Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

Cancer Immunology, Immunotherapy

Volumn 60, Issue 10, 2011, Pages 1405-1418

  Häusler, Sebastian F M ^a   Montalbán Del Barrio, Itsaso ^a   Strohschein, Jenny ^a   Anoop Chandran, P ^a   Engel, Jörg B ^a   Hönig, Arnd ^a   Ossadnik, Monika ^a   Horn, Evi ^a   Fischer, Birgitt ^a   Krockenberger, Mathias ^a   Heuer, Stefan ^a   Seida, Ahmed Adel ^a   Junker, Markus ^a   Kneitz, Hermann ^a   Kloor, Doris ^b,c   Klotz, Karl Norbert ^a   Dietl, Johannes ^a   Wischhusen, Jörg ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Adenosine; CD39; CD73; Immune escape; Ovarian cancer

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5' NUCLEOTIDASE; ADENOSINE; ADENOSINE A2 RECEPTOR; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; BETA,GAMMA DIBROMOMETHYLENE 6 N,N DIETHYLADENOSINE TRIPHOSPHATE; CD39 ANTIGEN; SMALL INTERFERING RNA;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACELLULAR SPACE; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; OVARY CANCER; OVARY TUMOR; PHARMACOLOGICAL BLOCKING; PRIMARY TUMOR; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

5'-NUCLEOTIDASE; ADENOSINE; ANTIGENS, CD; APYRASE; CELL LINE, TUMOR; CELL SEPARATION; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; GPI-LINKED PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; OVARIAN NEOPLASMS; RECEPTOR, ADENOSINE A2A; RNA INTERFERENCE; T-LYMPHOCYTES;

EID: 80054109170     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1040-4     Document Type: Article

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