Ito, S.4
-
71
-
-
84892939615
-
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
-
Terunuma, A., Putluri, N., Mishra, P., Mathe, E.A., Dorsey, T.H., Yi, M., Wallace, T.A., Issaq, H.J., Zhou, M., Killian, J.K., et al. (2014). MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J. Clin. Invest, 124, 398-412.
-
(2014)
J. Clin. Invest
, vol.124
, pp. 398-412
-
-
Terunuma, A.1
Putluri, N.2
Mishra, P.3
Mathe, E.A.4
Dorsey, T.H.5
Yi, M.6
Wallace, T.A.7
Issaq, H.J.8
Zhou, M.9
Killian, J.K.10
-
72
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M.G., Cantley, L.C., and Thompson, C.B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
73
-
-
84958567892
-
Hypoxia-driven adenosine accumulation: A crucial microenvironmental factor promoting tumor progression
-
Vaupel, P., and Mayer, A. (2016). Hypoxia-driven adenosine accumulation: a crucial microenvironmental factor promoting tumor progression. Adv. Exp. Med. Biol. 876, 177-183.
-
(2016)
Adv. Exp. Med. Biol
, vol.876
, pp. 177-183
-
-
Vaupel, P.1
Mayer, A.2
-
74
-
-
79953059789
-
Natural innate and adaptive immunity to cancer. Annu
-
Vesely, M.D., Kershaw, M.H., Schreiber, R.D., and Smyth, M.J. (2011). Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 29, 235-271.
-
(2011)
Rev. Immunol
, vol.29
, pp. 235-271
-
-
Vesely, M.D.1
Kershaw, M.H.2
Schreiber, R.D.3
Smyth, M.J.4
-
75
-
-
84859450097
-
Cancer stem cells and drug resistance: The potential of nanomedicine
-
Vinogradov, S., and Wei, X. (2012). Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine 7, 597-615.
-
(2012)
Nanomedicine
, vol.7
, pp. 597-615
-
-
Vinogradov, S.1
Wei, X.2
-
76
-
-
84859955788
-
The antifolates
-
Visentin, M., Zhao, R., and Goldman, I.D. (2012). The antifolates. Hematol. Oncol. Clin. North Am. 26, 629-648, ix.
-
(2012)
Hematol. Oncol. Clin. North Am
, vol.26
, pp. 629-648
-
-
Visentin, M.1
Zhao, R.2
Goldman, I.D.3
-
77
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang, F., Travins, J., DeLaBarre, B., Penard-Lacronique, V., Schalm, S., Hansen, E., Straley, K., Kernytsky, A., Liu, W., Gliser, C., et al. (2013). Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340, 622-626.
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
Delabarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
Straley, K.7
Kernytsky, A.8
Liu, W.9
Gliser, C.10
-
78
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. (1956). On the origin of cancer cells. Science 123, 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
79
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward, P.S., Patel, J., Wise, D.R., Abdel-Wahab, O., Bennett, B.D., Coller, H.A., Fantin, V.R., Hedvat, C.V., Perl, A.E., Rabinowitz, J.D., et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Fantin, V.R.7
Hedvat, C.V.8
Perl, A.E.9
Rabinowitz, J.D.10
-
80
-
-
81155159685
-
Dysregulated pH: A perfect storm for cancer progression
-
Webb, B.A., Chimenti, M., Jacobson, M.P., and Barber, D.L. (2011). Dysregulated pH: a perfect storm for cancer progression. Nat. Rev. Cancer 11, 671-677.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 671-677
-
-
Webb, B.A.1
Chimenti, M.2
Jacobson, M.P.3
Barber, D.L.4
-
81
-
-
84862632865
-
Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012). Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338.
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
Liu, L.7
Liu, Y.8
Yang, C.9
Xu, Y.10
-
82
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutaratedependent dioxygenases
-
Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.H., Ito, S., Yang, C., Wang, P., Xiao, M.T., et al. (2011). Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutaratedependent dioxygenases. Cancer Cell 19, 17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
Ito, S.7
Yang, C.8
Wang, P.9
Xiao, M.T.10
-
83
-
-
84883513587
-
Oncometabolites: Linking altered metabolism with cancer
-
Yang, M., Soga, T., and Pollard, P.J. (2013). Oncometabolites: linking altered metabolism with cancer. J. Clin. Invest. 123, 3652-3658.
-
(2013)
J. Clin. Invest
, vol.123
, pp. 3652-3658
-
-
Yang, M.1
Soga, T.2
Pollard, P.J.3
-
84
-
-
84988431514
-
Serine and one-carbon metabolism in cancer
-
Yang, M., and Vousden, K.H. (2016). Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16, 650-662.
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 650-662
-
-
Yang, M.1
Vousden, K.H.2
-
85
-
-
84915746768
-
Serine catabolism regulates mitochondrial redox control during hypoxia
-
Ye, J., Fan, J., Venneti, S., Wan, Y.W., Pawel, B.R., Zhang, J., Finley, L.W., Lu, C., Lindsten, T., Cross, J.R., et al. (2014). Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4, 1406-1417.
-
(2014)
Cancer Discov
, vol.4
, pp. 1406-1417
-
-
Ye, J.1
Fan, J.2
Venneti, S.3
Wan, Y.W.4
Pawel, B.R.5
Zhang, J.6
Finley, L.W.7
Lu, C.8
Lindsten, T.9
Cross, J.R.10
-
86
-
-
84856087055
-
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
-
Zhang, W.C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B.S., Sun, L.L., Tai, B.C., Nga, M.E., et al. (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-272.
-
(2012)
Cell
, vol.148
, pp. 259-272
-
-
Zhang, W.C.1
Shyh-Chang, N.2
Yang, H.3
Rai, A.4
Umashankar, S.5
Ma, S.6
Soh, B.S.7
Sun, L.L.8
Tai, B.C.9
Nga, M.E.10
|