LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Cell Metabolism

Volumn 24, Issue 5, 2016, Pages 657-671

  Brand, Almut ^a   Singer, Katrin ^a   Koehl, Gudrun E ^a   Kolitzus, Marlene ^a   Schoenhammer, Gabriele ^a   Thiel, Annette ^a   Matos, Carina ^a   Bruss, Christina ^a   Klobuch, Sebastian ^a   Peter, Katrin ^a   Kastenberger, Michael ^a   Bogdan, Christian ^b   Schleicher, Ulrike ^b   Mackensen, Andreas ^b   Ullrich, Evelyn ^b,c   Fichtner Feigl, Stefan ^a   Kesselring, Rebecca ^a   Mack, Matthias ^a   Ritter, Uwe ^d   Schmid, Maximilian ^a,d   Blank, Christian ^e   Dettmer, Katja ^d   Oefner, Peter J ^d   Hoffmann, Petra ^a   Walenta, Stefan ^f   Geissler, Edward K ^a   Pouyssegur, Jacques ^g,h   Villunger, Andreas ^i,j   Steven, André ^k   Seliger, Barbara ^k   Schreml, Stephan ^a   Haferkamp, Sebastian ^a   Kohl, Elisabeth ^a   Karrer, Sigrid ^a   Berneburg, Mark ^a   Herr, Wolfgang ^a   Mueller Klieser, Wolfgang ^f   Renner, Kathrin ^a   Kreutz, Marina ^a   more..

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^f UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^g UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

^h CENTRE SCIENTIFIQUE DE MONACO   (Monaco)

ⁱ INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^j TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

^k MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LACTATE DEHYDROGENASE; LACTIC ACID; LACTIC DEHYDROGENASE A; RAG2 PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; CYTOKINE; ISOENZYME; LACTATE DEHYDROGENASE 5; LACTATE SODIUM;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER PROGNOSIS; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; LYMPHOCYTE FUNCTION; MALE; MELANOMA; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ESCAPE; TUMOR GROWTH; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; DRUG EFFECTS; GLYCOLYSIS; IMMUNOLOGY; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

ANIMALS; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; GLYCOLYSIS; HUMANS; IMMUNOLOGIC SURVEILLANCE; INTERFERON-GAMMA; ISOENZYMES; KILLER CELLS, NATURAL; L-LACTATE DEHYDROGENASE; LACTIC ACID; MALE; MELANOMA; MICE, INBRED C57BL; NFATC TRANSCRIPTION FACTORS; PHENOTYPE; SODIUM LACTATE; T-LYMPHOCYTES; UP-REGULATION;

EID: 84994592466     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.08.011     Document Type: Article

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